Vijaya Institute of Pharmaceutical science for Women

andhra Pradesh, India

Vijaya Institute of Pharmaceutical science for Women

andhra Pradesh, India
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Venkateswara Rao S.,Vijaya Institute of Pharmaceutical science for Women | Vege S.R.,Vijaya Institute of Pharmaceutical science for Women | Padmalatha K.,Vijaya Institute of Pharmaceutical science for Women
Research Journal of Pharmacy and Technology | Year: 2017

The objective of the present study is to develop Aceclofenac control release matrix tablet formulations by wet granulation method employing starch citrate, a new modified starch. Starch acetate prepared by reacting potato starch with acetic anhydride in the presence of sodium hydroxide at elevated temperatures was insoluble in water and has poor swelling and gelling property when heated in water. The degree of substitution (DS) of starch acetate was found to be 1.60 and high DS develop hydrophobicity are insoluble acetone and chloroform. In the micromeritic evaluation, the angle of repose and compressibility index values revealed the excellent flow characteristic of starch acetate prepared. All the physical properties studied indicated that starch acetate is a promising pharmaceutical excipient in tablets. Aceclofenac, a widely prescribed anti inflammatory analgesic drug belongs to BCS class II and exhibit variable oral bioavailability due to its poor solubility and dissolution rate. Matrix tablets of Aceclofenac (100 mg) prepared employing starch acetate as matrix former in different proportions gave slow and controlled release more than 12 hr. Aceclofenac release was diffusion controlled and dependent on percentage of starch acetate. As the polymer concentration was increased, release rate was decreased. Good linear relationship was observed between percent polymer and release rate (K0). Thus drug release from the matrix tablets could be controlled by varying the proportion of drug: polymer in the matrix. © RJPT All rights reserved.


Arifa Begum S.K.,Vijaya Institute of Pharmaceutical science for Women | Arifa Begum S.K.,Jawaharlal Nehru University
Der Pharmacia Lettre | Year: 2016

Cimetidine loaded microspheres were prepared by Ionotropic gelation technique with different drug to carrier ratio. All the microspheres were characterized for particle size, scanning electron microscopy, FT-IR study, DSC, percentage yield, drug entrapment, stability studies and for in vitro release kinetics and found to be within the limits. Among all the formulations C10, was selected as optimized formulation based on the physic chemical and release studies. In the in vitro release study of formulation C10 showed 95.35%, after 12h in a controlled manner, which is essential for anti ulcer therapy. The innovator Cimetidine conventional tablet shows the drug release of 96.15 within 1 h. The drug release of optimized formulation C10 followed zero order and Higuchi kinetics indicating diffusion controlled drug release.


Arifa Begum S.K.,Vijaya Institute of Pharmaceutical science for Women | Arifa Begum S.K.,Jawaharlal Nehru University
Der Pharmacia Lettre | Year: 2016

Present study aims to prepare and evaluate Roxatidine acetate HCl microspheres by ionotropic gelation method. Among all the formulations R9 was selected as optimized formulations for based on the physico chemical parameters and drug release studies. In the in vitro release study of formulation R9 showed 95.12% after 12 h in a controlled manner, which is essential for disease like peptic ulcer. The in vitro release profiles from optimized formulations were applied on various kinetic models. The best fit with the highest correlation coefficient was observed in Higuchi model, indicating diffusion controlled principle. The innovator Rotane 150mg conventional tablet shows the drug release of 96.45 within 1 h. FT-IR and DSC analyses confirmed the absence of drug-polymer interaction. The results obtained from evaluation and performance study of different types of Roxatidine microspheres that system may be useful to achieve a controlled drug release profile suitable for peroral administration and may help to reduce the dose of drug, dosing frequency and improve patient compliance when compared with marketed product.


