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Kotov A.S.,Vladimirsky Moscow Regional Clinical and Research Institute
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2013

Two hundreds epileptic patients with nocturnal seizures were studied. The study included evaluation of anamnesis, clinical and neurological examination, routine EEG and/or video-EEG-monitoring, MRI of the brain. The period of observation was 6 months — 10 years (on average 3.5 years). Epilepsy started with nocturnal seizures in 48% cases, in 30.5% of patients all seizures persisted during sleep. In 25% patients, nocturnal seizures were different from seizures in awakening. In 18.5% cases, seizures were randomly dispersed in the sleep-wake cycle. Different types of nocturnal nonepileptic seizures were noted in 8.5% cases. The relationship between sleep and epilepsy as well as different types of parasomnias that mimicked epileptic seizures were described and analyzed. © 2013, Media Sphera. All rights reserved. Source


Shvarts P.G.,Russian Academy of Medical Sciences | Dutov V.V.,Vladimirsky Moscow Regional Clinical and Research Institute | Kadykov A.S.,Russian Academy of Medical Sciences | Shvedkov V.V.,Russian Academy of Medical Sciences | And 2 more authors.
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2013

Disorders of urination, along with motor and cognitive disorders, are characteristic of different forms of chronic cerebral vascular diseases (CCVD). Irritation symptoms are more frequent in subcortical arteriosclerotic encephalopathy (SAE) and multi infarct hypertonic encephalopathy (MIHE). Overactive urine bladder syndrome (OUBS) caused by neurogenic detrusive hyperactivity manifests itself in frequent urination, nocturia and imperative enuresis and thus decreases quality of life and results in disability of patents with CCVD. At the same time, the character of symptoms points indirectly to the localization of lacunar infarction or the extent of severity of leukoareosis. It is the most frequent form of disorders of urination in the first years of disease that significantly aggravates its course and needs timed diagnosis and pharmacological treatment. Competitive antagonists of muscarinic receptors M2, M3 subtypes are the most effective drugs for treatment of OUBS comorbid to CCVD. © 2013, Media Sphera. All rights reserved. Source


Kotov A.S.,Vladimirsky Moscow Regional Clinical and Research Institute
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2013

We examined 182 patients with epilepsy using the evaluation of anamnesis, clinical and neurological examination, routine EEG and/or video-EEG-monitoring, MRI of the brain. The period of observation was 1-11 years (on average 2 years). Anxiety and depression symptoms were screened with the Hospital anxiety and depression scale (HADS). Health-related quality of life was examined with the Quality of Life in Epilepsy Inventory (QOLIE-31, version 1). The diagnosis was confirmed in 166 cases and nonepileptic seizures were diagnosed in 16 cases. Subclinical anxiety (8-10 HADS scores) was identified in 23 (12.6%), clinical anxiety (>10 scores) - in 47 (25.8%), subclinical depression (8-10 scores) - in 25 (13.7%) and clinical depression (>10 scores) - in 23 (12.6%) cases. Comorbidity of anxiety and depression was noted in 33 (18.1%) patients. The high level of anxiety was correlated with the young age and short duration of epilepsy. Anxiety (r=0.7; p<0.05) and depression (r=0.63; p<0.05) were significantly correlated with the poor quality of life. Source


Kotov S.V.,Vladimirsky Moscow Regional Clinical and Research Institute | Kiselev A.M.,Vladimirsky Moscow Regional Clinical and Research Institute | Esin I.V.,Vladimirsky Moscow Regional Clinical and Research Institute | Furman O.E.,City Clinical Hospital No11
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2013

Indicators of intracranial pressure (ICP) and cerebral compliance in 48 patients with primary non-traumatic intracerebral hemorrhages who underwent surgery using precise aspiration and local fibrinolysis were studied. Based on clinical and neuroimaging data, ICP indicators and cerebral compliance, we can evaluate the compressive influence of the cerebral hematoma, perform the dynamic control of fibrinolysis efficacy and intracerebral hematoma aspiration as well as of dislocation syndrome′s regress and predict outcomes of disease. The restoration of ICP indicators, cerebral compliance and elimination of middle structure dislocation can be used as criteria of surgery effectiveness. At the same time, the residual volume of the hemorrhage (within 20 ml) during the elimination of compression does not exert any significant effect on the course and outcome. Source


Yakushina T.I.,Vladimirsky Moscow Regional Clinical and Research Institute | Lizhdvoy V.Y.,Vladimirsky Moscow Regional Clinical and Research Institute | Vasilenko I.A.,Vladimirsky Moscow Regional Clinical and Research Institute | Andryukhina O.M.,Vladimirsky Moscow Regional Clinical and Research Institute | Kotov S.V.,Vladimirsky Moscow Regional Clinical and Research Institute
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2013

The working experience of the Moscow oblast center for multiple sclerosis is analyzed. Along with standard methods of treatment efficacy evaluation, a cytokines (tumor necrosis factor alpha, gamma-interferon, interleukins 10 and 17) measurement, a morphological study of CD4 and CD8 lymphocytes with cell microelectrophoresis, a complex of morphometric and optic cell parameters using laser computed phase-interference microscopy and cell optic coherent tomography of the eye's retina are used. Preliminary results of the efficacy of these methods are presented. Source

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