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Melbourne, Australia

A broad range of fundamental free radical reactions, including hydrogen and halogen atom transfer, radical deoxygenations, radical cyclization reactions, radical additions to C=C and C=N double bonds utilizing β-cyclodextrin-ionic liquid(mono-6-(1-methyl-3-imidazolium) - 6 - deoxy - β -cyclodextrin tosylate (MIM-β-CDOTs) based molecular reactors/alternative media at room temperature are investigated. The reactions proceeded smoothly in moderate to excellent yield at ambient temperature, with noticable improvements in enantioselectivity observed in several key transformations. © 2011 Bentham Science Publishers. Source


Perchyonok V.T.,VTPCHEM PTY. LTD
Letters in Organic Chemistry | Year: 2011

The paper highlights an efficient methodology based on consecutive radical reaction for the preparation of cyclonucleoside derivatives. The reactions were performed in organic and aqueous media, using common and efficient free radical hydrogen donors in the range of innovative and conventional initiation conditions to afford good to excellent yields of corresponding cyclonucleosides. The mechanistic aspects of the transformations are also addressed. © 2011 Bentham Science Publishers Ltd. Source


Perchyonok V.T.,VTPCHEM PTY. LTD
Letters in Organic Chemistry | Year: 2011

Floricil (60-100nm, activated)-based Batch Molecular Reactors have been assembled and used in a variety of conventional synthetically useful free radical transformations (Hydrogen Transfer Reactions, Radical Cascade Reactions and Addition to C=C and C=N bonds). Reactions proceeded smoothly in all cases in good to excellent yields at ambient temperature in aqueous and organic media. The advantages of newly assembled setup are ease of setup, recyclability of the solid media, flexibility and scope of the transformations to be performed and ease of scale-up of methodology. © 2011 Bentham Science Publishers Ltd. Source


β-cyclodextrin based Batch, Flow-Through and "Teabag" Prototype Molecular Reactors have been assembled and used in variety of conventional synthetically useful free radical transformations (Hydrogen Transfer Reactions, Radical Cascade Reactions and Mn(OAc)3 mediated cascade/oxidation reactions. Reactions proceeded smoothly in all cases in good to excellent yields at ambient temperature in aqueous and organic media. The advantages of newly assembled setup are ease of setup, recyclability of the β-cyclodextrin media, flexibility and scope of the transformations to be performed and ease of scale-up of methodology. © 2011 Bentham Science Publishers. Source


Zhang S.,East China University of Science and Technology | Chen J.,East China University of Science and Technology | Lykakis I.N.,University of Crete | Perchyonok V.T.,VTPCHEM PTY. LTD
Current Organic Synthesis | Year: 2010

Increasing emphasis has been placed on producing synthetic organic compounds faster and more efficiently than can be produced using conventional methodology. It is often observed that tried and true methods for performing synthesis, work-up, and purification on individual or low number of reactions do not scale up well even to a modest level of parallel synthesis. As a result, novel methodologies or parallel and combinatorial chemical synthesis continues be developed at a rapid pace. In general, the specific structure of the target molecule(s) guides the selection of the synthetic methodology (e.g., solid or solution phase) used in given reaction sequence. The phrase "Streamline Organic Synthesis" has been coined as descriptor for methodology that lends itself to efficient application to parallel organic synthesis. The advantages of the past few years in microreactors have demonstrated the miniaturizing of chemistry that significant advantage with respect to cost, safety, throughput, kinetics and scale-up. The use of chemical microreactors for broad spectrum of important chemical transformation has illustrated the utility and benefits for both chemical discovery and development of novel and unique applications. The main objective of this tutorial review article is to bring together two important topics of synthetic free radical chemistry and its applications and advancements to "Streamline Organic Synthesis" on the interface of conventional and alternative materials, such as polymer supported reagents/reactants, use of ultraporous materials (PolyHIPEs) as well as continuous microflow systems of natural zeolite and commercial man-made microreactors. © 2010 Bentham Science Publishers Ltd. Source

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