VisualSonics is a manufacturer of real-time, in vivo, high-resolution micro-imaging systems designed specifically for preclinical research and is a wholly owned subsidiary of SonoSite, Inc.VisualSonics’ imaging technologies allow researchers at pharmaceutical and biotechnology companies, hospitals and universities to conduct research in cardiovascular, cancer, neurobiology and developmental biology areas. The micro-imaging technologies support research applications that include genetic research, phenotypic studies and drug development. VisualSonics high-frequency micro-imaging platforms combine high-resolution, real-time in vivo imaging with quantifiable data that have been published in over 850 scientific publications globally.VisualSonics is based out of Toronto, Ontario, Canada with operations in more than 30 countries. European operations are conducted out of Science Park, Amsterdam, Netherlands and Asia Pacific operations out of Singapore. Wikipedia.

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Bauer M.,Brigham and Women's Hospital | Cheng S.,Brigham and Women's Hospital | Jain M.,Brigham and Women's Hospital | Ngoy S.,Brigham and Women's Hospital | And 4 more authors.
Circulation Research | Year: 2011

Rationale: High-sensitivity in vivo phenotyping of cardiac function is essential for evaluating genes of interest and novel therapies in small animal models of cardiovascular disease. Transthoracic echocardiography is the principal method currently used for assessing cardiac structure and function; however, standard echocardiographic techniques are relatively insensitive to early or subtle changes in cardiac performance, particularly in mice. Objective: To develop and validate an echocardiographic strain imaging methodology for sensitive and rapid cardiac phenotyping in small animal models. Methods and Results: Herein, we describe a modified echocardiographic technique that uses speckle-tracking based strain analysis for the noninvasive evaluation of cardiac performance in adult mice. This method is found to be rapid, reproducible, and highly sensitive in assessing both regional and global left ventricular (LV) function. Compared with conventional echocardiographic measures of LV structure and function, peak longitudinal strain and strain rate were able to detect changes in adult mouse hearts at an earlier time point following myocardial infarction and predicted the later development of adverse LV remodeling. Moreover, speckle-tracking based strain analysis was able to clearly identify subtle improvement in LV function that occurred early in response to standard post-myocardial infarction cardiac therapy. Conclusions: Our results highlight the utility of speckle-tracking based strain imaging for detecting discrete functional alterations in mouse models of cardiovascular disease in an efficient and comprehensive manner. Echocardiography speckle-tracking based strain analysis represents a method for relatively high-throughput and sensitive cardiac phenotyping, particularly in evaluating emerging cardiac agents and therapies in mice. © 2011 American Heart Association, Inc.

