Vikrama Simhapuri University

www.simhapuriuniv.ac.in
Nellore, India

Vikrama Simhapuri University is a university located in the Nellore district of Andhra Pradesh, India. The university was established in 2008 with six courses. Now, the university is offering 17 Post Graduate courses in University College. Wikipedia.

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Munagapati V.S.,Ewha Womans University | Yarramuthi V.,Vikrama Simhapuri University | Kim D.-S.,Ewha Womans University
Journal of Molecular Liquids | Year: 2017

The adsorption of methyl orange (MO) onto goethite (G), chitosan beads (CSB) and goethite impregnated with chitosan beads (GCSB) as a new and potential adsorbents have been studied. Batch adsorption studies were conducted to evaluate the effect of various parameters such as pH, contact time, initial dye concentration and temperature. The adsorbents are characterized by using Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and Brunner-Emmet-Teller (BET) analysis, respectively. FTIR results revealed that hydroxyl, amine and carboxyl functional groups present on the surface of adsorbents. Experimental equilibrium data for adsorption of MO was analyzed by the Langmuir, Freundlich and Dubinin-Radushkevich models. The results showed that the best fit was achieved with the Langmuir isotherm equation with maximum adsorption capacities of 55, 73 and 84 mg/g for G, CSB and GCSB, respectively. The pseudo-first-order and pseudo-second-order model equations were used to analyze the kinetic data of the adsorption process and the data was fitted well with the pseudo-second-order kinetic model. The calculated thermodynamic parameters, namely ΔGo, ΔHo and ΔSo showed that adsorption of MO was spontaneous and endothermic in the temperature range 298–338 K. Desorption experiments were carried out to explore the feasibility of regenerating the adsorbent and the adsorbed MO from G, CSB and GCSB were desorbed using 0.1 M NaOH with an efficiency of 91, 94 and 96%, respectively, recovery. Findings of the present study indicated that G, CSB and GCSB can be successfully used for removal of MO from aqueous solution. © 2017 Elsevier B.V.


Pradeepkiran J.A.,Sri Venkateswara University | Sainath S.B.,University of Porto | Sainath S.B.,Vikrama Simhapuri University | Kumar K.K.,Sri Venkateswara University | Bhaskar M.,Sri Venkateswara University
Drug Design, Development and Therapy | Year: 2015

Brucella melitensis 16M is a Gram-negative coccobacillus that infects both animals and humans. It causes a disease known as brucellosis, which is characterized by acute febrile illness in humans and causes abortions in livestock. To prevent and control brucellosis, identification of putative drug targets is crucial. The present study aimed to identify drug targets in B. melitensis 16M by using a subtractive genomic approach. We used available database repositories (Database of Essential Genes, Kyoto Encyclopedia of Genes and Genomes Automatic Annotation Server, and Kyoto Encyclopedia of Genes and Genomes) to identify putative genes that are nonhomologous to humans and essential for pathogen B. melitensis 16M. The results revealed that among 3 Mb genome size of pathogen, 53 putative characterized and 13 uncharacterized hypothetical genes were identified; further, from Basic Local Alignment Search Tool protein analysis, one hypothetical protein showed a close resemblance (50%) to Silicibacter pomeroyi DUF1285 family protein (2RE3). A further homology model of the target was constructed using MODELLER 9.12 and optimized through variable target function method by molecular dynamics optimization with simulating annealing. The stereochemical quality of the restrained model was evaluated by PROCHECK, VERIFY-3D, ERRAT, and WHATIF servers. Furthermore, structure-based virtual screening was carried out against the predicted active site of the respective protein using the glycerol structural analogs from the PubChem database. We identified five best inhibitors with strong affinities, stable interactions, and also with reliable drug-like properties. Hence, these leads might be used as the most effective inhibitors of modeled protein. The outcome of the present work of virtual screening of putative gene targets might facilitate design of potential drugs for better treatment against brucellosis. © 2015 Pradeepkiran et al.


