Vimta Labs Ltd.

Hyderabad, India

Vimta Labs Ltd.

Hyderabad, India
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Venkateswarlu P.,Sri Venkateswara University | Kumar B.,Sri Venkateswara University | Seshaiah K.,Sri Venkateswara University | Prasad V.,Vimta Labs Ltd
Acta Pharmaceutica | Year: 2010

A high-performance liquid chromatography-tandem mass spectrometric method was developed and validated for the determination of metoprolol in human plasma. The analyte and internal standard, nevirapine, were extracted from plasma matrix by liquid-liquid extraction with ethyl acetate. Chromatographic separation was achieved on a C-18 analytical column with an isocratic mobile phase of 15:85 (V/V) 10 mmol L-1 ammonium acetate (pH 5.0)/acetonitrile. The atmospheric pressure chemical ionization technique was used for sample ionization in positive ion mode and enhanced selectivity was achieved by tandem mass spectrometric analysis via two multiple reaction monitoring (MRM) transitions, 268.2 → 116.2 for metoprolol and 267.1 → 226.2 for nevirapine, respectively. The assay was validated for human plasma over a concentration range of 1-200 ng mL-1 with the precision and accuracy ranging from 0.9 to 8.8 % and 89.9 to 105.8 %, respectively.

Verhaeghe T.,Janssen Research and Development | Barton H.H.,PPD Inc | Hara H.,Novartis | Hucker R.,A4P Consulting Ltd | And 5 more authors.
AAPS Journal | Year: 2014

The A8 Global Harmonization Team focused on the documentation needed to support both small and large molecule bioanalysis. Current regulatory requirements were compiled and compared. The scope of the team's discussions included the validation report, the bioanalytical report, study plans, raw data, and bioanalytical summaries for the common technical document (CTD). A common high-level table of contents for method validation and sample analysis reports is proposed. Suggestions have been made as to how the CTD can be standardized to improve usability and review. Additional comments have been made on reports of failure investigations, study plans, and raw data documentation. The recommendation is that no prescriptive guidelines are required in these areas but should be led by good scientific practices subject to particular circumstances. © 2014 American Association of Pharmaceutical Scientists.

Prasad P.M.N.,Sv University | Shyam Sundar E.,Vimta Labs Ltd | Hanuman R.V.,Sv University | Chenna Krishna Reddy R.,Sv University | Rami Reddy Y.V.,Sv University
International Journal of Research in Pharmaceutical Sciences | Year: 2013

Air pollution is one of the most important concerns in these present atmospheric conditions. Owing rapid industrialization, increased vehicular pollution and other manmade activities, the present atmospheric conditions are changed. It is very important to study the air pollutants on regular intervals in all cities and urban areas. Every year the pollution rate may increase rapidly depending upon the surrounding environmental activities of surrounding areas. In this study we made an attempt to study of the three inorganic hazardous air pollutants / trace carcinogenic metals (Arsenic, Nickel and Lead) concentration levels in AAQ in Tirupati in the years February 2011 and February 2012. For this study we were identified 5 sampling locations in Tirupati. Sampling was carried out 24 hourly and twice a week for P.M.10 in the years February 2011 and February 2012. For this study 15 P.M10 samples were collected. These samples were digested and subjected to analysis for Arsenic, Lead and Nickel using Inductively Coupled Plasma-Mass Spectrometer (ICP-MS) based on USEPA Compendium method IO 3.5.The concentration levels of present study (Arsenic, Nickel and Lead) in different areas of Tirupati are summarized, discussion and these results are compared with NAAQS amended by MoEF on November 14th, 2009. © JK Welfare & Pharmascope Foundation.

