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Patent
Visterra | Date: 2015-01-20

Antibody molecules that specifically bind to dengue virus are disclosed. In certain embodiments, the antibody molecule bind to dengue virus serotypes DV-1, DV-2, DV-3, and DV-4. The antibody molecules can be used to treat, prevent, and/or diagnose dengue virus.


Grant
Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: SBIR | Phase: Phase I | Award Amount: 149.99K | Year: 2016

Project Abstract While there are commercial monoclonal antibodies against several RNA modifications there is a general paucity of immunological tools for the andgt known RNA modifications This lack of immunological tools is hindering study of the emerging roles for modified ribonucleosides as critical players in the many basic cell and organismal processes in viruses bacteria parasites and single cell eukaryotes as well as in human health and disease Furthermore the specificity of available antibodies has not been rigorously or systematically validated against most other RNA modifications To meet this need we propose to exploit our expertise in antibody development and in nucleic acid modification chemistry and biology to pilot the development of a library of scFv antibody fragments capable of specifically binding modified ribonucleosides in RNA at the single nucleotide level Recombinant antibodies will be identified using a novel yeast display platform building off of murine immunization with a panel of ribonucleosides These ribonucleosides were selected both because of their biological relevance and because they are of interest to the research community Furthermore we propose to fine tune specificity and affinity by engineering the individual recombinant antibodies to recognize related structures using our paratope epitope optimization technology The resulting recombinant antibodies will be validated for common end user applications such as immunoprecipitation ELISAs and Northwestern blots We anticipate that there will be numerous applications for high quality antibody reagents including affinity purification of modified RNA species immunohistochemistry in cells and tissue sections Northwestern blots of total RNA and diagnostic tools for RNA modification based disease models Development and availability of immunological reagents has revolutionized many areas of biochemistry including examining and quantifying signaling pathways protein localization within the cell and intracellular trafficking among others We propose to couple ribonucleoside chemistry with state of the art library construction and antibody engineering to develop specific high affinity antibody based reagents for modified ribonucleosides


Patent
Visterra | Date: 2013-03-14

This disclosure relates to novel peptide agents, e.g., antibodies and antigen-binding fragments thereof, that bind hemagglutinin protein of influenza viruses, and methods of their use.


Patent
Visterra | Date: 2014-10-16

This disclosure relates to novel peptide agents, e.g., antibodies and antigen-binding fragments thereof, that bind hemagglutinin protein of influenza viruses, and methods of their use.


Patent
Visterra | Date: 2016-08-19

The present invention provides synthetic Moraxella catarrhalis lipooligosaccharide (LOS)-based oligosaccharides and conjugates containing various M. catarrhalis serotype-specific oligosaccharide antigens or various core M. catarrhalis oligosaccharide structures or motifs corresponding to one or more of the three major serotypes and/or members within a given serotype. The oligosaccharides may be synthesized by a chemical assembly methodology relying on a limited number of monosaccharide and disaccharide building blocks. The invention further provides M. catarrhalis LOS-based immunogenic and immunoprotective compositions and antibodies derived therefrom for diagnosing, treating, and preventing infections caused by M. catarrhalis.


Patent
Visterra | Date: 2013-10-10

This disclosure relates to novel peptide agents, e.g., antibodies and antigen-binding fragments thereof, that bind hemagglutinin protein of influenza viruses, and methods of their use.


Patent
Visterra | Date: 2015-10-23

Antibody molecules that specifically bind to dengue virus are disclosed. In certain embodiments, the antibody molecule bind to dengue virus serotypes DV-1, DV-2, DV-3, and DV-4. The antibody molecules can be used to treat, prevent, and/or diagnose dengue virus.


Patent
Visterra | Date: 2016-05-16

Antibody molecules that specifically bind to dengue virus are disclosed. In certain embodiments, the antibody molecule bind to dengue virus serotypes DV-1, DV-2, DV-3, and DV-4. The antibody molecules can be used to treat, prevent, and/or diagnose dengue virus.


