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Kuzminova N.V.,Vinnitsa National Medial University Named After rogov | Osovska N.Y.,Vinnitsa National Medial University Named After rogov | Lozinsky S.E.,Vinnitsa National Medical University | Knyazkova I.I.,Kharkiv National Medical University
Arterial Hypertension | Year: 2016

Background. Mechanisms of activation of the process of vascular wall remodelling in patients affected by arterial hypertension have not been studied in depth and require clarification. Materials and methods. The study included 381 patients with hypertension - 212 men and 169 women of the average age 53.0 (47; 60) years. The structural-functional vessel status was determined by the method of duplex scanning and colour duplex mapping of blood flow with the Logiq 500 MO apparatus (GE, USA). Statistical analyses were made using Microsoft Excel software kit , Statistica for Windows 6.0. Results. The patients with hypertension presented some left-right asymmetry of remodelling extracranial carotid arteries. Unlike the impact of remodelling of the right carotid artery, the most essential effect on the left carotid artery was the impact of daytime pulse arterial pressure and variability of the nocturnal systolic arterial pressure (the strength of impact 25.0 and 13.9%, respectively. The processes of remodelling of the right carotid artery are more sensible to the impact of high values of nocturnal diastolic arterial pressure (the strength of impact 16.4%). The beginning of some brain complication is associated with the significant increase in atherosclerotic affection not only of the left, but also of the right carotid artery. Conclusions. Remarkable remodelling of the right carotid artery is often associated with the severity of the disease and to some extent reflects the severity of the flow of the disease and can be regarded as an additional unfavourable feature. © 2015 Via Medica.


Osovska N.Y.,Vinnitsa National Medical University | Kuzminova N.V.,Vinnitsa National Medical University
Wiadomosci lekarskie (Warsaw, Poland : 1960) | Year: 2016

INTRODUCTION: isolated left ventricular non-compaction (LVNC) is a heart disease with rather distinct morphologic and clinical manifestations. Available in the literature information about LVNC considering multiple left ventricle abnormal chords (LVAC) as one of its criterion motivated us to review the results obtained in the study of young patients with this pathology. The aim of the research was to demonstrate different clinical variants of left ventricular non-compaction course in adult patients and to clarify some pathogenetic aspects of this pathology. Materials and metods: comprehensive examination of 28 patients with multiple LVAC, 12 patients with LVNC and dilated idiopathic cardiomyopathy aged 16-36 was performed.RESULTS: according to the results of our research, 16 of 28 patients with multiple LVAC of left ventricle had ejection fraction more than 55%, in 6 patients this index range was 50-54%, in 6 it was 45-49%. Multiple LVAC were found to be associated with significantly greater clinical, phenotypic, structural and hemodynamic changes when compared both to control and solitary LVAC of any location (р<0.05). There were 12 young patients with multiple LVAC and ejection faction 22-41%. The detailed analysis of echocardiographic data in dynamics revealed other criteria of LVNC in all the patients. The data obtained suggest the relationship between pathogenetic mechanisms of heart pathology development in patients with connective tissue dysplasia syndrome and in patients with LVNС. Echocardiographic evidences of multiple LVAC designate the necessity of targeted search of left ventricular non-compacted signs and timely detection of left ventricular dilation.


Yuriivna Osovska N.,Vinnitsa National Medical University | Vitaliivna Kuzminova N.,Vinnitsa National Medical University
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego | Year: 2016

Stable angina is the most frequent manifestation of ischemic heart disease (IHD) in women as compared to men (65% versus 37%). IHD in women has more favorable clinical course because myocardial infarction develops twice as rare as in men. Coronary angiography of angina patients demonstrates normal coronary arteries more frequently in women than in men. Microvascular angina (MVA) is found to be a rather common form of stable IHD as that particular diagnosis is made later in 20-30% of patients who previously underwent coronary angiography. The disease occurs three times as often in women than in men irrespective of age. Most of these patients are in their perimenopausal age - 45-60 years. The major role in MVA development is considered to be decreased coronary flow reserve resulting from evident endothelial dysfunction of minor coronary arteries. MVA is characterized by great variability of its course and low response to conventional antianginal therapy, particularly in women. In view of this the problem of antianginal drugs which can be used in addition to standard therapy remains to be solved. Ranolazine is a new original antianginal medicine which improves left ventricular diastolic filling by selective inhibition of late Na-flow leading to more effective coronary vessels filling in diastole. The article presents the results of multicenter studies of ranolazine as to its effect on diastolic and systolic functions of the left ventricle, clinical manifestations of angina and heart failure as well as the data on antiarrhythmic action of ranolazine. This article describes the case of successful use of ranolazine as an additional anti-anginal medicine in the 46- year-old female patient diagnosed with microvascular angina. Before taking ranolazine, on the background of conventional treatment of coronary heart disease, the patient developed stable angina and persistent left bundle branch block, atrial fibrillation. After receiving ranolazine, 1000 mg per day for a month, Holter ECG monitoring showed not only significantly reduced number of strokes, the left bundle branch block and atrial fibrillation dissappeared as well. The results indicate a high efficiency of ranolazine as an antianginal, anti-ischemic and anti-arrythmic medicine.


