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Tian L.-W.,CAS Kunming Institute of Botany | Tian L.-W.,University of Chinese Academy of Sciences | Xu M.,CAS Kunming Institute of Botany | Li Y.,CAS Kunming Institute of Botany | And 7 more authors.
Chemistry and Biodiversity | Year: 2012

Three new phenolic compounds, eucalmaidin F (1), (3S)-5-guaiacyl-3- hydroxypentanoic acid (2), and 8-β-C-glucopyranosyl-5,7-dihydroxy-2- isobutylchromone (3), were isolated from the branches of E. maideni, together with 30 known compounds, including four phenylpropanoids, three lignans, four phloroglucinol glucosides, five dihydroflavonoids, seven simple phenolic compounds, six terpenoids, and glycerol. The new structures were established by spectroscopic studies (MS, and 1D- and 2D-NMR), chemical degradation, and modified Mosher's method. Compounds 3, guaiacylglycerol, 3-hydroxy-1-(4- hydroxyphenyl)propan-1-one, caffeic acid, (2E)-3-(4-hydroxyphenyl)prop-2-enoic acid, (7′S,8R,8′R)-lyoniresinol, (+)-lyoresinol 3α-O-α- L-rhamnopyranoside, garcimangosone, phlorocetophenone 2′-glucopyranoside, (+)-taxifolin 3α-O-α-L-rhamnopyranoside, (+)-aromadendrin, (+)-taxifolin, resveratrol, piceatannol, 3,4,5-trihydroxyphenol. Tachiaside, gallic acid, macrocapals A und G, and oleuropeic acid were evaluated for their cytotoxicities against five human cancer cell lines. Resveratrol, piceatannol, gallic acid, and macrocapal G exhibited moderate inhibitory effects on human myeloid heukemia HL-60 cell, with IC 50 values of 22.05, 22.05, 7.75, and 31.93μM, respectively; and only macrocapal G showed inhibitory effect on hepatocellular carcinoma SMMC-7721 cell, with an IC 50 value of 26.75μM. Copyright © 2012 Verlag Helvetica Chimica Acta AG, Zürich. Source


Zhou M.,CAS Kunming Institute of Botany | Zhou M.,University of Chinese Academy of Sciences | Xu M.,CAS Kunming Institute of Botany | Wang D.,CAS Kunming Institute of Botany | And 4 more authors.
Helvetica Chimica Acta | Year: 2011

Phytochemical investigation of the rhizomes of Panax japonicus C. A. Meyer (Araliaceae) resulted in the isolation of two new dammarane-type triterpenoid saponins, yesanchinoside R1 (1) and yesanchinoside R2 (2), together with one new natural product, 6‴-O-acetylginsenoside Re (3). In addition, 25 known compounds, including 23 triterpenoid saponins, 4-26, β-sitosterol 3-O-β-D-glucopyranoside (27), and ecdysterone (28), were also identified. The known saponins 12, 15, and 18-22 were reported for the first time from the title plant. Their structures were elucidated on the basis of detailed spectroscopic analyses, including 1D- and 2D-NMR techniques, as well as acidic hydrolysis. Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich, Switzerland. Source


Wang X.-Y.,CAS Kunming Institute of Botany | Wang X.-Y.,Henan University | Xu M.,CAS Kunming Institute of Botany | Yang C.-R.,CAS Kunming Institute of Botany | And 2 more authors.
Food Chemistry | Year: 2011

The seed of Michelia hedyosperma Law (Magnoliaceae) is a commonly used spice by the local people living in the south of Yunnan province, China. From which, six new phenylpropanoid glycosides, michehedyosides A-F (1-6) were obtained, in addition to six known compounds, eugenol, eugenol 4-O-β-d-glucopyranoside, martynoside, alaschanioside C, 3,4-methylenedioxycinnamyl alcohol, and (+)-pinoresinol 4-O-β-d-glucoside. Their structures were elucidated on the basis of detailed spectroscopic analyses and chemical methods. © 2010 Elsevier Ltd. All rights reserved. Source


Tian L.-W.,CAS Kunming Institute of Botany | Tian L.-W.,University of Chinese Academy of Sciences | Yang C.-R.,CAS Kunming Institute of Botany | Yang C.-R.,Weihe Biotech Research and Development Center | Zhang Y.-J.,CAS Kunming Institute of Botany
Helvetica Chimica Acta | Year: 2010

Four new phenolic compounds, 7-O-methylcatechin 5-O-β-D- glucopyranoside (1), 6-O-feruloyl-D-glucopyranose (2), demethylpiperitol 4-O-β-D-glucopyranoside (3), and 2-episesaminol 2-O-β-D- glucopyranoside (4) were isolated from the fresh leaves of Eucalyptus maideni, together with six hydrolyzable tannins, 5-10, a flavonol glycoside, 11, three simple phenolics, 12-14, a monoterpene glucoside, 15, and a rosenoside, 16. Their structures were determined on the basis of detailed spectroscopic analysis, acidic hydrolysis, and enzymatic hydrolysis. The known compounds 10 and 13 were obtained from the genus Eucalyptus for the first time. © Copyright 2010 Verlag Helvetica Chimica Acta AG, Zürich, Switzerland. Source


Pei Y.,Jinan University | Du Q.,Jinan University | Liao P.-Y.,CAS Kunming Institute of Botany | Liao P.-Y.,Guangxi Traditional Chinese Medical University | And 7 more authors.
Journal of Asian Natural Products Research | Year: 2011

Further study on steam-treated notoginseng, the roots of Panax notoginseng (Burk.) F.H. Chen (Araliaceae), which is a famous traditional Chinese medicine that is used both in raw and treated forms for a long time, led to the isolation of a new dammarane-type saponin, namely notoginsenoside ST-4. Its structure was elucidated to be 3β,12β,20(S)-tri-hydroxydammar-24-ene-3-O-β-d- xylopyranosyl-(1→2)-β-d-glucopyranosyl-(1→2)-β-d-glu- copyranoside, based on the detailed analyses of the 1D and 2D NMR spectral data and acidic hydrolysis. Notoginsenoside ST-4 was investigated for its antiviral activity on herpes simplex type 1 (HSV-1) and type 2 (HSV-2) in vitro. The 50% effective concentration (EC50) values, determined by plaque reduction assay, were 16.47±0.67 and 19.44±1.16μM for HSV-1 and HSV-2, respectively, whereas the 50% cytotoxic concentration (CC50) determined by the XTT test on Vero cells was 510.64±4.56μM. As analyzed by attachment assay and penetration assay based on plaque reduction assay, the antiviral activity of notoginsenoside ST-4 was principally due to the penetration inhibition effects, which was confirmed by fluorescence microscopy observation that notoginsenoside ST-4 blocked the penetration of virus. Therefore, notoginsenoside ST-4 might be a promising agent for herpes simplex virus infection. © 2011 Taylor & Francis. Source

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