Agency: GTR | Branch: EPSRC | Program: | Phase: Research Grant | Award Amount: 5.00M | Year: 2013
Capsule endoscopy for medical diagnosis in the gastrointestinal (GI) tract has emerged only in the past 10 years. Now established in pillcams, which have benefitted more than 1 m patients worldwide, it is a clear candidate for further innovation. Most capsule endoscopy devices record and transmit video data representing the visual appearance of the inside of the gut, but work has begun on other diagnostic techniques, such as the measurement of pH, and there has been some research into the use of capsules for treatment as well. Medical ultrasound imaging is a safe, inexpensive technique which can be applied in real-time at the point of care. Ultrasound is also capable of treatment through focused ultrasound surgery and, in research, for targeted drug delivery. The core of the Sonopill programme is the exploration of ultrasound imaging and therapeutic capabilities deployed in capsule format. This will be supported by extensive pre-clinical work to demonstrate the complementary nature of ultrasound and visual imaging, along with studies of multimodal diagnosis and therapy, and of mechanisms to control the motion of the Sonopill as it travels through the GI tract. This brings research challenges and opportunities in areas including ultrasound device and systems design, microengineering and microelectronic packaging, autonomous capsule positioning, sensor suites for diagnosis and intervention, and routes to translation into clinical practice. Our carefully structured but open-ended approach maximises the possibility to meet these research challenges while delivering for the UK a sustainable international lead in multimodality capsule endoscopy, to provide greater capabilities for the clinician, more acceptable practice for the patient population, and lower costs for economic wellbeing.
Agency: Department of Defense | Branch: Air Force | Program: SBIR | Phase: Phase I | Award Amount: 149.60K | Year: 2015
ABSTRACT:This proposal describes an approach to meeting AFRLs goals of upgrading MEVA to accurately assess the cumulative damage effects of Multi-Hit targeting scenarios. The approach makes use of WAIs coupled NLFlex/VCFD software for the HFPB computational component of this effort and leverages WAIs wide ranging experience in using HFPB modeling to simulate the response of the full range of structural construction types to threats of interest. It also relies on WAIs experience in developing innovative FRM tools for evaluating blast effects of concrete components including breach and secondary debris and familiarity with the MEVA software.BENEFIT:The primary benefit of this R&D will be the extension of MEVA to address multi-strike attacks on high strength RC bunkers. The primary market for the cumulative damage blast response modules developed under this project would be DOD organizations in the U.S. For example, DTRA develops and maintains the IMEA software for offensive targeting needs and VAPO for terrorist threats to civil construction. The new modules have potential application to both VAPO and IMEA. A previous example of this type of commercialization synergy was the Multi-hit Progressive Collapse (MPC) FRM developed by WAI under AFRL funding for inclusion within the MEVA software. At a later date, WAI received funding from DTRA to extend the steel connection modeling capabilities of MPC. Once this extension was completed, DTRA funded WAI to incorporate MPC within DTRAs VAPO software. And more recently, the Department of Homeland Security funded WAI to incorporate MPC capability within its UrbanBlast software. UrbanBlast is a FRM tool developed under funding from DHS for quantifying blast pressure fields and structural damage (including collapse) resulting from vehicle borne threats in urban settings.
