Time filter

Source Type

Yan S.,Peoples Hospital of Jiangsu Province | Xu D.,Nanjing Medical University | Wang P.,Weifang Maternal and Child Health Hospital | Weng P.,Nanjing Medical University | And 14 more authors.
Tumor Biology | Year: 2014

Methylenetetrahydrofolate reductase (MTHFR) has been demonstrated to be involved in carcinogenesis. Increasing individual studies have investigated the role of MTHFR C677T polymorphism in gastric cancer pathogenesis, but with inconsistent findings. The aim of this study was to clarify the potential association of the MTHFR C677T polymorphism with gastric cancer risk by pooling all available data from published case-control studies. We searched the PubMed, Embase, Web of Science, and Wanfang databases for all relevant publications to date. The pooled odds ratio (OR) with corresponding 95 % confidence interval (95 % CI) was calculated. Stratified analysis and sensitivity analysis were also carried out to estimate the strength of this association. A total of 25 case-control studies with 6,572 cases and 9,584 controls were retrieved. Overall, the ORs under five contrast models indicated that the MTHFR C677T variant was positively associated with gastric cancer risk (ORT vs. C = 1.21, 95 % CI 1.10-1.34, P OR < 0.001; ORTT vs. CC = 1.47, 95 % CI 1.22-1.76, P OR < 0.001; ORTC vs. CC = 1.20, 95 % CI 1.03-1.40, P OR = 0.022; ORTT + TC vs. CC = 1.27, 95 % CI 1.10-1.47, P OR = 0.001; ORTT vs. CC + TC = 1.29, 95 % CI 1.15-1.46, P OR < 0.001). Stratified analyses according to ethnicity and source of controls further confirmed the significant correlations. The current meta-analysis provides strong evidence that the MTHFR C677T polymorphism may be a risk factor for gastric cancer among Asians and Caucasians. © 2013 International Society of Oncology and BioMarkers (ISOBM).


Gao J.,Weifang Maternal and Child Health Hospital | Yue B.,Weifang Maternal and Child Health Hospital | Li H.,Weifang Chest Hospital | Chen R.,Weifang Maternal and Child Health Hospital | And 2 more authors.
Experimental and Therapeutic Medicine | Year: 2015

Mycoplasma pneumoniae plays an important role in community-acquired pneumonia. However, epidemiological and clinical studies on the segmental/lobar pattern (S/L) radiographic-pathologic subtype of pediatric Mycoplasma pneumoniae pneumonia (MPP) are rare. The current study retrospectively analyzed the epidemiological and clinical characteristics of pediatric MPP patients. A total of 1,933 children with MPP received treatment at a single hospital between 2000 and 2009, of which 684 (35.4%) were diagnosed with S/L-MPP. The annual incidence of S/L-MPP in children with MPP increased throughout the duration of this study (from 6.4 to 59.6%, P<0.001), which was particularly evident after 2003. S/L-MPP was predominantly found in pre-school-aged children (4-6 years old; 56.6%). Compared with non-S/L-MPP, S/L-MPP was more closely associated with severe manifestations, including higher rates of fever (90.2 vs. 83.3%), pleural effusion (3.9 vs. 1.3%), extrapulmonary manifestations (26.2 vs. 21.2%), abnormal white blood cell counts (65.5 vs. 55.2%), abnormal C-reactive protein levels (30.9 vs. 23.7%) and bacterial co-infection (32.0 vs. 24.9%), as well as longer durations of fever (4.13±4.28 vs. 3.02±2.22 days) and hospitalization (12.70±4.54 vs. 9.22±5.12 days). Older S/L-MPP patients showed higher rates and longer durations of fever and cough; however, they also displayed a lower rate of extrapulmonary manifestations when compared with younger patients. In conclusion, the annual incidence of S/L-MPP has increased in recent years. Pre-school-aged children (4-6 years) with MPP are more likely to display a segmental/lobar pattern, which is associated with more severe clinical manifestations than other MPP infection patterns. © 2015, Spandidos Publications. All rights reserved.


Wang X.,Qingdao University | Ge L.,Qingdao University | Cui Y.,Qingdao University | Lang C.,Weifang Maternal and Child Health Hospital | Hao C.,Qingdao University
International Journal of Fertility and Sterility | Year: 2014

FSH-secreting pituitary adenomas can affect sexual and reproductive function. In this article, we have reported the case of a 32-year-old male with secondary infertility. The patient had sexual and reproductive disturbances. The test results of the blood samples indicated obviously decreased testosterone (T) and estradiol (E2) levels. Based on previous hormonal results, the patient received pituitary stimulation and human chorionic gonadotropin (hCG) tests. Both follicle stimulating hormone (FSH) and luteinizing hormone (LH) showed low response during the pituitary stimulation test. The results of the hCG test indicated that T/E2 could recover to a normal level. In addition, this patient was diagnosed with pituitary macroadenoma, which was supported by the pituitary MRI. The man's sexual and reproductive functions recovered following surgery. The pathological results confirmed that the tumor tissue was an FSH-secreting pituitary adenoma by immunohistochemical staining. The purpose of this report was to review the relative literature and discuss the influence of FSH-secreting pituitary adenomas on hormones through the hypothalamus-pituitary-testis axis.


