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Lin Y.,Fujian University of Traditional Chinese Medicine | Lin G.,Fujian University of Traditional Chinese Medicine | Fang W.,Fuzhou General Hospital | Zhu H.,Wangjing Hospital of CACMS | Chu K.,Fujian University of Traditional Chinese Medicine
Medical Oncology | Year: 2014

Annexin A1 (ANXA1) belongs to the annexin superfamily of proteins, which contribute to the pathological consequence and sequelae of most serious human diseases. Recent studies have reported diverse roles of ANXA1 in various human cancers; however, its involvement in human hepatocellular carcinoma (HCC) still remains controversial. To investigate the expression pattern of ANXA1 in HCC tissues and evaluate its associations with tumor progression and patients’ prognosis, immunohistochemistry was performed using 160 pairs of formalin-fixed and paraffin-embedded cancerous and adjacent non-cancerous tissues from patients with HCC. Then, the associations between ANXA1 expression, clinicopathological characteristics, and prognosis of HCC patients were statistically evaluated. In vitro migration and invasion assays of siRNA-targeted ANXA1-transfected cells were further performed. As a result, the expression levels of ANXA1 protein in HCC tissues were significantly higher than those in adjacent non-cancerous tissues (P < 0.001). High ANXA1 expression was closely correlated with advanced TNM stage (P = 0.001) and high Edmondson grade (P = 0.02). Then, univariate and multivariate analyses showed that the status of ANXA1 expression was an independent predictor for overall survival of HCC patients. Furthermore, knockdown of ANXA1 by transfection of siRNA–ANXA1 could suppress the migration and invasion abilities of HCC cells in vitro. Collectively, these findings offer the convincing evidence that ANXA1 may play an important role in HCC progression and can be used as a molecular marker to predict prognosis and a potential target for therapeutic intervention of HCC. © 2014, Springer Science+Business Media New York. Source


Gao Y.,Capital Medical University | Gao Y.,Beijing University of Chinese Medicine | Zhou H.,Beijing University of Chinese Medicine | Zhao H.,Beijing University of Chinese Medicine | And 11 more authors.
American Journal of Chinese Medicine | Year: 2013

To identify a safe and effective Impaired Glucose Tolerance (IGT) intervention program using Traditional Chinese Medicine (TCM) supported by Standard Health Care Advice (SHCA) for the evidence-based TCM intervention in IGT and evidence-based prevention of type 2 diabetes. A total of 510 IGT patients were randomly assigned into either control or TCM intervention group (255 patients for each group). The control group received standard health care according to SHCA. The intervention group also received TCM intervention in addition to standard health care. The study was conducted over a three-year follow-up. At the end of three years follow-up, accumulative incidence and average annual incidence rate of diabetes in the control group was 43.86% and 14.62% respectively. Accumulative incidence and average annual incidence rate of diabetes in the TCM intervention group was 22.17% and 7.39% respectively. Compared with the control treatment, TCM intervention can reduce the relative risk of IGT patients progressing to type 2 diabetes by 49.45% and absolute risk by 21.69%. In the TCM intervention group, oral glucose tolerance test (OGTT), 2 h glucose, glycated hemoglobin, insulin resistance and body mass index were all significantly improved when compared to the control group. No significant side effect was observed during the follow-up in the TCM group. The SHCA-supported TCM intervention can reduce the conversion rate of IGT to diabetes and improve insulin resistance; therefore, it is a safe and effective IGT intervention strategy. © 2013 World Scientific Publishing Company. Source


Bian Q.,Wangjing Hospital of CACMS | Hu H.-W.,Wangjing Hospital of CACMS | Wen J.-M.,Wangjing Hospital of CACMS | Yu Z.-Y.,Wangjing Hospital of CACMS | And 3 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2015

BACKGROUND: Currently, the material parameters of foot three-dimensional finite element models are almost all from abroad, which have no reports in China. OBJECTIVE: To preliminarily measure the parameters of foot muscle and tendon materials in Chinese people. METHODS: The dissection of flexor pollicis longus tendon and flexor pollicis brevis muscle and the medial and lateral heads, extensor hallucis longus muscle and tendon and the transverse head of adductor pollicis muscle and the oblique head, abductor pollicis brevis from the left leg and foot of fresh female specimens was performed. The cross-sectional area and length located in a fixture were measured and calculated for each sample. Sample loading was done, and one sample was measured four times to gather strength limit, maximum load data, and the load displacement curve. According to Hooke’s law, the elastic modulus of each specimen was calculated. RESULTS AND CONCLUSION: Relevant measurement data were harvested from nine samples, including the extensor hallucis longus, flexor pollicis longus, adductor muscle and abductor hallucis muscle cross head and oblique head, medial and lateral head of flexor pollicis brevis muscle and flexor hallucis longus tendon and the extensor hallucis longus tendon. These parameters included length, width, thickness, cross-sectional area, maximum loading, ultimate strength and elastic modulus test. © 2015 Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved. Source

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