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Venkateswara Rao S.,Vijaya Institute of Pharmaceutical science for Women | Vege S.R.,Vijaya Institute of Pharmaceutical science for Women | Padmalatha K.,Vijaya Institute of Pharmaceutical science for Women
Research Journal of Pharmacy and Technology | Year: 2017

The objective of the present study is to develop Aceclofenac control release matrix tablet formulations by wet granulation method employing starch citrate, a new modified starch. Starch acetate prepared by reacting potato starch with acetic anhydride in the presence of sodium hydroxide at elevated temperatures was insoluble in water and has poor swelling and gelling property when heated in water. The degree of substitution (DS) of starch acetate was found to be 1.60 and high DS develop hydrophobicity are insoluble acetone and chloroform. In the micromeritic evaluation, the angle of repose and compressibility index values revealed the excellent flow characteristic of starch acetate prepared. All the physical properties studied indicated that starch acetate is a promising pharmaceutical excipient in tablets. Aceclofenac, a widely prescribed anti inflammatory analgesic drug belongs to BCS class II and exhibit variable oral bioavailability due to its poor solubility and dissolution rate. Matrix tablets of Aceclofenac (100 mg) prepared employing starch acetate as matrix former in different proportions gave slow and controlled release more than 12 hr. Aceclofenac release was diffusion controlled and dependent on percentage of starch acetate. As the polymer concentration was increased, release rate was decreased. Good linear relationship was observed between percent polymer and release rate (K0). Thus drug release from the matrix tablets could be controlled by varying the proportion of drug: polymer in the matrix. © RJPT All rights reserved.

Sai Krishna P.,Vijaya Institute of Pharmaceutical Science for Women
Journal of Applied Pharmaceutical Science | Year: 2011

In the present study transdermal Lisinopril proniosomal gels was formulated by using Lecithin, Cholesterol as encapsulating agents, Surfactant, Span and permeation enhancers. The study methodology encompasses compatibility studies using FTIR spectra, evaluation of proniosomal gels for pH determination, Viscosity, Vesicle size analysis, rate of spontaneity, encapsulation efficiency, in vitro skin permeation studies and stability studies. The preliminary compatibility studies conducted revealed that there no interaction between Lisinopril and excipients which was as evident from FTIR spectral studies. The physical characterization of proniosomal gels was found to be within the acceptable limits. It was observed that the gel formulations showed good spreadability and viscosity. Determination of vesicle size was found to be 20.10-26.23μm. The proniosomes showed spherical and homogenous structure in optical microscopy. All formulations showed zero order drug release by diffusion mechanism. The stability studies showed that proniosomal gels were stable at 4 to 80C and 25±20C. The above results indicated that the proniosomal gels of could be formulated for controlled release of Lisinopril. The proniosomal gels are suitable for Lisinopril once a day controlled release formulation.

Arifa Begum S.K.,Vijaya Institute of Pharmaceutical science for Women | Arifa Begum S.K.,Jawaharlal Nehru University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2016

Present study aims to prepare and evaluate Roxatidine acetate HCl mucoadhesive microspheres by ionotropic gelation method. Among all the formulations, M13 was selected as optimized formulation for mucoadhesive microspheres based on the evaluation parameters and drug release studies. In vitro release study of formulation M13 showed 99.4% in 12 h in a controlled manner, which is essential for disease like peptic ulcer. The release order kinetics for M13 was best fit with the highest correlation coefficient was observed in Higuchi model, indicating diffusion controlled principle. The innovator Rotane 150 mg conventional tablet showed the drug release of 96.45% within 1 h. In vivo studies revealed that the optimized formulation M13 gave the highest AUC and Tmax. The controlled release of drug from M13 also provides for higher plasma drug content and improved bioavailability.

Vani M.,Vijaya Institute of Pharmaceutical science for Women | Latha K.P.,Vijaya Institute of Pharmaceutical science for Women | Nagini B.,Vijaya Institute of Pharmaceutical science for Women | Mounika S.N.,Vijaya Institute of Pharmaceutical science for Women | And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2016

The aim of the study was to carry out the pharmacognostical, quantitative phytochemical determination of flavonoids, phenolics, tannins, saponins and in vitro antioxidant studies by reducing power assay, scavenging of hydrogen peroxide radical assay and nitric oxide radical scavenging assay on the root extracts of Typha angustata. Quantitative microscopy, fluorescence analysis, physico chemical analysis has been carried out to produce quality control parameters for the Typha angustata roots and extracts. Quantitative determinations indicated the high amount of phenolics 107.94 ±0.70 mg/g and saponins 108.5 mg/g ±0.7 mg/g in the aqueous extract of roots of Typha angustata. The in vitro anti oxidant activity was studied at 30-180μg/ml by using quercetin as standard. The studies showed that significant activity was present in both aqueous and alcoholic extracts when compared with standard drug. Therefore the investigation on the root extracts of Typha angustata can be further explored inorder to study out more therapeutic benefits.

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