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Hyderabad, India

Prasad P.M.N.,Sri Venkateswara University | Shyam Sundar E.,Vimta Labs Ltd | Hanuman Redy V.,Sri Venkateswara University | Rami Reddy Y.V.,Sri Venkateswara University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

Due to the rapid industrialization, the waste generated from industries is growing more. The waste generated from an industry is may be hazardous or non-hazardous category. The minimization of waste is a main Hazardous Waste Management (HWM) is a very important issue and is assuming significance globally. Hazardous and non hazardous waste mixing with coal burning, when carried out in a safe and environmentally sound manner, is recognized for far-reaching environmental benefits. ETP sludge is a very common waste, which will generate from most of the industries. ETP Sludge which is having GCV > 2500 kcal/kg can burn along with coal in energy recovery process. In this study ETP Sludge is collected from pharmaceutical industry, different compositions of this ETP sludge is mixed with coal burning process. The trends of flue gas composition (SO2, NOx, CO, O2 CO2 & HC) of these emissions have studied in different composition mixed with coal burning. The summary of trends of flue gas composition is discussed in results and discussion. Source

Kavitha P.,National Institute of Technology Warangal | Rama Chary M.,Lb College | Singavarapu B.V.V.A.,Vimta Labs Ltd | Laxma Reddy K.,National Institute of Technology Warangal
Journal of Saudi Chemical Society | Year: 2013

In the present study a series of Co(II) complexes of formyl chromone Schiff bases have been synthesized characterized by analytical, molar conductance, IR, electronic, magnetic susceptibility, thermal, fluorescence and powder XRD measurements and screened for various biological activities (antimicrobial, antioxidant, nematicidal, DNA cleavage and cytotoxicity). In all the Co(II) complexes 1:2 metal to ligand molar ratio was obtained from analytical data. The molar conductance data confirm that all complexes are non-electrolytic in nature. Based on the electronic and magnetic data, an octahedral geometry is ascribed for all the Co(II) complexes. Thermal behaviour of the synthesized complexes illustrates the general decomposition patterns of the complexes. The X-ray analysis data show that all the Co(II) complexes have triclinic crystal system with different unit cell parameters. Metal complexes have greater antimicrobial activity than ligands. Antioxidant and nematicidal activities indicate that the ligands exhibit greater activity when compared to their respective Co(II) complexes. All ligands and Co(II) complexes of HL1 and HL2 showed considerable anticancer activity against Raw, MCF-7 and COLO 205 cell lines. All ligands and their Co(II) complexes showed more pronounced DNA cleavage activity in the presence of H2O2. © 2013. Source

Jinka R.,Acharya Nagarjuna University | Kapoor R.,Center for Cellular and Molecular Biology | Pavuluri S.,Vimta Labs Ltd | Raj A.T.,Center for Cellular and Molecular Biology | And 3 more authors.
BMC Cell Biology | Year: 2010

Background: Anchorage independent growth is an important hallmark of oncogenic transformation. Previous studies have shown that when adhesion dependent fibroblasts were prevented from adhering to a substrate they underwent anoikis. In the present study we have demonstrated how anoikis resistant cells gain the transformation related properties with sequential selection of genes. We have proposed this process as a model system for selection of transformed cells from normal cells.Results: This report demonstrates that some fibroblasts can survive during late stages of anoikis, at which time they exhibit transformation-associated properties such as in vitro colony formation in soft agar and in vivo subcutaneous tumour formation in nude mice. Cytogenetic characterisation of these cells revealed that they contained a t (2; 2) derivative chromosome and they have a selective survival advantage in non adherent conditions. Gene expression profile indicated that these cells over expressed genes related to hypoxia, glycolysis and tumor suppression/metastasis which could be helpful in their retaining a transformed phenotype.Conclusion: Our results reveal some new links between anoikis and cell transformation and they provide a reproducible model system which can potentially be useful to study multistage cancer and to identify new targets for drug development. © 2010 Jinka et al; licensee BioMed Central Ltd. Source

Chavali L.N.,Vimta Labs Ltd | Sireesh Chandra V.,Vimta Labs Ltd
Current Trends in Biotechnology and Pharmacy | Year: 2011

The enterprise server and storage products from most of OEMs like IBM, HP etc support virtualization and continuity, enabling Contract Research Organizations (CRO) to consolidate workloads across diverse operating environments and to deploy new solutions quickly, reliably and with a significantly lower total cost of ownership. The key requirement of the CRO at Hyderabad is that the existing application and database servers be replaced with HP blade and integrity servers, storage and backup solution to be provided for the servers; and replication is setup between primary and secondary sites for database (db) and non-db data. HP solution achieved the disaster tolerence by implementing Metro Cluster for databases and applications. The Lab requires 99.9% high availability for all servers and scientific applications to be migrated from the old platform to the new HP platform. Source

Poluri K.,S. N. Vanitha Pharmacy Maha Vidyalaya | Sistla R.,Indian Institute of Chemical Technology | Veerareddy P.R.,St Peters Institute Of Pharmaceutical Science | Narasu L.M.,Jawaharlal Nehru Technological University | And 2 more authors.
Current Trends in Biotechnology and Pharmacy | Year: 2011

The present study involves the formulation and evaluation of oral o/w nanoemulsions (NE) with two simple edible oils, avoiding the large quantities of surfactants and co-surfactants which were prepared by high energy emulsification technique. The particle size, polydispersity index (PDI), and zeta potential of prepared nano emulsions were determined by using zeta sizer and were found to be in the range of 33.4±3.9 nm, to 183.56±1.78nm, 0.051±0.04 to 0.38±0.06 and -2.87±0.65 to -14.2±0.72 mv respectively. Centrifugation, freeze-thaw cycling, storage at 4°C for 60days, X-ray diffraction (XRD) and Transmission electron microscopy (TEM) studies revealed the physical and chemical stability of the NEs. Entrapment efficiency and in-vitro release studies showed successful incorporation of carvedilol into NE with high drug loading efficiency and good stability. Comparative pharmacokinetic studies of NE and marketed dosage form in male SD rats revealed a significant increase in oral bio availability in NEs. Source

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