Vignan University

Guntūr, India

Vignan University

Guntūr, India
SEARCH FILTERS
Time filter
Source Type

Sudhir M.S.,Sri Subbaraya and Narayana College | Venkata Nadh R.,Vignan University
Drug Invention Today | Year: 2013

Objectives: To develop a reverse phase high performance liquid chromatographic method for validation and quantitative estimation of the synthesized drug rasagiline hemitartrate in bulk form. Methods: Rasagiline hemitartrate was synthesized and characterized by spectral (Infrared, Proton Nuclear Magnetic Resonance and Mass) as well as elemental analysis. Chromatographic separation was conducted on Agilent TC-C18 (250×4.6mm, 5μm) column at ambient temperature using mixture of 20mM potassium dihydrogen orthophosphate buffer (pH 7.0): methanol and acetonitrile in the ratio (30:30:40v/v) as a mobile phase and at a flow rate of 1.0mL/min, while UV detection was performed at 285nm. In addition to LOD and LOQ, other analytical parameters viz., linearity, precision, accuracy, ruggedness and robustness were detected by following the ICH (International Conference on Harmonization) guidelines. Results: The retention time for rasagiline hemitartrate was found to be 4.30±0.05min. The method was found to be linear in the range of 10-50μg/mL. The limit of detection and quantization for rasagiline hemitartrate are found to be 0.651 and 1.972μg/mL respectively. Analytical recovery was 100.47%. The percentage RSD for precision and accuracy of the method was found to be less than 2%. Correlation coefficient was found to be 0.9952. Conclusion: In this study, simple, sensitive, accurate and reliable RP-HPLC method was developed and validated as per the ICH guidelines for the determination of the synthesized drug rasagiline hemitartrate in bulk form. © 2013.


Babu V.,Vignan University | Krishna R.,Vignan University | Mani N.,UOH
Materials Today: Proceedings | Year: 2017

The scope of the paper is to review different works on fuel adulteration process detection using computational techniques. Gasoline (Motor Spirit/MS) and Diesel (High Speed Diesel/HSD) are major fuels used for transport/Electricity generation universally. Consumers are facing the threat of fuel adulteration. Adulterants are added to these fuels with other cheaper boiling point range hydrocarbons having more or less similar composition leading to alter and degrade the quality of the base fuels. These adulterants are added by the business community for their monetary gains. Detecting such adulterant in fuels is a foremost task in the interest of the end consumer. © 2017 Elsevier Ltd.


Sudhir M.S.,Sri Subbaraya and Narayana College | Venkata Nadh R.,Vignan University
Journal of Pharmacy Research | Year: 2013

Objectives: To determine anthelmintic activity of the synthesized novel 1,2,3 e benzotriazole derivatives under ultrasonication in solvent free conditions. Methods: Newer "1e(1Hebenzo[d][1,2,3]triazole-1-carbonyl) derivatives" (5A-5P) were synthesized by using "1Hebenzo[d][1,2,3]triazole" (1)as the starting material under ultrasonicated and solvent-free conditions. The resulting products were isolated and characterized by melting points and spectral studies. All the products were assayed for anthelmintic activity against Pheretima posthuma using albendazole and mebendazole as reference compounds. Results: All the newer 1,2,3 e benzotriazole derivatives synthesized by ultrasound activation in solventefree condition were obtained in moderate to good yields in the range of 71-82%. The data interpretation of the spectral values with reference to standard values confirmed the structures of the synthesized compounds. Out of the sixteen synthesized derivatives, four compounds (5B, 5F, 5J and 5N) showed anthelmintic activity in dose-dependent manner giving shortest time of paralysis and death with different concentrations of the derivatives. Among these four derivatives, 5J showed superior activity. Conclusion: Out of the sixteen synthesized derivatives, four compounds (5B, 5F, 5J and 5N) containing p-nitrophenyl substituent attached to azo group of benzotriazole moieties exhibited equal or comparable anthelmintic activity with reference to albendazole. The superior activity of compound 5J might be due to attachment of additional p-nitrophenyl substituent to the cyano group. © 2013, JPR Solutions.


