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Dineshshankar J.,Vivekanandha Dental College for Women | Sivakumar M.,Madha Dental College and Hospital | Karthikeyan M.,Madha Dental College and Hospital | Udayakumar P.,Madha Dental College and Hospital | And 2 more authors.
Journal of Pharmacy and Bioallied Sciences | Year: 2014

A successful pathogen is one that is able to effectively survive and evade detection by the host immune defense. Oral candidiasis has adopted strategies, which evade host defense and eventually cause disease in at-risk patients. Host defense against infections with Candida spp. depends on rapid activation of an acute inflammatory response by innate immunity, followed by an incremental stimulation of specific immune responses mediated by T-cells (cellular immunity) or B-cells (humoral immunity). Understanding these complex pathways of immune evasion can potentially contribute to the development of novel therapeutic strategies against oral candidiasis.


Dineshshankar J.,Vivekanandha Dental College for Women | Sivakumar M.,Madha Dental College and Hospital | Murali Balasubramanium A.,Sathyabama University | Kesavan G.,Madha Dental College and Hospital | And 2 more authors.
Journal of Pharmacy and Bioallied Sciences | Year: 2014

Taurodontism can be defined as a change in tooth shape caused by the failure of Hertwig′s epithelial sheath diaphragm to invaginate at the proper horizontal level. An enlarged pulp chamber, apical displacement of the pulpal floor, and no constriction at the level of the cemento-enamel junction are the characteristic features. Although permanent molar teeth are most commonly affected, this change can also be seen in both the permanent and deciduous dentition, unilaterally or bilaterally, and in any combination of teeth or quadrants. Whilst it appears most frequently as an isolated anomaly, its association with several syndromes and abnormalities has also been reported. Despite the clinical challenges, taurodontism has received little attention from clinicians. Due to the prevalence of taurodontism in modern dentitions and the critical need for its true diagnosis and management, this review addresses the etiology, clinical and radiographic features of taurodontism, its association with various syndromes and anomalies, as well as important considerations in various areas of expertise dental treatments of such teeth.


Jeelani S.,Indira Gandhi Institute of Dental science | Jagat Reddy R.C.,Chettinad Dental College and Research Institute | Maheswaran T.,Vivekanandha Dental College for Women | Asokan G.S.,Tagore Dental College and Hospital | Anand B.,Ragas Dental College and Hospital
Journal of Pharmacy and Bioallied Sciences | Year: 2014

Emerging as a targeted, safe, and efficient pharmacotherapy is the approach of theranostics, which focuses on patient-centered care. It is a combination of diagnosis and therapeutics. It provides a transition from conventional medicine to personalized medicine. It deals with the custom made treatment plan based on uniqueness of every individual thus resulting in right drug for the right patient at the right time. Genetics plays a significant role in theranostics. Theranostics provides a cost-effective specific successful treatment protocol. Pharmacogenetics, proteomics and biomarker profiling forms the backbone of theranostics. The role of theranostics is interestingly appreciated at multi levels with special consideration in oncology wherein nano formulations in the form of liposomes, dendrimers, polymeric nanoparticles, metallic nanoparticles, quantum dots and carbon nanotubes play a very important role. Thus, theranostics is a holistic transition from trial and error medicine to predictive, preventive and personalized medicine leading to improved quality care of pharmacotherapy.


Dineshshankar J.,Vivekanandha Dental College for Women | Ganapathi N.,Vivekanandha Dental College for Women | Yoithapprabhunath T.R.,Vivekanandha Dental College for Women | Maheswaran T.,Vivekanandha Dental College for Women | And 2 more authors.
Journal of Pharmacy and Bioallied Sciences | Year: 2013

Identification plays a major role in any crime investigation. The pattern of wrinkles on the lips has individual characteristics like fingerprints. Cheiloscopy is a forensic investigation technique that deals with identification of humans based on lips traces. In the past decades, lip-print studies attracted the attention of many scientists as a new tool for human identification in both civil and criminal issues. The lip crease pattern is on the vermilion border of the lip, which is quite mobile and lip prints may vary in appearance according to the pressure, direction and method used in making the print. It concludes by enlightening the readers with the fact that the possibilities to use the red part of lips to identify a human being are wider than it is commonly thought.


Yoithapprabhunath T.R.,Vivekanandha Dental College for Women | Maheswaran T.,Vivekanandha Dental College for Women | Dineshshankar J.,Vivekanandha Dental College for Women | Anusushanth A.,Educare Institute of Dental science | And 2 more authors.
Journal of Pharmacy and Bioallied Sciences | Year: 2013

Oral submucous fibrosis (OSF) is a chronic, progressive, potentially malignant condition affecting the oral cavity and frequently involving the upper part of the aerodigestive tract including the oropharynx and the upper part of the esophagus. It is characterized by juxtaepithelial inflammatory reaction and progressive fibrosis of lamina propria, leading to stiffening of the oral mucosa eventually causing trismus. This condition is associated with significant morbidity and high risk of malignancy. Over the years, several drugs and combinations have been tried for the treatment of submucous fibrosis, but with limited success, because of its unclear molecular pathogenesis. Till date, there are no known effective treatments for OSF. The aim of this article is to emphasize on the molecular changes taking place in OSF and possible therapeutic interventions.

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