Winston - Salem, NC, United States

Wake forest University

www.wfu.edu
Winston - Salem, NC, United States

Wake Forest University is a private, independent, nonprofit, non-sectarian, coeducational research university in Winston-Salem, North Carolina, founded in 1834. The university received its name from its original location in Wake Forest, north of Raleigh, North Carolina, the state capital. The Reynolda Campus, the university's main campus, has been located north of downtown Winston-Salem since the university moved there in 1956. The Wake Forest Baptist Medical Center campus is located near the Ardmore neighborhood in central Winston-Salem. The University also occupies lab space at Biotech Plaza, at the downtown Piedmont Research Park, and at the Center for Nanotechnology and Molecular Materials. The University's Babcock Graduate School of Management maintains a presence on the main campus in Winston-Salem and in Charlotte, North Carolina. In the 2014 U.S. News America's Best Colleges report, Wake Forest ranked 11th in terms of "Best Undergraduate Teaching" and 27th overall among national universities. Wikipedia.

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Patent
Wake forest University | Date: 2017-04-05

A device for use in delivering oxygen to a human patient while measuring carbon dioxide exhaled from that patient, comprises: (a) a base member having an oxygen delivery inlet port and a carbon dioxide detection outlet port formed therein separate from the oxygen delivery port; (b) a flexible cannula extending from the base, the cannula having a proximal end portion, an intermediate portion, a distal end portion, a first lumen formed therein, and a second lumen separate from the first lumen formed therein, with the distal end portion connected to the base member, the first lumen in fluid communication with the oxygen delivery inlet port, and the second lumen in fluid communication with the carbon dioxide detection outlet port.


Patent
Genethon and Wake forest University | Date: 2017-02-22

A composition comprising a molecule for use in the delivery of the molecule to the peripheral nervous system (PNS) and/or to the central nervous system (CNS), wherein the composition is administered by regional infusion.


Patent
Wake forest University and New York University | Date: 2017-04-12

A method of selectively depleting pathogenic T lymphocytes from a blood cell composition is carried out by (a) combining the cell composition ex vivo with an active compound in an effective amount, and then (b) irradiating the cells with light ex vivo for a time and at an intensity sufficient to selectively kill pathogenic T lymphocytes in said cell composition. Chalcogenorhodamine photosensitizers useful as such active compounds are also described.


Patent
Wake forest University | Date: 2017-02-10

The present invention provides methods and devices for improving cognitive function. In some embodiments, cognitive function is improved by detecting neuronal activity in the CA3 region of a patients hippocampus and stimulating the CA3 region of the patients hippocampus responsive to the neuronal activity detected.


Patent
University of Pittsburgh and Wake forest University | Date: 2017-02-10

The invention provides a method of diagnosing a disease or a predisposition to contract a disease by assaying for mutations of uromodulin (UMOD) within a test subject or patient. The presence of a mutation in the UMOD supports a diagnosis of a disease or a predisposition to contract a disease within the patient.


Patent
Wake forest University | Date: 2017-03-08

A composition comprising microcapsules, the microcapsules containing both live mammalian ovarian granulosa cells and live mammalian ovarian theca cells, is described. In some embodiments, the granulosa cells and the theca cells are contained in separate microcapsules in the composition; in some embodiments, the granulosa cells and the theca cells are contained together in the same microcapsules in the composition The composition is can be used for estrogen, and optionally also progesterone, delivery, and hence is preferably free or essentially free of oocytes. Methods of using the same and pharmaceutical formulations containing the same are also described.


The invention relates generally to systems and methods of bioenergetic profiling, uses thereof, and systems and devices relating thereto. In particular, methods of the invention are useful in assessing wellness, particularly in elderly subjects. Described are systems and methods of assessing likelihood of subject morbidity, life expectancy, positive clinical outcome, responsiveness to treatment, and certain disease states as well as of selecting treatment strategy, improving outcome to treatment strategy, and treating subjects with low bioenergetic profiles. Also described are devices and systems for measuring respiratory capacity.


In one aspect, methods are described herein for the selective detection and quantitative analysis of biological molecule compositions. A method described herein comprises providing a mixture comprising biological molecules, such as DNA, RNA or proteins, complexed with a translocating agent, such as another DNA or protein, and non-complexed biological molecules. The mixture is contacted with a membrane comprising at least one nanopore and an electric field is applied across the nanopore to selectively translocate the biological molecules complexed with the translocating agent through the at least one nanopore. Concentration of the complexed biological molecules is determined based on the translocation rate of said molecules.


Patent
Wake forest University | Date: 2017-01-20

Microcapsules are described that comprise (a) a liquid aqueous or hydrogel core; (b) a semipermeable membrane surrounding said core; (c) live animal cells (e.g., pancreatic cells) in the core; and (d) oxygen-generating particles in said core, said oxygen-generating particles included in said microcapsules in an amount sufficient to lengthen the duration of viability of said animal cells in said microcapsules. Compositions comprising such microcapsules and uses thereof, such as in treating diabetes, are also described.


Patent
Wake forest University | Date: 2017-02-15

The present invention relates to nanoparticle compositions and, in particular, to composite polymeric nanoparticle compositions. A composite nanoparticle described herein comprises a photoluminescent polymeric component and a photo-thermal polymeric component. The photoluminescent polymeric component and the photo-thermal polymeric component can each comprise a single polymeric species or multiple polymeric species.

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