Virginia Polytechnic Institute and State University, popularly known as Virginia Tech, is a public land-grant university with a main campus in Blacksburg, Virginia, educational facilities in six regions statewide, and a study-abroad site in Switzerland. The commonwealth's third-largest university and a leading research institution, Virginia Tech offers 225 undergraduate and graduate degree programs to some 31,000 students and manages a research portfolio of $454 million. The university fulfills its land-grant mission of transforming knowledge to practice through technological leadership and by fueling economic growth and job creation locally, regionally, and across Virginia.The Virginia Tech Board of Visitors serves as the university's governing body. The board comprises 13 members who are appointed by the governor of Virginia. Serving as ex-officio, non-voting representatives are the president of the state Board of Agriculture and Consumer Services; the presidents of the university's faculty senate and staff senate; and an undergraduate student and a graduate student selected through a competitive review process. Wikipedia.
Virginia Polytechnic Institute and State University | Date: 2015-03-03
Devices and methods for performing dielectrophoresis are described. The devices contain sample channel which is separated by physical barriers from electrode channels which receive electrodes. The devices and methods may be used for the separation and analysis of particles in solution, including the separation and isolation of cells of a specific type. As the electrodes do not make contact with the sample, electrode fouling is avoided and sample integrity is better maintained.
Virginia Polytechnic Institute and State University | Date: 2015-12-02
A low profile inductor structure suitable for use in a high power density power converter has one or more windings formed by vias through a thin, generally planar body of magnetic material forming the inductor core and conductive cladding on the body of magnetic material or material covering the magnetic material body. Variation of inductance with load current and other operational or environmental parameters is reduced to any desired degree by forming a slot that removes all or a portion of the magnetic material between the locations of the vias.
Virginia Polytechnic Institute and State University | Date: 2015-02-20
The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.
Virginia Polytechnic Institute and State University | Date: 2015-02-23
Zero voltage switching (ZVS) is provided in switches of a switching circuit in a second stage of a power converter by an inductor of a CLL resonant circuit connected in parallel with both a primary winding of one or more transformers connected in series and an output of the switching circuit so that the parasitic output capacitances of the switches can be charged and discharged, respectively, during the dead-time of the switching circuit by current in the inductor and independently of current in the magnetizing inductance of the transformer. Therefore, the magnetizing inductance of the transformer can be made sufficiently large to balance currents delivered to respective loads that may be unbalanced as is particularly desirable for driving a plurality of LED strings for illumination and is consistent with controlled dimming of the LED strings. A current sensor such as a resistance can be place in any LED string and all transformer modules and string currents cross regulated,
Virginia Polytechnic Institute and State University | Date: 2015-04-14
A method for treating a target tissue in a patient in need thereof is provided. The method includes the steps of identifying one or more characteristics of one or more cells of a target tissue; calculating a threshold electric field for inducing IRE in the target tissue based on the one or more characteristics; constructing a treatment protocol of one or more pulse parameters, wherein the treatment protocol is capable of inducing IRE in the target tissue; and delivering the treatment protocol to the target tissue. Systems for treatment planning for medical therapies involving administering electrical treatment energy are also provided.