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An apparatus and method for magnetic particle manipulation enables the particle to be rotated and translated independently using magnetic fields and field gradients, which produce the desired decoupled translational and rotational motion. The apparatus and the method for manipulation may be implemented in parallel, involving many particles. The rotational magnetic field used to induce rotational motion may be varied to induce particle motion, which is either in phase or out of phase with the rotational magnetic field. The magnetic fields and gradients described herein may be generated with permanent magnets, electromagnets, or some combination of permanent magnets and electromagnets.


Patent
Weinberg Medical Physics LLC | Date: 2016-11-04

An apparatus and method for stimulating one or more cells within a subjects brain by one or more magnetizable particles under the influence of at least one coil, wherein the coil is located outside the body of the subject, and is used to visualize and move the one or more magnetizable particles and to visualize the subjects underlying anatomy containing the one or more cells.


An apparatus and method for magnetic particle manipulation enables the particle to be rotated and translated independently using magnetic fields and field gradients, which produce the desired decoupled translational and rotational motion. The apparatus and the method for manipulation may be implemented in parallel, involving many particles. The rotational magnetic field used to induce rotational motion may be varied to induce particle motion, which is either in phase or out of phase with the rotational magnetic field. The magnetic fields and gradients described herein may be generated with permanent magnets, electromagnets, or some combination of permanent magnets and electromagnets.


Patent
Weinberg Medical Physics LLC | Date: 2015-10-05

An apparatus and method apply magnetic fields by generators external to a body or body part with sensors within an in vivo source that are sensitive to applied magnetic fields Through the use of these applied magnetic fields and sensitive sensors, disclosed embodiments can realize much better spatial resolution than is conventionally possible.


Grant
Agency: NSF | Branch: Standard Grant | Program: | Phase: SMALL BUSINESS PHASE II | Award Amount: 1.05M | Year: 2014

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is the development of a cost-effective replacement to x-ray-based imaging devices currently used in dentistry. Several peer-reviewed scientific studies have suggested a link between pediatric exposure to x-rays and subsequent development of head tumors. The recent introduction of CT-based dental imaging systems has actually increased x-ray exposure, going against the long-established public health policy of reducing exposure to levels as low as reasonably acceptable (ALARA). This project will provide a cost-effective alternative to dental x-rays (and hence reduce pediatric radiation exposure). The device will also improve the depiction of root disease, which is currently poorly described with x-ray-based systems. The ability to describe both hard and soft tissues with the instrument is valuable to oral surgeons, who must consider the cosmetic results of reconstructive surgery as well as the functional aspects. Commercial impact is demonstrated by the fact that a chain of 2,500 dental clinics, intrigued by the ability of the system to guide oral surgery, has already offered to invest in the project.

The proposed project involves the development of several novel and important research activities that address critical requirements of dental imaging: speed, spatial resolution, avoidance of imaging artifacts due to oral hardware, safety, spatial footprint, cost, and energy budget. The first three of these requirements are addressed through the use of MRI gradient pulses that are hundreds of times faster and stronger than are conventionally used. Safety, energy and spatial footprint, and cost are addressed with novel coil manufacturing techniques that reduce fabrication time from months to days. Energy costs are addressed with novel regenerative schemes similar to those used in hybrid cars. By the end of the project, a working MRI dental system will have been constructed, with demonstrations of its effectiveness (on animal specimens). These steps will ready the product for subsequent human studies that will be required for approval by the FDA. Follow-on applications of the technology to non-dental uses (e.g., trauma, cancer detection) are anticipated.


Grant
Agency: Department of Commerce | Branch: National Institute of Standards and Technology | Program: SBIR | Phase: Phase II | Award Amount: 298.71K | Year: 2016

New shape-engineered iron-based microscopic contrast agents (MCAs) for magnetic resonance imaging promise to increase diagnostic accuracy while reducing side effects, and enhance scientists’ ability to track stem cells. Currently, techniques used for making multispectral microscale contrast agent particles are cost prohibitive. In Phase I, an innovative technique (employing template-guided electroplating in a roll-to-roll construct) which combines the low cost of chemical synthesis methods, the high uniformity of template-based methods, and the high throughput of automated manufacturing methods to deliver a process for large-scale, cost-effective manufacturing of the new MCAs was described. In Phase II, the Phase I prototype process will be upgraded to include a section that will metallize PCTE reel stock in order to reduce costs, and another section which will measure the NMR resonance shift properties of the particles in situ in order to achieve high particle uniformity. Low-cost production and development of standard operating procedures that will assist in Phase III migration to contract manufacturing facilities will be demonstrated.


Disclosed embodiments enable apparatus and methodologies that are provided for three-dimensional construction of tissues in the body at locations internal to the body.


Patent
Weinberg Medical Physics LLC | Date: 2015-10-26

A method of fabrication produces one or more functional microparticles using a parallel pore working piece. In one embodiment, the method forms a particle that includes a segment for the oxidation of a biofuel (such as glucose) and the reduction of oxygen. The particle may be synthesized in a structure with defined and parallel, uniform, thin pores that completely penetrate the structure. Further, the functional microparticle may be configured to reside in a human or animal body or cell such that it may be self-contained fuel cell having an anode, a cathode, a separator membrane, and a magnetic component. In other embodiments, the functional microparticles may deliver energy or therapeutic materials in the body.


Grant
Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: SBIR | Phase: Phase II | Award Amount: 989.68K | Year: 2016

The company has shown that with by using ultra fast strong gradients inexpensive low field MRI systems can collect images that are comparable in quality signal to noise ratio resolution to conventional e g T MRI The company already has made large strides in commercializing this advantage by conducting human studies with a prototype and by attracting investors The prototype was built with th century technology e g electrolytic capacitors and cryogenic coils which were bulky and do not lend themselves to mass production In the proposed effort we will improve manufacturing capability by upgrading the electronics and power storage sub systems of our low field MRI without compromising image quality These new subsystem designs are based on ultra capacitor technology originally developed for hybrid cars and electropermanent magnets originally designed for drones The low field systems will be used in neuro operating rooms neuro ICUs battlefields athletic fields etc Inquiries for the product have come from serious distributors of products in the fields of neurology brain surgery trauma oncology and otolaryngology some of whom have already invested in the company Documentation of this interest from a subset of interested partners and or investors is included in the Letters of Support section of this proposal The company has shown that with by using ultra fast strong gradients inexpensive low field MRI systems can collect images that are comparable in quality to conventional MRI The company already has made large strides in commercializing this advantage by conducting human studies with a prototype and by attracting investors In the proposed effort we will improve manufacturing capability by upgrading the electronics and power storage sub systems of our low field MRI without compromising image quality


Patent
Weinberg Medical Physics LLC | Date: 2015-02-05

An apparatus, and method of constructing such an apparatus, conducts and insulates materials with intervening coolant channels, wherein the conducting materials form an electromagnet.

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