TORONTO--(BUSINESS WIRE)--FUJIFILM VisualSonics Inc., a world leader in ultra high frequency ultrasound and photoacoustic imaging systems and subsidiary of FUJIFILM SonoSite, Inc., today announced the launch of its new Vevo LAZR-X, the world’s only customizable imaging platform combining ultra high frequency ultrasound and photoacoustics for animal research applications. Featuring superior image resolution—down to 30 microns—the Vevo LAZR-X was designed for a variety of translational research applications including oncology, molecular biology, cardiology and neurobiology. “ Fujifilm VisualSonics is proud to debut another industry-first and a powerful innovation for today’s busy researchers,” said Diku Mandavia, MD, FACEP, FRCPC, chief medical officer and senior vice president, FUJIFILM SonoSite Inc. and FUJIFILM Medical Systems U.S.A., Inc. “ Our trusted Vevo technology is already used in hundreds of research laboratories. The new Vevo LAZR-X takes it to the next level, providing the ultimate preclinical imaging experience through a dual tool comprised of state-of-the-art ultra high frequency ultrasound and advanced photoacoustic technology.” Offering a fusion of anatomical, functional and molecular data, Vevo LAZR-X was designed for non-invasive, real-time, longitudinal studies. The all-in-one imaging platform puts more data at the users’ fingertips and is equipped with an array of software applications that allow researchers to conduct in-depth analysis and rapid quantification to advance research and get published faster. A portable, customizable system, Vevo LAZR-X pairs Fujifilm VisualSonics’ Vevo 3100 ultrasound system, which provides unparalleled resolution, with the compact LAZR-X cart featuring advanced laser technology for fast, sensitive acquisition along with dual wavelength ranges including signal (680-970 nm) and idler (1200-2000 nm). High-resolution MX linear array transducers can be paired with interchangeable, high-efficiency optical fibers—giving researchers the ability to customize depth, sensitivity and resolution for specific imaging needs. Other features include streamlined data management, an intuitive touchscreen interface, ergonomically-designed transducers, and a unique open imaging environment that allows the researcher to access and manipulate the subject animal during the scanning process. “ At Fujifilm VisualSonics our purpose is to boldly innovate new technologies that help scientists and researchers advance human health. Our new Vevo LAZR-X platform is a great example of this continual innovation. It is designed with flexibility in mind, allowing for application-specific imaging to collect robust data for exceptional translational research,” said Andrew Needles, director of marketing and product management, FUJIFILM VisualSonics, Inc. The Vevo LAZR-X is available worldwide. To learn more about the Vevo LAZR-X and upcoming events showcasing this new technology please visit FUJIFILM VisualSonics, Inc., is a global leader in real time, in vivo, ultra high frequency ultrasound and photoacoustic imaging systems. With headquarters in Toronto, Canada and offices around the world, FUJIFILM VisualSonics is represented globally across an integrated sales network. FUJIFILM VisualSonics is recognized worldwide for providing cutting edge imaging technologies for the advancement of preclinical research, particularly in cardiovascular, oncology, neurobiology and developmental biology areas. With the expansion of the product portfolio to include a new clinical product, FUJIFILM VisualSonics now broadens their range of imaging technologies across both preclinical and clinical markets. FUJIFILM VisualSonics is a subsidiary of FUJIFILM SonoSite, Inc. and a part of FUJIFILM Holdings Corporation. For more information, please go to: FUJIFILM SonoSite, Inc. is the innovator and world leader in bedside and point-of-care ultrasound, and an industry leader in ultra high-frequency micro-ultrasound technology. Headquartered near Seattle, the company is represented by 26 subsidiaries and a global distribution network in over 100 countries. SonoSite’s portable, compact systems are expanding the use of ultrasound across the clinical spectrum by cost-effectively bringing high-performance ultrasound to the point of patient care. For more information, go to: FUJIFILM Holdings Corporation, Tokyo, Japan brings continuous innovation and leading-edge products to a broad spectrum of industries, including: healthcare, with medical systems, pharmaceuticals and cosmetics; graphic systems; highly functional materials, such as flat panel display materials; optical devices, such as broadcast and cinema lenses; digital imaging; and document products. These are based on a vast portfolio of chemical, mechanical, optical, electronic, software and production technologies. In the year ended March 31, 2016, the company had global revenues of $22.1 billion, at an exchange rate of 112.54 yen to the dollar. Fujifilm is committed to environmental stewardship and good corporate citizenship. For more information, please visit: All product and company names herein may be trademarks of their registered owners.

Ram R.,University of Rochester | Mickelsen D.M.,University of Rochester | Theodoropoulos C.,VisualSonics | Blaxall B.C.,University of Rochester
American Journal of Physiology - Heart and Circulatory Physiology | Year: 2011

Systolic and diastolic dysfunction of the left ventricle (LV) is a hallmark of most cardiac diseases. In vivo assessment of heart function in animal models, particularly mice, is essential to refining our understanding of cardiovascular disease processes. Ultrasound echocardiography has emerged as a powerful, noninvasive tool to serially monitor cardiac performance and map the progression of heart dysfunction in murine injury models. This review covers current applications of small animal echocardiography, as well as emerg Roth DM, Swaney JS, Dalton ND ing technologies that improve evaluation of LV function. In particular, we describe speckle-tracking imaging-based regional LV analysis, a recent advancement in murine echocardiography with proven clinical utility. This sensitive measure enables an early detection of subtle myocardial defects before global dysfunction in genetically engineered and rodent surgical injury models. Novel visualization technologies that allow in-depth phenotypic assessment of small animal models, including perfusion imaging and fetal echocardiography, are also discussed. As imaging capabilities continue to improve, murine echocardiography will remain a critical component of the investigator's armamentarium in translating animal data to enhanced clinical treatment of cardiovascular diseases. © 2011 the American Physiological Society.

Seshadri M.,Roswell Park Cancer Institute | Sacadura N.T.,VisualSonics | Coulthard T.,VisualSonics
Angiogenesis | Year: 2011

Background: The overall goal of this study was to non-invasively monitor changes in blood flow of squamous cell carcinoma of the head and neck (SCCHN) xenografts using contrast-enhanced magnetic resonance (MR) and ultrasound (US) imaging. Methods: Experimental studies were performed on mice bearing FaDu tumors and SCCHN xenografts derived from human surgical tissue. MR examinations were performed using gadofosveset trisodium at 4.7T. Change in T1-relaxation rate of tumors (ΔR1) and tumor enhancement parameters (amplitude, area under the curve-AUC) were measured at baseline and 24 h after treatment with a tumor-vascular disrupting agent (tumor-VDA), 5,6-dimethylxanthenone-4-acetic acid (DMXAA; ASA404) and correlated with tumor necrosis and treatment outcome. CE-US was performed using microbubbles (Vevo MicroMarker ®) to assess the change in relative tumor blood volume following VDA treatment. Results: A marked decrease (up to 68% of baseline) in T1-enhancement of FaDu tumors was observed 1 day after VDA therapy indicative of a reduction in blood flow. Early (24 h) vascular response of individual tumors to VDA therapy detected by MRI correlated with tumor necrosis and volume estimates at 10 days post treatment. VDA treatment also resulted in a significant reduction in AUC and amplitude of patient tumor-derived SCCHN xenografts. Consistent with MRI observations, CE-US revealed a significant reduction in tumor blood volume of patient tumor-derived SCCHN xenografts after VDA therapy. Treatment with VDA resulted in a significant tumor growth inhibition of patient tumor derived SCCHN xenografts. Conclusions: These findings demonstrate that both CE-MRI and CE-US allow monitoring of early changes in vascular function following VDA therapy. The results also demonstrate, for the first time, potent vascular disruptive and antitumor activity of DMXAA against patient tumor-derived head and neck carcinoma xenografts. © 2011 Springer Science+Business Media B.V.

