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PubMed | Vinayaka Missions Medical College, Additional Professor, Chennai Medical College Hospital and Research Center, Phd Scholar and Mahatma Gandhi Institute
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2014

Pranayama has been assigned very important role in yogic system of exercises and is said to be much more important than yogasanas for keeping sound health. Also different pranayamas produce divergent physiological effects.To study the effect of 12 weeks training of slow and fast pranayama on handgrip strength and endurance in young, healthy volunteers of JIPMER population.Present study was conducted in the Department of Physiology, JIPMER in 2011-12 (1.06.11 to 1.04.12).Total of 91 volunteer subjects were randomised into slow pranayama (SPG) (n=29), fast pranayama (FPG) (n=32) and control groups (CG) (n=30). Supervised pranayama training (SPG - Nadisodhana, Pranav pranayama and Savitri pranayama; FPG - Kapalabhati, Bhastrika and Kukkuriya pranayama) was given for 30 minutes thrice a week for 12 weeks to both slow and fast pranayama groups by certified yoga trainer. Hand grip strength (HGS) and endurance (HGE) parameters were recorded using handgrip dynamometer (Rolex, India) at baseline and after 12 weeks of pranayama training.Longitudinal changes in each group were compared by using Students paired t-test. Delta changes in each group were analysed by ANOVA with Tukey post-hoc analysis.In SPG significant improvement occurred only in HGE parameter from 83.9545.06 to 101.6253.87 (seconds) (p<0.001) whereas in FPG, significant improvement was observed in HGS from 33.319.83 to 37.99.41 (Kilograms) (p=0.01) as well as in HGE from 92.7841.37 to 116.5658.54 (seconds) (p=0.004). Using Students unpaired t-test difference between the groups in HGS is found to be 1.175.485 in SPG and in FPG is 4.597.26 (p=0.39); HGE difference in SPG is 1.7721.17 and in FPG is 2.3843.27 (p>0.05).Pranayama training decreases sympathetic activity, resulting in mental relaxation and decreased autonomic arousal thereby, decreasing force fluctuations during isometric contraction. This is reflected as improvement in HGS and HGE.


Shankarappa V.,Vinayaka Missions Medical College | Prashanth P.,Vinayaka Missions Medical College | Annamalai N.,Vinayaka Missions Medical College | Varunmalhotra,Vinayaka Missions Medical College
Journal of Clinical and Diagnostic Research | Year: 2012

Introduction: Yoga is a science which has been practised in India from over thousands of years. Besides its spiritual achievements, the practice of yoga is accompanied by a number of beneficial physiological effects in the body. Pranayama is an art of controlling the life force of breath. It produces many systemic psycho-physical effects in the body, besides its specific effects on the respiratory functions. This study is designed to study the effects of short-term pranayama (6 weeks) on the pulmonary function parameters. Methods: The study group consisted of 50 young adults (26 males and 24 females) who were newly recruited for yoga training at the Patanjali Yoga Center, Kolar. They were motivated to undergo pranava, Nadishuddi and Savitri Pranayama training for 1 hour daily, for 6 days a week. The first phase of the recording of the pulmonary parameters was done at the beginning of their course. The second phase of the recording was done after 6 weeks of the regular pranayama practice. Results: The FVC - before pranayama showed a value of 2.60±0.40 and after pranayama, it showed a value of 3.20±0.43. The FEV1- before pranayama showed a value of 2.36±0.36 and after pranayama, it showed a value of 2.96±0.42. The PEFR - before pranayama showed a value of 6.09±1.03 and after pranayama, it showed a value of 7.38±1.12. The FEF (25%- 75%) - before pranayama showed a value of 2.93±0.47 and after pranayama, it showed a value of 3.74±0.45. The BHT - before pranayama showed a value of 38.34 ±4.34 and after pranayama, it showed a value of 56.62±9.01. For all the parameters, a P value of <0.001 was considered as statistically significant. Conclusion: There was a statistically significant increase in all the above lung parameters in the regular yoga practitioners. Pranayama is a type of yogic breathing exercise. This resultant effect of pranayama can be used as a lung strengthening tool to treat many lung diseases like asthma, allergic bronchitis, post pneumonia and tuberculosis recoveries, and many occupational diseases.


