Vyas Dental College and Hospital

Jodhpur, India

Vyas Dental College and Hospital

Jodhpur, India
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Verma D.K.,Vyas Dental College and Hospital | Rajan R.,SVS Institute of Dental science
Oral and Maxillofacial Surgery | Year: 2013

Background: Local anesthetics are utilized all over the world for performing painless dental procedures. Usually, the administration of local anesthetic is an uncomplicated process that passes off uneventfully. Complications, when seen, are not usually serious. However, blindness is an alarming complication both for the patient and for the dentist. Amaurosis can occur with both maxillary and mandibular nerve blocks. Amaurosis is usually associated with other ocular complications like ptosis, diplopia, and periorbital blanching. Case report: We report two rare cases of transient isolated amaurosis. Both the instances of amaurosis were seen after inferior alveolar nerve blocks. The condition was transient and resolved without any active intervention. Discussion: Though permanent amaurosis has been reported, it is usually transient in nature. Various causes have been proposed like intravascular injection, sympathetic impulse generation, and embolism. The etiology in the present case was believed to be intravascular injection. © 2012 Springer-Verlag.

Sharma A.,Vyas Dental College and Hospital
Journal of experimental therapeutics & oncology | Year: 2013

Cancer begins with multiple cumulative epigenetic and genetic alterations that sequentially transform a cell or a group of cells in a particular organ. The early genetic events might lead to clonal expansion of pre-neoplastic daughter cells in a particular tumor field. Subsequent genomic changes in some of these cells drive them towards the malignant phenotype. These transformed cells are diagnosed histopathologically as cancers owing to changes in cell morphology. Conceivably, a population of daughter cells with early genetic changes (without histopathology) remains in the organ, demonstrating the concept of field cancerization. The concept of "field cancerization" was first introduced by Slaughter et al in 1953 when studying the presence of histologically abnormal tissue surrounding oral squamous cell carcinoma. It was proposed to explain the development of multiple primary tumors and locally recurrent cancer. With present technological advancement and carefully designed studies using appropriate control tissue will enable identification of important molecular signatures in these genetically transformed but histologically normal cells. Such tumor-specific biomarkers should have excellent clinical utility. This review examines the concept of field cancerization in head and neck cancer and its possible utility in early detection, tumor progression and clinical significance.

Nayak M.T.,Vyas Dental College and Hospital | Singh A.,Vyas Dental College and Hospital | Desai R.S.,Nair Hospital Dental College | Vanaki S.S.,PMNM Dental College and Hospital
Journal of Cancer Epidemiology | Year: 2013

Background. Oral submucous fibrosis (OSF), a precancerous condition, is characterized by abnormal accumulation of collagen fibers in oral submucosa. Vimentin is a Class 2 intermediate filament (IF) and primarily expressed in cells of mesenchymal origin. Vimentin is also found to be involved in cell growth, cell cycling, and tumour differentiation. Objective. The purpose of the study was to compare the expression of vimentin in various histological grades of OSF. Materials and Methods. To assess the immunohistochemical expression of vimentin in 20 mild cases of OSF, 20 severe cases of OSF, and ten cases of normal oral buccal mucosa. Results. The overall staining intensity of vimentin significantly increased statistically (P<0.01) in OSF cases over normal control. A significant increase in the staining intensity of vimentin was also noted in the fibroblasts of severe cases of OSF (P=0.03). Conclusion. Considering the marked vimentin expression in the present study, future studies should include cytoskeleton IF and other filaments in the fibroblasts of OSF. © 2013 Meghanand T. Nayak et al.