Sandeepa G.M.,Vikrama Simhapuri University | Ammani K.,Acharya Nagarjuna University
Current Trends in Biotechnology and Pharmacy | Year: 2017

Two-phased experiment was conducted to investigate the effects of dietary supplementation of probiotic bacterium on shrimp physiology. In first phase shrimp fed with probiotic supplemented feed for 21 days, in second phase challenged with White spot syndrome virus (WSSV) and their physiological responses were investigated for 2 days post-challenged. The probiotic bacteria Lactobacillus sps was added to the formulated basal diet at 5%, 10% and 15%concentration. Growth, immune response, antioxidant status of shrimp were evaluated. The results showed that dietary supplementation of probiotics in shrimp had significant (P<0.01) impact on growth. The treated shrimp groups showed significant increase in THC, percentage of phagocytosis and phenoloxidase enzyme activity. IgG, IgA, and IgM like substances in the haemolymph of treated shrimp were significantly increased when compared to control. Higher levels of these substances were observed in 10% treated shrimp than other two groups. The antioxidant enzymes like catalse and superoxide dismutase enzymes also significantly increased in probiotic treated shrimp when compared to control. In addition, dietary supplementation of all the three concentrations of Lactobacillus sps probiotic bacterium was effective in improving the resistance of shrimp against WSSV as they had higher THC, higher percentage of phagocytosis, phenoloxidase enzyme and immunoglobin like substances level. © 2017, Association of Biotechnology and Pharmacy. All rights reserved.


Lo H.-H.,National Dong Hwa University | Gopal N.O.,National Dong Hwa University | Gopal N.O.,Vikrama Simhapuri University | Sheu S.-C.,Chang Jung Christian University | Ke S.-C.,National Dong Hwa University
Journal of Physical Chemistry C | Year: 2014

Regarding how photogenerated charge carriers are transferred in TiO 2(B)/anatase mixed-phase nanowires, no unified conclusion has been reached. Electron paramagnetic resonance (EPR) spectroscopy is employed to investigate the vectorial charge transfer in this material. When the material is subjected to UV irradiation, we show that holes stimulated in anatase are transferred to TiO2(B) by comparing EPR-detected amounts of trapped hole O- accumulated on TiO2(B) with X-ray diffraction (XRD)-determined TiO2(B) bulk phase compositions. Under visible-light irradiation which only activates the TiO2(B) phase, we unambiguously show that electron transfer occurs from TiO2(B) to anatase. Without intervention of other charge carriers generated by bandgap excitation, we monitor exclusively the fate of conducting electrons generated by specific excitation of N- midgap states of TiO2(B) with holes localized on the N atom in N-doped TiO2(B)/anatase. The result again clearly demonstrates that electrons migrate from TiO2(B) to anatase. Time-dependent decay of the N•-hole EPR signal shows that it is difficult for the transferred electron to return to TiO2(B). Both higher conduction band and valence band edge potentials in TiO2(B) than the corresponding ones of anatase are implicated. This study helps to point the way toward future development of TiO2(B) nanowire based material for photovoltaic and photocatalytic applications. © 2014 American Chemical Society.


Hari Krishna M.,Vikrama Simhapuri University | Thriveni P.,Vikrama Simhapuri University
Der Pharma Chemica | Year: 2016

Cr(NO3)3. 9H2O is used as an efficient catalyst in the reaction of phenols with ethyl acetoacetate (via Pechmann reaction) in solvent-free media leads to the formation of coumarin derivatives using microwave irradiation in excellent yields with good purity.


Venkatadri N.,Vikrama Simhapuri University | Reddy K.R.,Vikrama Simhapuri University
Proceedings - 6th International Advanced Computing Conference, IACC 2016 | Year: 2016

Ad Hoc wireless network is a type of wirelessnetwork, in which there is no any fixed infrastructure. Devices in Ad Hoc network can move around thenetwork within a given range. Currently most of thetransactions are performed through the computernetworks so they are more susceptible to many physicalsecurity threats. One of the major DOS Attacks thatdegrade the performance of the whole MANET is BlackHole attack. In the presence of black hole attack, nastynodes are not forward the packets rather they droppackets. In this work, black hole attack is detected andeliminated through implementing Digital Signaturewith Twofish Algorithm. We modified on-demandrouting protocol Temporally Ordered RoutingAlgorithm (TORA) and named it as STORA. Ourproposed STORA performs well under normalconditions and under black hole attack than original TORA. © 2016 IEEE.


Syed S.,Vikrama Simhapuri University | Ussenaiah M.,Vikrama Simhapuri University
Proceedings of the 2015 International Conference on Green Computing and Internet of Things, ICGCIoT 2015 | Year: 2015

Data security is one of the biggest concerns in adopting Cloud computing. © 2015 IEEE.


