Vrije Universtiteit Amsterdam

Amsterdam, Netherlands

Vrije Universtiteit Amsterdam

Amsterdam, Netherlands

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Scheerman J.F.M.,INHolland University of Applied Sciences | Scheerman J.F.M.,University of Amsterdam | van Loveren C.,University of Amsterdam | van Meijel B.,INHolland University of Applied Sciences | And 6 more authors.
Community Dentistry and Oral Epidemiology | Year: 2016

Objectives: This systematic and meta-analytic review aimed to quantify the association of psychosocial correlates with oral hygiene behaviour among 9- to 19-year olds. Methods: A systematic search up to August 2015 was carried out using the following databases: PubMed, PsycInfo, Embase, CINAHL and Web of Science. If necessary, authors of studies were contacted to obtain unpublished statistical information. A study was eligible for inclusion when it evaluated the association between the psychosocial correlates and oral hygiene behaviour varying from self-reports to clinical measurements, including plaque and bleeding scores. A modified New Castle Ottawa Scale was applied to examine the quality of the included studies. Results: Twenty-seven data sets (k) presented in 22 publications, addressing nine psychosocial correlates, were found to be eligible for the meta-analysis. For both tooth brushing and oral hygiene behaviour, random effect models revealed significant weighted average correlation (r+) for the psychosocial factors: ‘intention’, ‘self-efficacy’, ‘attitude’ (not significant for tooth brushing), ‘social influence’, ‘coping planning’ and ‘action planning’ (r+ ranging from 0.18 to 0.57). Little or no associations were found for ‘locus of control’, ‘self-esteem’ and ‘sense of coherence’ (r+ ranges from 0.01 to 0.08). Conclusions: The data at present indicates that ‘self-efficacy’, ‘intention’, ‘social influences’, ‘coping planning’ and ‘action planning’ are potential psychosocial determinants of oral health behaviour. Future studies should consider a range of psychological factors that have not been studied, but have shown to be important psychosocial determinants of health behaviours, such as ‘self-determination’, ‘anticipated regret’, ‘action control’ and ‘self-identity’. Effectiveness of addressing these potential determinants to induce behaviour change should be further examined by intervention trials. © 2016 The Authors. Community Dentistry and Oral Epidemiology Published by John Wiley & Sons Ltd.


Tagni G.,Vrije Universtiteit Amsterdam | Schlobach S.,Vrije Universtiteit Amsterdam | Ten Teije A.,Vrije Universtiteit Amsterdam | Van Harmelen F.,Vrije Universtiteit Amsterdam | Karafotias G.,Vrije Universtiteit Amsterdam
Frontiers in Artificial Intelligence and Applications | Year: 2010

Reasoning is computationally expensive. This is especially true for reasoning on the Web, where data sets are very large and often described by complex terminologies. One way to reduce this complexity is through the use of approximate reasoning methods which trade one computational property (eg. quality of answers) for others, such as time and memory. Previous research into approximation on the Semantic Web has been rather ad-hoc, and we propose a framework for systematically studying such methods. We developed a workbench which allows the structured combination of different algorithms for approximation, reasoning and measuring in one single framework. As a case-study we investigate an incremental method for instance retrieval through ontology approximation, and we use our workbench to study the computational behaviour of several approximation strategies. © 2011 The authors and IOS Press. All rights reserved.


Fagoe N.D.,Institute of the Royal Academy of Arts and science | Eggers R.,Institute of the Royal Academy of Arts and science | Verhaagen J.,Institute of the Royal Academy of Arts and science | Verhaagen J.,Vrije Universtiteit Amsterdam | Mason M.R.J.,Institute of the Royal Academy of Arts and science
Gene Therapy | Year: 2014

Adeno-associated viral (AAV) vectors based on serotype 5 are an efficient means to target dorsal root ganglia (DRG) to study gene function in the primary sensory neurons of the peripheral nervous system. In this study, we have developed a compact AAV dual promoter vector composed of the cytomegalovirus (CMV) and chicken beta-actin (CAG) promoters in a back-to-back configuration with a shared enhancer, and show efficient expression of two proteins simultaneously in DRG neurons. We demonstrate how this is useful for experiments on axonal regeneration, by co-expressing a gene of interest and an axonal marker. Using a farnesylated form of eGFP, which is actively transported along axons, we show superior long-distance labelling of axons of DRG neurons compared with normal eGFP. Additionally, we have efficiently transduced lumbar DRG neurons by injecting the AAV dual promoter vector into the dorsal intrathecal space, which is a less invasive delivery method. In summary, we have developed an AAV dual promoter vector designed for simultaneous expression of a gene of interest and a fluorescent protein to label long-distance axonal projections, which allows specific quantification of axons from transduced neurons after injury. © 2014 Macmillan Publishers Limited.


PubMed | Vrije Universtiteit Amsterdam and an Institute of the Royal Academy of Arts and science
Type: Journal Article | Journal: Gene therapy | Year: 2014

Adeno-associated viral (AAV) vectors based on serotype 5 are an efficient means to target dorsal root ganglia (DRG) to study gene function in the primary sensory neurons of the peripheral nervous system. In this study, we have developed a compact AAV dual promoter vector composed of the cytomegalovirus (CMV) and chicken beta-actin (CAG) promoters in a back-to-back configuration with a shared enhancer, and show efficient expression of two proteins simultaneously in DRG neurons. We demonstrate how this is useful for experiments on axonal regeneration, by co-expressing a gene of interest and an axonal marker. Using a farnesylated form of eGFP, which is actively transported along axons, we show superior long-distance labelling of axons of DRG neurons compared with normal eGFP. Additionally, we have efficiently transduced lumbar DRG neurons by injecting the AAV dual promoter vector into the dorsal intrathecal space, which is a less invasive delivery method. In summary, we have developed an AAV dual promoter vector designed for simultaneous expression of a gene of interest and a fluorescent protein to label long-distance axonal projections, which allows specific quantification of axons from transduced neurons after injury.

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