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Kosolapov V.A.,Volgograd State Medical Academy | Sorotskii D.V.,Volgograd State Medical Academy | Anisimova V.A.,Southern Federal University
Bulletin of Experimental Biology and Medicine | Year: 2015

Compound RU-792 showed pronounced anti-ischemic activity and improved survival of rats with brain ischemia by normalizing parameters of spontaneous motor activity and reducing neurological deficit within 3 post-operative days being superior to the reference drug mexidol by this parameter. RU-792 inhibited the formation of conjugated dienes and malonic dialdehyde and increased activity of the antioxidant enzyme glutathione peroxidase thereby modulating the parameters of free radical oxidation in rats subjected to ischemia more effectively than mexidol. © 2015, Springer Science+Business Media New York.


Kosolapov V.A.,Volgograd State Medical Academy | Eltsova L.V.,Volgograd State Medical Academy | Spasov A.A.,Volgograd State Medical Academy | Anisimova V.A.,Southern Federal University
Bulletin of Experimental Biology and Medicine | Year: 2013

We studied antioxidant activity of new derivative of pyrrolo[1,2-α] benzimidazole RU-792 and compared its effects on free radical processes with those of the reference antioxidant Trolox in four model free-radical systems. RU-792 had high antioxidant activity determined by its intrinsic antiradical properties. RU-792 was superior to Trolox by antioxidant activity in the models of Fe2+-induced chemiluminescence of lipids with 2,2-diphenyl-1- picrylhydrazyl and 2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid), but less effective in the model of luminol-dependent chemiluminescence. © 2013 Springer Science+Business Media New York.


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