Prasad P.M.N.,S V University | Syam Sundar E.,Vimta Labs Ltd | Chenna Krishna Reddy R.,S V University | Hanuman Reddy V.,S V University | Rami Reddy Y.V.,S V University
Journal of Chemical and Pharmaceutical Research | Year: 2012

Benzene and Benzo (a) Pyrene (BAP) are carcinogenic pollutants which will be emitted in the Atmospheric air through vehicular emission and burning of petroleum products. In this study we made an attempt to study the Benzene and BAP concentration levels in AAQ(Ambient air Quality) in Tirupati. For this study we were identified 5 sampling locations in Tirupati surrounding areas. Sampling was carried out 24 hourly and twice a week for in the month of February 2012. Totally 15 air samples were collected. The samples are subjected to analysis for Benzene and BAP using GC-MS based on USEPA Compendium method TO 3 for Benzene and TO 13A for BAP. By using GC-MS we can able to determine the Benzene levels in Ambient air minimum 0. 01μg/m 3 and by using GC we can able to determine the BAP levels of Ambient Air Particulate phase minimum 0. 01ng/ m 3. The concentration levels of Benzene and BAP in different areas of Tirupati are summarized in results and discussion. The levels of Benzene and BAP levels were compared with NAAQS(National Ambient air Quality Standard) amended by MoEF(Ministry of Environment and Forests), Govt. of India. The observed results of Benzene and BAP were found lesser than NAAQS.

Prasad P.M.N.,Sri Venkateswara University | Shyam Sundar E.,Vimta Labs Ltd | Hanuman Redy V.,Sri Venkateswara University | Rami Reddy Y.V.,Sri Venkateswara University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

Due to the rapid industrialization, the waste generated from industries is growing more. The waste generated from an industry is may be hazardous or non-hazardous category. The minimization of waste is a main Hazardous Waste Management (HWM) is a very important issue and is assuming significance globally. Hazardous and non hazardous waste mixing with coal burning, when carried out in a safe and environmentally sound manner, is recognized for far-reaching environmental benefits. ETP sludge is a very common waste, which will generate from most of the industries. ETP Sludge which is having GCV > 2500 kcal/kg can burn along with coal in energy recovery process. In this study ETP Sludge is collected from pharmaceutical industry, different compositions of this ETP sludge is mixed with coal burning process. The trends of flue gas composition (SO2, NOx, CO, O2 CO2 & HC) of these emissions have studied in different composition mixed with coal burning. The summary of trends of flue gas composition is discussed in results and discussion.

Jinka R.,Acharya Nagarjuna University | Kapoor R.,Center for Cellular and Molecular Biology | Pavuluri S.,Vimta Labs Ltd | Raj A.T.,Center for Cellular and Molecular Biology | And 3 more authors.
BMC Cell Biology | Year: 2010

Background: Anchorage independent growth is an important hallmark of oncogenic transformation. Previous studies have shown that when adhesion dependent fibroblasts were prevented from adhering to a substrate they underwent anoikis. In the present study we have demonstrated how anoikis resistant cells gain the transformation related properties with sequential selection of genes. We have proposed this process as a model system for selection of transformed cells from normal cells.Results: This report demonstrates that some fibroblasts can survive during late stages of anoikis, at which time they exhibit transformation-associated properties such as in vitro colony formation in soft agar and in vivo subcutaneous tumour formation in nude mice. Cytogenetic characterisation of these cells revealed that they contained a t (2; 2) derivative chromosome and they have a selective survival advantage in non adherent conditions. Gene expression profile indicated that these cells over expressed genes related to hypoxia, glycolysis and tumor suppression/metastasis which could be helpful in their retaining a transformed phenotype.Conclusion: Our results reveal some new links between anoikis and cell transformation and they provide a reproducible model system which can potentially be useful to study multistage cancer and to identify new targets for drug development. © 2010 Jinka et al; licensee BioMed Central Ltd.

Chawla N.,VIMTA Labs Ltd. | Reddy S.J.,VIMTA Labs Ltd. | Agrawal M.,VIMTA Labs Ltd.
Revista Espanola de Patologia | Year: 2013

Malignant amphicrine tumors are a group of tumors in which tumor cells show evidence of both epithelial as well as neuroendocrine differentiation. Malignant amphicrine tumors of gastric region though have been reported are not very common. Histopathological examination of these tumors show features of adenocarcinoma or grade 1 to 2 neuroendocrine tumor. Immunohistochemically, these tumors are positive for both neuroendocrine as well as epithelial markers indicating their amphicrine nature. Malignant amphicrine tumors are now classified as a new subgroup based on WHO classification. The rarity of this tumor in gastric antrum made us to report the case. © 2012 SEAP y SEC.

