Washington University Medical School

University City, MO, United States

Washington University Medical School

University City, MO, United States
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News Article | May 8, 2017
Site: www.businesswire.com

MARINA DEL REY, Calif.--(BUSINESS WIRE)--Grant Stevens, M.D., FACS, a board certified plastic surgeon, founder and medical director of Marina Plastic Surgery in Marina del Rey, CA, and an international traveling professor, was elected president-elect of the American Society of Aesthetic Plastic Surgery (ASAPS) at the Aesthetic Meeting this month in San Diego, CA. ASAPS is the leading national aesthetic medical organization comprising more than 2,600 board certified plastic surgeons who specialize in face and body aesthetic surgery. Also elected are Clyde H. Ishii, MD, Honolulu, president; Charles Thorne, MD, New York, vice president; Herluf G. Lund Jr., MD, St. Louis, treasurer; and William P. Adams, Jr., MD, Dallas, secretary. Dr. Stevens is a clinical professor of plastic surgery, University of Southern California, as well as Chairman of the USC-Marina Aesthetic Surgery Fellowship and Director of the USC Division of Aesthetic Surgery. He is featured in Castle Connolly's "Top Doctor Guide" recognizing him as one of the best plastic surgeons in America and is one of the select few to be featured in "Plastic Surgery: The World's Top Surgeons & Clinics." Dr. Stevens is an active member at Marina Del Rey Hospital, where he is the past Chairman of the Department of Surgery, the Chairman of the Liposuction Committee, and the Medical Director of The Breast Center. He is also on staff at St. John's Medical Center, the Marina Outpatient Surgery Center and USC. Dr. Stevens graduated with honors from Washington University Medical School in St. Louis where he was awarded the Senior Prize in Surgery. He completed his general surgery training at Harbor-UCLA Medical Center, then returned to Washington University-Barnes Hospital where he completed a Fellowship in Plastic and Reconstructive Surgery with Dr. Paul Weeks, Dr. Leroy Young, Dr. Tom Mustoe, Dr. Jeffrey Marsh and Dr. R. Christie Wray. He is a board-certified Diplomate of the American Board of Plastic Surgery, a Fellow of the American College of Surgeons and the International College of Surgeons. He was appointed by the governor of California to the Medical Board of California Medical Quality Review Board. Dr. Stevens is an ASAPS Traveling Professor and has been an invited visiting professor at numerous U.S. and international universities. Dr. Stevens is a third vice president on the board of directors of the International Society of Aesthetic Plastic Surgery (ISAPS) and he is on the Board of Directors and one of the International Traveling Professors. Dr. Stevens has authored more than 70 articles and chapters on aesthetic plastic surgery. He recently completed a chapter on mastopexy and mastopexy augmentation in Grabb and Smith. Dr. Stevens is a member of many medical societies, including ASAPS, ISAPS, the American Society of Plastic Surgeons, the International College of Surgeons, the American College of Surgeons and the American Society for Laser Medicine & Surgery. Dr. Stevens is the past Chairman of the California Medical Association Advisory Panel on Plastic Surgery. He received the California State Assembly and the California State Senate Certificate of Recognition. He has also received the Special Congressional Certificate of Recognition and the Distinguished Service Citation from the Medical Board of California. For more information, visit Marina Plastic Surgery; like Marina Plastic Surgery on Facebook; sign up for the blog BeautyByStevens.com and follow on Twitter @DrGrantStevens.

Glasser M.F.,Washington University Medical School | Coalson T.S.,Washington University Medical School | Robinson E.C.,University of Oxford | Robinson E.C.,Imperial College London | And 10 more authors.
Nature | Year: 2016

Understanding the amazingly complex human cerebral cortex requires a map (or parcellation) of its major subdivisions, known as cortical areas. Making an accurate areal map has been a century-old objective in neuroscience. Using multi-modal magnetic resonance images from the Human Connectome Project (HCP) and an objective semi-automated neuroanatomical approach, we delineated 180 areas per hemisphere bounded by sharp changes in cortical architecture, function, connectivity, and/or topography in a precisely aligned group average of 210 healthy young adults. We characterized 97 new areas and 83 areas previously reported using post-mortem microscopy or other specialized study-specific approaches. To enable automated delineation and identification of these areas in new HCP subjects and in future studies, we trained a machine-learning classifier to recognize the multi-modal 'fingerprint' of each cortical area. This classifier detected the presence of 96.6% of the cortical areas in new subjects, replicated the group parcellation, and could correctly locate areas in individuals with atypical parcellations. The freely available parcellation and classifier will enable substantially improved neuroanatomical precision for studies of the structural and functional organization of human cerebral cortex and its variation across individuals and in development, aging, and disease. © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.

