Xue H.,Georgia State University |
Gu F.,Voorhees College |
Hu X.,Georgia State University
ACM Transactions on Modeling and Computer Simulation | Year: 2012
Assimilating real-time sensor data into large-scale spatial-temporal simulations, such as simulations of wildfires, is a promising technique for improving simulation results. This asks for advanced data assimilation methods that can work with the complex structures and nonlinear behaviors associated with the simulation models. This article presents a data assimilation framework using Sequential Monte Carlo (SMC) methods for wildfire spread simulations. The models and algorithms of the framework are described, and experimental results are provided. This work demonstrates the feasibility of applying SMC methods to data assimilation of wildfire spread simulations. The developed framework can potentially be generalized to other application areas where sophisticated simulation models are used. © 2012 ACM.
Sharma S.C.V.,Voorhees College |
David E.,Thiruvalluvar University
Asian Pacific Journal of Tropical Biomedicine | Year: 2012
Objective: To isolate and make a comparative study of marine sediments actinomycetes from Pulicat estuary, Muttukadu estuary and Ennore estuary, TamilNadu, India. Methods: A unique selective enrichment procedure has resulted in the isolation and identification a total of 304 actinomycetes colonies which were isolated from different stations of marine soil sediments in Pulicat estuary, Muttukadu estuary and Ennore estuary, TamilNadu, India. Results: Among them, 277 isolates were morphologically distinct on the basis of spore mass colour, aerial and substrate mycelium formation and production of diffusible pigment. The majority (60%; 162 isolates) were assigned to the genus Streptomyces. (35%; 104 isolates) were assigned to the genus Actinopolyspora, (5%; 11 isolates) were assigned to the genus Nocardiodes. Conclusions: The present study concluded that the physiological characteristics of actinomycetes Streptomyces, Actinopolyspora and Nocardiodes varied by available nutrients in the medium and the physical conditions. © 2012 Asian Pacific Tropical Biomedical Magazine.
Ankanna S.,Sri Venkateswara University |
Prasad T.N.V.K.V.,Acharya N.G. Ranga Agricultural University |
Elumalai E.K.,Voorhees College |
Savithramma N.,Sri Venkateswara University
Digest Journal of Nanomaterials and Biostructures | Year: 2010
The synthesis, characterization and application of biologically synthesized nanomaterials have become an important branch of nanotechnology. In this paper, we report the synthesis of highly dispersed silver nanoparticles using a dried stem bark of Boswellia ovalifoliolata (An endemic plant) extract as the reducing agent. After exposing the silver ions to bark extract, rapid reduction of silver ions is observed leading to the formation of silver nanoparticles in solution. UV-VIS spectrum of the aqueous medium containing silver nanoparticles showed absorption peak at around 430 nm. Scanning electron microscopy (SEM) micrograph analysis of the silver nanoparticles indicated that they were well-dispersed and ranged in size 30-40nm. The most needed outcome of this work will be the development of value-added products from Boswellia ovalifoliolata for biomedical and nanotechnology based industries.
Prasad T.N.V.K.V.,Acharya N.G. Ranga Agricultural University |
Elumalai E.K.,Voorhees College
Asian Pacific Journal of Tropical Biomedicine | Year: 2011
Objective: To formulate a simple rapid procedure for bioreduction of silver nanoparticles using aqueous leaves extract of Moringa oleifera (M. oleifera). Methods: 10 mL of leaf extract was mixed to 90 mL of 1 mM aqueous of AgNO3 and was heated at 60-80 °C for 20 min. A change from brown to reddish color was observed. Characterization using UV-Vis spectrophotometry, Transmission Electron Microscopy (TEM) was performed. Results: TEM showed the formation of silver nanoparticles with an average size of 57 nm. Conclusions: M. oleifera demonstrates strong potential for synthesis of silver nanoparticles by rapid reduction of silver ions (Ag+ to Ag0). Biological methods are good competents for the chemical procedures, which are eco-friendly and convenient. © 2011 Asian Pacific Tropical Biomedical Magazine.
