Weihe Biotech Laboratory

Yuxi, China

Weihe Biotech Laboratory

Yuxi, China
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Zhu L.-F.,CAS Kunming Institute of Botany | Zhu L.-F.,University of Chinese Academy of Sciences | Xu M.,CAS Kunming Institute of Botany | Zhu H.-T.,CAS Kunming Institute of Botany | And 5 more authors.
Journal of Agricultural and Food Chemistry | Year: 2012

Camellia taliensis (W. W. Smith) Melchior, belonging to the genus Camellia sect. Thea (Theaceae), is an endemic species distributed from the west and southwest of Yunnan province, China, to the north of Myanmar. Known as a wild tea tree, its leaves have been used commonly for producing tea beverages by the local people of its growing area. One new flavan-3-ol dimer, talienbisflavan A (1), was isolated from green tea prepared from the leaves of C. taliensis collected from the east side of the Ai-Lao mountains, Yuanjiang county of Yunnan province, China. In addition, five hydrolyzable tannins (2-6), five flavonols and flavonol glycosides (9-13), three flavan-3-ols (14-16), nine simple phenolic compounds and glycosides (7, 8, and 17-23), and caffeine (24) were identified. Their structures were determined by detailed spectroscopic analysis. All of the isolated phenolic compounds were tested for their antioxidant activities by DPPH and ABTS+ radical scavenging assays. The contents of its main chemical compositions were also compared with those collected from the Lincang area of Yunnan province by high-performance liquid chromatography analysis. © 2012 American Chemical Society.


Xu M.,CAS Kunming Institute of Botany | Zhang M.,CAS Kunming Institute of Botany | Wang D.,CAS Kunming Institute of Botany | Yang C.-R.,CAS Kunming Institute of Botany | And 2 more authors.
Chemistry and Biodiversity | Year: 2011

Gentiana rhodantha Franch. ex Hemsl. (Gentianaceae), an annual herb widely distributed in the southwest of China, has been medicinally used for the treatment of inflammation, cholecystitis, and tuberculosis by the local people of its growing areas. Chemical investigation on the whole plants led to the identification of eight new phenolic compounds, rhodanthenones A-D (1-4, resp.), apigenin 7-O-glucopyranosyl-(1→3)-glucopyranosyl-(1→3)- glucopyranoside (5), 1,2-dihydroxy-4-methoxybenzene 1-O-α-L- rhamnopyranosyl-(1→6)-β-D-glucopyranoside (6), 1,2-dihydroxy-4,6- dimethoxybenzene 1-O-α-L-rhamnopyranosyl-(1→6)-β-D- glucopyranoside (7), and methyl 2-O-β-D-glucopyranosyl-2,4,6- trihydroxybenzoate (8), together with eleven known compounds, 9-19. Their structures were determined on the basis of detailed spectroscopic analyses and chemical methods. Acetylcholinesterase (AChE) inhibition and cytotoxicity tests against five human cancer cell lines showed that only rhodanthenone D (4) and mangiferin (12) exhibited 18.4 and 13.4% of AChE inhibitory effects at a concentration of 10 -4 M, respectively, while compounds 1-5 and the known xanthones lancerin (11), mangiferin (12), and neomangiferin (13) displayed no cytotoxicity at a concentration of 40 μM. Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich.


Xu M.,CAS Kunming Institute of Botany | Zhang Y.-J.,CAS Kunming Institute of Botany | Li X.-C.,University of Mississippi | Jacob M.R.,University of Mississippi | Yang C.-R.,Weihe Biotech Laboratory
Journal of Natural Products | Year: 2010

Six new steroidal saponins (1-6), angudracanosides A-F, were isolated from fresh stems of Dracaena angustifolia, together with eight known compounds. The structures of compounds 1-6 were determined by detailed spectroscopic analyses and chemical methods. Antifungal testing of all compounds showed that 6 and 7 were active against Cryptococcus neoformans with IC50s of 9.5 and 20.0 μg/mL, respectively. © 2010 The American Chemical Society and American Society of Pharmacognosy.


Xua M.,CAS Kunming Institute of Botany | Yanga C.-R.,CAS Kunming Institute of Botany | Yanga C.-R.,Weihe Biotech Laboratory | Zhang Y.-J.,CAS Kunming Institute of Botany
Helvetica Chimica Acta | Year: 2010

Two new steroidal bisdesmosides, cambodracanosides A and B (1 and 2, resp.), were isolated from the fresh stems of Dracaena cambodiana, together with seven known glycosides. The structures of the new saponins were elucidated on the basis of detailed spectroscopic analyses, including 1D- and 2D-NMR techniques, and acidic hydrolysis. © 2010 Verlag Helvetica Chimica Acta AG.

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