Wayne State University is a public research university located in Detroit, Michigan, United States, in the city's Midtown Cultural Center Historic District and Wayne State University Buildings Historic District. Founded in 1868, WSU consists of 13 schools and colleges offering 370 programs to nearly 28,000 graduate and undergraduate students. It is currently Michigan's third-largest university and one of the 100 largest universities in the United States.The WSU main campus encompasses 203 acres linking more than 100 education and research buildings in the heart of Detroit. It also has six extension centers in the metro Detroit area providing access to a limited selection of courses. The institution is a notable engine in metro Detroit's educational, cultural and economic landscape, as manifested through efforts such as its thriving research and technology park and hosting of the Detroit Windsor International Film Festival. Wikipedia.
Wayne State University | Date: 2016-09-06
Cell culture devices and methods of their use are provided according to aspects of the present invention which include a base having a pair of spaced apart wells and at least one fluid port defined from an exterior of the base to each of the wells, each fluid port being spaced above the base sheet by a distance sufficient to introduce a material above a matrix deposited on the base sheet in the wells; and a cover having a pair of spaced apart well covering portions that are each disposed above a respective one of the one spaced apart wells of the base body when the cover is covering the upper surface of the base body and having a gas passage defined between the spaced apart well covering portions and at least one gas port defined from an exterior of the cover to each of the well covering portions.
Wayne State University | Date: 2016-08-03
IgA-based Fc-folate conjugates as a treatment for cancer are provided. The conjugates utilize only the Fc portion of IgA to target its receptor on neutrophils (FcR1) to elicit antibody-dependent cellular-cytotoxicity (ADCC).
Wayne State University | Date: 2016-09-27
Injectable hydrogels in the form of crosslinked nano beads or particle in the size range 5 nm to 10 m, comprising PAMAM dendrimer with asymmetrical peripheral end groups such that one of the terminal groups is involved in formation of hydrogel and the other in involved in the conjugation of drugs or imaging agents are formed by reaction of the PAMAM dendrimer with asymmetrical end groups with linear, branched, hyperbranched or star shaped polymers with functionalized terminal groups. The PAMAM dendrimer with asymmetrical terminal groups consists of a Generation 2 and above PAMAM dendrimer with symmetrical end groups modified using the amino acids or their modified forms. The gel is formed as small crosslinked particles in the size range 25 nm to 10 m and is suitable for injectable delivery of hydrogel or ocular delivery for the purpose of therapeutic treatment and imaging.
University of the Sciences in Philadelphia and Wayne State University | Date: 2017-01-09
An ionizing system includes a channel and a heater coupled to the channel. The channel has an inlet disposed in a first pressure region having a first pressure and an outlet disposed in a second pressure region having a second pressure. The first pressure is greater than the second pressure. The heater is for heating the channel, and the channel is configured to generate charged particles of a sample in response to the sample being introduced into the channel.
Wayne State University, Semmelweis University, Office of Technology Transfer and Genesis Theranostix Korlatolt Felelossegu Tarsasag | Date: 2017-06-21
Disclosed are specific biomarkers that allow for early testing of preeclampsia/HELLP syndrome. Thus, a method is provided predicting preeclampsia in a pregnant woman. Also disclosed is a kit comprising means for assaying a sample from a pregnant woman for the concentrations of the specific biomarkers.
Wayne State University | Date: 2017-01-18
The invention provides nucleic acids and nucleic acid expression vectors containing optimized mGluR6 promoters for expression of transgenes in the retina. The compositions and methods of the invention are useful for expression of gene products to preserve, improve, or restore phototransduction or vision.
Wayne State University | Date: 2017-07-26
Systems and methods (S/M) to detect stress in stem cells are described. The S/M, including modified stem cells, assays and high throughput screens, can be used to identify compounds or other potential stressors that can negatively affect development potential.
Wayne State University | Date: 2017-02-23
Dendrimer-based compositions and methods are provided, that are useful for administering pharmaceutical compositions to target cells and tissues for treatment of ocular diseases including macular degeneration, diabetic retinopathy, and retinitis pigmentosa.
Wayne State University | Date: 2017-01-11
The present invention generally relates to carriers including polymers and lipids that comprise a CXCR4 inhibiting moiety. More specifically, these carriers are biodegradable and can be bioreducible polymers that comprise a CXCR4 inhibiting moiety. These carriers can be suitable for delivery of nucleic acids to cells. These carriers and pharmaceutical compositions comprising these carriers can be used to treat various conditions including cancers and inflammation conditions.
Wayne State University | Date: 2017-01-27
A novel class of drugs for treating androgen receptor (AR) positive cancer including prostate cancer and breast cancer are described. The drugs include the chemical scaffolds of a high affinity androgen receptor ligand and a histone deacetylase inhibitor. Also described are compositions including the novel drugs and methods of treating AR positive cancer using the compositions.