Vinyakrao Patil Mahavidyala Vaijapur

Aurangābād, India

Vinyakrao Patil Mahavidyala Vaijapur

Aurangābād, India
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Dekhane D.V.,Vinyakrao Patil Mahavidyala Vaijapur | Pawar S.S.,Vinyakrao Patil Mahavidyala Vaijapur | Gupta S.,Vinyakrao Patil Mahavidyala Vaijapur | Shingare M.S.,Dr. Babasaheb Ambedkar Marathwada University | Thore S.N.,Vinyakrao Patil Mahavidyala Vaijapur
Bioorganic and Medicinal Chemistry Letters | Year: 2011

A series of 4,5-dihydro-1,5-diaryl-1H-pyrazole-3-substituted-heteroazoles were designed and synthesized in order to obtain new compounds with potential anti-inflammatory activity. The title compounds were screened for in vivo anti-inflammatory activity by using Carrageenan induced rat paw edema method. Diclofenac sodium was used as a standard drug for comparison. Out of the 30 compounds tested, compound 19a, 19b, 25a, 25b exhibited significant anti-inflammatory activity. Selected compounds were also screened for in vitro COX-2 inhibition assay and analgesic activity in the acetic acid induced writhing model. ©2011 Elsevier Ltd. All rights reserved.


Dekhane D.V.,Vinyakrao Patil Mahavidyala Vaijapur | Pawar S.S.,Vinyakrao Patil Mahavidyala Vaijapur | Gupta S.V.,Vinyakrao Patil Mahavidyala Vaijapur | Shingare M.S.,Dr. Babasaheb Ambedkar Marathwada University | Thore S.N.,Vinyakrao Patil Mahavidyala Vaijapur
Chinese Chemical Letters | Year: 2010

The first successful lithium bromide mediated solvent free condensation of arylenediamine and esters to obtain 2-substituted benzimidazole and imidazopyridine in good to excellent yields is described. © 2009 Shivaji N. Thore.


Dekhane D.V.,Vinyakrao Patil Mahavidyala Vaijapur | Pawara S.V.,Vinyakrao Patil Mahavidyala Vaijapur | Gupta S.V.,Vinyakrao Patil Mahavidyala Vaijapur | Shingareb M.S.,Dr. Babasaheb Ambedkar Marathwada University | Thore S.N.,Vinyakrao Patil Mahavidyala Vaijapur
Letters in Organic Chemistry | Year: 2011

The lithium bromide mediated condensation of 1-amino-2-heteroaryl substrates with ethyl cyanoformate, to obtain versatile alkylcarbamate protected benzoheteroazolones was studied. This unprecedented reaction could be used to furnish different azolones like 2-benzimidazolones, 2-benooxazolones and 2-amino-thiazoles in good yields. 2011 Bentham Science Publishers Ltd. © 2011 Bentham Science Publishers Ltd.


PubMed | Vinyakrao Patil Mahavidyala Vaijapur
Type: Journal Article | Journal: Bioorganic & medicinal chemistry letters | Year: 2011

A series of 4,5-dihydro-1,5-diaryl-1H-pyrazole-3-substituted-heteroazoles were designed and synthesized in order to obtain new compounds with potential anti-inflammatory activity. The title compounds were screened for in vivo anti-inflammatory activity by using Carrageenan induced rat paw edema method. Diclofenac sodium was used as a standard drug for comparison. Out of the 30 compounds tested, compound 19a, 19b, 25a, 25b exhibited significant anti-inflammatory activity. Selected compounds were also screened for in vitro COX-2 inhibition assay and analgesic activity in the acetic acid induced writhing model.

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