Vani M.,Jawaharlal Nehru Technological University Kakinada | Vani M.,Vijaya Institute of Pharmaceutical science for Women | Rani A.P.,Acharya Nagarjuna University
Asian Journal of Pharmaceutics | Year: 2017

Aim: This investigation has been conducted to evaluate the antiasthmatic activity and phytochemical characterization using gas chromatography-mass spectrum (GC-MS) analysis of the leaf extracts of Talinum portulacifolium. Materials and Methods: Hydroalcoholic and acetone extracts of the plant were prepared. Preliminary phytochemical screening has been conducted. Antiasthmatic activity was determined by two experimental models. In vivo methods, histamine and acetylcholine (Ach)-induced bronchospasm in Guinea pigs were studied. Pre convulsion time (PCT) was calculated. In vitro, experimental methods such as histamine and Ach-induced contractions in ileum were also studied. Percentage inhibition of contractions was calculated. Phytochemical characterization was studied using GC-MS analysis. Results and Discussion: In histamine and Ach-induced bronchospasm studies acetone extracts of the plant have significantly increased PCT 10.69 and 10.52 (∗∗P < 0.01), one-way analysis of variance (ANOVA) Tukey's test compared with control. Histamine and Ach-induced ileum contraction studies also showed that the acetone extracts exhibited response 2.6 with 47% and 2.2 with 40% inhibition (∗P < 0.05). The results were expressed by one-way ANOVA, Dunnett's test. The results of GC-MS analysis depicted following phytoconstituents with major peak area, namely, 79.29% methoxy-bis (cyclopentadiene), 2.83% - 5,10-dihexyl-5,10-dihydroindolo[3,2-b]indole-2,7-dicarbaldehyde, and 1.84% - 1,2-bis[3,4-dimethoxy benzyl]-1,2-bis (methoxymethyl) ethane. Conclusion: The results of this study clearly indicate that the hydroalcoholic and acetone extracts of T. portulacifolium can be used as promising antiasthmatic agents. The activity may be due to the presence of phytochemicals reported through GC-MS.


Arifa Begum S.K.,Vijaya Institute of Pharmaceutical science for Women | Arifa Begum S.K.,Jawaharlal Nehru University
International Journal of PharmTech Research | Year: 2016

The present study was aimed to prepare Cimetidine floating microspheres by Ionotropic gelation technique with different drug to carrier ratio. All formulations of Cimetidine were characterized for particle size, scanning electron microscopy, FT-IR study, DSC, percentage yield, drug entrapment, stability studies and found to be within the limits. Among all the formulations, F13 was selected as optimized formulation based on the physicochemical and release studies. In the in vitro release study of formulation F13 showed 96.10% after 12 h in a controlled manner, which is essential for anti ulcer therapy. The innovator Cimetine conventional tablet showed the drug release of 96.15% within 1 h. The drug release of F13 formulation followed zero order and Higuchi kinetics indicating diffusion controlled drug release. © 2016, Sphinx Knowledge House. All rights reserved.


Arifa Begum S.K.,Vijaya Institute of Pharmaceutical science for Women | Arifa Begum S.K.,Jawaharlal Nehru University
International Journal of PharmTech Research | Year: 2016

Present study aims to prepare and evaluate mucoadhesive microspheres of Roxatidine acetate HCl by ionotropic gelation method. Among all the formulations, M13 was selected as optimized formulation for mucoadhesive microspheres based on the evaluation parameters and drug release studies. In vitro release study of formulation M13 showed 99.4% 12 h in a controlled manner, which is essential for disease like peptic ulcer. The release order kinetics for M13 was best fit with the highest correlation coefficient was observed in Higuchi model, indicating diffusion controlled principle. The innovator Rotane 150 mg conventional tablet shows the drug release of 96.45% within 1 h. FT-IR and DSC analyses confirmed the absence of drug-polymer interaction. The results obtained from evaluation studies of Roxatidine mucoadhesive microspheres that system may be useful to achieve a controlled drug release and targeting also achieved by mucoadhesion of the microspheres to the GIT may help to reduce the dose of drug, dosing frequency and improve patient compliance when compared with marketed product. © 2016, Sphinx Knowledge House. All rights reserved.


