Volos General Hospital

Vólos, Greece

Volos General Hospital

Vólos, Greece
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Triposkiadis F.K.,University of Thessaly | Butler J.,Emory University | Karayannis G.,University of Thessaly | Starling R.C.,Cleveland Clinic | And 18 more authors.
International Journal of Cardiology | Year: 2014

Aims The role of low-dose dopamine infusion in patients with acute decompensated heart failure (ADHF) remains controversial. We aim to evaluate the efficacy and safety of high- versus low-dose furosemide with or without low-dose dopamine infusion in this patient population. Methods and results 161 ADHF patients (78 years; 46% female; ejection fraction 31%) were randomized to 8-hour continuous infusions of: a) high-dose furosemide (HDF, n = 50, 20 mg/h), b) low-dose furosemide and low-dose dopamine (LDFD, n = 56, 5 mg/h and 5 μg kg- 1 min- 1 respectively), or c) low-dose furosemide (LDF, n = 55, furosemide 5 mg/h). The main outcomes were 60-day and one-year all-cause mortality (ACM) and hospitalization for HF (HHF). Dyspnea relief (Borg index), worsening renal function (WRF, rise in serum creatinine (sCr) ≥ 0.3 mg/dL), and length of stay (LOS) were also assessed. The urinary output at 2, 4, 6, 8, and 24 h was not significantly different in the three groups. Neither the ACM at day 60 (4.0%, 7.1%, and 7.2%; P = 0.74) or at one year (38.1%, 33.9% and 32.7%, P = 0.84) nor the HHF at day 60 (22.0%, 21.4%, and 14.5%, P = 0.55) or one year (60.0%, 50.0%, and 47%, P = 0.40) differed between HDF, LDFD, and LDF groups, respectively. No differences in the Borg index or LOS were noted. WRF was higher in the HDF than in LDFD and LDF groups at day 1 (24% vs. 11% vs. 7%, P < 0.0001) but not at sCr peak (44% vs. 38% vs. 29%, P = 0.27). No significant differences in adverse events were noted. Conclusions In ADHF patients, there were no significant differences in the in-hospital and post-discharge outcomes between high- vs. low-dose furosemide infusion; the addition of low-dose dopamine infusion was not associated with any beneficial effects. © 2014 Elsevier Ireland Ltd.


Ntelios D.,Volos General Hospital | Kargakis M.,Volos General Hospital | Topalis T.,Volos General Hospital | Drouzas A.,Aristotle University of Thessaloniki | Potolidis E.,Volos General Hospital
Hippokratia | Year: 2013

Background: A variety of organisms produce potent toxins that impact human health through compromising respiratory function. Case report: We describe a rare case of abrupt respiratory failure after Nicotiana glauca ingestion in a previously healthy sixty years old female patient. She presented complaining for gait instability and malaise after ingestion of cooked leaves of the wild plant and two hours after the onset she developed respiratory failure for which she was intubated and mechanically ventilated for two days. The patient fully recovered and was discharged from the hospital. Conclusion: Anabasine, the plant's main active ingredient, can cause severe systemic intoxication due to its nicotinic receptor agonist action with respiratory muscle paralysis being the main effect.


PubMed | Aristotle University of Thessaloniki and Volos General Hospital
Type: Journal Article | Journal: Hippokratia | Year: 2013

A variety of organisms produce potent toxins that impact human health through compromising respiratory function.We describe a rare case of abrupt respiratory failure afterNicotiana glaucaingestion in a previously healthy sixty years old female patient. She presented complaining for gait instability and malaise after ingestion of cooked leaves of the wild plant and two hours after the onset she developed respiratory failurefor which she was intubated and mechanically ventilated for two days. The patient fully recovered and was discharged from the hospital.Anabasine, the plants main active ingredient, can cause severe systemic intoxication due to its nicotinic receptor agonist action with respiratory muscle paralysis being the main effect.


Giamouzis G.,Larissa University Hospital | Butler J.,Emory University | Starling R.C.,Cleveland Clinic | Karayannis G.,Larissa University Hospital | And 11 more authors.
Journal of Cardiac Failure | Year: 2010

Background: Worsening renal function (WRF) and hypokalemia related to diuretic use for acute decompensated heart failure (ADHF) are common and associated with poor prognosis. Low-dose dopamine infusion improves renal perfusion; its effect on diuresis or renal function specifically in ADHF is not known. Methods and Results: Sixty consecutive ADHF patients (age 75.7 ± 11.2 years; 51.7% female; left ventricular ejection fraction 35.3 ± 12.1%) were randomized, after receiving a 40 mg intravenous furosemide bolus, to either high-dose furosemide (HDF, 20 mg/h continuous infusion for 8 hours) or low-dose furosemide combined with low-dose dopamine (LDFD, furosemide 5 mg/h plus dopamine 5 μg kg-1 min-1 continuous infusion for 8 hours). Both strategies were compared for total diuresis, WRF (defined as a rise in serum creatinine of >0.3 mg/dL from baseline to 24 hours), electrolyte balance, and 60-day postdischarge outcomes. Mean hourly excreted urine volume (272 ± 149 mL in HDF vs 278 ± 186 mL in LDFD group; P = .965) and changes in dyspnea score (Borg index: -4.4 ± 2.1 in HDF group vs -4.7 ± 2.0 in LDFD group; P = .575) during the 8 hours of protocol treatment were similar in the two groups. WRF was more frequent in the HDF (n = 9; 30%) than in the LDFD group (n = 2; 6.7%; P = .042). Serum potassium changed from 4.3 ± 0.5 to 3.9 ± 0.4 mEq/L at 24 hours (P = .003) in the HDF group and from 4.4 ± 0.5 to 4.2 ± 0.5 mEq/L at 24 hours (P = .07) in the LDFD group. Length of stay and 60-day mortality or rehospitalization rates (all-cause, cardiovascular, and worsening HF) were similar in the two groups. Conclusions: In ADHF patients, the combination of low-dose furosemide and low-dose dopamine is equally effective as high-dose furosemide but associated with improved renal function profile and potassium homeostasis. © 2010 Elsevier Inc. All rights reserved.


