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Pertegal M.,Virgen Of La Arrixaca Clinical Universitary Hospital | Fenoy F.J.,University of Murcia | Bonacasa B.,University of Murcia | Mendiola J.,University of Murcia | And 6 more authors.
Reproductive Sciences

We investigated whether clinical severity indices and biomarkers for preeclampsia (PE) are associated with low plasmatic 2-methoxyestradiol (2ME) in the third trimester of gestation. Blood was collected from 53 women with PE and 73 control pregnant women before parturition. The concentration of 2ME was significantly higher in controls than in patients with PE (2906.43 ±200.69 pg/mL vs 1818.41 ± 189.25 pg/mL). The risk of PE decreased as 2ME levels increased. The 2ME values were negatively correlated with systolic peak arterial pressure and proteinuria in PE. Additionally, those women with PE with lower 2ME had a more serious clinical situation and needed a more aggressive therapy. Finally, 2ME levels (in patients with PE and total population) were significantly correlated with concentrations of soluble fms-like tyrosine kinase 1 and placental growth factor. Summarizing, patients with PE had lower 2ME levels that were correlated with different clinical indices and biomarkers of severity, indicating that 2ME could be taken into account for the clinical management of this syndrome. © The Author(s) 2014. Source

Febrero B.,Virgen Of La Arrixaca Clinical Universitary Hospital | Rodriguez J.M.,Virgen Of La Arrixaca Clinical Universitary Hospital | Rios A.,Virgen Of La Arrixaca Clinical Universitary Hospital | Portillo P.,Virgen Of La Arrixaca Clinical Universitary Hospital | Parrilla P.,Virgen Of La Arrixaca Clinical Universitary Hospital
Journal of Endocrinological Investigation

Introduction: Papillary thyroid carcinoma (PTC) is exceptional in MEN 2. Results: The analysis in 135 patients revealed two PTC, without C-cell pathology; both being positive for V804M mutation (RET proto-oncogene). Conclusions: Few data are available about PTC in MEN 2, and without C-cell pathology is even less common. More studies are needed to correlate genetics and histology, and even for assessing PTC as only manifestation of MEN 2. © 2015 Italian Society of Endocrinology (SIE). Source

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