Vinayaka Missions University
Chennai, India

Vinayaka Missions University formerly Vinayaka Mission's Research Foundation is a higher education institution based in Salem, Tamil Nadu, India. In the year 2001 the "University" status was conferred on Vinayaka Missions by The Ministry of Human Resources Development, Government of India, with the recommendations of the UGC as an acknowledgement of its excellence, satisfaction of the highest level of academic standards and best infrastructural facilities provided to achieve preeminence in education and by virtue of this recognition Vinayaka Missions trascended to becoming Vinayaka Mission‘s University as the 48th University in India. Wikipedia.

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Karmegam N.,Vinayaka Missions University
International Journal of Global Environmental Issues | Year: 2010

Pre-decomposed (15 days) mango leaf litter with cowdung in 50:50 (wt/wt) was subjected to vermicomposting using Perionyx ceylanensis for 60 days. The electrical conductivity, total NPK, Ca, Na and other nutrients were higher in the vermicompost than in the worm unworked control substrate, whereas organic carbon and C/N ratio were lowered. The population of bacteria, fungi and actinomycetes at the start of the experiment (initial) increased progressively towards the end of vermicomposting. The final microbial population was higher and significantly different (p < 0.05) from the initial values. The incubation period of vermicompost showed significant positive correlation with microbial population (r = 0.99; p < 0.001). Copyright © 2010 Inderscience Enterprises Ltd.

Sankar D.,Vinayaka Missions University | Ali A.,Sultan Qaboos University | Sambandam G.,Prof Maniarasan Memorial Poly Hospital Chidambaram | Rao R.,Annamalai University
Clinical Nutrition | Year: 2011

Background & aims: Recently, studies have reported that sesame oil lowered blood pressure and improved antioxidant status in hypertensive and diabetic-hypertensive patients. The aim of this study was to evaluate the effectiveness of sesame oil with anti-diabetic (glibenclamide) medication as combination therapy in mild-to moderate diabetic patients. Methods: This open label study included sixty type 2 diabetes mellitus patients divided into 3 groups, receiving sesame oil (n = 18), 5 mg/day (single dose) of glibenclamide (n = 20), or their combination (n = 22). The patients were supplied with sesame oil [BNB Sesame oil TM] except glibenclamide group, and instructed to use approximately 35 g of oil/day/person for cooking, or salad preparation for 60 days. 12 h-fasting venous blood samples were collected at baseline (0 day) and after 60 days of the experiment for various biochemical analysis. Results: As compared with sesame oil and glibenclamide alone, combination therapy showed an improved anti-hyperglycemic effect with 36% reduction of glucose (P < 0.001 vs before treatment, P < 0.01 vs sesame oil monotherapy, P < 0.05 vs glibenclamide monotherapy) and 43% reduction of HbA 1c (P < 0.001 vs before treatment, P < 0.01 vs sesame oil monotherapy, P < 0.05 vs glibenclamide monotherapy) at the end point. Significant reductions in the plasma TC, LDL-C and TG levels were noted in sesame oil (20%, 33.8% and 14% respectively vs before treatment) or combination therapies (22%, 38% and 15% respectively vs before treatment). Plasma HDL-C was significantly improved in sesame oil (15.7% vs before treatment) or combination therapies (17% before treatment). Significant (P < 0.001) improvement was observed in the activities of enzymatic and non-enzymatic antioxidants in patients treated with sesame oil and its combination with glibenclamide. Conclusions: Sesame oil exhibited synergistic effect with glibenclamide and can provide a safe and effective option for the drug combination that may be very useful in clinical practice for the effective improvement of hyperglycemia. © 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism.

Muruhan S.,Vinayaka Missions University | Muruhan S.,University of North Dakota | Selvaraj S.,University of North Dakota | Viswanathan P.K.,Annamalai University
Asian Pacific Journal of Tropical Biomedicine | Year: 2013

Objective: To evaluate the antioxidant activity of alcoholic leaf-extract of Solanum surattense (Solanaceae) (S. surattense). Methods: Leaf extract were tested for in vitro free radical scavenging assays, such as hydroxyl radical and hydrogen peroxide, inhibition of superoxide anion radical and 2, 2-diphenyl-1-picryl hydrazyl radical (DPPH), total antioxidant activity and reducing ability. Further, total phenolic content of S. surattense was analyzed. Results: S. surattense extract effectively scavenged free radicals at all different concentrations and showed its potent antioxidant activity. Further, these effects were in a dose dependent manner. Results were compared to standard antioxidants such as butylated hydroxytoluene, ascorbic acid and α-tocopherol. Conclusions: S. surattense have strong antioxidant potential. Further the study validates the therapeutic benefits of the Indian system of medicine. © 2013 Asian Pacific Tropical Biomedical Magazine.

