Time filter

Source Type

Ujjain, India

Vikram University is a university in the city of Ujjain, Madhya Pradesh, India.The university, which is named after the ruler Vikramaditya, was established in 1957. The foundation stone was laid by the then Home Minister of India Govind Vallabh Pant. Wikipedia.

The substance used in all such preparations must be in the purest form available. Pharmaceutical analysis is a vital part of the pharmaceutical chemistry. Analysis is an important task for all the research and development activities involving medicinal substances. It forms the basis of quality, which is the prime concern regarding medicines of human life. Thus pharmaceutical analytical chemistry may be defined as that branch of practical chemistry which deals with the resolution, separation, identification, determination, and purification of a given sample of a medicine or a pharmaceutical; the detection and estimation of impurities that may be present therein is also included. System Suitability Passes. Tailing factor is not more than 2.0%. The Correlation coefficient for Losartan potassium is 0.99937 and for Hydrochlorothiazide is 0.99967. The method is validated for Linearity from 70% to 130% of target concentration. Chromatograms of Different concentration were performed. RSD for Peak area and retention time of five replicate injections is found within the specified limit. System suitability passes and method is validated for system precision. The allowable variation in the flow rate of the mobile phase is ± 10%. The Percent change is assay value is less than 2.0% after 24 hours for the sample solution. Therefore the solution is stable for 24 hours at ambient temperature. This validation has been carried out as per ICH Q2 (R1) and the method has been validated as per approved protocol. Source

Sharma P.,Ujjain Engineering College | Chhajlani R.K.,Vikram University
Physics of Plasmas | Year: 2014

The effect of spin induced magnetization and electrical resistivity incorporating the viscosity of the medium is examined on the Jeans instability of quantum magnetoplasma. Formulation of the system is done by using the quantum magnetohydrodynamic model. The analysis of the problem is carried out by normal mode analysis theory. The general dispersion relation is derived from set of perturbed equations to analyse the growth rate and condition of self-gravitational Jeans instability. To discuss the influence of resistivity, magnetization, and viscosity parameters on Jeans instability, the general dispersion relation is reduced for both transverse and longitudinal mode of propagations. In the case of transverse propagation, the gravitating mode is found to be affected by the viscosity, magnetization, resistivity, and magnetic field strength whereas Jeans criterion of instability is modified by the magnetization and quantum parameter. In the longitudinal mode of propagation, the gravitating mode is found to be modified due to the viscosity and quantum correction in which the Jeans condition of instability is influenced only by quantum parameter. The other non-gravitating Alfven mode in this direction is affected by finite electrical resistivity, spin induced magnetization, and viscosity. The numerical study for the growth rate of Jeans instability is carried out for both in the transverse and longitudinal direction of propagation to the magnetic field. The effect of various parameters on the growth rate of Jeans instability in quantum plasma is analysed. © 2014 AIP Publishing LLC. Source

Parihar M.S.,Vikram University | Brewer G.J.,University of Illinois at Springfield
Journal of Alzheimer's Disease | Year: 2010

Alzheimer's disease is associated with synapse loss, memory dysfunction, and pathological accumulation of amyloid-β (Aβ) in plaques. However, an exclusively pathological role for Aβ is being challenged by new evidence for an essential function of Aβ at the synapse. Aβ protein exists in different assembly states in the central nervous system and plays distinct roles ranging from synapse and memory formation to memory loss and neuronal cell death. Aβ is present in the brain of symptom-free people where it likely performs important physiological roles. New evidence indicates that synaptic activity directly evokes the release of Aβ at the synapse. At physiological levels, Aβ is a normal, soluble product of neuronal metabolism that regulates synaptic function beginning early in life. Monomeric Aβ40 and Aβ42 are the predominant forms required for synaptic plasticity and neuronal survival. With age, some assemblies of Aβ are associated with synaptic failure and Alzheimer's disease pathology, possibly targeting the N-methyl-D-aspartic acid receptor through the nicotinic acetylcholine receptor, mitochondrial Aβ alcohol dehydrogenase, and cyclophilin D. But emerging data suggests a distinction between age effects on the target response in contrast to the assembly state or the accumulation of the peptide. Both aging and Aβ independently decrease neuronal plasticity. Our laboratory has reported that Aβ, glutamate, and lactic acid are each increasingly toxic with neuron age. The basis of the age-related toxicity partly resides in age-related mitochondrial dysfunction and an oxidative shift in mitochondrial and cytoplasmic redox potential. In turn, signaling through phosphorylated extracellular signal-regulated protein kinases is affected along with an age-independent increase in phosphorylated cAMP response element-binding protein. This review examines the long-awaited functional impact of Aβ on synaptic plasticity. © 2010 IOS Press and the authors. All rights reserved. Source

Rathod P.,Vikram University
Cellular and molecular biology (Noisy-le-Grand, France) | Year: 2011

Increase in the cellular burden of oxidative stress is critically involved in various pathological manifestations of aging, including age-related neurological disorders. Dietary restriction can lower reactive oxygen species formation, and thereby lower oxidative damage in the brain. The brain consists of a diverse group of neurons with varying functions. However, attenuating role of dietary restriction on oxidative stress in different regions of brain is not well known. In the present study we demonstrated that by restricting diet intake for a period of six months, mice lowered the endogenous levels of oxidative stress markedly by decreasing lipid peroxidation and protein carbonyl contents in cerebral cortex, hippocampus and striatum regions of the brain. Based on these results we suggest that dietary restriction can significantly reduce oxidative stress in various regions of the brain by virtue of lowering endogenous levels of reactive oxygen species, which might prove beneficial for preserving normal brain function with age. Source

Shrivastava B.D.,Vikram University
Journal of Physics: Conference Series | Year: 2012

The X-ray absorption fine structure (XAFS) spectra are best recorded when a highly intense beam of X-rays from a synchrotron is used along with a good resolution double crystal or curved crystal spectrometer and detectors like ionization chambers, scintillation counters, solid state detectors etc. Several synchrotrons around the world have X-ray beamlines dedicated specifically to XAFS spectroscopy. Fortunately, the Indian synchrotron (Indus-2) at Raja Ramanna Centre for Advanced Technology (RRCAT) at Indore has started operation. A dispersive type EXAFS beamline called BL-8 has been commissioned at this synchrotron and another beamline having double crystal monochromator (DCM) is going to be commissioned shortly. In Indian context, in order that more research workers use these beamlines, the study of XAFS spectroscopy using synchrotron radiation becomes important. In the present work some of the works done by our group on XAFS spectroscopy using synchrotron radiation have been described. © Published under licence by IOP Publishing Ltd. Source

Discover hidden collaborations