Deshpande N.,Stanford University | Needles A.,VisualSonics | Willmann J.K.,Stanford University
Clinical Radiology | Year: 2010

Targeted contrast-enhanced ultrasound (molecular ultrasound) is an emerging imaging strategy that combines ultrasound technology with novel molecularly-targeted ultrasound contrast agents for assessing biological processes at the molecular level. Molecular ultrasound contrast agents are nano- or micro-sized particles that are targeted to specific molecular markers by adding high-affinity binding ligands onto the surface of the particles. Following intravenous administration, these targeted ultrasound contrast agents accumulate at tissue sites overexpressing specific molecular markers, thereby enhancing the ultrasound imaging signal. High spatial and temporal resolution, real-time imaging, non-invasiveness, relatively low costs, lack of ionising irradiation and wide availability of ultrasound systems are advantages compared to other molecular imaging modalities. In this article we review current concepts and future directions of molecular ultrasound imaging, including different classes of molecular ultrasound contrast agents, ongoing technical developments of pre-clinical and clinical ultrasound systems, the potential of molecular ultrasound for imaging different diseases at the molecular level, and the translation of molecular ultrasound into the clinic. © 2010 The Royal College of Radiologists.

This invention employs multiple ultrasound pulse firings of either alternating phase and/or amplitude to detect nonlinear fundamental and subharmonic signals from microbubble contrast agents within living tissue, at high frequencies (15 MHz), e.g., with a linear array transducer. It can be shown that the contrast-to-tissue ratio (CTR) decreases with increasing ultrasound frequency because of nonlinear ultrasound propagation in tissue. However, using the subharmonic signal in addition to the nonlinear fundamental harmonic component, rather than the conventional second harmonic used at lower frequencies, provides appreciable signal strength to overcome the limitations of nonlinear tissue propagation. Additionally, the method provides for the ability to switch, at some desired frequency above 20 MHz, into a purely alternating phase inversion acquisition, in combination with bandpass filtering of the subharmonic frequency band, minimizing the losses in CTR as the frequency increases. This maintains contrast sensitivity for more limited fields of view, as penetration depth will be limited at higher frequencies. Thus, within the same micro-ultrasound imaging system, many applications of microbubble detection can be achieved with a wide range of frequencies that covers both resolution and sensitivity requirements.

In one aspect, matching layers for an ultrasonic transducer stack having a matching layer comprising a matrix material loaded with a plurality of micron-sized and nano-sized particles. In another aspect, the matrix material is loaded with a plurality of heavy and light particles. In another aspect, an ultrasound transducer stack comprises a piezoelectric layer and at least one matching layer. In one aspect, the matching layer comprises a composite material comprising a matrix material loaded with a plurality of micron-sized and nano-sized particles. In a further aspect, the composite material can also comprise a matrix material loaded with a plurality of heavy and light particles. In a further aspect, a matching layer can also comprise cyanoacrylate.

VisualSonics | Date: 2010-04-30

Photoacoustic imaging systems and methods that allow for the creation of three-dimensional (3D) images of a subject are described herein. The systems include one or more optical fibers attached to an ultrasound transducer. Ultrasonic waves are generated by laser light emitted from the optical fiber(s) and detected by the ultrasound transducer. 3D images are acquired by ultrasound signals from a series of adjacent scan planes or frames that are then stacked together to create 3D volume data.

A method for producing an ultrasound image comprises monitoring the subjects respiration cycle or waveform, acquiring ultrasound data from the subject, producing an ultrasound image from the received ultrasound data received during the time when the subjects motion due to breathing had substantially stopped.

News Article | July 20, 2015

Siemens (NYSE:SI) said it lured Abbott (NYSE:ABT) executive David Pacitti to lead its North American Healthcare business, succeeding Dr. Gregory Sorensen. Siemens Healthcare made Pacitti, whose resume includes a 14-year spell at Guidant, president of Siemens Medical Solutions USA and head of its North America regional organization effective Oct. 19. “David Pacitti’s leadership experience at Abbott […]

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