Hari Prasad K.,Pondicherry University | Naresh N.,Pondicherry University | Nageswara Rao B.,Vignan University | Venkateswarlu M.,Amara Raja Batteries Ltd | Satyanarayana N.,Pondicherry University
Materials Today: Proceedings | Year: 2016

Spinel LiMn2O4nanorods were prepared by rapid two steps synthesis process, which involves a novel microwave hydrothermal synthesis and followed by a solid-state reaction. LiMn2O4nanoparticles were prepared by pechini process. X-ray diffraction (XRD) studies of the prepared samples confirmed the formation of crystalline pure spinel phase of LiMn2O4nanoparticles and nanorods. Fourier transform infrared (FTIR) studies of the prepared samples confirmed the formation of the LiMn2O4structured nanoparticles and nanorods. Scanning electron microscopy (SEM) micrographs of the prepared samples showed the formation of the LiMn2O4nanorods and nanoparticles. Electrical conductivities studies of LiMn2O4nanorods and nanoparticles were studied through impedance spectroscopy measurements. © 2016 Elsevier Ltd. All rights reserved.


Muvvala S.S.,Sri Subbaraya and Narayana College | Ratnakaram V.N.,Vignan University | Nadendla R.R.,Chalapathi Institute of Pharmaceutical science
International Journal of PharmTech Research | Year: 2012

An accurate, sensitive, precise and robust reverse phase high performance liquid chromatographic (RP-HPLC) method for the estimation of Febuxostat in bulk forms has been developed and validated. Chromatographic separation is conducted on Nucleosil C18 (250 x 4.6mm, 5μm) column at ambient temperature using mixture of 10 mM ammonium acetate buffer (buffer of pH 4.0 adjusted with 0.2% triethyl amine) and acetonitrile in the ratio (15: 85, v/v) as a mobile phase and at a flow rate of 1.2 ml / min, while UV detection is performed at 275nm. The retention time for Febuxostat is found to be 3.45 ± 0.05 min. The method is found to be linear in the range of 50.0 - 400.0 μg/mL. The limit of detection and quantization for Febuxostat are found to be 9.98 and 30.23 μg /mL respectively. Analytical recovery is 99.29 %. The percentage RSD for precision and accuracy of the method is found to be less than 2%. The method is validated as per the ICH guidelines and applied for the quantitative analysis of Febuxostat in bulk forms.


Venkata Rao K.,Vignan University | Murthy B.S.N.,Gandhi Institute of Technology and Management | Mohan Rao N.,JNTUK
Measurement: Journal of the International Measurement Confederation | Year: 2013

The vibration is one of the intensive problems in boring process. Machining and tool wear are affected more by vibration of tool due to length of boring bar. The present work is to estimate the effect of cutting parameters on work piece vibration, roughness on machined surface and volume of metal removed in boring of steel (AISI1040). A laser Doppler vibrometer (LDV) was used for online data acquisition and a high-speed FFT analyzer used to process the AOE signals for work piece vibration. A design of experiments was prepared with eight experiments with two levels of cutting parameters such as spindle rotational speed, feed rate and tool nose radius. Taguchi method has been used to optimize the cutting parameters and a multiple regression analysis is done to obtain the empirical relation of Tool life with roughness of machined surface, volume of metal removed and amplitude of work piece vibrations. © 2013 Elsevier Ltd. All rights reserved.


Venkata Rao K.,Vignan University | Murthy B.S.N.,Gandhi Institute of Technology and Management | Mohan Rao N.,JNTUK
Measurement: Journal of the International Measurement Confederation | Year: 2014

Machining of stainless steel is difficult due to their hardening tendency. In boring of stainless steels, tool wear and surface roughness are affected by vibration of boring bar. In this paper, tool wear, surface roughness and vibration of work piece were studied in boring of AISI 316 steel with cemented carbide tool inserts. A Laser Doppler Vibrometer was used for online data acquisition of work piece vibration and a high-speed Fast Fourier Transform analyzer was used to process the acousto optic emission signals for the work piece vibration. Experimental data was collected and imported to artificial neural network techniques. A multilayer perceptron model was used with back-propagation algorithm using the input parameters of nose radius, cutting speed, feed and volume of material removed. The artificial neural network was used to predict surface roughness, tool wear and amplitude of work piece vibration. The predicted values were compared with the collected experimental data and percentage error was computed. © 2014 Elsevier Ltd. All rights reserved.