Bairagi K.K.,Vinayaka Missions Medical College | Barbhuiyan S.I.,Assam Medical College and Hospital | Hazarika N.,Vinayaka Missions Medical College
Indian Journal of Forensic Medicine and Toxicology | Year: 2010

Background: In modern times, increase in number of road traffic accidents has become an epidemiological concern. Accidents involving two wheelers are also becoming common. Materials and methods: All two-wheeler accidents involving riders and pillion riders were taken up for the study period of one year from 1st September 2004 to 31st August 2005. A pretested proforma was used to determine the nature of the incident and type of vehicle involved. All 76 cases were autopsied and findings recorded and analyzed. Results: Incidence of fatal two wheeler accidents was 16.59%. Most fatal riders were between 21- 30 years (35.52%) while pillion riders were between 31- 40 years. M:F ratio was 4. 43:1. Maximum cases (31.59%) were seen in spring season. Most accidents occurred between 6PM - 12 Mid Night. Accidents in the urban areas accounted for 42(55.26%) cases. Skull fracture was present in 22(64%) pillion riders and in only 16(38%) riders. Rib fractures were seen in 33.3% of riders and 17.64% of pillion riders. Laceration to the brain was seen in 16(38%) riders and 18(52.94%) pillion riders. Laceration to the liver and spleen constituted 19% each in riders while it was 14.7% and 17.6% respectively in pillion riders. Laceration of the heart was seen in 3 riders (7.14%) and 2 pillion riders (4.76%). Conclusion: The study highlights the importance of enforcing speed limits on roads, enforcing laws requiring riders and pillion riders of two wheelers to wear helmets, upgrade road infrastructure and lastly to strengthen the health facilities for the victims.


Murugan M.,Vinayaka Missions Medical College | Bairagi K.K.,Vinayaka Missions Medical College
Indian Journal of Forensic Medicine and Toxicology | Year: 2011

Date rape is forced or coerced sex between; partners, dates, friends, friends of friends or general acquaintances. As there are many cases coming to lime light day by day, a quick overview of the common drugs and what specimen can be collected at what point of time is discussed in this paper.


Lahon K.,Mahatma Gandhi Institute | Bairagi K.K.,Vinayaka Missions Medical College | Chaturvedi R.K.,SAIMS
Indian Journal of Public Health Research and Development | Year: 2012

Counterfeit or fake medicines are drugs which are previously expired, fraudulently diluted, adulterated, substituted, completely misrepresented, or sold with a false brand name. They constitute 10% of the global drug market and mostly originate in the developing world, where regulatory and enforcement measures are weakest. Lack of expected clinical benefit, direct harm and emergence of drug resistance can occur due to counterfeit medicines. WHO, along with national and international organizations are taking legislative, regulatory, enforcement, technological and quality assurance initiatives to prevent and detect counterfeit medicines, besides raising awareness about the issue. However, despite making good progress, the threat looms large for the consumer as long as he is not empowered to differentiate between genuine and counterfeit medicines.


Divyashanthi C.M.,Vinayaka Missions Medical college | Manivannan E.,Salem College
International Journal of Pharma and Bio Sciences | Year: 2014

Corticosteroids remain the most important and frequently prescribed drugs for cutaneous diseases. This study is an effort to assess the drug prescribing patterns of corticosteroids for various skin diseases, to analyse the rationale behind and also to affirm the physicians' adherence to dosages and formulations in accordance with the recent guidelines.A prospective analysis of 291 in-patients admitted in the department of Dermatology, Karaikal over a period of one year (January2013-December2013) was carried out to ascertain the pattern of usage of corticosteroids for various dermatological diseases in terms of its potency, frequency, duration and routes of administration. The results were expressed in averages, ratios and proportions.Out of the total 291 prescriptions scrutinized, 60.48% were male and 39.51% were female. The average number of drugs per prescription was 6.37 ± 2.06.The topical preparations prescribed were highly potent steroids like Clobetasol (33.33%), followed by moderately potent like Mometasone (28.24%) and low potent Desonide (14.69%).The various formulations utilized were Lotions (48.02%),followed by creams(30.51%),ointments (14.68%) and paste (6.78%). Oral corticosteroids were prescribed for 77 patients (26.46%), the most of which were for contact dermatitis (32.5%).Among the parenteral corticosteroids prescribed for 14 patients(4.81%) the maximum prescribed were for Eczema (28.56%).Dexamethasone was the only parenteral corticosteroid (4.81%) prescribed as injection.The prescribing pattern of corticosteroids by the Dermatologists was analyzed to appraise the conformity with the guidelines. The usage of steroids through topical, oral and parenteral routes was compliant with the guidelines.


