Vilnius, Lithuania
Vilnius, Lithuania

Vilnius University is the oldest university in the Baltic states and one of the oldest in Northern Europe. It is the largest university in Lithuania.The university was founded in 1579 as the Jesuit Academy of Vilnius by Grand Duke of Lithuania and King of Poland - Stephen Báthory. It was the third oldest university in the Polish-Lithuanian Commonwealth. In the aftermath of the Third Partition of Poland and the November Uprising , the university was closed down and suspended its operation until 1919. In the aftermath of World War I the university saw failed attempts to restart it by Lithuania and invading Soviet forces . It finally resumed operations as Stefan Batory University in Poland , a period followed by another Soviet occupation in 1920, and the less than two-years of the Republic of Central Lithuania, incorporated into Poland in 1922.Following Soviet invasion of Poland in September 1939, the university was briefly administered by the Lithuanian authorities , and then after Soviet annexation of Lithuania , punctuated by a period of German occupation after German invasion of the Soviet Union , administrated as Vilnius State University by the Lithuanian Soviet Socialist Republic. In 1945 the Polish community of students and scholars of Stafan Batory University was transferred to Nicolaus Copernicus University in Toruń. After Lithuania regained its independence in 1990, following the dissolution of the Soviet Union, it resumed its status as one of the prominent universities in Lithuania: Vilnius University.The wide-ranging Vilnius University ensemble represents all major architectural styles that predominated in Lithuania: Gothic, Renaissance, Baroque and Classicism. Wikipedia.


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The present invention relates to targeted conversion of alpha-hydroxyalkylated residues in biomolecules in the presence of a directing methyltransferase, namely to targeted removal of the alpha-hydroxyalkyl moieties to give unmodified residues, or targeted derivatization of the alpha-hydroxyalkyl groups by covalent coupling of non-cofactor compounds represented by formula HQ-LX, wherein X represents a functional group or a reporter group attached via a linker moiety L, and QH is selected from HS, HSe, HOH_(2)N, HN_(3 )or HCN in the presence of a directing methyltransferase. Further development of the method of targeted conversion comprises methods for targeted labeling a biomolecule and method for detecting hydroxymethylated target sites in a biomolecule according to the present invention.


Patent
President And Fellows Of Harvard College and Vilnius University | Date: 2017-03-01

The present invention generally relates to microfluidics and labeled nucleic acids. For example, certain aspects are generally directed to systems and methods for labeling nucleic acids within microfluidic droplets. In one set of embodiments, the nucleic acids may include barcodes or unique sequences that can be used to distinguish nucleic acids in a droplet from those in another droplet, for instance, even after the nucleic acids are pooled together. In some cases, the unique sequences may be incorporated into individual droplets using particles and attached to nucleic acids contained within the droplets (for example, released from lysed cells). In some cases, the barcodes may be used to distinguish tens, hundreds, or even thousands of nucleic acids, e.g., arising from different cells or other sources.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC5-11d-2015 | Award Amount: 9.78M | Year: 2016

SOLSA is the first automated expert system for on-site cores analysis. With access to data on-line, great savings are expected on the number of drill holes, the accuracy of geo-models and economic evaluation of ore reserves. SOLSA responds perfectly to the need for New sustainable exploration technologies and geo-models of SC5-11d-2015. The objective is to develop new or improved highly efficient and cost-effective, sustainable exploration technologies. It includes (1) integrated drilling optimized to operate in the difficult lateritic environment with the challenge of a mixture of hard and soft rocks, extensible also to other ore types, (2) fully automated scanner and phase identification software, usable as well in other sectors. SOLSA combines for the first time the non-destructive sensors X-ray fluorescence, X-ray diffraction, vibrational spectroscopies and 3D imaging along the drill core. For that purpose, SOLSA will develop innovative, user-friendly and intelligent software, at the TRL 4-6 levels. To minimize the risk and capitalize on the newest technologies, the subsystems for the hardware, will be selected on the market of miniaturized sensors. To align SOLSA to the industrial needs and to guarantee market uptake at the end of the project, the SOLSA multidisciplinary consortium includes an end-user (ERAMET) with mining and commercial activities in laterite ores, the case study selected for the project. Industrially driven, the consortium is composed of LE, SMEs and academic experts (ERAMET (PI), F; SSD, NL; BRGM, F; INEL, F; Univ. Vilnius, Lt; CNRS-CRISMAT, F; Univ. Trento, I; Univ. Verona, I; TU Delft, NL) covering exploration, database management, instrumentation and software development, drilling rigs, analytical prototypes and marketing strategies. SOLSA is expected to revolutionize exploration and push Europe in front, by reducing the exploration time at 50%, the analysis time from 3 - 6 months to real-time and thus the environmental footprint.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 10.00M | Year: 2015