Wang L.,Weifang Maternal and Child Health Hospital | Ma K.,Weifang Medical University | Wang Z.,Weifang Maternal and Child Health Hospital | Mou Y.,Weifang Maternal and Child Health Hospital | And 2 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

Purpose: The objective of this study was to evaluate the influence of the TNF-α rs1800629 polymorphism on the risk of cervical cancer. Methods: A comprehensive search of EMBASE, PubMed, Wanfang database and China National Knowledge Infrastructure (CNKI) was conducted and the papers published were retrieved. The fixed effects or random effects model was appropriately used to calculate the odds ratio (OR) along with 95% confidence interval (CI). Results: Data from sixteen articles containing nineteen studies were summarized in this meta-analysis. In general, we observed a marginal association between the TNF-α rs1800629 polymorphism and cervical cancer risk under the AA + AG vs. GG comparison model (OR=1.17, 95% CI=1.00-1.38, P=0.019 for heterogeneity). Interestingly, significantly increased risk was observed in the allele model (A vs. G: OR=1.19, 95% CI=1.02-1.38, P=0.006 for heterogeneity). In the stratified analysis by ethnicity, we found significant results in Caucasians. Conclusions: Our results reveal that the Caucasian population may be at increased risk of developing invasive cervical cancer associated with the TNF-α rs1800629 polymorphism. © 2015, Int J Clin Exp Med.All rights reserved.


Zhang W.,Shandong University | Tian X.,Shandong University | Tian X.,Weifang Maternal and Child Health Hospital | Mumtahana F.,Shandong University | And 6 more authors.
BMC Cancer | Year: 2015

Background: Recently, it is found that T-helper (Th) 22 cells are involved in different types of autoimmune and tumor diseases. But, till now, no study has been carried out to understand the involvement of these cells in cervical cancer (CC). Methods: Flow cytometry was used to determine the expression of interferon gamma (IFN-γ), Interleukin-22 (IL-22), IL-17 in the peripheral blood of healthy controls (HC), CIN and cervical cancer patients. From peripheral blood mononuclear cells (PBMCs), mRNA expression levels of Aryl hydrocarbon receptor (AHR), RAR-related orphan receptor C (RORC), TNF-aα and IL-6 were respectively determined. Using the method of ELISA, plasma concentrations of IL-22, IL-17 and TNF-aα were examined. Results: Th22 and Th17 cells were elevated in CC and CIN patients. Th1 cells and the plasma concentrations of IL-22 in CC patients were significantly increased compared with HC. In CC patients, an increased prevalence of Th22 cells was associated with lymph node metastases. There was a positive correlation between Th22 and Th17 cells, but an approximately negative correlation between Th22 and Th1 cells in CC patients. The mRNA expression of RORC, TNF-aα and IL-6 was significantly high in CC patients. Conclusions: Our results indicate that there is a higher circulatory frequency of Th22, Th17 and Th1 cells in CC which may conjointly participate in the pathogenesis and growth of CC. © 2015 Zhang et al.


Mou Y.,Weifang Maternal and Child Health Hospital | Wang L.,Weifang Maternal and Child Health Hospital | Xiu X.,Weifang Maternal and Child Health Hospital | Ma L.,Weifang Maternal and Child Health Hospital | Fan L.,Weifang Maternal and Child Health Hospital
International Journal of Clinical and Experimental Pathology | Year: 2016

Aims: The purpose of the study was to investigate the expression level of serum pigment epithelium derived factor (PEDF) and analyze the relationship of serum PEDF concentration with blood lipid in pregnant women with gestational diabetes mellitus (GDM). Methods: 40 GDM pregnant women (case group) in obstetrics clinic of Weifang Maternal and Child Health Hospital and 40 healthy pregnant women (control group) were enrolled into this study. Serum PEDF concentration, blood biochemistry, and clinical features were tested in 24-28 weeks of pregnancy. Results: Compared to the control group the following factors levels were all higher in GDM group, including serum PEDF, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C), fasting blood glucose (FBG), blood glucose 1 h after oral glucose tolerance test (OGTT), blood glucose 2 h after OGTT, and homeostasis model assessment of insulin resistance (HOMA-IR), and the differences were statistical significance (P<0.01). However, the serum high-density lipoprotein (HDL-C) and adiponectin levels were lower in GDM group than in control group (P<0.05). Moreover, the univariate analyses showed that serum PEDF level had positive correlation with FBG, TC, TG, LDL-C, and HOMA-IR levels but negative correlation with adiponectin. In multiple linear regression analysis, the serum PEDF level was independently associated with TG, FBG, and HOMA-IR (P<0.05). Conclusion: Serum PEDF concentration was higher in GDM pregnant women than in healthy pregnant women. Independent correlation existed between serum PEDF concentration and TG, FBG, and HOMA-IR levels, which indicated that serum PEDF could serve as a new marker for GDM.

Loading Weifang Maternal and Child Health Hospital collaborators
Loading Weifang Maternal and Child Health Hospital collaborators