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Lin S.,Beijing Sciecure Pharmaceutical Co. | Shen J.J.,Beijing Sciecure Pharmaceutical Co. | Janarthanam K.,Beijing Sciecure Pharmaceutical Co. | Beishya H.,Beijing Sciecure Pharmaceutical Co. | And 3 more authors.
International Journal of Pharmacy and Technology | Year: 2016

The bioequivalence of test formulation of Fluvastatin ER tablets 80mg of Beijing Sciecure Pharmaceutical Co.,LTD,China was evaluated with respect to the corresponding reference drug formulation,of Lescol®XL (Fluvastatin sodium) Extended Release Tablets of Novartis Pharmaceuticals Corporation East Hanover,New Jersey 07936. This study was an open-label,randomized,single oral dose,two treatment,two sequence,two period,two way crossover bioequivalence study was performed under fasting conditions with 36 healthy adult,human male genders. There was a seven-day washout period. The study formulations were administered after an overnight fast of at least 10-hours before dosing in each period,and blood samples were collected at 0.00 hrs (pre dose),00.33,00.67,01.00,01.50,02.00,02.50,03.00,03.50,04.00,05.00,06.00,08.00,10.00,12.00,14.00,16.00 and 18.00 hours (post dose) after administration. The concentrations of Fluvastatin in K3EDTA human plasma was estimated using precise andaccurate LC-MS/MS procedure. The GM Ratio and the 90% CI of Ratio estimates of Cmax,AUC0-t,and AUC0-∞ values of the Fluvastatin ER Tablets 80 mg (Test formulation) over those of Lescol®XL (Fluvastatin sodium 80 mg) Extended Release Tablets(Reference formulation) were 92.24 [83.60,101.77],91.48 [83.12,100.67] and 93.59 [85.04,103.00],respectively. The 90% CI for Cmax,AUC0-t and AUC0-∞ were within 80.00-125.00% range. Based on results,it’s been concluded that the two formulations of Fluvastatin ERTablets 80 mg were bioequivalent in terms of the rate and extent of absorption. © 2016,International Journal of Pharmacy and Technology. All rights reserved.


Prasad P.M.N.,Sri Venkateswara University | Shyam Sundar E.,Vimta Labs Ltd | Hanuman Redy V.,Sri Venkateswara University | Rami Reddy Y.V.,Sri Venkateswara University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

Due to the rapid industrialization, the waste generated from industries is growing more. The waste generated from an industry is may be hazardous or non-hazardous category. The minimization of waste is a main Hazardous Waste Management (HWM) is a very important issue and is assuming significance globally. Hazardous and non hazardous waste mixing with coal burning, when carried out in a safe and environmentally sound manner, is recognized for far-reaching environmental benefits. ETP sludge is a very common waste, which will generate from most of the industries. ETP Sludge which is having GCV > 2500 kcal/kg can burn along with coal in energy recovery process. In this study ETP Sludge is collected from pharmaceutical industry, different compositions of this ETP sludge is mixed with coal burning process. The trends of flue gas composition (SO2, NOx, CO, O2 CO2 & HC) of these emissions have studied in different composition mixed with coal burning. The summary of trends of flue gas composition is discussed in results and discussion.


Jinka R.,Acharya Nagarjuna University | Kapoor R.,Center for Cellular and Molecular Biology | Pavuluri S.,Vimta Labs Ltd | Raj A.T.,Center for Cellular and Molecular Biology | And 3 more authors.
BMC Cell Biology | Year: 2010

Background: Anchorage independent growth is an important hallmark of oncogenic transformation. Previous studies have shown that when adhesion dependent fibroblasts were prevented from adhering to a substrate they underwent anoikis. In the present study we have demonstrated how anoikis resistant cells gain the transformation related properties with sequential selection of genes. We have proposed this process as a model system for selection of transformed cells from normal cells.Results: This report demonstrates that some fibroblasts can survive during late stages of anoikis, at which time they exhibit transformation-associated properties such as in vitro colony formation in soft agar and in vivo subcutaneous tumour formation in nude mice. Cytogenetic characterisation of these cells revealed that they contained a t (2; 2) derivative chromosome and they have a selective survival advantage in non adherent conditions. Gene expression profile indicated that these cells over expressed genes related to hypoxia, glycolysis and tumor suppression/metastasis which could be helpful in their retaining a transformed phenotype.Conclusion: Our results reveal some new links between anoikis and cell transformation and they provide a reproducible model system which can potentially be useful to study multistage cancer and to identify new targets for drug development. © 2010 Jinka et al; licensee BioMed Central Ltd.


