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Vinnytsia Oblast, Ukraine

Lysenko S.A.,Vinnitsa National Medical University
Voprosy Onkologii | Year: 2013

A qualitative and quantitative immunohistochemical evaluation of expression of oncoprotein Bcl-2 in 140 patients with lung cancer (LC) was performed: 57 patients with paraneoplastic rheumatic syndrome (PNRS) and 83 - without symptoms of the syndrome. It was established that in the group of lung cancer patients with manifestations of PNRS the expression of Bcl-2 was rarely observed, and the average level of expression of Bcl-2 was much lower when compared to similar patients with lung cancer but without symptoms of the given syndrome. The presence of PNRS in patients with lung cancer leads to reduced tumor expression by Bcl-2, indicating a higher malignancy and aggressive nature of the tumors. Source


Ukrainets I.V.,National University of Pharmacy | Davidenko A.A.,Vinnitsa National Medical University | Mospanova E.V.,East Ukrainian National University | Sidorenko L.V.,National University of Pharmacy | Svechnikova E.N.,National University of Pharmacy
Chemistry of Heterocyclic Compounds | Year: 2010

We have carried out the synthesis and a comparative analysis of the acidic properties of a large group of 4-R-2-oxo-1,2-dihydroquinoline-3-carboxylic acids. Features of the recorded NMR spectra of these compounds are discussed together with their analgesic properties. © 2010 Springer Science+Business Media, Inc. Source


Ukrainets I.V.,National University of Pharmacy | Mospanova E.V.,East Ukrainian National University | Davidenko A.A.,Vinnitsa National Medical University | Shishkina S.V.,Ukrainian Academy of Sciences
Chemistry of Heterocyclic Compounds | Year: 2010

A targeted synthesis was carried out of a series of 1-allyl-4-hydroxy-6,7- dimethoxy-2-oxo-1,2-di-hydroquinoline-3-carboxylic acid alkylamides which show interest for biological study as potential analgesics. It was found that, in the presence of one equivalent of bromine, the compounds indicated undergo halocyclization to the corresponding 2-bromomethyl-7,8-dimethoxy-5-oxo-1,2- dihydro-5H-oxa-zolo[3,2-a]quinoline-4-carboxylic acid alkylamides. However, with an excess of bromine the reaction occurs somewhat differently and concludes with the formation of complexes of bromine with 4-alkyl-carbamoyl-2-bromomethyl- 5-hydroxy-7,8-dimethoxy-1,2-dihydrooxazolo[3,2-a]quinolinium ditri- bromides. According to the results of pharmacological screening there are found compounds within the substances discovered with high analgesic activity. © 2010 Springer Science+Business Media, Inc. Source


Lysenko S.A.,Vinnitsa National Medical University
Experimental Oncology | Year: 2013

Aim: To study p53 expression in the tumor tissue of lung cancer (LC) patients with paraneoplastic rheumatic syndrome (PNRS). Materials and Methods: There have been used either biopsy or surgically resected tumor samples of 140 LC patients (83 patients without PNRS, 57 patients with PNRS). For evaluation of p53 expression in LC samples, immunohistochemical analysis was performed. Results: It has been shown that p53 expression in tumor samples from LC patients with PNRS was significantly higher compared to that in LC patients without PNRS. It has been shown that p53 expression is more frequently registered in patients with lung adenocarcinoma with PNRS than in patients with lung adenocarcinoma without this syndrome. Conclusion: The presence of PNRS in LC patients with p53 expression is associated with higher aggressiveness of tumor. Source


Lysenko S.A.,Vinnitsa National Medical University
Experimental oncology | Year: 2013

To study p53 expression in the tumor tissue of lung cancer (LC) patients with paraneoplastic rheumatic syndrome (PNRS). There have been used either biopsy or surgically resected tumor samples of 140 LC patients (83 patients without PNRS, 57 patients with PNRS). For evaluation of p53 expression in LC samples, immunohistochemical analysis was performed. It has been shown that p53 expression in tumor samples from LC patients with PNRS was significantly higher compared to that in LC patients without PNRS. It has been shown that p53 expression is more frequently registered in patients with lung adenocarcinoma with PNRS than in patients with lung adenocarcinoma without this syndrome. The presence of PNRS in LC patients with p53 expression is associated with higher aggressiveness of tumor. Source

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