Vanderheyden W.M.,University of Michigan | Vanderheyden W.M.,Washington University Medical School | Gerstner J.R.,University of Pennsylvania | Tanenhaus A.,University of Wisconsin - Madison | And 2 more authors.
PLoS ONE | Year: 2013

Given the relationship between sleep and plasticity, we examined the role of Extracellular signal-regulated kinase (ERK) in regulating baseline sleep, and modulating the response to waking experience. Both sleep deprivation and social enrichment increase ERK phosphorylation in wild-type flies. The effects of both sleep deprivation and social enrichment on structural plasticity in the LNvs can be recapitulated by expressing an active version of ERK (UAS-ERK SEM) pan-neuronally in the adult fly using GeneSwitch ( Gsw) Gsw-elav-GAL4. Conversely, disrupting ERK reduces sleep and prevents both the behavioral and structural plasticity normally induced by social enrichment. Finally, using transgenic flies carrying a cAMP response Element (CRE)-luciferase reporter we show that activating ERK enhances CRE-Luc activity while disrupting ERK reduces it. These data suggest that ERK phosphorylation is an important mediator in transducing waking experience into sleep. © 2013 Vanderheyden et al.

Gerdts J.,Washington University Medical School | Brace E.J.,Washington University Medical School | Sasaki Y.,Washington University Medical School | DiAntonio A.,Washington University Medical School | And 3 more authors.
Science | Year: 2015

Axon degeneration is an intrinsic self-destruction program that underlies axon loss during injury and disease. Sterile alpha and TIR motif-containing 1 (SARM1) protein is an essential mediator of axon degeneration. We report that SARM1 initiates a local destruction program involving rapid breakdown of nicotinamide adenine dinucleotide (NAD+) after injury. We used an engineered protease-sensitized SARM1 to demonstrate that SARM1 activity is required after axon injury to induce axon degeneration. Dimerization of the Toll-interleukin receptor (TIR) domain of SARM1 alone was sufficient to induce locally mediated axon degeneration. Formation of the SARM1 TIR dimer triggered rapid breakdown of NAD+, whereas SARM1-induced axon destruction could be counteracted by increased NAD+ synthesis. SARM1-induced depletion of NAD+ may explain the potent axon protection in Wallerian degeneration slow (Wlds) mutant mice.

Zhou D.,Washington University Medical School | Kim S.H.,Urbana University | Carroll V.M.,Urbana University | Dence C.S.,Washington University Medical School | Katzenellenbn J.A.,Urbana University
Organic and Biomolecular Chemistry | Year: 2014

The development of methods for the facile conjugation and radiolabeling of poly(amido)amine (PAMAM) dendrimers would be of great benefit in evaluating biomedical applications of these intriguing molecularly defined polymers. Two anionic N-hydroxysuccinimide (NHS) esters (7 and 10) were developed and radio-labeled with fluorine-18 using Cu(I)-catalyzed click reactions. The radiolabeling of a primary amine-terminated PAMAM generation-6 (G6) dendrimer with [18F]7 or [18F]10 was complete in water or methanol within 5 min at room temperature. This highly efficient conjugation reaction benefits from a high, localized concentration of these NHS esters on the surface of PAMAM dendrimers, due to the electrostatic attraction between the anionic NHS esters and the positively-charged PAMAM dendrimers. The large medium effect (pH, salt, solvent) observed for these conjugation reactions is consistent with this mechanism. This novel strategy of utilizing electrostatic interactions provides a novel, facile, and efficient method for the conjugation and radiolabeling of PAMAM dendrimers that also has potential for radiolabeling other appropriate nanoparticles. © The Royal Society of Chemistry 2014.

