VNS Group of Institutions

Bhopal, India

VNS Group of Institutions

Bhopal, India
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Srivastava A.K.,Sapience Bio analytical Research Laboratory | Patil U.K.,Dr Hari Singh Gour University | Singhai A.,VNS Group of Institutions | Kumar M.,VNS Group of Institutions
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2015

Objective: Nelumbo nucifera Gaertn. (Nymphaeceae) is a well known aquatic herb which has been extensively used traditionally for the treatment of different diseases. Therefore present study was designed to evaluate the anti-ulcer activity of methanolic extract of Nelumbo nucifera Gaertn. (Nymphaeceae) stalks. Methods: Anti-ulcer activity of methanolic extract of Nelumbo nucifera (100 mg/kg and 200 mg/kg) were evaluated in rats using the pylorus ligation and indomethacin induced gastric ulcer models. Biochemical investigation of stomach tissues was also done to evaluate the effect of methanolic extract of Nelumbo nucifera on oxidant and antioxidant parameters in stomach tissue. Results: Methanolic extract of Nelumbo nucifera exhibit significant ulcer protection in the pylorus ligation and Indomethacin induced ulcer model in a dose dependent manner. The results suggested that the Nelumbo nucifera methanolic extract increased the resistance to necrotizing agents, providing a direct, protective effect on the gastric mucous due to their potent oxidant and antioxidant activity. Conclusion: The results obtained from the present study demonstrated that methanolic extract of Nelumbo nucifera Gaertn stalks possesses significant anti-ulcer activity in addition to potent oxidant and antioxidant activity. © 2015, International Journal of Pharmacy and Pharmaceutical Science. All rights reserved.


Srivastava A.K.,Sapience Bio analytical Research Laboratory | Singour P.K.,VNS Group of Institutions | Gouda P.,Khallikote Autonomous College
Central Nervous System Agents in Medicinal Chemistry | Year: 2016

Monoamine oxidases A and B (MAO-A and B) play a critical role in the metabolism of intracellular neurotransmitters of the central nervous system. For decades, MAO inhibitors have proven their clinical efficacy as potential drug targets for several neurological and neurodegenerative diseases. Use of first generation non selective MAO inhibitors as neuropsychiatric drugs elicited several side effects like hypertensive crisis and cheese reaction. Therefore their use is now limited due to non-selectivity towards MAO isoforms and inhibition of metabolizing enzymes like cytochrome P450. Development of selective and specific MAO inhibitors like moclobemide, toloxatone improves their efficacy as disease-modifying effects in monotherapy as well as adjunctive therapy. Recently a lot of research has been done to elucidate the pharmacological potential of medicinal plants and their isolated bioactive constituents having MAO inhibitory activity. Herbs containing MAO inhibitors are extensively used for the development of potent synthetic drugs and as safe and effective alternatives to the available synthetic drugs in the treatment of neurodegenerative diseases such as depression, Parkinson and Alzheimer’s. In several diseases like Parkinson natural MAO inhibitors prevented the neuron denaturalization by their dual action via enhancing neurotransmission of dopamine as well as lowering the generation of free radicals and toxins. Currently development of selective MAO inhibitors is still under study to achieve more effective therapies by using Computer Aided Drug Designing, Ligand-based models and structure-activity hypothesis. These approaches also facilitate understanding the interaction of newly designed molecule with MAO enzymes and the rationalization of probable mechanisms of action. © 2016 Bentham Science Publishers.


Pal A.,VNS Group of Institutions | Toppo F.A.,VNS Group of Institutions | Chaurasiya P.K.,VNS Group of Institutions | Singour P.K.,VNS Group of Institutions | Pawar R.S.,VNS Group of Institutions
Pharmacognosy Research | Year: 2014

Objective: Ajuga bracteosa Wall ex Benth (Labiatae) is popularly known in India as "Neelkanthi." A decoction of the leaves, flowers, and barks is used in India for the treatment of cancer including diabetes, malaria, and inflammation etc. The main objective of this study is to investigate the cytotoxic potential of Ajuga bracteosa. Materials and Methods: Successive solvent extraction of Ajuga bracteosa in petroleum ether, methanol, and water extracts was done. These extracts were tested against human breast adenocarcinoma (MCF-7) and larynx carcinoma (Hep-2) tumor cell lines, using the thiazolyl blue test (MTT) assay. Results: The methanolic fraction of Ajuga bracteosa had shown the significant results against MCF-7 and Hep-2 tumor cell lines. The methanolic, petroleum ether and aqueous extract from Ajuga bracteosa, presented an IC50 value at 24 h of 10, 65, 70 μg/ml and 5, 30, 15 μg/ml on MCF-7 and Hep-2 cells, respectively. Steroids compounds namely β-sitosterol and unknown constituents were identified in the most active methanol extract of Ajuga bracteosa wall ex Benth. These known and unknown compounds exhibited cytotoxic potential against MCF-7 and Hep-2 cancer cells. Conclusion: Among all the tested extracts, methanolic extract can be considered as potential sources of anti-cancer compounds. Further studies are necessary for more extensive biological evaluations.


