Ujjain, India
Ujjain, India

Vikram University is a university in the city of Ujjain, Madhya Pradesh, India.The university, which is named after the ruler Vikramaditya, was established in 1957. The foundation stone was laid by the then Home Minister of India Govind Vallabh Pant. Wikipedia.

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Pare B.,Vikram University | Sarwan B.,Vikram University | Jonnalagadda S.B.,University of KwaZulu - Natal
Applied Surface Science | Year: 2011

Manganese doped BiOCl has been synthesized by hydrolysis method and characterized by X-ray diffraction (XRD), scanning electron micrographs (SEM) and diffusive reflectance spectra (DRS) methods. Interesting results have been obtained from diffusive reflectance spectra. XRD results show a decrease in the lattice parameter for Mn-doped BiOCl and UV-vis measurement reveals that there is a shift in the optical absorption edge toward higher wavelength, which indicates a decrease in the band gap upon Mn doping. The increased photocatalytic activity in degradation of malachite green dye by Mn-doped BiOCl might be due to increase in life time of photogenerated electrons and holes due to scavenging of electrons by Mn, charging the particle surface due to electron on the surface, which enhances the adsorption of dye molecules, or/and decreased crystallite size. The effect of key operating parameters have also been investigated. Complete mineralization has been confirmed by COD analysis. An assumptive reaction mechanism has also been proposed. © 2011 Elsevier B.V. All rights reserved.

Pare B.,Vikram University | Sarwan B.,Vikram University | Jonnalagadda S.B.,University of KwaZulu - Natal
Journal of Molecular Structure | Year: 2012

BiOCl was synthesized by hydrolysis method. In order to evaluate their photocatalytic activity, this compound was tested on the degradation reaction of methylene green in aqueous solution. The characterization of the compound included: X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopic image (TEM). MG could be efficiently degraded in aqueous suspension of BiOCl under visible light irradiation. Complete removal of aqueous methylene green (MG) was realized after visible light irradiation for 120 min with existing BiOCl as a catalyst. The decrease of the chemical oxygen demand (COD), the formation of inorganic products (SO42- and NO3-) confirmed complete mineralization of aqueous MG during the photocatalytic process. © 2011 Elsevier B.V. All rights reserved.

Parihar M.S.,Vikram University | Brewer G.J.,University of Illinois at Springfield
Journal of Alzheimer's Disease | Year: 2010

Alzheimer's disease is associated with synapse loss, memory dysfunction, and pathological accumulation of amyloid-β (Aβ) in plaques. However, an exclusively pathological role for Aβ is being challenged by new evidence for an essential function of Aβ at the synapse. Aβ protein exists in different assembly states in the central nervous system and plays distinct roles ranging from synapse and memory formation to memory loss and neuronal cell death. Aβ is present in the brain of symptom-free people where it likely performs important physiological roles. New evidence indicates that synaptic activity directly evokes the release of Aβ at the synapse. At physiological levels, Aβ is a normal, soluble product of neuronal metabolism that regulates synaptic function beginning early in life. Monomeric Aβ40 and Aβ42 are the predominant forms required for synaptic plasticity and neuronal survival. With age, some assemblies of Aβ are associated with synaptic failure and Alzheimer's disease pathology, possibly targeting the N-methyl-D-aspartic acid receptor through the nicotinic acetylcholine receptor, mitochondrial Aβ alcohol dehydrogenase, and cyclophilin D. But emerging data suggests a distinction between age effects on the target response in contrast to the assembly state or the accumulation of the peptide. Both aging and Aβ independently decrease neuronal plasticity. Our laboratory has reported that Aβ, glutamate, and lactic acid are each increasingly toxic with neuron age. The basis of the age-related toxicity partly resides in age-related mitochondrial dysfunction and an oxidative shift in mitochondrial and cytoplasmic redox potential. In turn, signaling through phosphorylated extracellular signal-regulated protein kinases is affected along with an age-independent increase in phosphorylated cAMP response element-binding protein. This review examines the long-awaited functional impact of Aβ on synaptic plasticity. © 2010 IOS Press and the authors. All rights reserved.