Marionneau C.,University of Nantes | Townsend R.R.,Washington University Medical School | Nerbonne J.M.,Washington University Medical School
Seminars in Cell and Developmental Biology | Year: 2011

Voltage-gated K + (Kv) channels are key determinants of membrane excitability in the nervous and cardiovascular systems, functioning to control resting membrane potentials, shape action potential waveforms and influence the responses to neurotransmitters and neurohormones. Consistent with this functional diversity, multiple types of Kv currents, with distinct biophysical properties and cellular/subcellular distributions, have been identified. Rapidly activating and inactivating Kv currents, typically referred to as I A (A-type) in neurons, for example, regulate repetitive firing rates, action potential back-propagation (into dendrites) and modulate synaptic responses. Currents with similar properties, referred to as I to,f (fast transient outward), expressed in cardiomyocytes, control the early phase of myocardial action potential repolarization. A number of studies have demonstrated critical roles for pore-forming (α) subunits of the Kv4 subfamily in the generation of native neuronal I A and cardiac I to,f channels. Studies in heterologous cells have also suggested important roles for a number of Kv channel accessory and regulatory proteins in the generation of functional I A and I to,f channels. Quantitative mass spectrometry-based proteomic analysis is increasingly recognized as a rapid and, importantly, unbiased, approach to identify the components of native macromolecular protein complexes. The recent application of proteomic approaches to identify the components of native neuronal (and cardiac) Kv4 channel complexes has revealed even greater complexity than anticipated. The continued emphasis on development of improved biochemical and analytical proteomic methods seems certain to accelerate progress and to provide important new insights into the molecular determinants of native ion channel protein complexes. © 2010 Elsevier Ltd.

Duvall L.B.,Washington University Medical School | Taghert P.H.,Washington University Medical School
Current Biology | Year: 2011

The 24 hour molecular oscillator requires precisely calibrated degradation of core clock proteins, like PERIOD. New studies shed light on a sequential series of PERIOD phosphorylation events that first inhibits, then accelerates PERIOD degradation. © 2011 Elsevier Ltd.

Taghert P.H.,Washington University Medical School
Current Biology | Year: 2011

Circadian (∼24 hour) pacemaking mechanisms exist within single cells. Which cellular properties contrive to produce a precise clockworks, and which cell properties are downstream of it? The literature is conflicted as to whether membrane excitability contributes to the mechanism. Now, a new conditional genetic strategy argues excitability is largely dispensable. © 2011 Elsevier Ltd. All rights reserved.

Bai M.-Y.,Washington University in St. Louis | Bai M.-Y.,National Taiwan University of Science and Technology | Moran C.H.,Washington University in St. Louis | Zhang L.,Washington University Medical School | And 5 more authors.
Advanced Functional Materials | Year: 2012

Polystyrene (PS) hollow beads with holes on the surfaces are employed as containers for quick loading and encapsulation of a variety of contrast enhancement agents: saline solutions for thermoacoustic tomography, iodinated organic compounds for micro-computed tomography, and perfluorooctane for magnetic resonance. Because of the hole on the surface of the PS hollow bead, the contrast agent to be encapsulated could quickly enter the hollow interior via direct flow rather than slow diffusion through the wall. After loading, the hole on the surface is conveniently sealed by annealing the sample at a temperature (e.g., 95°C) slightly above the glass-transition temperature of PS. In vitro methods are also used to investigate the effectiveness of encapsulation by quantifying the contrast enhancement enabled by the contrast agents. A facile method based on hollow beads with holes on the surfaces for quick encapsulation of various types of contrast agents is described. The potential uses of these encapsulated contrast agents for biomedical imaging is also demonstrated. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Visvikis O.,Massachusetts General Hospital | Ihuegbu N.,Washington University Medical School | Labed S.A.,Massachusetts General Hospital | Luhachack L.G.,Massachusetts General Hospital | And 5 more authors.
Immunity | Year: 2014

Animal host defense against infection requires the expression of defense genes at the right place and the right time. Understanding such tight control of host defense requires the elucidation of the transcription factors involved. By using an unbiased approach in the model Caenorhabditis elegans, we discovered that HLH-30 (known as TFEB in mammals) is a key transcription factor for host defense. HLH-30 was activated shortly after Staphylococcus aureus infection, and drove the expression of close to 80% of the host response, including antimicrobial and autophagy genes that were essential for host tolerance of infection. TFEB was also rapidly activated in murine macrophages upon S.aureus infection and was required for proper transcriptional induction of several proinflammatory cytokines and chemokines. Thus, our data suggest that TFEB is apreviously unappreciated, evolutionarily ancient transcription factor in the host response to infection. © 2014 Elsevier Inc.

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