Vignan Pharmacy College

Guntūr, India

Vignan Pharmacy College

Guntūr, India
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Puttagunta S.B.,Vignan Pharmacy College | Pulipati S.,Vignan Pharmacy College
Pharma Times | Year: 2017

Pharmacy students should be given opportunity to learn and practice interpersonal communication skills. Pharmacists are the medication experts and are the healthcare professionals the public can have easy and direct access to resolve their concerns. Clinical pharmacists work directly with doctors, health professionals and patients to ensure that the medications prescribed for patients contribute to the best possible health outcomes. This study reviews the role of the preceptor in facilitating development of communication skills for pharmacy students participating in community, hospital, industry and academia etc. Preceptors need to set a stage to incorporate precepting into the workflow and to provide efficient and effective teaching opportunities. Students should undergo practical activities like patient counseling, interviewing, attending educational sessions and participating in collaborative work with health care professionals. Preceptors should incorporate the teaching in a lively and demonstrative way for a better impact on their students. The incorporation of communication skills to pharmacy practice can positively impact the pharmacy site, preceptor, student and more importantly patient. By following a strategic approach in the methods of teaching the preceptors can effectively and likely enhance the communication skills of the students. © 2017, Indian Pharmaceutical Association. All rights reserved.

Srinivasa Babu P.,Vignan Pharmacy College | Koushik O.S.,Vignan Pharmacy College | Karthikeyan R.,Vignan Pharmacy College
Pharma Times | Year: 2017

In vaccine development, Nanotechnology plays a significant role increasingly. The formulations that boost antigen effectiveness are increasingly needed, whereas vaccine development orientates toward less immunogenic minimalist compositions. In vaccine formulations, the use of nanoparticles permits not only slow release and targeted delivery, but also immunogenicity and improved antigen stability. However, tasks remain due to a lack of fundamental understanding regarding the In vivo behaviour of nanoparticles, which can operate as either a delivery system to enhance antigen processing and enhance immunity. A broad overview of recent advances in prophylactic nanovaccinology is discussed in this review. Types of nanoparticles and their interaction with immune cells and the biological system are discussed. Due to concerns about the weak intrinsic instability in vivo, toxicity, immunogenicity of these vaccines, and the need for multiple administrations, improvements of conventional vaccines advancements are undoubtedly required. To overcome such problems, vaccine development has been incorporated with nanotechnology platforms. The study of nanotechnology for epicutaneous delivery of pharmaceuticals and vaccines is escalating. The possibility of targeted therapy, combined with novel pharmacokinetics, nanotechnology-based vaccines mighthave the potential to open therapeutic avenues for treating infectious disease and malignancy than the present vaccines. © 2017, Indian Pharmaceutical Association. All rights reserved.

Vidya Sagar G.,Veerayatan Institute of Pharmacy | Shaik A.B.,Vignan Pharmacy College
Journal of Chemical and Pharmaceutical Research | Year: 2015

Plants from the natural world are linked with the treatment of different human ailments. This is due to the presence of different classes of chemical constituents. Flavonoids are one such class of natural constituents responsible for the activity of plants. Chalcones are a class of natural open chain flavonoids that are linked by a three carbon spacer between two aromatic rings. Chalcones and their heterocyclic analogues enjoy a range of biological activities such as antimicrobial, antioxidant, cytotoxic, anticancer, antiprotozoal, antihistaminic, antiulcer and antiinflammatory activities which makes these compounds as a special attraction for investigation. Additionally the bielectrophilic, ketovinyl chain between the two rings is highly reactive and acts as an important chemical synthon for constructing different five, six and seven membered heterocyclic scaffolds containing different hetero atoms like nitrogen, oxygen and sulfur atoms by abridgment with a variety of binucleophilic reagents. This review highlights on the chemical and biological potentials of chalcones. © 2015, Journal of Chemical and Pharmaceutical Research. All rights reserved.

Ramadoss K.,Vignan Pharmacy College | Oruganti S.K.,Vignan Pharmacy College
Eurasian Journal of Analytical Chemistry | Year: 2016

Nordihydroguaiaretic acid (NDGA) is a lignan found in large amounts in the ethnobotanically important plant, Larrea tridentata (Moc. & Sess.) Cov. (Zygophyllaceae). So far NDGA was not isolated and estimated in larrea tridentata (moc. & sess.) cov. In this study isolation of Nordihydroguaiaretic acid was achieved by preparative TLC and the compound thus isolated was characterised by Ultraviolet and Mass spectral analysis. Mass spectral data shows molecular ion peak of m/z=302.2. An isocratic RP-HPLC method was developed for the estimation of Nordihydroguaiaretic acid in marketed formulation. Retention time of Nordihydroguaiaretic acid was found as 4.173 min. This method has obeyed linearity over the concentration range of 10-50μg/ml and the regression coefficient obtained from linearity plot for Nordihydroguaiaretic acid was found as 0.999. RP-HPLC method was validated in pursuance of International conference on Harmonization (ICH) guidelines. This method is simple and economic one and it could be used for the estimatimation and routine analysis of the NDGA in any crude drug extract and in any formulation. © 2016 by authors.