Divani S.N.,Volos General Hospital | Giovani A.M.,Volos General Hospital
Archive of Oncology | Year: 2012

Background: HPV infection is the most commonly distributed sexually transmitted disease. Human papillomavirus has also been linked to malignant tumors of many human organs. The presence of viral DNA in breast cancer cells is controversial. The aim of the present study was to investigate the presence of HPV-DNA in a group of Greek women with breast carcinoma. Methods: Liquid cytology specimens from 35 malignant breast cases and 35 cases with benign breast lesions were investigated by PCR (clinical arrays technique). In addition, in situ hybridization was performed on all HPV positive cases. Results: HPV-DNA was detected in 17.14% of the carcinoma cases and HPV16 DNA was present in 83.3% of them. All benign breast lesions were negative for HPV-DNA. Conclusion: Our report confirmed the presence of HPV in breast cancer cells while the most prevalent type was HPV16. More studies are necessary in order to elucidate the pathogenesis of HPV and a possible way of prevention of some breast cancers. © 2012, Oncology Institute of Vojvodina, Sremska Kamenica.


Ntelios D.,Volos General Hospital | Mpei E.,Volos General Hospital | Gousi E.,Volos General Hospital | Potolidis E.,Volos General Hospital | And 2 more authors.
American Journal of Emergency Medicine | Year: 2013

Troponin (I or T) is the principal marker of myocardial injury used in clinical practice. Although immune-based methods to determine troponin I levels are generally reliable, the presence of human antibodies interfering with the assays components could lead to erroneous results. In this report, we will discuss the case of a patient with misleadingly elevated troponin I due to high rheumatoid factor titer and provide an insight into the responsible molecular mechanisms. © 2013 Elsevier Inc.


Potolidis E.,Volos General Hospital | Mandros C.,Volos General Hospital
Case Reports in Oncology | Year: 2012

We describe a 65-year-old female with relapsed ovarian cancer who developed a severe hypersensitivity reaction during the second cycle of carboplatin treatment. The patient developed respiratory failure, acute respiratory distress syndrome and hypotension, requiring admission to the intensive care unit. Copyright © 2012 S. Karger AG, Basel.


Divani S.N.,Volos General Hospital | Kardasis N.D.,Volos General Hospital
Journal of B.U.ON. | Year: 2015

Purpose: Lobular carcinoma, the second most frequent type of breast cancer, accounts for 8-14% of all invasive breast cancers and presents a wide spectrum of differences from tumors of ductal origin. Its cytomorphologic features can create diagnostic problems. The purpose of this study was to identify the cytological and immunocytological features that support the diagnosis of lobular breast cancer. Methods: We retrospectively reviewed and analyzed a series of 46 fine needle aspirates (FNA) of invasive lobular carcinomas confirmed histopathologically. All findings were classified and analyzed in order to identify possible sources of diagnostic failure. Results: Mammographic features were very subtle in most cases. The detailed cytomorphologic analysis revealed mainly discohesive architecture (95%), little or no nuclear atypia (91.3%), smooth regular nuclear membrane (93.47%) and low mitotic rate (97.8%). Loss ofE-Cadherin immunoexpres- sion was found in all cases. Estrogen (ER) and progesterone (PR) receptors were positive in the majority of the cases, whereas C-erbB2 (HER2/neu) was negative. Conclusion: Discohesive architecture, low grade of nuclear atypia and plasmatoid appearance were the most important features .The correct preoperative diagnosis of lobular carcinoma permits a more specialized therapeutic approach.


PubMed | Volos General Hospital
Type: Journal Article | Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology | Year: 2015

Lobular carcinoma, the second most frequent type of breast cancer, accounts for 8-14% of all invasive breast cancers and presents a wide spectrum of differences from tumors of ductal origin. Its cytomorphologic features can create diagnostic problems. The purpose of this study was to identify the cytological and immunocytological features that support the diagnosis of lobular breast cancer.We retrospectively reviewed and analyzed a series of 46 fine needle aspirates (FNA) of invasive lobular carcinomas confirmed histopathologically. All findings were classified and analyzed in order to identify possible sources of diagnostic failure.Mammographic features were very subtle in most cases. The detailed cytomorphologic analysis revealed mainly discohesive architecture (95%), little or no nuclear atypia (91.3%), smooth regular nuclear membrane (93.47%) and low mitotic rate (97.8%). Loss of E-Cadherin immunoexpression was found in all cases. Estrogen (ER) and progesterone (PR) receptors were positive in the majority of the cases, whereas C-erbB2 (HER2/neu) was negative.Discohesive architecture, low grade of nuclear atypia and plasmatoid appearance were the most important features .The correct preoperative diagnosis of lobular carcinoma permits a more specialized therapeutic approach.


PubMed | Volos General Hospital
Type: Journal Article | Journal: Case reports in oncology | Year: 2012

We describe a 65-year-old female with relapsed ovarian cancer who developed a severe hypersensitivity reaction during the second cycle of carboplatin treatment. The patient developed respiratory failure, acute respiratory distress syndrome and hypotension, requiring admission to the intensive care unit.

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