Parimala M.,Voorhees College |
Shoba F.G.,Voorhees College
Asian Pacific Journal of Tropical Biomedicine | Year: 2013
Objective: To evaluate the phytochemical constituents and the antioxidant activity of hydroalcoholic extract of Nymphaea nouchali seed locally prescribed as a diet for diabetes mellitus. Methods: The antioxidant and free radical scavenging activity of hydroalcoholic extract of the plant was assessed against 1,1 diphenyl-2-picryl hydrazyl (DPPH), nitric oxide and lipid peroxidation using standard protocols. Total phenolics, flavonoids and tannins were also determined. Results: Phytochemical analysis revealed the presence of phenols, flavones, tannins, protein, reducing sugars, glycosides, saponins, alkaloids and steroids. The activities of plant extract against DPPH, nitric oxide and lipid peroxidation was concentration dependent with IC50 value of 42.82, 23.58 and 54.65 μg/mL respectively. The total antioxidant capacity was high with 577.73 mg vitamin E/g of the extract and showed a moderately high vitamin C content of 197.22 mg/g. The total tannin content of hydroalcoholic seed extract was high (195.84 GE/g), followed by phenolics (179.56 GE/g) and flavonoids (23.55 QE/g). Conclusion: Our findings provide evidence that the crude extract of Nymphaea nouchali is a potential source of natural antioxidants and this justifies its use in folkloric medicine. © 2013 Asian Pacific Tropical Biomedical Magazine.
Vimala G.,Voorhees College |
Gricilda Shoba F.,Voorhees College
International Journal of Microbiology | Year: 2014
Ulcer is a common gastrointestinal disorder which is seen among many people. It is basically an inflamed break in the skin or the mucus membrane lining the alimentary tract. Ulceration occurs when there is a disturbance of the normal equilibrium caused by either enhanced aggression or diminished mucosal resistance. It may be due to the regular usage of drugs, irregular food habits, stress, and so forth. Peptic ulcers are a broad term that includes ulcers of digestive tract in the stomach or the duodenum. The formation of peptic ulcers depends on the presence of acid and peptic activity in gastric juice plus a breakdown in mucosal defenses. A number of synthetic drugs are available to treat ulcers. But these drugs are expensive and are likely to produce more side effects when compared to herbal medicines. The literature revealed that many medicinal plants and polyherbal formulations are used for the treatment of ulcer by various ayurvedic doctors and traditional medicinal practitioners. The ideal aims of treatment of peptic ulcer disease are to relieve pain, heal the ulcer, and delay ulcer recurrence. In this review attempts have been made to know about some medicinal plants which may be used in ayurvedic as well as modern science for the treatment or prevention of peptic ulcer. © 2014 G. Vimala and F. Gricilda Shoba.
Baskaran C.,Presidency College at Chennai |
Ramachandran M.,Voorhees College
Asian Pacific Journal of Tropical Disease | Year: 2012
Objective: Cancer can be described as the uncontrolled growth of abnormal cells. Lung cancer is one of the commonest malignant neoplasms all over the world. Oncogenic fusion genes consisting of EML4 and anaplastic lymphoma kinase (ALK) are present in non-small-cell lung cancers, representing 2 to 7% of such tumors. ALK proteins play a vital role in deactivating the apoptosis process in cancer disease. Some of the most commonly used non-small-cell lung cancers drugs are Crizotinib, Sunitinibmalate, Tandutinib etc..., Non-small-cell lung cancer Cells need anaplastic lymphoma kinase (ALK) to cell growth and proliferation the role of ALK in malignant proliferation and as a valid drug target. These drugs mainly work against the effects of ALK on these cells. Methods: The Protein- Ligand interaction plays a significant role in structural based drug designing. In our research work we have taken the Human anaplastic lymphoma kinase (ALK) and the commercially available drugs against non-small-cell lung cancer. The ALK was docked to the above said drugs and the energy value obtained as follows Crizotinib(-9.86), Sunitinib malate(-8.26), Tandutinib(-8.05) using the Argus Lab docking software. Results: Depending on the energy values we have chosen the best two drugs they are Crizotinib(-9.86) and Sunitinib malate(-8.26). We tried to improve the binding efficiency and steric compatibility of the two drugs namely Crizotinib(-9.86) and Sunitinib malate(-8.26). Several modifications were made to the probable functional groups which were interacting with the receptor molecule. Analogs of this drug molecule were prepared using ACD ChemSketch and docked using Argus Lab docking software. Conclusions: Crizotinib Analog 2 and Sunitinib malate analog 1 were detected with significant energy values and probable lead molecules. The Modified drugs was sketched using Chemsketch were found to be better than the conventional drugs available. Further from this work we can improve the steric compatibility and then ADME/T properties of the Analogs can be analyzed using Inslico ADME/T tools available. © 2012 Asian Pacific Tropical Medicine Press.
Agency: NSF | Branch: Standard Grant | Program: | Phase: HIST BLACK COLLEGES AND UNIV | Award Amount: 199.81K | Year: 2014
Research Initiation Awards provide support for junior and mid-career faculty at Historically Black Colleges and Universities who are building new research programs or redirecting and rebuilding existing research programs. It is expected that the award helps to further the faculty members research capability and effectiveness, improves research and teaching at his home institution, and involves undergraduate students in research experiences. The project at Voorhees College has potential broader impacts in a number of areas. The goal of the project is develop an analytical methodology for the speciation analysis of various arsenic species in the natural environment, particularly those with high sulfide levels. The project will also enhance the research experience and training of undergraduate students at Voorhees College and promises to provide collaboration between the College and the local community through public education and environmental monitoring services for municipal facilities.
