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PubMed | Virgen Of La Victoria Hospital Investigation Unit Imabis
Type: Journal Article | Journal: Nutricion hospitalaria | Year: 2015

Programs of weight loss and a healthy diet are recommended for patients with cardiovascular risk but the effectiveness of these programs in decreasing cardiovascular mortality is controversial.To examine the acute and long-term effects of a 2-month cardiac rehabilitation program on chemokines related to inflammation in subjects with cardiovascular disease.Prospective cohort study.Twenty-six patients with cardiovascular disease enrolled in a cardiac rehabilitation program based on nutritional and exercise interventions were studied. Lifestyle and clinical, metabolic and inflammatory variables were analysed.88.5% were men and the mean age was 54.9 7.8 years. At the end of the cardiac rehabilitation program the levels of carbohydrate and lipid metabolism were lower, except for high density lipoprotein cholesterol which was higher. The levels of uric acid, interleukin-6, interleukin-1Beta, adiponectin and leptin remained stable. Interleukin-6 correlated positively with levels of C-reactive protein and negatively with blood glucose. Interleukin-1Beta correlated positively with C-reactive protein levels and negatively with blood pressure figures. Significant correlations were seen between the changes in levels of interleukin-6 and interleukin-1Beta and changes in metabolic equivalents, and in C-reactive protein levels before and after the cardiac rehabilitation program. No significant correlations were observed with weight, waist circumference or fat mass.A cardiac rehabilitation program decreased anthropometric variables and blood pressure figures, and improved lipid metabolism and ergometry data. However, no changes regarding the inflammatory state were observed.


Roca-Rodriguez M.M.,Virgen Of La Victoria Hospital Investigation Unit Imabis | Roca-Rodriguez M.M.,Virgen Of La Victoria Hospital | Roca-Rodriguez M.M.,CIBER ISCIII | Garcia-Almeida J.M.,Virgen Of La Victoria Hospital | And 10 more authors.
Oncology Reports | Year: 2014

Malnutrition affects 40-50% of patients with ear, nose and throat (ENT) cancer. The aim of this study was to assess changes induced by a specific nutritional supplement enriched with n-3 polyunsaturated fatty acids, fiber and greater amounts of proteins and electrolytes, as compared with a standard nutritional supplement, on markers of inflammation, oxidative stress and metabolic status of ENT cancer patients undergoing radiotherapy (RT). Fourteen days after starting RT, 26 patients were randomly allocated to one of two groups, 13 supplemented with Prosure®, an oncologic formula enriched with n-3 polyunsaturated fatty acids, fiber and greater amounts of proteins and electrolytes (specific supplement), and 13 supplemented with Standard-Isosource® (standard supplement). Patients were evaluated before RT, and 14, 28 and 90 days after starting RT. The results showed that there were no significant differences between the groups, but greater changes were observed in the standard supplement group, such as a decline in body mass index (BMI), reductions in hematocrit, erythrocyte, eosinophil and albumin levels, and a rise in creatinine and urea levels. We concluded that metabolic, inflammatory and oxidative stress parameters were altered during RT, and began to normalize at the end of the study. Patients supplemented with Prosure showed an earlier normalization of these parameters, with more favorable changes in oxidative stress markers and a more balanced evolution, although the difference was not significant.


Roca-Rodriguez M.M.,Virgen Of La Victoria Hospital | Lopez-Tinoco C.,Puerta del Mar Hospital | Fernandez-Deudero A.,Puerta del Mar Hospital Investigation Unit | Murri M.,Virgen Of La Victoria Hospital Investigation Unit Imabis | And 4 more authors.
Diabetes/Metabolism Research and Reviews | Year: 2012

Background: Gestational diabetes mellitus (GDM) has been recognized as a significant risk factor for metabolic syndrome and CVD. The aim of the study was to evaluate the relationships between levels of cytokines, components of metabolic syndrome and cardiovascular risk markers in women with previous gestational diabetes. Methods: Women (n=41) with gestational diabetes background (cases) and 21 healthy women (controls) in the postpartum period were enrolled. Demographic and clinical data, lipid and carbohydrate metabolism and uric acid and adipokine levels (TNF-α, IL-6, leptin and adiponectin) were compared and their relationships analysed. Metabolic syndrome prevalence was calculated by WHO and NCEP-ATPIII definitions. Results: There were significant differences between cases and controls: body mass index (kg/m2) 27.4±5.6 vs 23.9±3.6 (p=0.013), waist circumference (cm) 85.2±12.9 vs 77.5±9.0 (p=0.017), metabolic syndrome (WHO definition) 14.6% vs 0% (p=0.012), metabolic syndrome (NCEP-ATPIII definition) 22% vs 0% (p=0.002), low HDL 36.6% vs 9.5% (p=0.024), fasting glucose (mmol/L) 5.4±0.6 vs 4.9±0.2 (p<0.001), glucose 120′ oral glucose tolerance test (mmol/L) 5.8±1.7vs 4.7±0.8 (p=0.007), fasting insulin (μU/mL) 13.4±8.1 vs 8.4±4.3 (p=0.004), HOMA index 3.3±2.3 vs 1.8±1.0 (p=0.002), HbA1c (%) 5.4±0.2 vs 5.2±0.2 (p=0.021), uric acid (mg/dL) 4.1±1 vs 3.5±0.6 (p=0.009), leptin (ng/mL) 32025.5±19917.3 vs 20258.9±16359.9 (p=0.023), respectively. Conclusions: Women with previous gestational diabetes have central adiposity, atherogenic lipid profile, carbohydrate intolerance and adverse adipokine profile, all of which are risk factors for the future development of metabolic disease and CVD. © 2012 John Wiley & Sons, Ltd.