Sharma P.,Ujjain Engineering College | Chhajlani R.K.,Vikram University
Physics of Plasmas | Year: 2014

The effect of spin induced magnetization and electrical resistivity incorporating the viscosity of the medium is examined on the Jeans instability of quantum magnetoplasma. Formulation of the system is done by using the quantum magnetohydrodynamic model. The analysis of the problem is carried out by normal mode analysis theory. The general dispersion relation is derived from set of perturbed equations to analyse the growth rate and condition of self-gravitational Jeans instability. To discuss the influence of resistivity, magnetization, and viscosity parameters on Jeans instability, the general dispersion relation is reduced for both transverse and longitudinal mode of propagations. In the case of transverse propagation, the gravitating mode is found to be affected by the viscosity, magnetization, resistivity, and magnetic field strength whereas Jeans criterion of instability is modified by the magnetization and quantum parameter. In the longitudinal mode of propagation, the gravitating mode is found to be modified due to the viscosity and quantum correction in which the Jeans condition of instability is influenced only by quantum parameter. The other non-gravitating Alfven mode in this direction is affected by finite electrical resistivity, spin induced magnetization, and viscosity. The numerical study for the growth rate of Jeans instability is carried out for both in the transverse and longitudinal direction of propagation to the magnetic field. The effect of various parameters on the growth rate of Jeans instability in quantum plasma is analysed. © 2014 AIP Publishing LLC.

Rathod P.,Vikram University
Cellular and molecular biology (Noisy-le-Grand, France) | Year: 2011

Increase in the cellular burden of oxidative stress is critically involved in various pathological manifestations of aging, including age-related neurological disorders. Dietary restriction can lower reactive oxygen species formation, and thereby lower oxidative damage in the brain. The brain consists of a diverse group of neurons with varying functions. However, attenuating role of dietary restriction on oxidative stress in different regions of brain is not well known. In the present study we demonstrated that by restricting diet intake for a period of six months, mice lowered the endogenous levels of oxidative stress markedly by decreasing lipid peroxidation and protein carbonyl contents in cerebral cortex, hippocampus and striatum regions of the brain. Based on these results we suggest that dietary restriction can significantly reduce oxidative stress in various regions of the brain by virtue of lowering endogenous levels of reactive oxygen species, which might prove beneficial for preserving normal brain function with age.

The substance used in all such preparations must be in the purest form available. Pharmaceutical analysis is a vital part of the pharmaceutical chemistry. Analysis is an important task for all the research and development activities involving medicinal substances. It forms the basis of quality, which is the prime concern regarding medicines of human life. Thus pharmaceutical analytical chemistry may be defined as that branch of practical chemistry which deals with the resolution, separation, identification, determination, and purification of a given sample of a medicine or a pharmaceutical; the detection and estimation of impurities that may be present therein is also included. System Suitability Passes. Tailing factor is not more than 2.0%. The Correlation coefficient for Losartan potassium is 0.99937 and for Hydrochlorothiazide is 0.99967. The method is validated for Linearity from 70% to 130% of target concentration. Chromatograms of Different concentration were performed. RSD for Peak area and retention time of five replicate injections is found within the specified limit. System suitability passes and method is validated for system precision. The allowable variation in the flow rate of the mobile phase is ± 10%. The Percent change is assay value is less than 2.0% after 24 hours for the sample solution. Therefore the solution is stable for 24 hours at ambient temperature. This validation has been carried out as per ICH Q2 (R1) and the method has been validated as per approved protocol.

