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Pandiamunian J.,Vinayaka Missions Medical College And Hospital | Ishwarya T.,Leonard Hospital
Asian Journal of Pharmaceutical and Clinical Research | Year: 2017

Objective: This study was done to evaluate the knowledge of primary health-care workers about the newborn care components. Methods: The Institutional Ethics Committee approval was obtained, and a cross-sectional study was carried out among the primary health-care workers of Karaikal using a pretested questionnaire from January 2015 to March 2015. The questionnaire contained questions on various domains of newborn care components. The study participants were explained about the study. Verbal informed consent was obtained, and the questionnaire was introduced to 383 health-care workers. The answered questionnaires were collected and analyzed. Results: A total of 349 participants (192-government employees; 157-private employees) were willing to take part in the study. Most (54.7%) of the government participants were nurses and auxiliary nurse midwives (43.2%) whereas the private sector participants were predominantly (79%) nurses. The knowledge level about some of the newborn care components, namely, positioning and attachment, advice on discharge, time of follow-up checkup, bad child rearing practices, and danger signs of newborn were assessed to be predominantly inadequate among a majority of health workers of both sectors. 22.29% and 41.1% of the private health-care workers and government health-care workers respectively, were having an overall adequate knowledge (overall score >75%) on newborn care components. Knowledge of the government health workers was significantly better than private health-care staff (P < 0.001). Conclusion: Knowledge is found to be inadequate among health-care workers on some newborn care components which necessitate measures to improve. © 2017 The Authors.


PubMed | Vinayaka Missions Medical College and Hospital and Jawaharlal Institute of Postgraduate Medical Education & Research
Type: Journal Article | Journal: Journal of anaesthesiology, clinical pharmacology | Year: 2015

A successful peripheral nerve block not only involves a proper technique, but also a thorough knowledge and understanding of the physiology of nerve conduction and pharmacology of local anesthetics (LAs). This article focuses on what happens after the block. Pharmacodynamics of LAs, underlying mechanisms of clinically observable phenomena such as differential blockade, tachyphylaxis, C fiber resistance, tonic and phasic blockade and effect of volume and concentration of LAs. Judicious use of additives along with LAs in peripheral nerve blocks can prolong analgesia. An entirely new group of drugs-neurotoxins has shown potential as local anesthetics. Various methods are available now to prolong the duration of peripheral nerve blocks.


Sharma V.K.,JIPMER | Rajajeyakumar M.,Chennai Medical College Hospital and Research Center | Velkumary S.,JIPMER | Subramanian S.K.,JIPMER | And 4 more authors.
Journal of Clinical and Diagnostic Research | Year: 2014

Objectives: To compare the cumulative effect of commonly practised slow and fast pranayama on cognitive functions in healthy volunteers. Settings and Design: 84 participants who were in self-reported good health, who were in the age group of 18-25 years, who were randomized to fast pranayama, slow pranayama and control group with 28 participants in each group. Material and Methods: Fast pranayama included kapalabhati, bhastrika and kukkuriya. Slow pranayama included nadishodhana, Pranav and Savitri. Respective pranayama training was given for 35 minutes, three times per week, for a duration of 12 weeks under the supervision of a certified yoga trainer. Parameters were recorded before and after 12 weeks of intervention: Perceived stress scale (PSS), BMI, waist to hip ratio and cognitive parameters-letter cancellation test, trail making tests A and B, forward and reverse digit spans and auditory and visual reaction times for red light and green light. Statistical Analysis: Inter-group comparison was done by one way ANOVA and intra group comparison was done by paired t-test. Results and Conclusion: Executive functions, PSS and reaction time improved significantly in both fast and slow pranayama groups, except reverse digit span, which showed an improvement only in fast pranayama group. In addition, percentage reduction in reaction time was significantly more in the fast pranayama group as compared to that in slow pranayama group. Both types of pranayamas are beneficial for cognitive functions, but fast pranayama has additional effects on executive function of manipulation in auditory working memory, central neural processing and sensory-motor performance.