Rajendran E.S.,Vinayaka Missions University
International Journal of High Dilution Research | Year: 2015

As a therapeutic tool high dilutions (HDs) are always at the center of controversies due to problems to validate them as a function of Avogadro's number. Nevertheless, homeopathy is practiced around the world as a complementary and alternative medicine. The present study sought to evaluate HDs of homeopathic drug Ferrum metallicum (Ferr) 6, 30, 200, 1M, 10Mc and 50Mc, all of which except for 6c surpass Avogadro's number. Using HRTEM and EDS it was conclusively shown that: 1) all the investigated HDs of Ferr contained plenty of nanoparticles (NPs); 2) the size of NPs were within the quantum dots (QD) size range, except for 50Mc, in which larger particles were found (12.61nm); 3) NPs contained iron in various weight percentages; 4) the weight percentage of iron was highest in HDs 10Mc and 50Mc. © International Journal of High Dilution Research.

Prashar D.,Vinayaka Missions University
International Journal of ChemTech Research | Year: 2012

Self assembly provides a simple route to organise suitable organic molecules on noble metal surface by using long chain organic molecules with various functionalities like -SH,-COOH,-NH 2, Silanes etc. These surfaces can be used to build up interesting nano level architectures. Self assembly is an interesting process for biological relevance because it provides a novel approach to complex structure having nanometre scale dimensions. The self assembled monolayers (SAMs) can be characterized by the number of techniques such as Contact angle goniometry, X-ray photoelectron spectroscopy, Infra red and scanning probe microscopy which provides the valuable information about the SAMs.

Leprosy is an infectious disease caused by Mycobacterium leprae. The increasing drug and multi-drug resistance of M. leprae enforce the importance of finding new drug targets. Mycobacterium has unusually impermeable cell wall that contributes to considerable resistance to many drugs. Peptidoglycan is an important component of the cell wall of M. leprae. UDP-N-acetylmuramoyl-glycyl- D-glutamate-2, 6-diaminopimelate ligase (MurE) plays a crucial role in the peptidoglycan biosynthesis and hence it could be considered as a potential drug target for leprosy. Structure of this enzyme for M. leprae has not yet been elucidated. We modeled the three-dimensional structure of MurE from M. leprae using comparative modeling methods based on the X-ray crystal structure of MurE from E. coli and validated. The 3D-structure of M. leprae MurE enzyme was docked with its substrates meso-diaminopimelic acid (A2pm) and UDP-N-acetyl muramoyl-glycyl-D- glutamate (UMGG) and its product UDP-N-acetyl muramoyl-glycyl-D-glu-meso-A 2pm (UTP) and also with ATP. The docked complexes reveal the amino acids responsible for binding the substrates. Superposition of these complex structures suggests that carboxylic acid group of UMGG is positioned in proximity to γ-phosphate of the ATP to facilitate the formation of acylphosphate intermediate. The orientation of an amino group of A 2pm facilitates the nucleophilic attack to form the product. Overall, the proposed model together with its binding features gained from docking studies could help to design a truly selective ligand inhibitor specific to MurE for the treatment of leprosy. © 2011 Springer-Verlag.

Ray S.K.,Vinayaka Missions University
Asian Journal of Microbiology, Biotechnology and Environmental Sciences | Year: 2014

There is a consensus that diabetes is associated with a spectrum of breast cancers but the underlying mechanisms are largely unknown. On the other hand, there are ongoing debates about the risk association of insulin use with cancer. We have briefly reviewed recent related research on exploration of risk factors for breast cancer and diabetes and also link between them. Epidemiological studies have shown an association between diabetes mellitus and breast cancer: there is a twofold increased risk for breast cancer in women with late onset diabetes. Hyperinsulinemia and hyperglycemia are biomarkers for insulin resistance. Both of these disorders are critical to the initial development and progression of breast cancer. The hyperinsulinaemia seen in late onset diabetes may promote breast cancer because insulin is a growth factor for human breast cancer cells. At least four mechanisms may associate diabetes mellitus and breast cancer: activation of the insulin pathway, activation of the insulin-like growth factor (IGF) pathway, altered regulation of endogenous sex hormones and altered regulation of adipocytokines. © Global Science Publications.