LASERLAB-EUROPE is the European consortium of major national laser research infrastructures, covering advanced laser science and applications in most domains of research and technology, with particular emphasis on areas with high industrial and social impact, such as bio- and nanophotonics, material analyses, biology and medicine. Recently the field of advanced lasers has experienced remarkable advances and breakthroughs in laser technologies and novel applications. Laser technology is a key innovation driver for highly varied applications and products in many areas of modern society, thereby substantially contributing to economic growth. Through its strategic approach, LASERLAB-EUROPE aims to strengthen Europes leading position and competitiveness in this key area. It facilitates the coordination of laser research activities within the European Research Area by integrating major facilities in most European member states with a long-term perspective and providing concerted and efficient services to researchers in science and industry. The main objectives of LASERLAB-EUROPE are to: promote, in a coordinated way and on a European scale, the use of advanced lasers and laser-based technologies for research and innovation, serve a cross-disciplinary user community, from academia as well as from industry, by providing access to a comprehensive set of advanced laser research installations, including two free-electron laser facilities, increase the European basis of human resources in the field of lasers by training new users, including users in new domains of science and technology and from geographical regions of Europe where laser user communities are still less developed, improve human and technical resources through technology exchange and sharing of expertise among laser experts and operators across Europe, and through coordinated Joint Research Activities enabling world-class research, innovations and applications beyond the present state-of-the-art.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 10.23M | Year: 2015

The Europlanet 2020 Research Infrastructure (EPN2020-RI) will address key scientific and technological challenges facing modern planetary science by providing open access to state-of-the-art research data, models and facilities across the European Research Area. Its Transnational Access activities will provide access to world-leading laboratory facilities that simulate conditions found on planetary bodies as well as specific analogue field sites for Mars, Europa and Titan. Its Virtual Access activities will make available the diverse datasets and visualisation tools needed for comparing and understanding planetary environments in the Solar System and beyond. By providing the underpinning facilities that European planetary scientists need to conduct their research, EPN2020-RI will create cooperation and effective synergies between its different components: space exploration, ground-based observations, laboratory and field experiments, numerical modelling, and technology. EPN2020-RI builds on the foundations of successful FP6 and FP7 Europlanet programmes that established the Europlanet brand and built structures that will be used in the Networking Activities of EPN2020-RI to coordinate the European planetary science communitys research. It will disseminate its results to a wide range of stakeholders including industry, policy makers and, crucially, both the wider public and the next generation of researchers and opinion formers, now in education. As an Advanced Infrastructure we place particular emphasis on widening the participation of previously under-represented research communities and stakeholders. We will include new countries and Inclusiveness Member States, via workshops, team meetings, and personnel exchanges, to broaden/widen/expand and improve the scientific and innovation impact of the infrastructure. EPN2020-RI will therefore build a truly pan-European community that shares common goals, facilities, personnel, data and IP across national boundaries


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 13.00M | Year: 2015

Particle physics is at the forefront of the ERA, attracting a global community of more than 10,000 scientists. With the upgrade of the LHC and the preparation of new experiments, the community will have to overcome unprecedented challenges in order to answer fundamental questions concerning the Higgs boson, neutrinos, and physics beyond the Standard Model. Major developments in detector technology are required to ensure the success of these endeavours. The AIDA-2020 project brings together the leading European infrastructures in detector development and a number of academic institutes, thus assembling the necessary expertise for the ambitious programme of work. In total, 19 countries and CERN are involved in this programme, which follows closely the priorities of the European Strategy for Particle Physics. AIDA-2020 aims to advance detector technologies beyond current limits by offering well-equipped test beam and irradiation facilities for testing detector systems under its Transnational Access programme. Common software tools, micro-electronics and data acquisition systems are also provided. This shared high-quality infrastructure will ensure optimal use and coherent development, thus increasing knowledge exchange between European groups and maximising scientific progress. The project also exploits the innovation potential of detector research by engaging with European industry for large-scale production of detector systems and by developing applications outside of particle physics, e.g. for medical imaging. AIDA-2020 will lead to enhanced coordination within the European detector community, leveraging EU and national resources. The project will explore novel detector technologies and will provide the ERA with world-class infrastructure for detector development, benefiting thousands of researchers participating in future particle physics projects, and contributing to maintaining Europes leadership of the field.


Grant
Agency: European Commission | Branch: H2020 | Program: IA | Phase: BG-04-2014 | Award Amount: 7.40M | Year: 2015

INMARE stands for Industrial Applications of Marine Enzymes: Innovative screening and expression platforms to discover and use the functional protein diversity from the sea. It is a collaborative Innovation Action to streamline the pathways of discovery and industrial applications of new marine enzymes and bioactives for targeted production of fine chemicals, drugs and in environmental clean-up applications. The INMARE consortium will unify the multidisciplinary expertise and facilities of academic and industry partners. This will include integrating the following core activities: advanced technologies to access and sample unique marine biodiversity hot-spots; state-of-the art technologies for construction of metagenomic libraries; innovative enzyme screening assays and platforms; cutting-edge sequence annotation pipelines and bioinformatics resources; high-end activity screening technology; bioanalytical and bioprocess engineering facilities and expertise, nanoparticle-biocatalysts; high-quality protein crystallization and structural analysis facilities and experts in IP management for biotechnology. The companies involved in the project are market leaders in enzyme production and biocatalysis processes designed to efficiently deliver safer (pharmaceuticals) cheaper (agriculture) and biobased (biopolymers) products. They also have impressive track record in environmental clean-up technologies and are committed to promoting public understanding, awareness and dissemination of scientific research. The main emphasis will be focused on streamlining and shortening the pipelines for enzyme and bioactive compound discovery towards industrial applications through the establishing of marine enzyme collections with a high proportion of enzymes-allrounders. The project will also prioritize the identification of novel lead products and the delivery of improved prototypes for new biocatalytic processes.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: INT-08-2015 | Award Amount: 2.67M | Year: 2016