Chawla N.,VIMTA Labs Ltd. | Reddy S.J.,VIMTA Labs Ltd. | Agrawal M.,VIMTA Labs Ltd.
Revista Espanola de Patologia | Year: 2013

Malignant amphicrine tumors are a group of tumors in which tumor cells show evidence of both epithelial as well as neuroendocrine differentiation. Malignant amphicrine tumors of gastric region though have been reported are not very common. Histopathological examination of these tumors show features of adenocarcinoma or grade 1 to 2 neuroendocrine tumor. Immunohistochemically, these tumors are positive for both neuroendocrine as well as epithelial markers indicating their amphicrine nature. Malignant amphicrine tumors are now classified as a new subgroup based on WHO classification. The rarity of this tumor in gastric antrum made us to report the case. © 2012 SEAP y SEC.


Pavuluri S.,Vimta Labs Ltd | Chandragiri R.,Vimta Labs Ltd | Seshaiah K.,Vimta Labs Ltd | Chaganty S.,Vimta Labs Ltd
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

A simple, sensitive and rugged quantitative method for the determination of Disopyramide (DIS), and N-Despropyl disopyramide (N-DIS), in human serum using a gas chromatography-tandem mass spectrometric (GC-MS/MS) method has been developed and validated. Disopyramide-d5 (DIS d5) and N-Despropyl disopyramide-d5 (N-DIS d5) were used as internal standards. Analytes and the internal standards were extracted from human serum by liquid-liquid extraction technique using dichloromethane and methyl tertiary-butyl ether as extraction solvents. The reconstituted samples were chromatographed on an Ultra 1, 12m × 0.2mm, 0.33μM film thickness by using helium as the carrier gas. The method was validated over the concentration range of 100 to 6000 ng/mL for DIS and 25 to 1500 ng/mL for N-DIS. Waters Quattro Micro mass spectrometer was operated under the multiple reaction-monitoring mode (MRM) for quantification of ion transitions at m/z 212>195, 217>200, 280>194 and 285>201 for DIS, DIS d5, N-DIS, N-DIS d5 respectively. The results of the intra and inter batch precision and accuracy studies were well within the acceptable limits. The method has been proved to be simple, sensitive, fast, reliable, rugged and reproducible. A run time of 16.0 min for each sample made it possible to analyze more than 36 serum samples per day. The validated method can be applied for the estimation of the drug in real time serum samples for pharmacokinetic studies.


Dsilva L.C.,Glaxosmithkline | Palmer J.,Glaxosmithkline | Sudershan V.,Vimta Labs Ltd. | Ghorpade S.A.,Glaxosmithkline | Joglekar S.J.,Glaxosmithkline
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

Objectives: Sustained release (SR) metformin hydrochloride formulations are usually administered with meals, which can result in dose dumping, which in turn can affect their safety profile. We examined the effect of co-administration of food on the bioavailability of metformin from SR formulations in healthy Indian volunteers.Methods: In an open-label, three-period, six-sequence crossover study, 30 healthy males, aged 18 to 43 (mean 29) years were randomly assigned to a single tablet of treatment A (metformin hydrochloride SR 1000mg, fasted condition), B (metformin hydrochloride SR 1000mg, fed state) or C (metformin hydrochloride SR 1000mg/glimepiride 2mg, fed state) with a one week washout between treatments. Plasma concentrations of metformin were measured using LC-MS/MS. Log-transformed AUC and Cmax fed: fasted ratios were used to determine bioavailability. Tolerability was assessed using physical examination and laboratory analysis.Results: Pharmacokinetic analysis was performed on the first 24/25 volunteers who completed the study. Following a high fat meal, Cmax from treatments B and C increased by nine and seven percent; AUC increased by 17% and seven percent respectively compared to treatment A. Seven mild adverse events were reported in six participants.Conclusions: Food slightly increased the bioavailability of metformin from metformin hydrochloride 1000mg SR tablet and from a fixed dose combination of metformin hydrochloride 1000mg SR/glimepiride 2mg, with no evidence of dose-dumping of metformin from either formulation. The treatments were well tolerated.