Commonly encountered arsenic species in natural aquatic environments include arsenite, arsenate , monomethylarsonic acid, and dimethylarsinic acid. Another type of arsenic species,thioarsenates, has been found recently in environments with high sulfide levels. This project seeks the simultaneous detection of thioarsenate species and common inorganic and organic arsenic species, which has not been previously reported. The project will consist of three stages. First liquid chromatographic techniques will be explored to determine their suitability for the separation and analysis of both inorganic and organic arsenic analysis. A methodology based on chromatography and mass spectrometry will be developed and validated. Then, laboratory experiments will be conducted to analyze arsenic speciation in simulated sulfidic waters, and finally field samples will be collected and analyzed to investigate the fate of arsenic in real sulfidic environments. The occurrence mechanisms and the results on the fate and transport of thioarsenate species will provide helpful background for the development of strategies in controlling and remediating arsenic mobilization in a sulfidic environment.
Agency: NSF | Branch: Standard Grant | Program: | Phase: Cyber Secur - Cyberinfrastruc | Award Amount: 113.50K | Year: 2016
Threats to scientific instruments and data that are accessible via the Internet are ubiquitous. The SouthEast SciEntific Cybersecurity for University REsearch (SECURE) project helps protect the National Science Foundations investments in scientific research while providing scientists with tools to safeguard intellectual property and ensure data integrity. The project team provides education, training, and selected cybersecurity services to NSF-funded researchers across the Southeast. The team is multidisciplinary, comprised of cybersecurity experts (both research and practitioner), scientists, and experts in communication. Team members are located in South Carolina, Alabama and Mississippi, with strong representation from Historically Black Colleges and Universities (HBCU). This program raises investigators awareness of their essential role in creating a secure and trustworthy cyberspace and offers concrete assistance in risk assessment, vulnerability testing, and mitigation tailored to NSF-funded scientists workflow and program size. Through past collaborations, the team is well positioned to leverage both national and regional cybersecurity organizations and programs to effectively reach the target audience.
SouthEast SECURE impacts the region by raising cybersecurity awareness; providing concise training, assessment, tools and one-on-one help; and assisting in preparation of select cybersecurity metrics. Student interns are conducting many of these activities by means of practicum-based deployment and support, thus developing capabilities in the next generation of cyber professionals. An online survey of NSF-funded investigators in the region will be conducted to learn about their primary cybersecurity challenges and concerns. Training is then tailored to provide concrete and practical assistance in how to do right-sized risk assessment and mitigation. A toolkit is provided to test and validate local cybersecurity, and measures of cybersecurity are created and field-tested. The teams approach facilitates communication between research faculty and university IT/Data Security staff. A long-term goal is building communities with common interests in cybersecurity and a commitment to helping others; and building connections with other regions and with national centers and programs.
Agency: NSF | Branch: Standard Grant | Program: | Phase: HIST BLACK COLLEGES AND UNIV | Award Amount: 199.88K | Year: 2013
The Research Initiation Award project entitled - Spatial-temporal Information Fusion and Real-time Sensor Data Assimilation Using Sequential Monte Carlo Methods - has the overarching goal to develop tractable approaches for spatial-temporal information fusion and real time sensor data assimilation using state of the art probabilistic techniques based on sequential Monte Carlo (SMC) methods. New algorithms and methods will be developed to enhance the effectiveness and efficiency of information fusion and data assimilation for large-scale spatial temporal systems. A special focus is to effectively use real-time information and sensor data from geographically distributed data sources for more accurate state inference using SMC methods. Specific objectives of this project include: developing innovative algorithms to exploit the spatial-temporal state of a system for more effective sampling/resampling and convergence of SMC methods; developing advanced data integration methods to support assimilating real-time information and sensor data from distributed data sources; and developing new computing methods and infrastructure based on parallel environment to enhance performance of large-scale information fusion and data assimilation.
The project promises to have an impact on both theoretical and practical aspects of spatial-temporal information fusion and real time sensor data assimilation. The newly developed methods will increase the capability of seamlessly integrating real time data streams to support better analysis and prediction and real time decision making. The project involves undergraduate students by training them to conduct research in a stepwise manner, broadening their network, and preparing them for graduate studies or the workforce. The project will enhance the teaching of computer science classes on campus of Voorhees College by remotely accessing the cluster system at Georgia State University on which students can run parallel and distributed programs.