PubMed | Vinayaka Missions Medical College and Hospital and Guntur Medical College
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2017

Although cancer remains a major health problem all over the world, its treatment is limited by affordability of patients in a developing country like India. Information generated from cost analysis studies will be helpful for both the doctors in choosing the correct medicine for their patients and also for policy makers in successfully utilizing the meager resources that are available.The aim of the present observational study was to analyse the price variations of anti-cancer drugs available in India.The cost of a particular anti-cancer drug being manufactured by different companies, in the same dose and dosage form, was obtained from latest issue of Current Index of Medical Specialties (CIMS) January-April, 2016. The difference between the maximum and minimum prices of various brands of the same drug was analysed and percentage variation in the prices was calculated. The results of the study were expressed as absolute numbers and percentages.Overall, the price of a total of 23 drugs belonging to 6 different categories available in 52 different formulations were analysed. Among alkylating agents, oxaliplatin (50mg; injection) showed the maximum price variation of 125.02%. In anti-metabolites, methotrexate (2.5mg; tablet) showed the maximum price variation of 75.30%. The maximum price variation among natural products was seen with paclitaxel (260 mg; injection) of 146.98%, among hormonal drugs, was seen with flutamide (250mg; tablet) of 714.24%, among targeted drugs was seen with imatinib mesylate (100mg; film coated tablet) of 5.56% and among supportive drugs, granisetron (1mg; tablet) showed the maximum price variation of 388.68%.The average percentage variations of different brands of the same anti-cancer drug in same dose and dosage form manufactured in India is very wide. The government and drug manufacturing companies must direct their efforts in reducing the cost of anti-cancer drugs and minimizing the economic burden on the patients.


Lanka P.,Vinayaka Missions Medical College and Hospital | Lanka L.R.,Vinayaka Missions Medical College and Hospital | Manivachagam D.,Annamalai University
Indian Journal of Dermatology | Year: 2015

Porokeratosis, a keratinization disorder, is probably a group of unrelated conditions with same distinctive histological appearance, featuring cornoid lamellae. A case of punctate porkeratosis in a 24 year old male patient is reported for its rarity.


Vadhanan P.,Vinayaka Missions Medical College and Hospital | Tripaty D.K.,Indira Gandhi Center for Atomic Research | Adinarayanan S.,Jawaharlal Institute of Postgraduate Medical Education & Research
Journal of Anaesthesiology Clinical Pharmacology | Year: 2015

A successful peripheral nerve block not only involves a proper technique, but also a thorough knowledge and understanding of the physiology of nerve conduction and pharmacology of local anesthetics (LAs). This article focuses on what happens after the block. Pharmacodynamics of LAs, underlying mechanisms of clinically observable phenomena such as differential blockade, tachyphylaxis, C fiber resistance, tonic and phasic blockade and effect of volume and concentration of LAs. Judicious use of additives along with LAs in peripheral nerve blocks can prolong analgesia. An entirely new group of drugs-neurotoxins has shown potential as local anesthetics. Various methods are available now to prolong the duration of peripheral nerve blocks.


Kolasani B.P.,Vinayaka Missions Medical College and Hospital | Sasidharan P.,Vinayaka Missions Medical College and Hospital | Kumar A.,Vinayaka Missions Medical College and Hospital
International Journal of Nutrition, Pharmacology, Neurological Diseases | Year: 2016

Background: The evidence that oxidative stress is involved in the pathogenesis of ALD and Vitamin E deficiency being well documented in patients of ALD, an antioxidant like Vitamin E could likely be beneficial in patients with ALD. Methods: This is a prospective, open labeled, randomized comparative study of eight weeks duration, involving a total of 30 adult patients diagnosed with ALD who were randomized into two groups of 15 each and were designated as group A who received standard treatment and group B who received vitamin E along with standard treatment. Biochemical parameters like Liver Function Tests, De Ritis Ratio, Hb and TLC; prognostic parameters like Child Pugh Score and Model for End-Stage Liver Disease score were recorded before and after the treatment period in each group and compared. Results: In group A, the change observed in total protein and child pugh score were significant (P < 0.05) whereas that seen in PT was highly significant (P < 0.001). In group B, the changes observed in total protein, A:G ratio, bilirubin, PT, MELD score, Hb and TLC were significant (P < 0.05) whereas those seen in albumin, PT-INR, Child Pugh Score were highly significant (P < 0.001). When the differences observed in various parameters in Group A were compared with those seen in Group B, the changes in albumin, globulin and A:G ratio observed in Group B were statistically significant compared to their respective changes observed in Group A. Conclusion: These findings suggest that Vitamin E given in adequate dose will be a useful addition for treating alcoholic liver disease, although larger studies involving more number of patients should be done. © 2016 International Journal of Nutrition, Pharmacology, Neurological Diseases | Published by Wolters Kluwer - Medknow.