Singh P.,Vyas Dental College and Hospital | Dutta S.R.,M B Kedia Dental College | Guha D.,University of Calcutta
Saudi Journal of Gastroenterology | Year: 2015

Background/Aims: Serotonin (5-hydroxytryptamine; 5-HT) released from enterochromaffin (EC) cells in gastric mucosa inhibits gastric acidity by increasing the gastric mucus secretion. In the present study, we evaluated the effect of aqueous extract of Aegle marmelos (AM) ripe fruit pulp (250 mg/kg body weight) on mean ulcer index (MUI), EC cells, 5-HT content, and adherent mucosal thickness of ulcerated gastric tissue in adult albino rats. Material and Methods: Ulceration was induced by using aspirin (500 mg/kg, p.o.), cerebellar nodular lesion and applying cold-restraint stress. Results: In all cases increased MUI in gastric tissue along with decreased EC cell count was observed with concomitant decrease of 5-HT content and adherent mucosal thickness (P < 0.05). Pretreatment with AM for 14 days decreased MUI, increased EC cell count, and 5-HT content as well as adherent mucosal thickness in all ulcerated group (P < 0.05). Conclusion: AM produces gastric mucosal protection mediated by increased EC cell count and 5-HT levels.

Srivastava P.,CSIR - Central Electrochemical Research Institute | Upreti D.K.,CSIR - Central Electrochemical Research Institute | Dhole T.N.,Institute of Medical science | Srivastava A.K.,Saraswati Dental and Medical College | Nayak M.T.,Vyas Dental College and Hospital
Interdisciplinary Perspectives on Infectious Diseases | Year: 2013

Context. Usnea ghattensis G. Awasthi (Usneaceae) endemic fruticose lichen found growing luxuriantly in Northern Western Ghats of India, it also contains Usnic acid as a major chemical and tested against some human pathogenic bacteria. Objective. To explore antimicrobial properties of Usnea ghattensis against some human pathogenic bacteria. Materials and Methods. The lichen was extracted in acetone, methanol, and ethanol. In vitro antimicrobial activity was tested initially by Kirby-Bauer technique of disc diffusion method and was confirmed by minimum inhibitory concentration using Broth microdilution method according to the NCCLS guidelines. Results. Ethanol extract was most effective against Bacillus cereus and Pseudomonas aeruginosa with a zone of inhibition 29.8 ± 0.6 mm and 12.3 ± 0.5 mm diameters at a concentration of 0.2 mg/mL. Acetone and methanol extract demonstrated almost similar activity against Staphylococcus aureus and the zone of inhibition was 24.6 ± 0.5 and 24.7 ± 0.4 mm. Only methanol extract was showing activity against Streptococcus faecalis with a 13.5 ± 0.8 mm zone. MIC value noted against Staphylococcus aureus and Streptococcus faecalis was 6.25 g/mL and 25 g/mL, whereas against Bacillus cereus and Pseudomonas aeruginosa, MIC calculated was 3.125 g/mL and 200 g/mL, respectively. Conclusion. The present study demonstrates the relatively higher activity of this lichen against not only gram (+) but significantly also against gram (-) bacteria. This indicates that this lichen might be a rich source of effective antimicrobial agents. © 2013 Priya Srivastava et al.

Solanki J.,Vyas Dental College and Hospital | Gupta S.,Vyas Dental College and Hospital | Chand S.,SGT Dental College and Hospital
Safety and Health at Work | Year: 2014

Background: Occupational injuries cause major health problems, which the developed, developing, and underdeveloped nations worldwide are facing today. The present study aimed to assess dental caries, periodontal health of stone mine workers, and the relationship between wasting diseases and the years of working experience.Methods: The study population comprised 510 men, selected based on the stratified cluster sampling procedure. Clinical oral examinations were carried out, and periodontal disease, dental caries, and wasting diseases were recorded.Results: Workers were in the age group of 17e56 years; the prevalence of dental caries in the workers was found to be 74%, with a mean decayed, missing, filled teeth index of 2.89. A periodontal pocket of more than 6 mm was observed in 6% of the workers.Conclusion: The oral health of mine workers is in a poor state; steps should be taken so as to provide basic medical and dental care facilities. ©2014, Occupational Safety and Health Research Institute. Published by Elsevier. All rights reserved.