Roca-Rodriguez M.M.,Virgen Of La Victoria Hospital | Roca-Rodriguez M.M.,Virgen Of La Victoria Hospital Investigation Unit Imabis | Lopez-Tinoco C.,Puerta del Mar Hospital | Murri M.,Virgen Of La Victoria Hospital Investigation Unit Imabis | And 7 more authors.
Journal of Endocrinological Investigation | Year: 2014

Background: Relationships between adhesion molecules (AM), oxidative stress, gestational diabetes mellitus (GDM) and future development of type 2 diabetes mellitus are unclear. We investigated AM and oxidant/antioxidant markers in women with previous history of GDM. Subjects and methods: Postpartum women with GDM (cases; n = 41) and healthy women (controls; n = 21) had clinical and laboratory variables measured, including indicators of vascular damage (ICAM-1, VCAM-1 and E-selectin), oxidative stress (LPO, GSH and GST) and antioxidant markers (catalase, SOD, GPX and TAC). Results: Previous GDM versus control women presented higher body mass index: 27.4 ± 5.6 versus 23.9 ± 3.6 (p = 0.013); waist circumference: 85.2 ± 12.9 versus 77.5 ± 9.0 (p = 0.017); MetS (WHO definition): 14.6 versus 0 % (p = 0.012); MetS (NCEP-ATPIII definition): 22 versus 0 % (p = 0.002); low HDL: 36.6 versus 9.5 % (p = 0.024); fasting glucose (mmol/L): 5.4 ± 0.6 versus 4.9 ± 0.2 (p < 0.001); glucose 120 min (mg/dL): 105.0 ± 30.2 versus 85.1 ± 14.2 (p = 0.007); fasting insulin (μU/mL): 13.4 ± 8.1 versus 8.4 ± 4.3 (p = 0.004); HOMA index: 3.3 ± 2.3 versus 1.8 ± 1.0 (p = 0.002); HbA1c (%/mmol/mol): 5.4 ± 0.2 versus 5.2 ± 0.2/36 ± 1.4 versus 33 ± 1.4 (p = 0.021); uric acid (mg/dL): 4.1 ± 1 versus 3.5 ± 0.6 (p = 0.009); catalase (nmol/min/mL): 38.7 ± 15.6 versus 28.9 ± 11.1 (p = 0.013). There were no significant differences in hypertension prevalence, lipid fractions, albumin/creatinine ratio and AM. Conclusions: Women with previous GDM have high catalase levels which correlate positively with glucose intolerance, indicating the potential effect of oxidative stress on postpartum dysglycemic status. © 2014 Italian Society of Endocrinology (SIE).


Roca-Rodriguez M.M.,Virgen Of La Victoria Hospital | Roca-Rodriguez M.M.,Virgen Of La Victoria Hospital Investigation Unit Imabis | Garcia-Almeida J.M.,Virgen Of La Victoria Hospital | Ruiz-Nava J.,Virgen Of La Victoria Hospital | And 6 more authors.
Journal of Cardiopulmonary Rehabilitation and Prevention | Year: 2014

PURPOSE: The aim of the study was to determine the effect of lifestyle changes in patients participating in a cardiac rehabilitation program. METHODS: Patients with cardiovascular disease (N = 59) were enrolled in cardiac rehabilitation, which included nutritional and exercise interventions. All patients completed the program, but only 44 attended the reassessment after 12 months because of work reasons or lack of time or interest. RESULTS: Ergometry before and after cardiac rehabilitation showed significant differences in exercise tolerance time (5.2 ± 1.8 minutes vs 7.1 ± 2.1 minutes; P< .001), metabolic equivalents (6.5 ± 1.8 vs 8.8 ± 2.2; P< .001), and the Börg rating of perceived exertion scale (12 ± 1.8 points vs 13.7 ± 1.6 points; P= .005). At the end of the intervention program, significant improvements were seen in body weight (82.6 ± 15.2 kg vs 80.8 ± 14.3 kg; P< .001), waist circumference (100.3 ± 12.4 cm vs 98.0 ± 11.0 cm; P= .002), and levels of fasting glucose (126.5 ± 44.6 mmol/L vs 109.6 ± 24.8 mmol/L; P< .001), low-density lipoprotein cholesterol (2.7 ± 0.9 mmol/L vs 2.5 ± 0.8 mmol/L; P= .033), and C-reactive protein (5.1 ± 8.7 μg/mL vs 4.1 ± 2.6 μg/mL; P= .008), as well as in adherence to a healthy diet as estimated by the Trichopoulou questionnaire score (7.9 ± 2.3 vs 10.6 ± 1.5; P< .001). Twelve months later, however, many of these benefits had either remained stable or worsened. CONCLUSIONS: Cardiac rehabilitation is an appropriate program for the improvement of clinical and analytical variables, such as functional capacity, carbohydrate and lipid metabolism, anthropometric measures, and diet. However, 12 months later, many of these benefits either remained stable or worsened. Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.

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