Sai Krishna P.,Vijaya Institute of Pharmaceutical Science for Women
Journal of Applied Pharmaceutical Science | Year: 2011

In the present study transdermal Lisinopril proniosomal gels was formulated by using Lecithin, Cholesterol as encapsulating agents, Surfactant, Span and permeation enhancers. The study methodology encompasses compatibility studies using FTIR spectra, evaluation of proniosomal gels for pH determination, Viscosity, Vesicle size analysis, rate of spontaneity, encapsulation efficiency, in vitro skin permeation studies and stability studies. The preliminary compatibility studies conducted revealed that there no interaction between Lisinopril and excipients which was as evident from FTIR spectral studies. The physical characterization of proniosomal gels was found to be within the acceptable limits. It was observed that the gel formulations showed good spreadability and viscosity. Determination of vesicle size was found to be 20.10-26.23μm. The proniosomes showed spherical and homogenous structure in optical microscopy. All formulations showed zero order drug release by diffusion mechanism. The stability studies showed that proniosomal gels were stable at 4 to 80C and 25±20C. The above results indicated that the proniosomal gels of could be formulated for controlled release of Lisinopril. The proniosomal gels are suitable for Lisinopril once a day controlled release formulation.


Arifa Begum S.K.,Vijaya Institute of Pharmaceutical science for Women | Arifa Begum S.K.,Jawaharlal Nehru University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2016

Present study aims to prepare and evaluate Roxatidine acetate HCl mucoadhesive microspheres by ionotropic gelation method. Among all the formulations, M13 was selected as optimized formulation for mucoadhesive microspheres based on the evaluation parameters and drug release studies. In vitro release study of formulation M13 showed 99.4% in 12 h in a controlled manner, which is essential for disease like peptic ulcer. The release order kinetics for M13 was best fit with the highest correlation coefficient was observed in Higuchi model, indicating diffusion controlled principle. The innovator Rotane 150 mg conventional tablet showed the drug release of 96.45% within 1 h. In vivo studies revealed that the optimized formulation M13 gave the highest AUC and Tmax. The controlled release of drug from M13 also provides for higher plasma drug content and improved bioavailability.


Mamillapalli V.,Vijaya Institute of Pharmaceutical science for Women | Atmakuri A.M.,Vijaya Institute of Pharmaceutical science for Women | Khantamneni P.,Vijaya Institute of Pharmaceutical science for Women
Asian Journal of Pharmaceutics | Year: 2016

Herbal medicines have been widely used all over the world since ancient times and have been recognized by physicians and patients for their better therapeutic value as they have fewer adverse effects as compared with modern medicines. Phytotherapeutics need a scientific approach to delivering the components in a sustained manner to increase patient compliance and avoid repeated administration. This can be achieved by designing novel drug delivery systems (NDDSs) for herbal constituents. NDDSs not only reduce the repeated administration to overcome non-compliance but also help to increase the therapeutic value by reducing toxicity and increasing the bioavailability. One such novel approach is nanotechnology. Nano-sized drug delivery systems of herbal drugs have a potential future for enhancing the activity and overcoming problems associated with plant medicines. Hence, integration of the nanocarriers as an NDDS in the traditional medicine system is essential to conflict more chronic diseases such as asthma, diabetes, cancer, and others. The article describes nano drug delivery systems, properties, advantages, disadvantages, types of nanoparticles, their method of preparation, different nano herbal medicines, and nano herbal cosmetics available in the market.


Vani M.,Vijaya Institute of Pharmaceutical science for Women | Latha K.P.,Vijaya Institute of Pharmaceutical science for Women | Nagini B.,Vijaya Institute of Pharmaceutical science for Women | Mounika S.N.,Vijaya Institute of Pharmaceutical science for Women | And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2016

The aim of the study was to carry out the pharmacognostical, quantitative phytochemical determination of flavonoids, phenolics, tannins, saponins and in vitro antioxidant studies by reducing power assay, scavenging of hydrogen peroxide radical assay and nitric oxide radical scavenging assay on the root extracts of Typha angustata. Quantitative microscopy, fluorescence analysis, physico chemical analysis has been carried out to produce quality control parameters for the Typha angustata roots and extracts. Quantitative determinations indicated the high amount of phenolics 107.94 ±0.70 mg/g and saponins 108.5 mg/g ±0.7 mg/g in the aqueous extract of roots of Typha angustata. The in vitro anti oxidant activity was studied at 30-180μg/ml by using quercetin as standard. The studies showed that significant activity was present in both aqueous and alcoholic extracts when compared with standard drug. Therefore the investigation on the root extracts of Typha angustata can be further explored inorder to study out more therapeutic benefits.

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