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Guntūr, India

Devadasu C.H.,Vignan Pharmacy College
Journal of Chemical and Pharmaceutical Sciences | Year: 2014

Hypertension is one of the major causes of cardio vascular system (CVS) disease, kidney failure and mortality in all over the world. It is said that in our country there are 200 million patients have been suffering from hypertension but only half of them were aware of their illness and out of them only 30% are taking medications under constant medical care. This is one of the deadliest non communicable diseases in the world leading to around 9.4 million deaths occurred in every year. The estimated market share of anti-hypertensive agents is $30 billion by 2016. Hypertension affects approximately 50 million individuals in the US and approximately 1 billion worldwide. There are significant health and economic gains achieved owing to early detection, adequate treatment and good control of hypertension. Hypertension prevails where ever weak health conditions exist all over the world irrespective of either advanced or low per capita income countries. It is alarming to know one in three American adults chronically suffering from high blood pressure. Many people don't aware that they have B.P till they badly affected because negligence of high blood pressure as no symptoms or warning signs appears and then only they abruptly rushed for the medical aid. Elevated chronic blood pressure enhanced cholesterol and blood sugar levels abnormally which causes serious damage to the arteries, kidneys, and heart. Fortunately, high blood pressure is easy to detect and treat due to invention of advanced medical instruments and techniques and introduction of new pharmaceutical drugs. People can keep blood pressure in a healthy range of normal conditions simply by altering lifestyle changes by reducing overweight, by regulating food habits with natural foods and regular practice of exercises and yoga. This report includes tips on how to use a home blood pressure monitor, as well as advice on choosing an appropriate drug treatment strategy based on the age and severity of B.P keeping in view any other medical problems existing in the body. © 2014, SPB Pharma Society. All rights reserved. Source

Madhusudhan Reddy A.,Acharya Nagarjuna University | Srinivasa Babu P.,Vignan Pharmacy College
Research Journal of Pharmacy and Technology | Year: 2016

Agents that are capable of killing pathogenic microorganisms are known as Antimicrobial Substances. Due to their potential to provide quality and safety benefits to many materials antimicrobials gain interest from both industry and academic research. Antimicrobial functional groups can be introduced into polymer molecules to overcome problems associated with the low molecular weight antimicrobial agents. For enhancing the efficacy of some existing antimicrobial agents, selectivity, increasing their efficiency and prolonging the lifetime of the antimicrobial agents the use of antimicrobial polymers can be employed. The development of antimicrobial polymers research represents a great a challenge for both the academic world and industry. The polymer research that presents great modern interest, yet has received lacking consideration, is that of the development of polymers with antimicrobial activities, commonly known as polymeric biocides. Biocides immobilized on dendrimers can be more effective if the target sites are cell walls or membranes. It has been shown that small quaternary ammonium compounds exert their antimicrobial action by disintegrating and disrupting the cell membrane, converting functional end groups of dendrimer to ammonium salts, dendrimer biocides can be synthesized. These dendrimer biocides have been shown to be more potent than their small molecule counterparts as they bear high local density active groups. Thus, dendrimer biocides may be very beneficial in terms of activity, reduced toxicity, localization in specific organs and increased duration of action. This review will find complete solution for an antimicrobial agent facing problems and advantages of the dendrimeric biocides. © RJPT All right reserved. Source

Ravisankar P.,Vignan Pharmacy College | Ravisankar P.,Sri Chandrasekharendra Saraswathi Viswa Mahavidyalaya
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