Kavitha P.,National Institute of Technology Warangal | Rama Chary M.,Lb College | Singavarapu B.V.V.A.,Vimta Labs Ltd. | Laxma Reddy K.,National Institute of Technology Warangal
Journal of Saudi Chemical Society | Year: 2013

In the present study a series of Co(II) complexes of formyl chromone Schiff bases have been synthesized characterized by analytical, molar conductance, IR, electronic, magnetic susceptibility, thermal, fluorescence and powder XRD measurements and screened for various biological activities (antimicrobial, antioxidant, nematicidal, DNA cleavage and cytotoxicity). In all the Co(II) complexes 1:2 metal to ligand molar ratio was obtained from analytical data. The molar conductance data confirm that all complexes are non-electrolytic in nature. Based on the electronic and magnetic data, an octahedral geometry is ascribed for all the Co(II) complexes. Thermal behaviour of the synthesized complexes illustrates the general decomposition patterns of the complexes. The X-ray analysis data show that all the Co(II) complexes have triclinic crystal system with different unit cell parameters. Metal complexes have greater antimicrobial activity than ligands. Antioxidant and nematicidal activities indicate that the ligands exhibit greater activity when compared to their respective Co(II) complexes. All ligands and Co(II) complexes of HL1 and HL2 showed considerable anticancer activity against Raw, MCF-7 and COLO 205 cell lines. All ligands and their Co(II) complexes showed more pronounced DNA cleavage activity in the presence of H2O2. © 2013.


Chavali L.N.,Vimta Labs Ltd | Sireesh Chandra V.,Vimta Labs Ltd
Current Trends in Biotechnology and Pharmacy | Year: 2011

The enterprise server and storage products from most of OEMs like IBM, HP etc support virtualization and continuity, enabling Contract Research Organizations (CRO) to consolidate workloads across diverse operating environments and to deploy new solutions quickly, reliably and with a significantly lower total cost of ownership. The key requirement of the CRO at Hyderabad is that the existing application and database servers be replaced with HP blade and integrity servers, storage and backup solution to be provided for the servers; and replication is setup between primary and secondary sites for database (db) and non-db data. HP solution achieved the disaster tolerence by implementing Metro Cluster for databases and applications. The Lab requires 99.9% high availability for all servers and scientific applications to be migrated from the old platform to the new HP platform.


Poluri K.,S. N. Vanitha Pharmacy Maha Vidyalaya | Sistla R.,Indian Institute of Chemical Technology | Veerareddy P.R.,St Peters Institute Of Pharmaceutical Science | Narasu L.M.,Jawaharlal Nehru Technological University | And 2 more authors.
Current Trends in Biotechnology and Pharmacy | Year: 2011

The present study involves the formulation and evaluation of oral o/w nanoemulsions (NE) with two simple edible oils, avoiding the large quantities of surfactants and co-surfactants which were prepared by high energy emulsification technique. The particle size, polydispersity index (PDI), and zeta potential of prepared nano emulsions were determined by using zeta sizer and were found to be in the range of 33.4±3.9 nm, to 183.56±1.78nm, 0.051±0.04 to 0.38±0.06 and -2.87±0.65 to -14.2±0.72 mv respectively. Centrifugation, freeze-thaw cycling, storage at 4°C for 60days, X-ray diffraction (XRD) and Transmission electron microscopy (TEM) studies revealed the physical and chemical stability of the NEs. Entrapment efficiency and in-vitro release studies showed successful incorporation of carvedilol into NE with high drug loading efficiency and good stability. Comparative pharmacokinetic studies of NE and marketed dosage form in male SD rats revealed a significant increase in oral bio availability in NEs.

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