CAMBRIDGE, Mass.--(BUSINESS WIRE)--Visterra, Inc., a clinical-stage biotechnology company that uses its proprietary technology platform to identify unique disease targets and design novel therapeutics for infectious diseases, today announced that VIS410, a novel monoclonal antibody in development for the treatment of seasonal and pandemic influenza A, demonstrated a statistically significant viral response in its Phase 2a influenza viral challenge study and achieved its primary endpoint of reduction in viral shedding. The primary endpoint was achieved after a pre-specified interim analysis and therefore Visterra has stopped the comparative portion of the study. Subjects treated with VIS410 experienced a 92% reduction in viral shedding and resolved upper respiratory symptoms two days earlier than subjects in the placebo group. Based on these results, Visterra intends to advance VIS410 into further clinical trials in patients with influenza A. “There is a critical need for effective new therapies to treat patients hospitalized with influenza, as exemplified by the severity of the past several flu seasons. This study provided an important proof of concept for VIS410 by demonstrating its ability to reduce viral shedding in a Phase 2a challenge study utilizing a clinically relevant influenza A strain,” said José Trevejo, MD, PhD, Vice President of Development of Visterra. “The 2009 H1N1 pandemic virus used in this study exhibited peak viral loads of between 5.0 and 7.1 logs, and we were impressed by the 1.5 to 2.2 log reduction in these peak viral measures following administration of VIS410. Moreover, the study achieved its primary endpoint – reduction in viral shedding – with statistical significance after a pre-specified interim analysis of just over half of the subjects that we had intended to study.” “We are very encouraged by the success of this Phase 2a trial and these results further support the continued development of VIS410 as a single administration treatment for hospitalized patients with influenza A infection,” said Brian J. G. Pereira, MD, President and CEO of Visterra. “Our clinical progress with VIS410 demonstrates the value of our innovative drug discovery and development platform and its potential ability to create novel therapeutics to meet important unmet needs in infectious diseases.” The randomized, placebo‐controlled, double‐blind Phase 2a trial was designed to assess the efficacy and safety of VIS410 in healthy human volunteers challenged with a 2009 pandemic strain of H1N1 influenza virus. The study was designed to enroll 60 subjects (35 subjects treated with VIS410 and 25 subjects treated with placebo) with a pre-specified interim analysis after approximately 30 subjects were enrolled. Twenty‐four hours after viral inoculation, subjects were randomized to receive either VIS410 or placebo and monitored for viral shedding by nasal swabs, clinical symptoms and pharmacokinetics. A total of 31 subjects were randomized, all of whom either received intravenously administered VIS410 at a dose of 2,300 mg, or placebo. A total of 20 subjects met the definition of laboratory‐confirmed infection (VIS410, n=13; and placebo, n=7) and thus were included in the pre-specified interim analysis. The study achieved its primary endpoint of reducing the viral shedding area-under-the-curve (AUC) in the VIS410 treatment group. Based on these favorable results the comparative portion of the study was stopped early. The overall AUC of the viral shedding for the VIS410 treated subjects was reduced by 92% (p=0.019), as measured by the cell based assay TCID , and 77% (p=0.024), as measured by viral RNA quantitation (qPCR) versus the placebo group. In addition, the peak viral load for the VIS410 treatment group was reduced by 2.2 logs (p=0.009), as measured by the cell based assay TCID , and 1.5 logs (p=0.043), as measured by viral RNA quantitation (qPCR) versus the placebo group. Analysis of subject-reported upper respiratory symptoms showed a two-day faster resolution of symptoms in the VIS410 treatment group versus placebo (median time to resolution from peak: 1.1 days for the VIS410 treatment group, 3.1 days for the placebo group). Data highlights include: VIS410 was generally safe and well tolerated with a pre-treatment regimen that included over-the-counter oral anti-histamines. There were no drug-related discontinuations, serious adverse events (SAEs), or deaths reported in this study. Complete efficacy and safety data from this Phase 2a challenge study will be presented at an upcoming medical conference. This project has been funded in whole or in part with Federal funds from the Department of Health and Human Services; Office of the Assistant Secretary for Preparedness and Response; Biomedical Advanced Research and Development Authority, under Contract No. HHSO100201500018C. VIS410 is a broad spectrum human monoclonal antibody designed and engineered to neutralize all strains of influenza A, including mutated strains and strains that have recently emerged. VIS410 is a direct acting anti-viral that inhibits hemagglutinin-mediated cell membrane fusion, thereby preventing viral replication. Visterra is developing VIS410 as a single administration for the treatment of hospitalized patients with influenza A infection, including seasonal and potential pandemic strains. Influenza virus infection is one of the most common infectious diseases and can lead to severe illness, and death. Influenza epidemics occur seasonally in most countries, resulting in about three to five million cases of severe illness and about 250,000 to 500,000 deaths worldwide. Although the usual strains of influenza that circulate annually are of a significant public health concern, far more lethal influenza strains have emerged periodically, leading in some cases to pandemics. Recently, both H5N1 and H7N9 isolates have emerged in humans, causing severe disease with high mortality, although to this point only limited human-to-human transmission has been observed. Nonetheless, predicted mutations in both H5 and H7 strains have the potential to enhance human-to-human transmission and create pandemic potential. In addition, data that H7N9 strains are more readily transmitted from poultry to humans compared to other avian influenza viruses, and documentation of resistance of H7N9 to existing anti-viral drugs, have fueled increased concern. Visterra is a biotechnology company that uses its proprietary Hierotope™ Platform to identify unique disease targets and design and engineer effective therapeutics. The company’s technology is powered by computational tools and techniques, the core of which is Atomic Interaction Network (AIN) analysis, which identifies a specific area, or epitope, on the target site that is fundamental to its structure and function. This ideal epitope, or hierotope, becomes the target against which the company designs a novel therapeutic with the potential to effectively and durably combat the disease. The company is currently focused on therapeutics for infectious diseases, and its lead product candidate, VIS410, is a broad spectrum human monoclonal antibody for the treatment of both seasonal and pandemic influenza. The company’s second product candidate, VIS513, is a human monoclonal antibody for the treatment of dengue that has been shown to broadly neutralize all four dengue virus serotypes. Visterra was founded based on scientific work developed in the laboratory of Dr. Ram Sasisekharan and licensed from MIT. For more information, please visit www.visterrainc.com.