Swetha C.,Sri Venkateswara University | Sainath S.B.,Vikrama Simhapuri University | Reddy P.S.,Sri Venkateswara University
Journal of Experimental Zoology Part A: Ecological Genetics and Physiology | Year: 2014

The objective of this study was to investigate the mode of action of dopamine in regulating hemolymph sugar level in the fresh water edible crab, Oziothelphusa senex senex. Injection of dopamine produced hyperglycemia in a dose-dependent manner in intact crabs but not in eyestalkless crabs. Administration of dopamine resulted in a significant decrease in total carbohydrates and glycogen levels with a significant increase in glycogen phosphorylase activity levels in hepatopancreas and muscle of intact crabs, indicating dopamine-induced glycogenolysis resulting in hyperglycemia. Bilateral eyestalk ablation resulted in significant increase in the total carbohydrates and glycogen levels with a significant decrease in the activity levels of phosphorylase in the hepatopancreas and muscle of the crabs. Eyestalk ablation resulted in significant decrease in hemolymph hyperglycemic hormone levels. The levels of hyperglycemic hormone in the hemolymph of dopamine injected crabs were significantly higher than in control crabs. However, no significant changes in the levels of hemolymph hyperglycemic hormone and sugar and tissue carbohydrate and phosphorylase activity were observed in dopamine injected eyestalk ablated crabs when compared with eyestalk ablated crabs. These results support an earlier hypothesis in crustaceans that dopamine acts as a neurotransmitter and induces hyperglycemia by triggering the release of hyperglycemic hormone in the crab, O. senex senex. © 2014 Wiley Periodicals, Inc.


Chalamcherla V.L.,Vikrama Simhapuri University | Singaracharya M.A.,Kakatiya University | Vijaya Lakshmi M.,A.N.U.
BioResources | Year: 2010

Defining and quantifying amino acid requirements will become an important consideration in the next generation of feeding schemes for dairy cattle beyond the current emphasis on identification of limiting amino acids. In this context different amino acid profiles of untreated, urea treated, fungal treated, and urea plus fungal treated lignocellulosic feed by both P. ostreatus wild and its two cellulase-minus/less lignolytic mutants were analyzed. Cellulase-free mutant strains were obtained after 20 minutes of exposure to UV light and 0.4 seconds to X-rays. A UV mutant of P. ostreatus (POM1) exhibited better performance than the X-ray mutant (POM2) in terms of production of less cellulolytic and more lignolytic enzymes. Urea treatment of straw enhanced the total amino acid content by less than a factor of two, while the fungal treatment improved it by 13-14 times. Fungal treatment of urea-treated straw improved the total amino acid content by a factor of 15, indicating the importance of urea in the straw. Further, the fungal treatment of ureatreated straw enhanced the quantity of amino acids such as glutamine, glycine, aspergine, etc. by 15-20 times. The quantity of limiting amino acids such as methionine, lysine, and histidine was also enhanced by 8 to 10 times through the fungal treatment. Maximum amounts of all the amino acids were found in urea plus fungal (POM1) treated paddy straw than in only fungal treated and only urea treated paddy straws.


Subashchandrabose S.R.,University of South Australia | Megharaj M.,University of South Australia | Venkateswarlu K.,Vikrama Simhapuri University | Naidu R.,University of South Australia
Environmental Toxicology and Chemistry | Year: 2012

The nontarget effects, in terms of biochemical changes induced by p-nitrophenol (PNP) in three soil microalgae, Chlorella sp., Chlorococcum sp., and Heterochlamydomonas sp., and the PNP removal efficiency of these isolates, were determined. On exposure to 20mgL-1 PNP, Chlorella sp. showed greater activity of peroxidase, superoxide dismutase, and glutathione reductase as well as high contents of proline and carotenoids. While Heterochlamydomonas sp. exhibited higher levels of catalase and protein, Chlorococcum sp. produced greater amounts of malondialdehyde, a measure of lipid peroxidation, in the presence of PNP. Chlorella sp. tolerated PNP by producing large quantities of antioxidants coupled with less lipid peroxidation, while Chlorococcum sp. was susceptible, as evidenced by low antioxidant production and high lipid peroxidation. During 7-d exposure, Chlorella sp., Heterochlamydomonas sp., and Chlorococcum sp. were able to remove 39, 18, and 4% of 20mgL-1 PNP, respectively. The present results indicate that proline, carotenoids and malondialdehyde are the potential biomarkers for assessing PNP toxicity toward microalgae, and their response could be considered for differentiating tolerant and susceptible strains. Moreover, there is a clear correlation between PNP removal and antioxidant synthesis in microalgae on exposure to the pollutant. © 2012 SETAC.

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