Geotrichum capitatum septicaemia in a haematological patient after acute myeloid leukaemia relapse: Identification using MALDI-TOF mass spectrometry and review of the literature [Setticemia da Geotrichum capitatum in un paziente ematologico dopo recidiva da leucemia mieloide acuta: Identificazione tramite MALDI-TOF e recensione della letteratura]
Miglietta F.,Laboratory of Microbiology |
Vella A.,Catholic University of the Sacred Heart |
Faneschi M.L.,Laboratory of Microbiology |
Lobreglio G.,Vito Fazzi Regional Hospital |
And 4 more authors.
Infezioni in Medicina
Emerging fungal pathogens, such as Geotrichum capitatum, are often associated with poor prognosis and represent a new challenge in modern medicine. Invasive Geotrichum capitatum infection is rare and has been reported exclusively in patients who showed signs of severe immunodeficiency, particularly those affected by haematological malignancies. The optimal therapy against systemic geotricosis has not yet been identified due to limited data about its antifungal susceptibility. The use of several therapeutic strategies and the low number of cases treated does not allow identification of specific therapeutic protocols. Furthermore, in spite of antifungal therapy, mortality rates reach very high levels. We report a case of systemic Geotrichum capitatum infection in a 78-yearold male treated with salvage therapy after acute myeloid leukaemia (AML) relapse. Geotrichum capitatum was isolated from his blood culture and identified by using Vitek 2 and Maldi time-of-flight system (MALDI- TOF). The infection was unsuccessfully treated, despite in vitro susceptibility, with micafungin and liposomal amphotericin B. © 2015 EDIMES Edizioni Medico Scientifiche. All rights reserved. Source