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Weihai, China

He J.M.,WeGo Group Co. | Wu Y.D.,WeGo Group Co. | Wang F.W.,WeGo Group Co. | Cheng W.L.,WeGo Group Co. | And 2 more authors.
Fibers and Polymers | Year: 2014

In this research, the oxidized regenerated cellulose (ORC) gauze was prepared by oxidation of regenerated cellulose using NO2/CCl4, subsequently treated with the dissolved chitosan (CTS) in aqueous acetic acid (CTS/ORC) and finally neutralized with NaOH/C2H5OH (CTS/ORC-Na). The hemostatic, antibacterial and degradable properties of treated ORC-based gauze were evaluated. The results of the hemostatic test on rabbit liver and ear-artery injuries showed that the attachment of high molecular weight chitosan to the surface of ORC gauze significantly improved the hemostatic effect of ORC without compromising the antibacterial and degradability of ORC. It is found that the water-soluble CTS/ORC-Na gauze was more suitable as the hemostatic material applied in rabbit liver injury in comparison with in ear-artery injury and it further improved the hemostatic efficacy and enhanced the degradable rate. It is promised that the CTS/ORC gauze and the water-soluble CTS/ORC-Na gauze would be applicable in medical fields such as surgical absorbable hemostats for control bleeding. © 2014 The Korean Fiber Society and Springer Science+Business Media Dordrecht.

Cheng W.,Harbin Institute of Technology | He J.,Harbin Institute of Technology | Wu Y.,Harbin Institute of Technology | Song C.,Harbin Medical University | And 3 more authors.
Cellulose | Year: 2013

Hemostatic effects of oxidized regenerated cellulose (ORC) are well-known but its mechanism has never been demonstrated clearly. Since thrombus formation is a kind of surface phenomenon, we changed the morphology of cellulose to form a kind of membrane with ionic liquid as solution, and also we prepared ORC films with nitrogen dioxide(NO2)/carbon tetrachloride(CCl4) oxidation system reacting for 16, 40, 64 and 88 h, respectively. FTIR and NMR spectra showed that NO2/CCl4 oxidation system had a high selectivity on hydroxyl group at C6 of regenerated cellulose. With the oxidation time prolonging, the carboxyl content was enhanced and the DP was reduced. The XPS results suggested that a new carboxyl bond was formed due to the increasing of oxygen content. From contact angle analysis, the wettability of blood on the ORC film surface was better than that of the regenerated cellulose film, which was beneficial for the blood to spread. SEM photographs showed that the ORC film oxidized for 40 h could adsorb and activate more platelets and erythrocytes. Hemostatic evaluation and enzyme-linked immunosorbent assay indicated that the ORC film had a dramatic hemostatic performance, and the products of platelets release reaction, activated platelets glycoprotein and activated clotting enzymes were increased simultaneously. Moreover, the possible mechanism of the hemostasis for ORC film was discussed. © 2013 Springer Science+Business Media Dordrecht.

He J.,Harbin Institute of Technology | Wang F.,Harbin Institute of Technology | Wu Y.,Harbin Institute of Technology | Huang Y.,Harbin Institute of Technology | Zhang H.,WeGo Group Co.
Cellulose | Year: 2011

A water-soluble chitosan-coated oxidized regenerated cellulose (ORC) gauze was prepared by the oxidation of a viscose gauze with NO2/CCl4 and subsequent treatment with a solution of chitosan in aqueous acetic acid and finally neutralization with NaOH/C2H5OH solution. A series of C6 ORC samples with different -COOH content were prepared and coated by chitosans (CTS) with different molecular weight (Mw) of 2,000, 50,000, 100,000 (denoted as CTS1, CTS2, CTS3). FT-IR and TG suggested the formation of the amide bond between the carboxyl group of ORC and the amino group of CTS. Kjeldahl nitrogen analysis of ORC gauze treated with CTS (CTS-ORC) showed that the percentage of chitosan with the lowest Mw of 2,000 introduced on ORC surface was highest and increased with oxidation time, while chitosans with medium and high Mw showed that the maximum percentage of chitosan introduced on ORC surface occurred at the oxidation time of 8 h. The neutralized chitosan-coated ORC gauze could still maintain its original morphological form and was water-soluble, and could form a transparent gel quickly for 5 s in water. The prepared water-soluble gauze could be anticipated to possess the improved hemostatic and antibacterial properties. © 2011 Springer Science+Business Media B.V.

He J.-M.,Harbin Institute of Technology | Wang F.-W.,Harbin Institute of Technology | Zhang H.-W.,WeGo Group Co. | Wu Y.-D.,Harbin Institute of Technology | And 2 more authors.
Xiandai Huagong/Modern Chemical Industry | Year: 2010

In this paper, the functional modification and application of typical biomedical absorbable hemostatic agents including oxidized cellulose or oxidized regenerated cellulose, cellulose ethers, chitosan, fibrin glue commonly used at home and abroad, are introduced, with the emphasis on the modification of the hemostatic agents to promote clotting loaded by thrombin, calcium, polyphosphates and so on, and the modification to enhance the antibacterial properties combined with different kinds of antibiotics and other antibacterial drugs. Finally, the development tendency of functional modification for biomedical absorbable hemostatic agents is summarized and looked-out.

Wu Y.D.,Harbin Institute of Technology | He J.M.,Harbin Institute of Technology | Huang Y.D.,Harbin Institute of Technology | Tang F.,WeGo Group Co. | Wang F.W.,Harbin Institute of Technology
Fibers and Polymers | Year: 2012

The selective oxidation of nitrogen dioxide in CCl 4 for regenerated cellulose to C6 oxidized regenerated cellulose (ORC) was proved using FTIR and NMR, and the ORC were dried under three different conditions, including vacuum-dried at high temperature, air-dried at room temperature and frozen-dried at low temperature. The degrees of polymerization (DP) of ORC gradually decreased with the increase of the oxidation time, which was probably due to the decarboxylation reaction. The DP of ORC further decreased and the color became deep as the increase of drying temperature, which was probably due to the β-elimination reaction from C2 or C3-carbonyl group, and the yellow color of ORC was due to chromophoric enol structure. The final DP was determined by two kinds of degradation process based on the oxidation of C6 and little C2 or C3, respectively. © 2012 The Korean Fiber Society and Springer Netherlands.

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