Thakur R.S.,VNS Group of Institutions | Toppo F.A.,VNS Group of Institutions | Singour P.K.,VNS Group of Institutions | Chaurasiya P.K.,VNS Group of Institutions | Pawar R.S.,VNS Group of Institutions
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

Polyalthia longifolia is known to be used traditionally for the treatment of many diseases such as helminthiasis, diabetes and hypertension etc., and it is not investigated earlier for the treatment of osteoporosis. The aim of the present work is to investigate the effects of Polyalthia longifolia for the management of dexamethasone induced osteoporosis in rats. Female Wister rats were used to investigate antiosteoporotic activity of various extracts i. e. petroleum ether, chloroform, ethyl acetate, ethanol and water of Polyalthia longifolia at the dose of 100mg/kg b. wt. and 200mg/kg b. w. and observed various parameters i. e. alkaline phosphatase estimation, change in body weight, bone density, bone mechanical strength, and ash value were determined in dexamethasone induced osteoporosis. Alkaline phosphatase (ALP) level was found to be increased in osteoporotic group than normal control group. Ethyl acetate extract shows best results in bone density and percentage ash value. While aqueous extract shows best results in biomechanical strength and body weight of rats. The results obtained in the present study provide evidence that Polyalthia longifolia contributes to the healing of osteoporosis.


Toppo F.A.,VNS Group of Institutions | Pawar R.S.,VNS Group of Institutions
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2015

Objective: This study was done for comparative evaluation of different herbal formulations used for topical delivery of therapeutic agents at the time of injury to accelerate skin repair in the shortest time possible, with minimal pain, discomfort and scarring to the patient during the wound healing process. Methods: Topical application of ointments and gels prepared from the methanolic extract of Aegle marmelos leaves and Mucuna pruriens seeds were formulated and evaluated for its efficacy and safety. General formulation approaches towards achieving optimum physical properties and topical delivery characteristics for an active wound healing dosage form were considered for different herbal formulations. Results: All formulation showed good stability during storage and no major changes observed after carrying out other physiochemical evaluations and during entire storage period. Differences in wound healing were observed between the various treatments and compared to the herbal formulation which has promising effect on the wound healing process. Conclusions: The results obtained were encouraging and gel-based formulations produced better wound healing than emulsifying ointment formulations. The results demonstrated that the tested hydrogel had promising healing effect in skin injuries and it will aid in identifying and targeting the many aspects of the complex wound healing process. © 2015, International Journal of Pharmacy and Pharmaceutical Sciences.All right reserved.


Pawar R.S.,VNS Group of Institutions | Chaurasiya P.K.,VNS Group of Institutions | Rajak H.,Guru Ghasidas University | Singour P.K.,VNS Group of Institutions | And 2 more authors.
Indian Journal of Pharmacology | Year: 2013

Introduction: The present study provides a scientific evaluation for the wound healing potential of ethanolic (EtOH) extract of Sida cordifolia Linn. (SCL) plant. Materials and Methods: Excision, incision and burn wounds were inflicted upon three groups of six rats each. Group I was assigned as control (ointment base). Group II was treated with 10% EtOH extract ointment. Group III was treated with standard silver sulfadiazine (0.01%) cream. The parameters observed were percentage of wound contraction, epithelialization period, hydroxyproline content, tensile strength including histopathological studies. Result: It was noted that the effect produced by the ethanolic extract of SCL ointment showed significant (P < 0.01) healing in all wound models when compared with the control group. All parameters such as wound contraction, epithelialization period, hydroxyproline content, tensile strength and histopathological studies showed significant (P < 0.01) changes when compared with the control. Conclusion: The ethanolic extract ointment of SCL effectively stimulates wound contraction; increases tensile strength of excision, incision and burn wounds.


PubMed | VNS Group of Institutions
Type: Journal Article | Journal: Nigerian journal of clinical practice | Year: 2016

The use of a simple and reproducible model is inevitable for an objective statement of the effects of external factors on wound healing. Hence, the present study was conducted to evaluate wound healing activities of sequential different extracts of Aegle marmelos leaves (AM) and Mucuna pruriens seeds (MP) by in vivo experimental models.Wistar albino rats were subjected to excision, incision and dead space wounds measuring approximately 250 mm2, 3 cm and implanting sterilized polyvinyl chloride tube on the back of each rat near either side of the vertebral column respectively. The experimental animals were randomized into eight groups (n = 6), control, standard and treatment groups. Hydrogel of different extracts were applied topically once daily. The parameters observed were percentage of wound contraction, epithelization period, tensile strength, hydroxyproline content of the granulation tissue, and histological changes during wound healing.The statistical study revealed that in excision, incision, and dead space wound models all formulations have significant (P < 0.01) wound healing potential. However, methanolic extract formulation was found to be superior to all other treatments as evidenced by rapid wound contraction, lesser number of days required for complete epithelization, increased tensile strength and significant increase in hydroxyproline content.As compared to the reference standard treated group the wound healing process of the experimental groups was decelerated. All extracts obtained from AM and MP facilitated the wound healing process in all experimental models.


