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Ostrowski J.,Diaverum Dialysis Unit | Rutkowski B.,Medical University of Gdansk | Muszytowski M.,Voivodship Hospital
Journal of Nephrology

Peritoneal dialysis is one of the methods of renal replacement therapy. The first research using a patient's peritoneal membrane for this purpose appeared at the turn of the 19th to 20th century. Among the many scientists dealing with this field of medicine during that period were also Polish representatives: Prof. Marceli Landsberg, Prof. Henryk Gnoiński and Dr. Tadeusz Szenkier. In the 1920s, independent of their foreign colleagues, they carried out and published interesting experiments on animals in Polish and foreign magazines. They indicated the possibility of using the peritoneal membrane and also the intestines, in uremia treatment. After a long period in which the development of peritoneal dialysis was restrained by the rapidly expanding development of hemodialysis, one saw its resurgent development. And here again Polish scientists made their contribution: among others, Profs. Zbylut Twardowski and Zofia Wańkowicz contributed in a significant way and are still contributing to the development of peritoneal dialysis in the world and in Poland. © 2011 Società Italiana di Nefrologia. Source

Ben-Skowronek I.,Medical University of Lublin | Szewczyk L.,Medical University of Lublin | Ciechanek R.,Voivodship Hospital | Korobowicz E.,Medical University of Lublin
Hormone Research in Paediatrics

Background: The mechanism of autoimmune reaction, a diffuse process consisting of a combination of epithelial cell destruction, lymphoid cellular infiltration, and fibrosis in Hashimoto's thyroiditis, is not well known. The aim of this study was to analyse the cell subsets in thyroid tissue of patients with Hashimoto's thyroiditis. Methods: We studied paraffin-embedded thyroid specimens obtained from children with Hashimoto's thyroiditis and children without an autoimmune thyroid disease. Mononuclear T cells were detected by means of CD3+, CD4+, CD8+ antibodies, B cells by CD79 alpha+ antibodies, and antigen-presenting cells by CD1a+ antibodies, and they were counted in every 1,000 cells. The specimens from each patient were routinely estimated and investigated under the electron microscope. Results: In Hashimoto's thyroiditis, we observed a statistically significant increase in T suppressor/cytotoxic cells CD8+ (20.54 ± 0.68%) in comparison to the control group (0.65 ± 0.30%), simple goitre (4.01 ± 5.54%) and nodular goitre (8.53 ± 2.37%), and a statistically significant increase in plasma CD79 alpha+ cells (31.65 ± 9.11%) in comparison to the control group (4.11 ± 1.94%), simple goitre (1.83 ± 0.64%) and nodular goitre (5.22 ± 1.63%). Simultaneously, we observed a low number of CD4+ T helper cells in the thyroid gland (0.93 ± 0.99%) in Hashimoto's thyroiditis (0.19 ± 0.05% in the control group, 1.05 ± 2.71% in simple goitre, 2.03 ± 1.06% in nodular goitre). The ultrastructural investigations showed interactions between T cells, plasmocytes, fibrocytes and thyrocytes leading to apoptosis of thyrocytes. An immunological synapse between T cells, plasmocytes and thyrocytes in the thyroid gland was noticed. Conclusions: In Hashimoto's thyroiditis, autoantigen presentation in combination with a low number of CD4+ T helper cells and a high number of CD8+ cells and plasmocytes caused the development of a cytotoxic reaction against thyrocytes, leading to apoptosis of the thyrocytes. © 2011 S. Karger AG, Basel. Source

Tubek S.,Voivodship Hospital | Tubek S.,Institute of Technology | Bunio A.,Institute of Technology | Szygula R.,Institute of Technology | Krasowski G.,Institute of Technology
Biological Trace Element Research

The relationship between chemical elements in rainwater and the frequency of hospitalizations for gastric and duodenal peptic ulcers was studied on the population of the province (Voivodship) of Opole, Poland, during the years 2000-2002. There is a high positive correlation between hospitalized cases of gastric peptic ulcers with chromium in rainwater (r = 0.71), cadmium (r = 0.63), and lead (r = 0.70). Mild positive correlations were found with zinc (r = 0.55), copper (r = 0.56), iron (r = 0.57), chloride (r = 0.60), and sulfate (r = 0.52). These correlations were higher on men, suggesting that there are gender correlations involved. In duodenal peptic ulcers, we observed a high positive correlation between chromium in rainwater and hospitalized cases (r = 0.61) and mild positive correlations with lead (r = 0.57), copper (r = 0.52), and cadmium (r = 0.51). Significant gender differences were not found. These positive correlations may be due to the biological activity of the elements, such as their cytotoxic activity, enhanced local adrenergic stimulation on mucosal vasculature, ion channel (mainly calcium channels) remodeling, and, for example promoting infection by Helicobacter pylori. © 2010 Springer Science+Business Media, LLC. Source

Sobieszczanska M.,Wroclaw Medical University | Tubek S.,Voivodship Hospital | Poplicha D.,Voivodship Hospital | Grabelus A.,Voivodship Hospital | Pawelczak J.,Voivodship Hospital
Human Vaccines and Immunotherapeutics

A 52-y old man was admitted to our Department because of abdominal pains and diarrhea with fresh blood, with concomitant purpura over the whole body and edema of the both tarsal joints. The medical history of the patient included skin changes of similar character identified once 10-12 y before. The family history revealed prostate cancer (brother and father) and pulmonary carcinoma (mother and mother's sister). An administration of immunoglobulins in the course of HSP is a non-standard clinical procedure and in case of our patient-clinically effective. In the literature, we have found only few articles about intravenous immunoglobulin treatment for acute, adult-onset HSP and only one article about GI bleeding from colonic ecchymoses in HSP . In these cases HSP wasn't associated with prostate cancer. In the first article, authors had seen dramatic responses to intravenous immunoglobulin, like in the case presented by us. IV-IG acts as an immunomodulator by suppression of antibody production, Fc-receptor blockade and anti-idiotypic reaction. In our case, the last two mechanisms could be perceived as favorable effects of IV-IG. © 2014 Landes Bioscience. Source

Kochanowski J.,Voivodship Hospital | Sobieszczanska M.,Wroclaw Medical University | Tubek S.,Voivodship Hospital | Zurek M.,Voivodship Hospital | Pawelczak J.,Voivodship Hospital
Human Vaccines and Immunotherapeutics

Hereditary hemorrhagic telangiectasia (HHT), genetic disorder manifested by uncontrolled multisystem angiogenesis with epistaxis, gastrointestinal bleeding, iron-deficiency anaemia, and arteriovenous malformations (AVM) is often related with increased levels of vascular endothelial growth factor (VEGF). Bevacizumab, a VEGF inhibitor, reduces epistaxis, telangiectasias, and iron-deficiency anaemia. A case of a female patient with HHT and chronic gastrointestinal bleeding is presented. The patient required iron supplementation and multiple blood transfusions. Bevacizumab brought marked symptomatic improvement and allowed for transfusion-independence. It is intended to apply for approval of the indications for bevacizumab administration in HHT as the 'orphan drug'. © 2015 Taylor & Francis Group, LLC. Source

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