Viva College

Navi Mumbai, India

Viva College

Navi Mumbai, India

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Bhalerao S.A.,Wilson College | Bhalerao S.A.,VIVA College | Verma D.R.,Wilson College | Verma D.R.,VIVA College | And 6 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

Chemoinformatics is a modern computational tool that works by bringing together both information technology and chemistry to solve problems related to drug discovery. These methods can also be used in chemical and allied industries in various other forms. Chemoinformatics gives us an opportunity to transform the data obtained via linking the two fields into knowledge which can then be extended to make proper and better decisions in areas such as drug discovery, understanding chemical interaction, standardization of drug manufacturing protocols etc. The primary application of chemoinformatics is in the storage, indexing and search of information relating to compounds. The efficient search of such stored information includes topics that are dealt with in computer science as data mining, information retrieval, information extraction and machine learning. Chemoinformatics can help us to carry out virtual experiments, which provides insights as to how our body might actually respond to the drug. Apart from that the technique is very fast; so that the time is saved along with it no practical working is required which is an added advantage. However everything in Chemoinformatics is hypothetical and we cannot surely say that the drug will act the way it was predicted too.As more drug discovery research is carried out in academia, institutes and small companies, and solutions will require pieces from chemoinformatics, bioinformatics and other disciplines, chemoinformatics knowledge and tools should be made as widely available as possible. All problems in chemistry require novel approaches for managing large amounts of chemical structures and data and for modelling complex relationships. This is where chemoinformatics methods can come in.


Jagdish P.,Viva College | Deepa V.,Viva College | Rohan G.,Viva College | Bhagat R.D.,Viva College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

Lipase (triacyl glycerol acylhydrolases, EC 3.1.1.3) catalyses hydrolysis of long chain acyl glycerol at an oil water interface. Microbial lipase has various applications in industries so microorganism producing lipase was isolated and screened for the lipolitic activity from curd and was biochemically characterised. Organism from curd sample was found to be of Lactobacillus sps. It was subjected to submerge fermentation process using waste oil as an substrate. The extracellular enzyme obtained was partially purified using ammonium sulfate precipitation & the purified enzyme was used to carry out titrimetric assays, the molecular weight was found to be 29 kDa for Lactobacillus sps & the specific activity was found to be 0.082 U/mg.

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