Shivhare M.K.,VNS Group of Institutions | Singour P.K.,VNS Group of Institutions | Chaurasiya P.K.,VNS Group of Institutions | Pawar R.S.,VNS Group of Institutions
Pharmacognosy Reviews | Year: 2012

World Health Organization (WHO) has recommended that traditional health and folk medicine systems are proved to be more effective in health problems worldwide. Trianthema portulacastrum Linn. is a herb used in Ayurvedic medicine. The principal constituent of T. portulacastrum Linn. is ecdysterone and the other constituents are trianthenol, 3-acetylaleuritolic acid, 5,2′-dihydroxy-7-methoxy-6,8-dimethylflavone, leptorumol, 3,4-dimethoxy cinnamic acid, 5-hydroxy-2-methoxybenzaldehyde, p-methoxybenzoic acid, and beta cyanin. Different parts of Trianthema portulacastrum Linn. are traditionally used as analgesic, stomachic, laxative, treatment of blood disease, anemia, inflammation, and night blindness. Laboratory investigations on extracts of the plant have demonstrated significant pharmacological activities, such as antioxidant, diuretic, analgesic, hepatoprotective, and anticarcinogenic. This article compiles all updated information related to T. portulacastrum Linn. Scientifically proved activities are co-related with traditional concepts. Scientific evidence exists with respect to their major and minor constituents. The novelty and applicability of T. portulacastrum are hidden. Such things should be overcome through modern scientific concepts.


Swami P.D.,Samrat Ashok Technological Institute | Sharma R.,Samrat Ashok Technological Institute | Jain A.,Samrat Ashok Technological Institute | Swami D.K.,VNS Group of Institutions
Speech Communication | Year: 2015

Abstract This paper focuses on employing adaptive scales for computation of perceptually scaled continuous wavelet transform coefficients (CWT) and adaptive thresholding of these coefficients for speech enhancement. The adaptive scales and thresholds both were decided on the basis of the noise level of the noisy speech signal. The CWT coefficients were scaled perceptually and the proposed algorithm suggests selection of number of scales required for analysis on the basis of noise level. The CWT coefficients were then thresholded and for this a novel method of generating adaptive thresholds that too depends on the noise level of the noisy signal has also been proposed. Speech signals were acquired from the TIMIT database and evaluation of the proposed method is done by corrupting these signals by white Gaussian noise (at -10, -5, 0, 5, 10, 15 and 20 dB SNRs) and four real world noises (each at 0 dB SNR); pink, babble, car interior and F16 cockpit noise from the NOISEX-92 database. Enhancement results are compared on the basis of signal to noise ratio (SNR), segmental SNR (SSNR), spectral distortion (SD) and perceptual evaluation of speech quality (PESQ). Results of the proposed method are evaluated against Ephraim Malah filtering, Stein's unbiased risk estimate (SURE) thresholding of bionic wavelet transform (BWT) coefficients (BWT-SURE), Wiener filtering (WF), perceptually scaled wavelet packet transform (PWT), multi-model WF and multi-model sparse code shrinkage (MultiSCS) enhancement methods. For the white Gaussian noise case, at all noise levels, SNR and SSNR of the proposed method were better than all the methods under comparison. SD and PESQ results were lower than multiSCS method at 10 dB SNR but better at 15 dB and 20 dB SNRs. For the babble noise case, the obtained results were lower than Ephraim Malah but better than BWT-SURE. SNR and SSNR results for the cockpit noise were comparable with Ephraim Malah and BWT-SURE while for the pink noise case, the proposed method gives the best results. © 2015 Elsevier B.V. All rights reserved.


PubMed | VNS Group of Institutions
Type: Journal Article | Journal: Indian journal of pharmacology | Year: 2015

The aim of the study was to assess the curcumin containing ethanolic extract (EtOH) obtained from Curcuma longa (Cl) against retardation of wound healing by aspirin.Wound healing process was retarded by administering the dose of 150 mg/kg body weight of aspirin orally for 9 days to observe the effect of EtOH obtained from Cl using excision and incision wound model in rats. The various parameters such as % wound contraction, epithelialization period, hydroxyproline, tensile strength were observed at variant time intervals and histopathological study was also performed.Curcumin containing 5% and 10% ethanolic extract ointment have shown significant (P < 0.01) wound healing activity against an aspirin (administered 150 mg/kg body weight orally for 9 days) retarded wound healing process. Topical application of ointment showed significant (P < 0.01) difference as compared to the control group. Histopathological studies also showed healing of the epidermis, increased collagen, fibroblasts and blood vessels.Ethanolic extract of Cl ointment (EtOHCl) containing 10% curcumin displayed remarkable healing process against wound retardation by aspirin.

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