Agency: Department of Defense | Branch: Air Force | Program: SBIR | Phase: Phase I | Award Amount: 149.92K | Year: 2015
ABSTRACT:The main objective of the proposed work is to develop and implement a Multiscale-Multiphysics analysis tool for design, development and analysis CMC components. The multiscale-multiphysics analysis methodology will effectively capture the complex multi-axial stress states in SiC-SiC based CMC sub-elements and components under relevant operating conditions. The unique features of the Multiscale-Multiphysics analysis tool are as enumerated below: Ability to model inherent heterogeneities including manufacturing defects that exist at the microscale and upscale their effect on the response at the structural scale Micromechanics models at the fine scale of interest to characterize damage and failure in the CMC constituent phases Coupled multiphysics based models to determine the environmental degradation of mechanical properties due to oxygen embrittlement at elevated temperatures A temporal-multiscale approach based fatigue life prediction model Material calibration module to characterize properties of the fine scale constituents Model reduction techniques for robustness and computation efficiency The deliverable will be in the form of a plugin for Abaqus or any other commercial finite element (FE) package used by OEMs. The software tool is envisaged to facilitate OEMs in testing of new designs and offer tremendous savings in cost and time during the development process prior to full scale component testing. BENEFIT:The current thrust areas for technology development in CMCs include small component fabrication, ceramic joining and integration, material and component testing and characterization and design and analysis of concept components. As these manufacturing technologies mature, more and more of the metal-alloy based hot section components will be replaced by components made from CMCs. And as the applications of CMCs grow, the market for failure and fatigue life prediction technologies is also expected to grow significantly. The proposed comprehensive analysis tool will not only allow for strength and life prediction of CMC sub-elements and components, but also create a general framework for future development. The features of the spatial-multiscale approach allows microstructural details including imperfections to be taken into account. The multiphysics aspect incorporates constitutive relations to model coupled physical phenomena occurring at the microstructural length scale. The temporal multiscale feature allows the physical phenomena of cyclic loading and the resulting damage progression to be resolved under disparate time scales. These fundamental features of the proposed approach are essential in the softwares ability to reliably and accuracy predict the response of CMC components. The tool will assist OEMs in characterizing CMC material properties based on coupon testing and then use these validated models in component testing. The tool is also envisaged to promote design, development and testing of concept components and offer tremendous savings in cost and time. The technology developed under this SBIR project, has the potential to generate numerous opportunities for commercialization. Through direct cooperation with prospective OEMs and AFRL, we will initiate the commercialization process through technology insertion into this initial group of highly-motivated end-users. In addition, implementation of the tool as an Abaqus plugin provides access to a Simulias customer base which includes a number of aerospace, mechanical, civil, offshore, shipbuilding and transportation industries. Our strategic partnership with Simulia increases the opportunity of commercialization of the technology proposed here.
Agency: Department of Defense | Branch: Navy | Program: SBIR | Phase: Phase II | Award Amount: 750.00K | Year: 2013
In Phase I, WAI performed an assessment of the critical deficiencies in the Aero-F/DYNA3D suite of physics-based computational analysis tools for implosion applications. This assessment resulted in the identification of three specific areas for improvement: 1. Material constitutive modeling and calibration in DYNA3D; 2. Modeling capabilities for composite implodables; 3. Enhancements to the functionality and usability of X-FEM in DYNA3D. This Phase II proposal addresses these three areas through the following developments. First, an improved constitutive model will be implemented in DYNA3D the WAI damage model which addresses the deficiencies in the currently available material models. A new software mc^2: Material Constitutive Calibrator will be developed in parallel for automated calibration of this (and other) model(s). Second, a new element the WAI composite element will be implemented in DYNA3D for accurate calculation of the stress field in composite implodable and therefore accurate assessment of the material failure criterion. Calibration of this element for material failure will also be performed in mc^2. Lastly, the X-FEM capabilities in DYNA3D will be improved through linkage with WAI damage model and removal of ad hoc user input parameters that make calibration problematic. Calibration will be similarly performed using the mc^2 software.
Agency: Department of Defense | Branch: Navy | Program: SBIR | Phase: Phase II | Award Amount: 450.05K | Year: 2014
Weidlinger Associates Inc. proposes to continue the development of metamaterial-based acoustic cloaking technology, and proposes to formulate and manufacture prototype cloak materials and demonstrate their effectiveness through in-water acoustic scattering tests of cloaked cylindrical shells. The Subsequent Phase II Project will be implemented as a 1218 month Base task followed by two Option tasks. In the base effort, success is defined as a satisfactory TRL 4 proof-of-concept demonstration. If continued, the two option tasks will culminate in successful design, manufacturing and laboratory water tank demonstration of a torpedo-sized prototype acoustic cloak. Specific objectives include: To mature the theory and practice of pentamode-based acoustic metamaterials, To design and manufacture prototype acoustic cloak materials, To conduct laboratory experiments to validate the design methods and acoustic scattering properties
Weidlinger Associates, Inc. | Date: 2015-02-19
An injector comprising one or more piezoelectric driving stacks wherein a flow control member of the injector is driven directly by the one or more piezoelectric stacks without additional amplification means or interposing elements while a flow area of the nozzle is variably adjustable to deliver controlled flow rates in a desired flow profile to improve engine performance and reduce emissions. The injector is configured to support required flow rates with minimal linear movement of the flow control member. The injector and drive electronics are configured to deliver higher frequency operation and response with increased operational stability due to minimal response lag.