Shanmugapriya V.,Vinayaka Missions Medical College and Hospital | Balaji K.,Vinayaka Missions Medical College and Hospital | Gowtham A.,Vinayaka Missions Medical College and Hospital
Biomedicine (India) | Year: 2014

Introduction: Diabetes Mellitus is a metabolic disease due to absolute or relative insulin deficiency. Magnesium (Mg) plays a key role in regulating insulin action, insulin mediated glucose uptake and in overall carbohydrate metabolism.Aim: This present study was designed to find out serum magnesium level, insulin resistance and coronary lipid risk factors in type 2 diabetic patients.Materials and Methods: 33 known type 2 diabetic patients and 20 controls were evaluated for their fasting and postprandial glucose level, lipid profile, fasting insulin, HbAlc, Body Mass Index (BMI) and cardiac risk factors.Results: The mean duration of diabetes among the patients was 6.03 years. The serum magnesium level among the diabetic patients was 1.86 ± 0.14 mg/dl when compared to the control group 2.3 ±0.14 mg/dl. All the lipid parameters were significantly elevated in diabetic patients than the controls except for HDL-C which was found to have a negative correlation. As expected HbAlc and serum insulin levels were elevated in diabetics than the controls. Serum fasting glucose had negative correlation with magnesium level and positive correlation with insulin level, HbA1c, TC, TGL, LDL, VLDL and coronary risk factors like LDL/HDL-C ratio, TC/HDL ratio and Non HDL-C(NHDL).Conclusion: Type 2 diabetic patients were known for hypomagnesaemia and treatment should include dietary modification with magnesium supplementation along with strict blood glucose control and regular monitoring of their lipid status for cardiac complications.


Palanisamy A.P.,Vinayaka Missions Medical College and Hospital | Samuel S.,Vinayaka Missions Medical College and Hospital | Vadivel S.,Vinayaka Missions Medical College and Hospital | Kothandapany S.,Vinayaka Missions Medical College and Hospital
Indian Journal of Sexually Transmitted Diseases | Year: 2015

Inguinal and femoral buboes are defined as localized enlargement of lymph nodes in the groin that are painful, and may or may not be fluctuant. We report a case of 42-year-old female who presented with bilateral inguinal swelling of 6 months duration. After a complete evaluation, she was found to be a case of isolated inguinal tuberculous lymphadenitis. There was complete resolution with standard antituberculous therapy. Isolated inguinal tuberculous lymphadenitis though a rare entity in developed countries is not uncommon in developing nations. In this era of syndromic management of sexually transmitted diseases, which carries its own pros and cons, this case report emphasizes the need to look beyond the venereal causes and calls for thorough evaluation and management.


PubMed | Vinayaka Missions Medical College and Hospital
Type: Journal Article | Journal: Indian journal of sexually transmitted diseases | Year: 2015

Inguinal and femoral buboes are defined as localized enlargement of lymph nodes in the groin that are painful, and may or may not be fluctuant. We report a case of 42-year-old female who presented with bilateral inguinal swelling of 6 months duration. After a complete evaluation, she was found to be a case of isolated inguinal tuberculous lymphadenitis. There was complete resolution with standard antituberculous therapy. Isolated inguinal tuberculous lymphadenitis though a rare entity in developed countries is not uncommon in developing nations. In this era of syndromic management of sexually transmitted diseases, which carries its own pros and cons, this case report emphasizes the need to look beyond the venereal causes and calls for thorough evaluation and management.

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