Gnaneswara Rao N.,Vignan University | Vijaya Kumar V.,Anurag Group of Institutions
International Journal of Multimedia and Ubiquitous Engineering | Year: 2014

Content Based Image Retrieval (CBIR) has been the most significant area in the applications of Pattern recognition and Computer Vision for the last three decades. However, there are many open problems left unresolved. Among these, one of the current problems of CBIR is to obtain an effective Similarity Measure. The CBIR systems make use of Integrated Region Matching (IRM) to match segmented images which is computationally economic, but it is not a metric distance whereas systems that use Minimum Cost Region Matching (MiCRoM) as a similarity measure is a metric distance, but computationally expensive. In order to address the above problem, this paper has developed the Optimal Cost Region Matching (OCRM) similarity measure for region based image retrieval. The proposed OCRM uses the north-west corner rule of the Transportation problem that fulfills the monge property. The experiment carried out on 1000 color images taken from the Corel database that are compared with IRM, and MiCRoM similarity measures. © 2014 SERSC.


Tirumalasetty V.R.,Vignan University | Avireni S.,Vignan University
Radioengineering | Year: 2012

Full adder is an essential component for the design and development of all types of processors like digital signal processors (DSP), microprocessors etc. In most of these systems adder lies in the critical path that affects the overall speed of the system. So enhancing the performance of the 1-bit full adder cell is a significant goal. In this paper, we proposed two modified level restorers using current sink and current source inverter structures for branch-based logic and pass-transistor (BBL-PT) full adder [1]. In BBL-PT full adder, there lies a drawback i.e. voltage step existence that could be eliminated in the proposed logics by using the current sink inverter and current source inverter structures. The proposed full adders are compared with the two standard and well-known logic styles, i.e. conventional static CMOS logic and Complementary Pass transistor Logic (CPL), demonstrated the good delay performance. The implementation of 8-bit ripple carry adder based on proposed full adders are finally demonstrated. The CPL 8-bit RCA and as well as the proposed ones is having better delay performance than the static CMOS and BBL-PT 8-bit RCA. The performance of the proposed BBL-PT cell with current sink & current source inverter structures are examined using PSPICE and the model parameters of a 0.13 μm CMOS process.


Bangaraiah P.,Vignan University | Ashok Kumar P.,Vignan University
International Journal of Pharma and Bio Sciences | Year: 2013

This investigation handles the adsorption of methylene blue dye from aqueous solution using "Grewia orbiculata Rottl." Leaves. Effects of different parameters such as agitation time, adsorbent size, adsorbent dosage, initial concentration of methylene blue in aqueous solution, volume, pH of aqueous solution on removal of methylene blue are determined. From these investigations, one gram of "Grewia orbiculata "Leaf powder of 82.5μm size is found to remove 90% of 20 mg/l methylene blue from 30ml of aqueous solution in 30min. These results indicate that adsorption of methylene blue is increased with an increase in adsorbent dosage and decrease in adsorbent size. A significant increase in percentage removal of methylene blue is observed as pH value increased from 4 to 7.28 and percentage removal is marginally increased from 1 to 4. The percentage removal decreased as pH value increased beyond 7.28. Freundlich and Langmuir isotherm models describe the adsorption data very well indicating favorable adsorption of methylene blue adsorbent. Freundlich isotherm is relatively more suitable than Langmuir isotherm. Hence based on results obtained it is found that Grewia orbiculata Leaf powder is effective in methylene blue removal and can be appreciably considered as most versatile, economical and feasible adsorbent for removal of methylene blue from aqueous solutions.

Loading Vignan University collaborators
Loading Vignan University collaborators