A reverse phase isocratic HPLC was developed and validated for the determination of levamisole in bulk and tablet dosage forms. Method development was carried out on Welchrom C18 isocratic column, (250 mm × 4.6 mm i.d., particle size 5 μm, maintained at ambient temperature), Shimadzu LC-20AT Prominence Liquid Chromatograph. The mobile phase was a mixture of Methanol: Acetonitrile: Water 50:30:20 v/v, with apparent pH of 4.6 and the flow rate was set at 1.0 ml/min and UV detection at 225 nm. Validation parameters were evaluated for the method according to the ICH (Q2R1) guidelines. In the linearity study, linearity was observed from 2-10 μg/ml with correlation coefficient of 0.9999 and regression coefficient of 0.9998. The limit of detection and limit of quantitation for the method were 0.1219 μg/ml and 0.3695 μg/ml, respectively. The statistical analysis shows that the method was found to be accurate, reliable, simple and reproducible. The intra- and inter-assay precisions were satisfactory; the values of relative standard deviations did not exceed 2%. The accuracy of the method was proved; the mean recovery of levamisole was 99.36% to 100.56%. The chromatographic retention time of proposed method was 2.790 min and the mean assay of content was found to be 102.135 ± 0.933%. The proposed method was successfully applied for the quantitative determination of levamisole in bulk form and could be used for routine analysis with phenomenal accuracy and precisions. Source

Nadella T.R.,Alkem Research Center | Suryadevara V.,Chebrolu Hanumaiah Institute of Pharmaceutical science | Lankapalli S.R.,Chebrolu Hanumaiah Institute of Pharmaceutical science | Mandava V.B.R.,Krishna University | Bandarupalli D.,Vignan Pharmacy College
Journal of Pharmaceutical and Biomedical Analysis | Year: 2016

A simple, rapid, specific and precise liquid chromatography-tandem mass spectrophotometric (LC-MS/MS) method was developed and validated for quantification of busulfan, in human plasma. busulfan d8 was used as internal standard, added to plasma sample prior to extraction using acetonitrile as a precipitating agent. Chromatographic separation was achieved on phenomenex kinetex C18 column (50mm×2.1mm, 2.6μm) with acteonitrile: 10 mM ammonium formate buffer (80:20v/v) as an isocratic mobile phase with a flow rate of 0.5mLmin-1. Quantitation was performed by transition of 264.1→151.1 (m/z) for busulfan and 272.1→159.1 (m/z) for busulfan d8. The lower limit of quantitation was 0.2 ng mL-1 with a 100μL plasma sample. The concentrations of nine working standards showed linearity between 0.2 and 100 ng mL-1 (r2≥0.9986). Chromatographic separation was achieved within 2.0min. The average extraction recoveries of 3quality control concentrations were 92.52% for busulfan and 90.75% for busulfan d8. The coefficient of variation was ≤15% for intra- and inter-batch assays. The developed method was successfully applied for the determination of Busulfan pharmacokinetics after oral administration. © 2015 Elsevier B.V. Source

Ravisankar P.,Vignan Pharmacy College | Ravisankar P.,Sri Chandrasekharendra Saraswathi Viswa Mahavidyalaya
International Journal of Pharma and Bio Sciences | Year: 2013

This study was designed to develop and validate a simple, sensitive, precise, economical, reproducible and accurate isocratic reversed phase high performance liquid chromatographic method for separation and analysis of 6 fluoroquinolones in bulk and their pharmaceutical dosage forms. The effects of mobile phase composition, buffers, pH, and acetonitrile concentrations were investigated on the separation of third generation fluoroquinolones (levofloxacin, sparfloxacin, balofloxacin) and fourth generation fluoroquinolones (gatifloxacin, moxifloxacin, prulifloxacin) were assayed without any interference. RPHPLC method was developed by using Welchrom C18 Column (4.6 × 250mm, 5μm), Shimadzu LC-20AT prominence liquid chromatograph. The mobile phase consisting of phosphate buffer pH-3.1 and acetonitrile in the portion of 70:30 v/v. Isocratic elution at a flow rate of 1ml/min was employed. The responses were measured at 293 nm using Shimadzu SPD-20A prominence UV-Vis detector. The method was successfully applied to Moxifloxacin pharmaceutical dosage form. During method validation parameters such as linearity, precision, specificity, robustness, ruggedness were evaluated from spiked tablet samples according to ICH guidelines, which remained within acceptable limits. The proposed method can also be extended for the determination of other five fluoroquinolones or their combinations. This method provides a fast simple method with good retention, excellent peak shape and high resolution. Source

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