Weidlinger Associates, Inc. | Date: 2014-11-06
An apparatus and method use a hybrid absorbing element defined by a novel implementation of perfectly matched layer and infinite element concepts to model time-domain and frequency domain wave propagation finite element calculations. The hybrid absorbing element comprises three or more semi-infinite facets providing an essentially reflectionless interface for outgoing waves. Perfectly matched layer conditions are coupled to finite-element wavefield computation regions and infinite element conditions, which effectively disperse advancing waves at infinity. The disclosed apparatus and method result in the rapid attenuation of waves arriving at arbitrary angles, leading to elimination of reflection artifacts. The hybrid absorbing element modeling approach reduces memory usage and related computational costs, especially when applied to large three-dimensional models and simulations and to large-scale simulations on massively parallel computing structures, cloud resources, or similar clustered or distributed compute and storage resources. The hybrid absorbing element can use a lumped, diagonal inertial operator for compatibility with explicit time-domain computations.
Agency: Department of Defense | Branch: Navy | Program: SBIR | Phase: Phase I | Award Amount: 80.00K | Year: 2015
Component acceptance by a shock Qualification by Extension (QBE) process takes advantage of the similarities between a candidate equipment item and previously qualified components to save cost, while continuing to mitigate risk attributed to high-intensity shock. WAI will develop a software tool which will facilitate the comparison of new (candidate) designs to designs that have been previously tested and successfully shock qualified, thereby making the shock QBE justification process more predictable, repeatable, and inexpensive to execute. The framework for the tool will consist of a guided QBE review process with questions/answers, and recommended comparative assessments between a candidate item and previously shock tested/qualified equipment. Candidates of different levels of complexities will be used to verify the framework, demonstrating the frameworks flexibility. One of the key objectives in this development is to identify opportunities to reduce the amount of analysis that is required to develop a high level of engineering confidence in a successful QBE. If analysis must be conducted to increase the probability of a successful QBE, the guided process will recommend which analysis (or series of analyses) will be most effective in demonstrating similarity between the candidate and equipment of similar categories and classifications that has been tested/shock qualified.
Agency: Department of Defense | Branch: Air Force | Program: SBIR | Phase: Phase I | Award Amount: 150.00K | Year: 2014
ABSTRACT: This proposal describes an innovative approach to meeting AFRL"s goals of upgrading MEVA to address limitations in its current FRM simulation tools in order to allow it to accurately assess embedded detonations of small munitions in civil construction. The approach makes use of WAI"s coupled NLFlex/VCFD software for the HFPB computational component of this effort and leverages WAI"s wide ranging experience in using HFPB modeling to simulate the response of the full range of structural construction types to threats of interest. It also relies on WAI"s experience in developing innovative FRM tools for characterizing blast effects on concrete components including breach size and secondary debris and familiarity with the MEVA software. BENEFIT: Upon successful completion of the Phase 1 effort, WAI will have demonstrated the practicality of using the NLFlex/VCFD software to simulate complex embedded detonations problems of interest to AFRL and demonstrated its ability to provide the necessary response measures from an FRM generated from the HFPB cases. Once proven, this end-to-end approach to generating FRM response modules in MEVA will be adapted to the full range of construction and load types of interest to AFRL in a follow-on Phase II effort. The primary market for the embedded detonation blast response modules that will be developed under this project would primarily be DHS and DOD organizations in the U.S.(such as DTRA).
Weidlinger Associates, Inc. | Date: 2015-04-20
A pulse detonation engine including one or more fuel injectors comprising one or more piezoelectric driving stacks wherein a flow control member of each injector is driven directly by the one or more piezoelectric stacks without additional amplification means or interposing elements while a flow area of the nozzle is variably adjustable to deliver controlled flow rates in a desired flow profile to improve engine performance and reduce emissions. The pulse detonation engine configured to support variable mission and operational requirements including delivery of required thrust using specific fuel types and with power and performance of the pulse detonation engine variably adaptable. The fuel injectors associated with the pulse detonation engine configure to deliver specified flow rates with minimal linear movement of the flow control member. The injector and drive electronics configured to deliver higher frequency operation and response with increased operational stability.