Parihar P.,Vikram University | Solanki I.,Vikram University | Mansuri M.L.,Vikram University | Parihar M.S.,Vikram University
Experimental Gerontology | Year: 2015

The energy production and metabolic homeostasis are well-orchestrated networks of carbohydrate, lipid and protein metabolism. These metabolic pathways are integrated by a key cytoplasmic organelle, the mitochondria, leading to production of many metabolic intermediates and harvest cellular energy in the form of ATP. Sirtuins are a highly conserved family of proteins that mediate cellular physiology and energy demands in response to metabolic inputs. Mitochondria inhabit three main types of sirtuins classified as Sirt3, Sirt4 and Sirt5. These sirtuins regulate mitochondrial metabolic functions mainly through controlling post-translational modifications of mitochondrial protein. However, the biological mechanism involved in controlling mitochondrial metabolic functions is not well understood at this stage. In this review the current knowledge on how mitochondrial sirtuins govern mitochondrial functions including energy production, metabolism, biogenesis and their involvement in different metabolic pathways are discussed. The identifications of potential pharmacological targets of sirtuins in the mitochondria and the bioactive compounds that target mitochondrial sirtuins will increase our understanding on regulation of mitochondrial metabolism in normal and disease state. © 2014 Elsevier Inc.

Gaur A.,Vikram University | Shrivastava B.D.,Vikram University
Acta Physica Polonica A | Year: 2012

Determination of the chemical forms along with the relative quantity of the different species in a given sample, termed as speciation, can be done by analyzing X-ray absorption fine structure spectra. The different methods that can be used for speciation are: principal component analysis, target transformation, methods based on derivative spectra, method based on the relative position of the absorption edge, residual phase analysis, normalized difference absorption edge spectra analysis and linear combination fitting. An attempt has been made to make a comparative study of these different methods of speciation by recording the X-ray absorption fine structure at the copper K-edge in a mixture having cuprous oxide and cupric oxide in a specific ratio. The X-ray absorption fine structure spectra of the two oxides have also been recorded separately and the different characteristic X-ray absorption near edge structure features have been identified and their origins have been discussed. Speciation of the mixture has been done using these different methods and the results obtained have been compared and discussed.

Gaur A.,Vikram University | Shrivastava B.D.,Vikram University
Spectroscopy Letters | Year: 2013

Studies on speciation have been done in the mixtures of mixed ligand copper complexes. Three heterogeneous mixtures have been studied, each having one Cu(I) complex and one Cu(II) complex. The Cu(I) complex is [Cu(thu)Cl 0.5H 2O] (1) and the Cu(II) complexes are [Cu(L-phen)(bpy) H2O] (2), [Cu(L-tyr)(phn) 2.5H2O] (3), and [Cu(dien)(ina) 4H 2O.1/2SO4] (4) (where thu = thiourea, phen = 1,10-phenanthroline, bpy = 2,2′-bipyridine, tyr = tyrosine, dien = diethylenetriamine, and ina = isonicotinate anion). The mixtures have been prepared by mixing the Cu(I) complex with each of the Cu(II) complexes in the ratio of 1:1 by mole percentage. The X-ray absorption fine structure (XAFS) spectra have been recorded at the K-edge of copper in the mixtures as well as in the complexes, separately. The aim of the present work is to make a study of the different methods of speciation using XAFS, viz., principal component analysis (PCA) and the target transformation (TT) method, the linear combination fitting (LCF) method, derivative spectra methods, and normalized difference absorption edge spectra (NDAES) analysis. It has been shown that these methods can be used to determine the relative quantity of the mixed ligand complexes in their mixtures. © 2013 Taylor and Francis Group, LLC.

Shrivastava B.D.,Vikram University
Journal of Physics: Conference Series | Year: 2012

The X-ray absorption fine structure (XAFS) spectra are best recorded when a highly intense beam of X-rays from a synchrotron is used along with a good resolution double crystal or curved crystal spectrometer and detectors like ionization chambers, scintillation counters, solid state detectors etc. Several synchrotrons around the world have X-ray beamlines dedicated specifically to XAFS spectroscopy. Fortunately, the Indian synchrotron (Indus-2) at Raja Ramanna Centre for Advanced Technology (RRCAT) at Indore has started operation. A dispersive type EXAFS beamline called BL-8 has been commissioned at this synchrotron and another beamline having double crystal monochromator (DCM) is going to be commissioned shortly. In Indian context, in order that more research workers use these beamlines, the study of XAFS spectroscopy using synchrotron radiation becomes important. In the present work some of the works done by our group on XAFS spectroscopy using synchrotron radiation have been described. © Published under licence by IOP Publishing Ltd.

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