Ten years after its inception, the European Neighbourhood Policy (ENP) has fallen short of accomplishing its mission. The war in Ukraine and the rising tensions with Russia have made a re-assessment of the ENP both more urgent and more challenging. EU-STRAT will address two questions: First, why has the EU fallen short of creating peace, prosperity and stability in its Eastern neighbourhood? Second, what can be done to strengthen the EUs transformative power in supporting political and economic change in the six Eastern Partnership (EaP) countries? Adopting an inside-out perspective on the challenges of transformation the EaP countries and the EU face, EU-STRAT will develop a conceptual framework for the varieties of social orders in EaP countries to explain the propensity of domestic actors to engage in change; investigate how bilateral, regional and global interdependencies shape the scope of action and the preferences of domestic actors in the EaP countries; de-centre the EU by studying the role of selected member states and other external actors active in the region; evaluate the effectiveness of the Association Agreements and alternative EU instruments, including scientific cooperation, in supporting change in the EaP countries; analyse normative discourses used by the EU and Russia to enhance their influence over the shared neighbourhood. formulate policy recommendations to strengthen the EUs capacity to support change in the EaP countries by advancing different scenarios for developmental pathways. EU-STRAT features an eleven-partner consortium including six universities, three think-tanks, one civil society organization and one consultancy. This consortium will achieve the research and policy relevant objectives of the project by bringing together various disciplinary perspectives and methodologies and strengthening links with academics and policy makers across six EU member states, Switzerland and three of the EaP countries.


Grant
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2014-ETN | Award Amount: 3.27M | Year: 2015

SELECTA is a highly inter-disciplinary initiative which has the primary goal of training young researchers in the field of smart electrodeposited metallic alloys suitable for environmental / sustainable development applications. The Network encompasses the fabrication and in-depth characterization of: (i) innovative protective coatings, (ii) resilient micro/nano-electromechanical systems, and (iii) wirelessly actuated micro/nano-robotic platforms for cutting-edge environmental applications. The project will explore new types of electrodeposited alloys (based on Fe, Cu or Al; free from hazardous and scarce raw elements), with tunable structure (amorphous, nanocrystalline), morphology (dense, nanoporous) and geometry (films, micropillars, nanowires), to meet specific technological demands (high wear/corrosion resistance, superior magnetic properties or hydrophobicity). SELECTA aims to integrate technological progress with environmental sustainability concerns, which is one of the major Societal Challenges listed in the Horizon 2020 Work Programme. Several disciplines (Physics, Electrochemistry, Engineering, Environmental Sciences, Biology and Robotics) converge together to provide a holistic approach to accomplish the SELECTA goals. The project brings together 10 Beneficiaries and 7 Partner Organizations (including 5 private companies), belonging to 10 EU Member States (plus Switzerland and Serbia). Special efforts will be devoted to bridge fundamental science with commercialisation of the research outcome. The complementarities among partners will render a high-level, multi-faceted educational programme. World-class research will be combined with unique training opportunities in soft skills, such as career planning, dissemination, intellectual property rights, entrepreneurship or management. The Network aims to provide highly-qualified specialists able to face future professional challenges in either Academia or Industry in an independent manner.


Grant
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: GARRI-10-2015 | Award Amount: 1.50M | Year: 2016

The European Network of Research Ethics and Research Integrity (ENERI) establishes an operable platform of actors in the fields of research ethics and research integrity. The reliability and credibility of research and science do not depend only on its excellence and productivity but also on the players awareness of highest standards of ethics in research and commitment to a responsible conduct of research. Research ethics addresses the application of ethical principles to the various fields of research. This includes ethical aspects of the design and conduct of research, the way human participants or animals within research projects are treated, and aspects of scientific misconduct. Research integrity is recognized as the attitude and habit of the researchers to conduct research according to appropriate ethical, legal and professional frameworks and standards. The fields of research ethics and research integrity combine general ethical reflections, ethics and law as academic disciplines addressing research activities, moral attitudes of researchers, normative policies of stakeholders like sponsors or funding organizations, and various ethical expectations of the civil society. ENERI is based on existing networks, projects and infrastructures that already initiated and developed important steps in sharing information, training and capacity building. Research ethics committees, review boards, ombudspersons offices, research integrity offices and supporting structures are the established bodies monitoring, accompanying and assisting the process of responsible and justifiable research. Therefore the European Network of Research Integrity Offices (ENRIO) and the European Network of Research Ethics Committees (EUREC) mutually initiated ENERI in collaborations with experts in academic research ethics (RE) and responsible research and innovation (RRI), practitioners in training and education in research ethics, and specialists in e-communication and database design.

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