Shanmugam A.,Vinayaka Missions University | Natarajan J.,Bharathiar University
Journal of Molecular Modeling | Year: 2012

Multi drug resistance capacity for Mycobacterium leprae (MDR-Mle) demands the profound need for developing new anti-leprosy drugs. Since most of the drugs target a single enzyme, mutation in the active site renders the antibiotic ineffective. However, structural and mechanistic information on essential bacterial enzymes in a pathway could lead to the development of antibiotics that targets multiple enzymes. Peptidoglycan is an important component of the cell wall of M. leprae. The biosynthesis of bacterial peptidoglycan represents important targets for the development of new antibacterial drugs. Biosynthesis of peptidoglycan is a multi-step process that involves four key Mur ligase enzymes: MurC (EC:, MurD (EC:6.3. 2,9), MurE (EC: and MurF (EC: Hence in our work, we modeled the three-dimensional structure of the above Mur ligases using homology modeling method and analyzed its common binding features. The residues playing an important role in the catalytic activity of each of the Mur enzymes were predicted by docking these Mur ligases with their substrates and ATP. The conserved sequence motifs significant for ATP binding were predicted as the probable residues for structure based drug designing. Overall, the study was successful in listing significant and common binding residues of Mur enzymes in peptidoglycan pathway for multi targeted therapy. © Springer-Verlag 2011.

Raja Sekar K.,Vinayaka Missions University | Karmegam N.,Vinayaka Missions University
Scientia Horticulturae | Year: 2010

Vermicast was used with lignite in different combinations (0:1, 1:1, 2:1, 3:1, 4:1, 5:1, 6:1 and 1:0) as carrier substrate for biofertilizers (Azotobacter chroococcum, Bacillus megaterium and Rhizobium leguminosarum). The viability count of biofertilizer organisms in stored carrier material was individually carried out once in 15 days for a total period of ten months. More than 1 × 107 g-1 viable cells of A. chroococcum, B. megaterium and R. leguminosarum were observed in 4:1, 5:1, 6:1 and 1:0 combination of carrier materials (vermicast:lignite) at the end of 10th month. In case of lignite carrier material, no viable cells were observed in 107 g-1 at the end of 6th month for A. chroococcum and R. leguminosarum and 5th month for B. megaterium. The correlation of viable cells of the biofertilizers was negative with reference to incubation period. The increase of vermicast proportion in carrier materials showed increase in the survival rate. The results of the present study suggest that the vermicasts can be used as an alternate carrier material for A. chroococcum, B. megaterium and R. leguminosarum. © 2010 Elsevier B.V. All rights reserved.

Anusuya S.,Vinayaka Missions University | Anusuya S.,Bharathiar University | Natarajan J.,Bharathiar University
Infection, Genetics and Evolution | Year: 2012

Leprosy remains a major public health problem, since single and multi-drug resistance has been reported worldwide over the last two decades. In the present study, we report the novel multi-targeted therapy for leprosy to overcome multi drug resistance and to improve therapeutic efficacy. If multiple enzymes of an essential metabolic pathway of a bacterium were targeted, then the therapy would become more effective and can prevent the occurrence of drug resistance. The MurC, MurD, MurE and MurF enzymes of peptidoglycan biosynthetic pathway were selected for multi targeted therapy. The conserved or class specific active site residues important for function or stability were predicted using evolutionary trace analysis and site directed mutagenesis studies. Ten such residues which were present in at least any three of the four Mur enzymes (MurC, MurD, MurE and MurF) were identified. Among the ten residues G125, K126, T127 and G293 (numbered based on their position in MurC) were found to be conserved in all the four Mur enzymes of the entire bacterial kingdom. In addition K143, T144, T166, G168, H234 and Y329 (numbered based on their position in MurE) were significant in binding substrates and/co-factors needed for the functional events in any three of the Mur enzymes. These are the probable residues for designing newer anti-leprosy drugs in an attempt to reduce drug resistance. © 2012 Elsevier B.V.

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