Jaikumar D.,Voorhees College |
Kalainathan S.,Vellore Institute of Technology |
Bhagavannarayana G.,National Physical Laboratory India
Physica B: Condensed Matter | Year: 2010
A new organic nonlinear optical crystal, urea l-alanine acetate (ULAA) has been grown by solution growth using slow cooling technique with the vision to improve the properties of the l-alanine crystals. Urea and l-alanine material were mixed in the molar ratio 1:4. Solubility and metastable zone width were determined. Single crystal XRD analyses revealed that the crystal lattice of ULAA is orthorhombic system, primitive lattice with cell parameters a=5.7971 Å, b=6.0391 Å, c=12.3276 Å with space group P212121 (D24). High-resolution X-ray diffraction (HR-XRD) analysis was carried out to study their crystalline perfection. FTIR spectrum was recorded to identify the presence of functional groups and molecular structure was confirmed by 1H NMR spectrum. From the mass spectrum, the ratio of compound formation of ULAA was analyzed. Thermal strength of the grown crystal has been studied using thermo-gravimetric (TG) and differential thermal analysis (DTA). Dielectric measurements reveal that the grown crystals have very low dielectric loss. The mechanical behavior was studied by Vickers microhardness test. The grown crystals were found to be transparent in the entire visible region. Preliminary measurement using Kurtz powder technique with Nd-YAG laser light of wavelength 1064 nm indicates that their second harmonic generation (SHG) efficiency is roughly equal to that of pure KDP. © 2010 Elsevier B.V. All rights reserved.
Prasad T.N.V.K.V.,Acharya N.G. Ranga Agricultural University |
Elumalai E.K.,Voorhees College
Asian Pacific Journal of Tropical Biomedicine | Year: 2011
Objective: To formulate a simple rapid procedure for bioreduction of silver nanoparticles using aqueous leaves extract of Moringa oleifera (M. oleifera). Methods: 10 mL of leaf extract was mixed to 90 mL of 1 mM aqueous of AgNO3 and was heated at 60-80 °C for 20 min. A change from brown to reddish color was observed. Characterization using UV-Vis spectrophotometry, Transmission Electron Microscopy (TEM) was performed. Results: TEM showed the formation of silver nanoparticles with an average size of 57 nm. Conclusions: M. oleifera demonstrates strong potential for synthesis of silver nanoparticles by rapid reduction of silver ions (Ag+ to Ag0). Biological methods are good competents for the chemical procedures, which are eco-friendly and convenient. © 2011 Asian Pacific Tropical Biomedical Magazine.
Sharma S.C.V.,Voorhees College |
David E.,Thiruvalluvar University
Asian Pacific Journal of Tropical Biomedicine | Year: 2012
Objective: To isolate and make a comparative study of marine sediments actinomycetes from Pulicat estuary, Muttukadu estuary and Ennore estuary, TamilNadu, India. Methods: A unique selective enrichment procedure has resulted in the isolation and identification a total of 304 actinomycetes colonies which were isolated from different stations of marine soil sediments in Pulicat estuary, Muttukadu estuary and Ennore estuary, TamilNadu, India. Results: Among them, 277 isolates were morphologically distinct on the basis of spore mass colour, aerial and substrate mycelium formation and production of diffusible pigment. The majority (60%; 162 isolates) were assigned to the genus Streptomyces. (35%; 104 isolates) were assigned to the genus Actinopolyspora, (5%; 11 isolates) were assigned to the genus Nocardiodes. Conclusions: The present study concluded that the physiological characteristics of actinomycetes Streptomyces, Actinopolyspora and Nocardiodes varied by available nutrients in the medium and the physical conditions. © 2012 Asian Pacific Tropical Biomedical Magazine.
Baskaran C.,Presidency College at Chennai |
Ramachandran M.,Voorhees College
Asian Pacific Journal of Tropical Disease | Year: 2012
Objective: Cancer can be described as the uncontrolled growth of abnormal cells. Lung cancer is one of the commonest malignant neoplasms all over the world. Oncogenic fusion genes consisting of EML4 and anaplastic lymphoma kinase (ALK) are present in non-small-cell lung cancers, representing 2 to 7% of such tumors. ALK proteins play a vital role in deactivating the apoptosis process in cancer disease. Some of the most commonly used non-small-cell lung cancers drugs are Crizotinib, Sunitinibmalate, Tandutinib etc..., Non-small-cell lung cancer Cells need anaplastic lymphoma kinase (ALK) to cell growth and proliferation the role of ALK in malignant proliferation and as a valid drug target. These drugs mainly work against the effects of ALK on these cells. Methods: The Protein- Ligand interaction plays a significant role in structural based drug designing. In our research work we have taken the Human anaplastic lymphoma kinase (ALK) and the commercially available drugs against non-small-cell lung cancer. The ALK was docked to the above said drugs and the energy value obtained as follows Crizotinib(-9.86), Sunitinib malate(-8.26), Tandutinib(-8.05) using the Argus Lab docking software. Results: Depending on the energy values we have chosen the best two drugs they are Crizotinib(-9.86) and Sunitinib malate(-8.26). We tried to improve the binding efficiency and steric compatibility of the two drugs namely Crizotinib(-9.86) and Sunitinib malate(-8.26). Several modifications were made to the probable functional groups which were interacting with the receptor molecule. Analogs of this drug molecule were prepared using ACD ChemSketch and docked using Argus Lab docking software. Conclusions: Crizotinib Analog 2 and Sunitinib malate analog 1 were detected with significant energy values and probable lead molecules. The Modified drugs was sketched using Chemsketch were found to be better than the conventional drugs available. Further from this work we can improve the steric compatibility and then ADME/T properties of the Analogs can be analyzed using Inslico ADME/T tools available. © 2012 Asian Pacific Tropical Medicine Press.
Agency: NSF | Branch: Standard Grant | Program: | Phase: HIST BLACK COLLEGES AND UNIV | Award Amount: 199.81K | Year: 2014
Research Initiation Awards provide support for junior and mid-career faculty at Historically Black Colleges and Universities who are building new research programs or redirecting and rebuilding existing research programs. It is expected that the award helps to further the faculty members research capability and effectiveness, improves research and teaching at his home institution, and involves undergraduate students in research experiences. The project at Voorhees College has potential broader impacts in a number of areas. The goal of the project is develop an analytical methodology for the speciation analysis of various arsenic species in the natural environment, particularly those with high sulfide levels. The project will also enhance the research experience and training of undergraduate students at Voorhees College and promises to provide collaboration between the College and the local community through public education and environmental monitoring services for municipal facilities.
Commonly encountered arsenic species in natural aquatic environments include arsenite, arsenate , monomethylarsonic acid, and dimethylarsinic acid. Another type of arsenic species,thioarsenates, has been found recently in environments with high sulfide levels. This project seeks the simultaneous detection of thioarsenate species and common inorganic and organic arsenic species, which has not been previously reported. The project will consist of three stages. First liquid chromatographic techniques will be explored to determine their suitability for the separation and analysis of both inorganic and organic arsenic analysis. A methodology based on chromatography and mass spectrometry will be developed and validated. Then, laboratory experiments will be conducted to analyze arsenic speciation in simulated sulfidic waters, and finally field samples will be collected and analyzed to investigate the fate of arsenic in real sulfidic environments. The occurrence mechanisms and the results on the fate and transport of thioarsenate species will provide helpful background for the development of strategies in controlling and remediating arsenic mobilization in a sulfidic environment.