Osovska N.Y.,Vinnitsa National Medical University | Kuzminova N.V.,Vinnitsa National Medical University | Knyazkova I.I.,Kharkiv National Medical University
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego | Year: 2016

Loeffler endocarditis is a rare acquired endocardial and myocardial disease characterized by a sharp decrease in the compliance of either or both ventricles with an acute diastolic dysfunction and massive mural thrombosis. This disease is presented in the classification of cardiomyopathies and is a variant of restrictive cardiomyopathy. Today Loeffler endocarditis is considered as a manifestation of hypereosinophilic syndrome with predominant heart involvement. The life-time diagnosis of myocardial injury due to eosinophilic infiltration is rare, or it is diagnosed at the stage of necrotizing endomyocarditis, when the treatment is no longer effective. A number of issues regarding the individual aspects of the pathogenesis of hypereosinophilic syndrome and Loeffler endocarditis are still not fully understood, as well as the long-term prospects for the use of drugs for the treatment of hypereosinophilic syndrome, especially in young and middle-aged persons. Loeffler endocarditis can be suspected in the presence of hypereosinophilia on the background of causeless (unexplainable) hypertrophy of the left ventricle or both ventricles. The article includes a case of the life-time diagnosis of this disease in a young woman with the retrospective analysis of the early stages of the disease, echocardiographic and radiologic imaging at the advanced stage of the disease and quite successful treatment option for this disease. © 2016 MEDPRESS.


PubMed | National University of Pharmacy and Vinnitsa National Medical University
Type: Journal Article | Journal: Scientia pharmaceutica | Year: 2017

In continuing the search for new analgesics among derivatives of 2,1-benzothiazines, a series of corresponding toluidides and xylidides of 4-hydroxy-2,2-dioxo-1


Lysenko S.A.,Vinnitsa National Medical University
Experimental oncology | Year: 2013

To study p53 expression in the tumor tissue of lung cancer (LC) patients with paraneoplastic rheumatic syndrome (PNRS). There have been used either biopsy or surgically resected tumor samples of 140 LC patients (83 patients without PNRS, 57 patients with PNRS). For evaluation of p53 expression in LC samples, immunohistochemical analysis was performed. It has been shown that p53 expression in tumor samples from LC patients with PNRS was significantly higher compared to that in LC patients without PNRS. It has been shown that p53 expression is more frequently registered in patients with lung adenocarcinoma with PNRS than in patients with lung adenocarcinoma without this syndrome. The presence of PNRS in LC patients with p53 expression is associated with higher aggressiveness of tumor.


Lysenko S.A.,Vinnitsa National Medical University
Voprosy Onkologii | Year: 2013

A qualitative and quantitative immunohistochemical evaluation of expression of oncoprotein Bcl-2 in 140 patients with lung cancer (LC) was performed: 57 patients with paraneoplastic rheumatic syndrome (PNRS) and 83 - without symptoms of the syndrome. It was established that in the group of lung cancer patients with manifestations of PNRS the expression of Bcl-2 was rarely observed, and the average level of expression of Bcl-2 was much lower when compared to similar patients with lung cancer but without symptoms of the given syndrome. The presence of PNRS in patients with lung cancer leads to reduced tumor expression by Bcl-2, indicating a higher malignancy and aggressive nature of the tumors.


Bondarchuk A.O.,Vinnitsa National Medical University | Gavrilyuk A.A.,Vinnitsa National Medical University
Voprosy Onkologii | Year: 2016

Experimental study results confirm morphologically usefulness of benzofurocain for correction of microcirculation changes manifested as a side-effect of cyclophosphamide on the small intestine tissue. The experiment was conducted on 63 white purebred rats. The morphological and morphometric analysis of small intestine tissue was carried out in the control group, the group that was injected intraperitoneally with cyclophosphamide and the group that was injected intraperitoneally with cyclophosphamide and benzofurocain. It was reliably proven that the structure of microcirculation damaged by cyclophosphamide morphologically and morphometrically rose up to values of control group on the third day.


Purpose: to elucidate the prognostic role of angiotensin receptor (ATR,) gene polymorphism relative to progression of the disease and effectiveness of antihypertensive therapy. Material and methods. We included in this study 132 consecutive patients (48 women [36.4%, mean age 51.6 years] and 84 men [63.6%, mean age 49.4 yearsP with diagnosis of arterial hypertension (AH), who underwent echocardiography not less than 10 months from the date of entry into the study. Mean duration of follow-up was about 5 years. In all patients we determined belonging to one of variants of polymorphic A1166C gene: AA, AC, or CC. This allowed us to divide them into 2 groups: carriers of allele A (group A) and allele Ñ (group Q. In both groups we observed significant regression of left ventricular myocardial mass (LVMM) in those patients who achieved target BP. No significant changes of LVMM were noted in patients with partially effective or ineffective antihypertensive treatment (AHT). Regression of LVMM was observed more frequently among patients taking angiotensin receptor blockers (ARBs) compared with those who used angiotensin converting enzyme inhibitors (ACEI). Conclusion. Thus it was established that irrespective of the structure of polymorphic ATRt gene there existed a parallelism of antihypertensive and antiremodelling efficacy of treatment of AH. Besides that, the ATR1 gene polymorphism can be considered as an additional factor determining efficacy of AHT. In particular, carriers of Ñ allele respond better to therapy with ARBs, and carriers of A allele - with ACEI. In this case, the carriers of allele Ñ can be expected to decrease their LVMM more expressive than carriers of the allele A.


Lysenko S.A.,Vinnitsa National Medical University
Experimental Oncology | Year: 2013

Aim: To study p53 expression in the tumor tissue of lung cancer (LC) patients with paraneoplastic rheumatic syndrome (PNRS). Materials and Methods: There have been used either biopsy or surgically resected tumor samples of 140 LC patients (83 patients without PNRS, 57 patients with PNRS). For evaluation of p53 expression in LC samples, immunohistochemical analysis was performed. Results: It has been shown that p53 expression in tumor samples from LC patients with PNRS was significantly higher compared to that in LC patients without PNRS. It has been shown that p53 expression is more frequently registered in patients with lung adenocarcinoma with PNRS than in patients with lung adenocarcinoma without this syndrome. Conclusion: The presence of PNRS in LC patients with p53 expression is associated with higher aggressiveness of tumor.

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