Kavitha P.,National Institute of Technology Warangal | Rama Chary M.,Lb College | Singavarapu B.V.V.A.,Vimta Labs Ltd. | Laxma Reddy K.,National Institute of Technology Warangal
Journal of Saudi Chemical Society | Year: 2013

In the present study a series of Co(II) complexes of formyl chromone Schiff bases have been synthesized characterized by analytical, molar conductance, IR, electronic, magnetic susceptibility, thermal, fluorescence and powder XRD measurements and screened for various biological activities (antimicrobial, antioxidant, nematicidal, DNA cleavage and cytotoxicity). In all the Co(II) complexes 1:2 metal to ligand molar ratio was obtained from analytical data. The molar conductance data confirm that all complexes are non-electrolytic in nature. Based on the electronic and magnetic data, an octahedral geometry is ascribed for all the Co(II) complexes. Thermal behaviour of the synthesized complexes illustrates the general decomposition patterns of the complexes. The X-ray analysis data show that all the Co(II) complexes have triclinic crystal system with different unit cell parameters. Metal complexes have greater antimicrobial activity than ligands. Antioxidant and nematicidal activities indicate that the ligands exhibit greater activity when compared to their respective Co(II) complexes. All ligands and Co(II) complexes of HL1 and HL2 showed considerable anticancer activity against Raw, MCF-7 and COLO 205 cell lines. All ligands and their Co(II) complexes showed more pronounced DNA cleavage activity in the presence of H2O2. © 2013.

Chavali L.N.,Vimta Labs Ltd | Sireesh Chandra V.,Vimta Labs Ltd
Current Trends in Biotechnology and Pharmacy | Year: 2011

The enterprise server and storage products from most of OEMs like IBM, HP etc support virtualization and continuity, enabling Contract Research Organizations (CRO) to consolidate workloads across diverse operating environments and to deploy new solutions quickly, reliably and with a significantly lower total cost of ownership. The key requirement of the CRO at Hyderabad is that the existing application and database servers be replaced with HP blade and integrity servers, storage and backup solution to be provided for the servers; and replication is setup between primary and secondary sites for database (db) and non-db data. HP solution achieved the disaster tolerence by implementing Metro Cluster for databases and applications. The Lab requires 99.9% high availability for all servers and scientific applications to be migrated from the old platform to the new HP platform.

Poluri K.,S. N. Vanitha Pharmacy Maha Vidyalaya | Sistla R.,Indian Institute of Chemical Technology | Veerareddy P.R.,St Peters Institute Of Pharmaceutical Science | Narasu L.M.,Jawaharlal Nehru Technological University | And 2 more authors.
Current Trends in Biotechnology and Pharmacy | Year: 2011

The present study involves the formulation and evaluation of oral o/w nanoemulsions (NE) with two simple edible oils, avoiding the large quantities of surfactants and co-surfactants which were prepared by high energy emulsification technique. The particle size, polydispersity index (PDI), and zeta potential of prepared nano emulsions were determined by using zeta sizer and were found to be in the range of 33.4±3.9 nm, to 183.56±1.78nm, 0.051±0.04 to 0.38±0.06 and -2.87±0.65 to -14.2±0.72 mv respectively. Centrifugation, freeze-thaw cycling, storage at 4°C for 60days, X-ray diffraction (XRD) and Transmission electron microscopy (TEM) studies revealed the physical and chemical stability of the NEs. Entrapment efficiency and in-vitro release studies showed successful incorporation of carvedilol into NE with high drug loading efficiency and good stability. Comparative pharmacokinetic studies of NE and marketed dosage form in male SD rats revealed a significant increase in oral bio availability in NEs.

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