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Chennai, India

Vinayaka Missions University formerly Vinayaka Mission's Research Foundation is a higher education institution based in Salem, Tamil Nadu, India. In the year 2001 the "University" status was conferred on Vinayaka Missions by The Ministry of Human Resources Development, Government of India, with the recommendations of the UGC as an acknowledgement of its excellence, satisfaction of the highest level of academic standards and best infrastructural facilities provided to achieve preeminence in education and by virtue of this recognition Vinayaka Missions trascended to becoming Vinayaka Mission‘s University as the 48th University in India. Wikipedia.

Rajendran E.S.,Vinayaka Missions University
International Journal of High Dilution Research | Year: 2015

As a therapeutic tool high dilutions (HDs) are always at the center of controversies due to problems to validate them as a function of Avogadro's number. Nevertheless, homeopathy is practiced around the world as a complementary and alternative medicine. The present study sought to evaluate HDs of homeopathic drug Ferrum metallicum (Ferr) 6, 30, 200, 1M, 10Mc and 50Mc, all of which except for 6c surpass Avogadro's number. Using HRTEM and EDS it was conclusively shown that: 1) all the investigated HDs of Ferr contained plenty of nanoparticles (NPs); 2) the size of NPs were within the quantum dots (QD) size range, except for 50Mc, in which larger particles were found (12.61nm); 3) NPs contained iron in various weight percentages; 4) the weight percentage of iron was highest in HDs 10Mc and 50Mc. © International Journal of High Dilution Research. Source

Sankar D.,Vinayaka Missions University | Ali A.,Sultan Qaboos University | Sambandam G.,Prof. Maniarasan Memorial Poly Hospital Chidambaram | Rao R.,Annamalai University
Clinical Nutrition | Year: 2011

Background & aims: Recently, studies have reported that sesame oil lowered blood pressure and improved antioxidant status in hypertensive and diabetic-hypertensive patients. The aim of this study was to evaluate the effectiveness of sesame oil with anti-diabetic (glibenclamide) medication as combination therapy in mild-to moderate diabetic patients. Methods: This open label study included sixty type 2 diabetes mellitus patients divided into 3 groups, receiving sesame oil (n = 18), 5 mg/day (single dose) of glibenclamide (n = 20), or their combination (n = 22). The patients were supplied with sesame oil [BNB Sesame oil TM] except glibenclamide group, and instructed to use approximately 35 g of oil/day/person for cooking, or salad preparation for 60 days. 12 h-fasting venous blood samples were collected at baseline (0 day) and after 60 days of the experiment for various biochemical analysis. Results: As compared with sesame oil and glibenclamide alone, combination therapy showed an improved anti-hyperglycemic effect with 36% reduction of glucose (P < 0.001 vs before treatment, P < 0.01 vs sesame oil monotherapy, P < 0.05 vs glibenclamide monotherapy) and 43% reduction of HbA 1c (P < 0.001 vs before treatment, P < 0.01 vs sesame oil monotherapy, P < 0.05 vs glibenclamide monotherapy) at the end point. Significant reductions in the plasma TC, LDL-C and TG levels were noted in sesame oil (20%, 33.8% and 14% respectively vs before treatment) or combination therapies (22%, 38% and 15% respectively vs before treatment). Plasma HDL-C was significantly improved in sesame oil (15.7% vs before treatment) or combination therapies (17% before treatment). Significant (P < 0.001) improvement was observed in the activities of enzymatic and non-enzymatic antioxidants in patients treated with sesame oil and its combination with glibenclamide. Conclusions: Sesame oil exhibited synergistic effect with glibenclamide and can provide a safe and effective option for the drug combination that may be very useful in clinical practice for the effective improvement of hyperglycemia. © 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. Source

Prashar D.,Vinayaka Missions University
International Journal of ChemTech Research | Year: 2012

Self assembly provides a simple route to organise suitable organic molecules on noble metal surface by using long chain organic molecules with various functionalities like -SH,-COOH,-NH 2, Silanes etc. These surfaces can be used to build up interesting nano level architectures. Self assembly is an interesting process for biological relevance because it provides a novel approach to complex structure having nanometre scale dimensions. The self assembled monolayers (SAMs) can be characterized by the number of techniques such as Contact angle goniometry, X-ray photoelectron spectroscopy, Infra red and scanning probe microscopy which provides the valuable information about the SAMs. Source

Karmegam N.,Vinayaka Missions University
International Journal of Global Environmental Issues | Year: 2010

Pre-decomposed (15 days) mango leaf litter with cowdung in 50:50 (wt/wt) was subjected to vermicomposting using Perionyx ceylanensis for 60 days. The electrical conductivity, total NPK, Ca, Na and other nutrients were higher in the vermicompost than in the worm unworked control substrate, whereas organic carbon and C/N ratio were lowered. The population of bacteria, fungi and actinomycetes at the start of the experiment (initial) increased progressively towards the end of vermicomposting. The final microbial population was higher and significantly different (p < 0.05) from the initial values. The incubation period of vermicompost showed significant positive correlation with microbial population (r = 0.99; p < 0.001). Copyright © 2010 Inderscience Enterprises Ltd. Source

Leprosy is an infectious disease caused by Mycobacterium leprae. The increasing drug and multi-drug resistance of M. leprae enforce the importance of finding new drug targets. Mycobacterium has unusually impermeable cell wall that contributes to considerable resistance to many drugs. Peptidoglycan is an important component of the cell wall of M. leprae. UDP-N-acetylmuramoyl-glycyl- D-glutamate-2, 6-diaminopimelate ligase (MurE) plays a crucial role in the peptidoglycan biosynthesis and hence it could be considered as a potential drug target for leprosy. Structure of this enzyme for M. leprae has not yet been elucidated. We modeled the three-dimensional structure of MurE from M. leprae using comparative modeling methods based on the X-ray crystal structure of MurE from E. coli and validated. The 3D-structure of M. leprae MurE enzyme was docked with its substrates meso-diaminopimelic acid (A2pm) and UDP-N-acetyl muramoyl-glycyl-D- glutamate (UMGG) and its product UDP-N-acetyl muramoyl-glycyl-D-glu-meso-A 2pm (UTP) and also with ATP. The docked complexes reveal the amino acids responsible for binding the substrates. Superposition of these complex structures suggests that carboxylic acid group of UMGG is positioned in proximity to γ-phosphate of the ATP to facilitate the formation of acylphosphate intermediate. The orientation of an amino group of A 2pm facilitates the nucleophilic attack to form the product. Overall, the proposed model together with its binding features gained from docking studies could help to design a truly selective ligand inhibitor specific to MurE for the treatment of leprosy. © 2011 Springer-Verlag. Source

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