Kadalmani B.,Bharathidasan University | Saravana Kumar M.,Vinayaka Missions Medical College | Revathi P.,SRM University | Prakash Shyam K.,Bharathidasan University
International Journal of Pharma and Bio Sciences | Year: 2011

Calcium ions have been considered as a serious contender for the development of various types of ulcers. Calcium ion influx seems to play an essential role in the stimulationsecretion coupling in mammalian oxyntic cells, an effect that can be inhibited by the calcium channel blockers. Calcium channel blockers (CCBs) are a class of drugs and natural substances that disrupt the calcium (Ca2+) conduction of calcium channels, the present study aims to evaluate comparative effect of Verapamil, Nifedipine, Diltiazem and Ranitidine against gastric ulcers induced in rats. The study was carried out in Sixty Wistar male albino rats (180-220 g) as two phase simultaneous study, one as acute and the other evaluated chronic effect. Gastric Ulcer was induced using aspirin (200 mg/kg) body weight (b.w) and treated orally using Verapamil (40mg/kg b.w) Nifedipine (40mg/kg b.w), Diltiazem (60mg/kg b.w) and Inj. Ranitidine 50mg/kg b.w intraperitoneally. The rats were anaesthetised under ether; Ulcer Pulse and Index were calculated.The results of comparison indicate that Nifedipine had shown but highly significant ulcer protective effect in both acute and chronic studies, than Verapamil, Diltiazem and Ranitidine.


Christina A.S.,PRIST University | Jayasingh C.M.S.,Vinayaka Missions Medical College
Biomedicine (India) | Year: 2013

Introduction: Proinflammatory cytokines promote cancer progression. Aim: The present study was aimed to evaluate the role of two proinflammatory cytokines namely, Interleukin 6 (IL-6) and Tumor Necrosis Factor-α (TNF-α) in breast cancer patients. Materials and Methods: This study comprises of 75 breast cancer patients and 25 healthy subjects. They were categorized into three groups, based on the disease stage, age and menopausal status. Serum concentrations of IL-6 and TNF-α were estimated by quantitative sandwich ELISA method. Results: Significantly elevated concentrations of IL-6 and TNF-α were observed in breast cancer patients when compared with healthy subjects. Furthermore, elevated concentrations were seen with advancement of disease. No association has been found with age and menopausal status. Conclusion: This clearly indicates their positive role in breast cancer progression.


PubMed | Vinayaka Missions Medical College
Type: | Journal: Indian journal of pediatrics | Year: 2016

To describe the clinical profile of Hand Foot and Mouth Disease (HFMD) like illness in a cluster of cases.Children presenting with papulovesicular skin lesions with or without oral lesions were clinically examined, treated and followed up.Out of 21 cases, 18 (85.7%) were less than 3y and 15 (71.4%) were males. Skin lesions were seen in 100% with predominant involvement of dorsum of hands, feet, palms and soles. Oral lesions were noticed in 20 (95.2%), fever in 14 (66.6%) and upper respiratory infection in 6 (28.6%). Irritability was the presenting feature in infants. Only clinical diagnosis was made. All the children recovered completely. On follow up of 16 (76.2%) cases for 3 mo, no nail changes or any other sequelae were noticed.Early clinical diagnosis of HFMD is needed for monitoring and prevention of its spread.


PubMed | Vinayaka Missions Medical College
Type: Journal Article | Journal: Journal of anaesthesiology, clinical pharmacology | Year: 2011

Spinocerebellar degeneration or olivopontocerebellar degeneration denotes a group of disorders of various etiologies manifesting as degenerative changes of various part of the central nervous system. We describe the anesthetic management of a patient with severe olivopontocerebellar degeneration posted for vaginal hysterectomy. A combined spinal epidural technique was performed at the level of L2-L3. The anesthetic implications of the various aspects of spinocerebellar degeneration are discussed.

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