CAMBRIDGE, Mass.--(BUSINESS WIRE)--Visterra, Inc., a clinical-stage biotechnology company that uses its proprietary technology platform to identify unique disease targets and design novel therapeutics for infectious diseases, today announced that the Biomedical Advanced Research and Development Authority (BARDA) of the U.S. Department of Health and Human Services (HHS) has awarded Visterra a five-year contract valued at up to $204.5 million for the development of VIS410, Visterra’s novel monoclonal antibody in development for the treatment of seasonal and potential pandemic influenza A. “We are pleased that BARDA has awarded this contract covering the development of VIS410,” said Brian Pereira, MD, President and Chief Executive Officer of Visterra. “Visterra is proud to play an important role in addressing the significant public health concern of seasonal influenza A and the growing threat of emerging strains of influenza A. This award from BARDA will support the continued development of VIS410, our lead product candidate, which was designed and engineered using our proprietary technology platform.” The BARDA contract includes funding for performing pre-clinical toxicology studies, conducting clinical trials, manufacturing of materials for clinical trials and continued optimization of manufacturing processes, and associated regulatory activities intended to advance VIS410. The contract includes a 40-month base period with committed funding of $29.1 million and option periods that, if exercised in full by BARDA, would extend the contract to a total of 5 years and increase the total funding up to $204.5 million. The full funding, if received, will support Visterra’s plans to submit a Biologics License Application (BLA) for VIS410 to the U.S. Food & Drug Administration (FDA). This project has been funded in whole or in part with Federal funds from the Department of Health and Human Services; Office of the Assistant Secretary for Preparedness and Response; Biomedical Advanced Research and Development Authority, under Contract No. HHSO100201500018C. VIS410 is a broad spectrum human monoclonal antibody designed and engineered to neutralize all strains of influenza A, including mutated strains and strains that have recently emerged. VIS410 is a direct acting anti-viral that inhibits hemagglutinin-mediated cell membrane fusion, thereby preventing viral replication. Visterra is developing VIS410 as a single administration treatment for hospitalized patients with influenza A infection, including seasonal and potential pandemic strains. Influenza virus infection is one of the most common infectious diseases and can lead to severe illness and death. Influenza epidemics occur seasonally in most countries, resulting in about three to five million cases of severe illness and about 250,000 to 500,000 deaths worldwide. Although the usual strains of influenza that circulate annually are of a significant public health concern, far more lethal influenza strains have emerged periodically, leading in some cases to pandemics. Recently, both H5N1 and H7N9 isolates have emerged in humans, causing severe disease with high mortality, although to this point only limited human-to-human transmission has been observed. Nonetheless, predicted mutations in both H5 and H7 strains have the potential to enhance human-to-human transmission and create pandemic potential. In addition, data that H7N9 strains are more readily transmitted from poultry to humans compared to other avian influenza viruses, and documentation of resistance of H7N9 to existing anti-viral drugs, have fueled increased concern. Visterra is a biotechnology company that uses its proprietary Hierotope™ Platform to identify unique disease targets and design and engineer effective therapeutics. The company’s technology is powered by computational tools and techniques, the core of which is Atomic Interaction Network (AIN) analysis, which identifies a specific area, or epitope, on the target site that is fundamental to its structure and function. This ideal epitope, or hierotope, becomes the target against which the company designs a novel therapeutic with the potential to effectively and durably combat the disease. The company is currently focused on therapeutics for infectious diseases, and its lead product candidate, VIS410, is a broad spectrum human monoclonal antibody for the treatment of both seasonal and pandemic influenza. The company’s second product candidate, VIS513, is a human monoclonal antibody for the treatment of dengue that has been shown to broadly neutralize all four dengue virus serotypes. Visterra was founded based on scientific work developed in the laboratory of Dr. Ram Sasisekharan and licensed from MIT. For more information, please visit www.visterrainc.com.

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