Sahni P.,Vyas Dental College and Hospital | Nayak M.T.,Vyas Dental College and Hospital | Singhvi A.,Vyas Dental College and Hospital | Sharma J.,Vyas Dental College and Hospital
Journal of Oral and Maxillofacial Pathology | Year: 2012

Calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic neoplasm of the jaws, accounting for less than 3% of all odontogenic tumors. It rarely extends into the maxillary sinus. Till date, six cases involving maxillary sinus have been reported. In this paper, we report the seventh case of a 52-year-old male with CEOT in maxilla extending from distal surface of the right maxillary canine to retromolar area and involving maxillary sinus with no association with impacted teeth. The diagnosis was confirmed by aspiration cytology and histologically, the tumor was composed of sheets of epithelial cells, with areas of clear cell changes. The presence of clear cells in the histological sections, accounts for the aggressive nature of the tumor simulating the clinical appearance. Prevention of recurrence can be achieved by radical resection.

Nayak M.T.,Vyas Dental College and Hospital | Singh A.,Vyas Dental College and Hospital | Singhvi A.,Vyas Dental College and Hospital | Sharma R.,Vyas Dental College and Hospital
Journal of Natural Science, Biology and Medicine | Year: 2013

The classification of odontogenic cysts is complicated and can create confusion for both clinicians and pathologists. The odontogenic keratocyst (OKC) is an enigmatic developmental cyst that deserves special attention. It has characteristic histopathological and clinical features; but, what makes this cyst special is its aggressive behavior and high recurrence rate. Despite of many classifications and nomenclature, unfortunately the clinicians still have to face difficulties in the management of this commonly found jaw lesion. This article is an effort to provide an overview of various aspects of OKC with emphasis on nomenclature, recurrence, molecular aspects, and management of OKC.

Verma Dr. D.K.,Vyas Dental College and Hospital
Oral Surgery | Year: 2012

Ankylosis of the temporomandibular joint is a very debilitating condition. A case report of a 12-year-old girl with ankylosis between the mandibular notch and the skull base is presented. Trauma was identified as the probable cause. Al Kayat and Bramley approach followed by osteotomy and lateral swing of the zygomatic arch gained extraoral access to the site. Osteotomy of the bony mass was done between the mandibular notch and the skull base. The patient had good mouth opening at 1-year follow up. © 2012 John Wiley&Sons A/S.

Gupta G.,Vyas Dental College and Hospital | Mitra D.,Vyas Dental College and Hospital | Ashok K.P.,Vyas Dental College and Hospital | Gupta A.,Vyas Dental College and Hospital | And 3 more authors.
Journal of Periodontology | Year: 2014

The aerosol generated by an ultrasonic scaler contains microorganisms that can penetrate into the body through the respiratory system of dental surgeons and patients. The aim of this pilot study is to evaluate and compare the efficacy of commercially available preprocedural mouthrinses containing 0.2% chlorhexidine gluconate, an herbal mouthwash, and water in reducing the levels of viable bacteria in aerosols. Methods: This single-center, double-masked, placebocontrolled, randomized, three-group parallel design was conducted over a period of 45 days. Twenty-four patients with chronic periodontitis were divided randomly into three groups (A, B, and C) of eight patients each to receive 0.2% chlorhexidine gluconate, herbal mouthwash, and water, respectively, as a preprocedural rinse. The aerosol produced by the ultrasonic unit was collected at patient's chest area, doctor's chest area, and assistant's chest area on blood agar plates in all three groups. The blood agar plates were incubated at 37°C for 48 hours, and the total number of colony-forming units (CFUs) was counted and statistically analyzed. Results: The results showed that CFUs in groups A and B were significantly reduced compared with group C, P <0.001 (analysis of variance). Also, CFUs in group A were significantly reduced compared with group B, P <0.05 (independent t-test). The numbers of CFUs were highest at the patient's chest area and lowest at the assistant's chest area. Conclusion: This study suggests that a routine preprocedural mouthrinse could eliminate the majority of bacterial aerosols generated by the use of an ultrasonic unit, and that 0.2% chlorhexidine gluconate is more effective than herbal mouthwash. J Periodontol 2014;85:562-568. © 2013 American Academy of Periodontology.

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