Ravisankar P.,Vignan Pharmacy College | Ravisankar P.,Sri Chandrasekharendra Saraswathi Viswa Mahavidyalaya
International Journal of Pharma and Bio Sciences | Year: 2013

This study was designed to develop and validate a simple, sensitive, precise, economical, reproducible and accurate isocratic reversed phase high performance liquid chromatographic method for separation and analysis of 6 fluoroquinolones in bulk and their pharmaceutical dosage forms. The effects of mobile phase composition, buffers, pH, and acetonitrile concentrations were investigated on the separation of third generation fluoroquinolones (levofloxacin, sparfloxacin, balofloxacin) and fourth generation fluoroquinolones (gatifloxacin, moxifloxacin, prulifloxacin) were assayed without any interference. RPHPLC method was developed by using Welchrom C18 Column (4.6 × 250mm, 5μm), Shimadzu LC-20AT prominence liquid chromatograph. The mobile phase consisting of phosphate buffer pH-3.1 and acetonitrile in the portion of 70:30 v/v. Isocratic elution at a flow rate of 1ml/min was employed. The responses were measured at 293 nm using Shimadzu SPD-20A prominence UV-Vis detector. The method was successfully applied to Moxifloxacin pharmaceutical dosage form. During method validation parameters such as linearity, precision, specificity, robustness, ruggedness were evaluated from spiked tablet samples according to ICH guidelines, which remained within acceptable limits. The proposed method can also be extended for the determination of other five fluoroquinolones or their combinations. This method provides a fast simple method with good retention, excellent peak shape and high resolution.

Ravisankar P.,Vignan Pharmacy College | Ravisankar P.,Sri Chandrasekharendra Saraswathi Viswa Mahavidyalaya
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

A reverse phase isocratic HPLC was developed and validated for the determination of levamisole in bulk and tablet dosage forms. Method development was carried out on Welchrom C18 isocratic column, (250 mm × 4.6 mm i.d., particle size 5 μm, maintained at ambient temperature), Shimadzu LC-20AT Prominence Liquid Chromatograph. The mobile phase was a mixture of Methanol: Acetonitrile: Water 50:30:20 v/v, with apparent pH of 4.6 and the flow rate was set at 1.0 ml/min and UV detection at 225 nm. Validation parameters were evaluated for the method according to the ICH (Q2R1) guidelines. In the linearity study, linearity was observed from 2-10 μg/ml with correlation coefficient of 0.9999 and regression coefficient of 0.9998. The limit of detection and limit of quantitation for the method were 0.1219 μg/ml and 0.3695 μg/ml, respectively. The statistical analysis shows that the method was found to be accurate, reliable, simple and reproducible. The intra- and inter-assay precisions were satisfactory; the values of relative standard deviations did not exceed 2%. The accuracy of the method was proved; the mean recovery of levamisole was 99.36% to 100.56%. The chromatographic retention time of proposed method was 2.790 min and the mean assay of content was found to be 102.135 ± 0.933%. The proposed method was successfully applied for the quantitative determination of levamisole in bulk form and could be used for routine analysis with phenomenal accuracy and precisions.

Pulipati S.,Vignan Pharmacy College | Babu P.S.,Vignan Pharmacy College | Narasu M.L.,Vignan Pharmacy College
International Journal of Phytomedicine | Year: 2014

Medicinal plants are important in the traditional medicine and as well as modern pharmaceutical drugs. In traditional system of medicine various plant parts like leaves, flowers, stems, fruits, seeds, barks and even whole plants are used for the treatment. Traditionally the leaves, seeds, roots and entire plant of Amaranthus viridis Linn is used in the treatment of many diseases. Its uses include diuretic, analgesic, antipyretic, vermifuge, antiulcer antidiabetic, anti-cholesterolemic, laxative, asthma and veneral diseases. This review encompasses the available literature on Amaranthus virddis with respect to its pharmacognostic characters, physicochemical parameters, synopsis of pharmacological activities and traditional uses. This attempt provides a direction towards further research. © 2014, Advanced Research Journals. All rights reserved.

Madhusudhan Reddy A.,Acharya Nagarjuna University | Srinivasa Babu P.,Vignan Pharmacy College
Research Journal of Pharmacy and Technology | Year: 2016

Agents that are capable of killing pathogenic microorganisms are known as Antimicrobial Substances. Due to their potential to provide quality and safety benefits to many materials antimicrobials gain interest from both industry and academic research. Antimicrobial functional groups can be introduced into polymer molecules to overcome problems associated with the low molecular weight antimicrobial agents. For enhancing the efficacy of some existing antimicrobial agents, selectivity, increasing their efficiency and prolonging the lifetime of the antimicrobial agents the use of antimicrobial polymers can be employed. The development of antimicrobial polymers research represents a great a challenge for both the academic world and industry. The polymer research that presents great modern interest, yet has received lacking consideration, is that of the development of polymers with antimicrobial activities, commonly known as polymeric biocides. Biocides immobilized on dendrimers can be more effective if the target sites are cell walls or membranes. It has been shown that small quaternary ammonium compounds exert their antimicrobial action by disintegrating and disrupting the cell membrane, converting functional end groups of dendrimer to ammonium salts, dendrimer biocides can be synthesized. These dendrimer biocides have been shown to be more potent than their small molecule counterparts as they bear high local density active groups. Thus, dendrimer biocides may be very beneficial in terms of activity, reduced toxicity, localization in specific organs and increased duration of action. This review will find complete solution for an antimicrobial agent facing problems and advantages of the dendrimeric biocides. © RJPT All right reserved.

Karthikeyan R.,Vignan Pharmacy College | Devadasu C.,Vignan Pharmacy College | Srinivasa Babu P.,Vignan Pharmacy College
International Journal of Analytical Chemistry | Year: 2015

P-coumaric acid is a nonflavonoid phenolic acid and is a major constituent of the species Cynodon dactylon Linn. (Pers.). In this study isolation of P-coumaric acid was achieved by preparative TLC and the compound thus isolated was characterised by UV, mass, and H1 NMR spectral analysis. An isocratic RP-HPLC method was developed for the estimation of P-coumaric acid from methanolic extracts of durva grass. The chromatographic separations were achieved by RP-C18 column (250 mm × 4.6 mm, 5), Shimadzu LC-20AT Prominence liquid chromatograph, and a mobile phase composed of water: methanol: glacial acetic acid (65: 34: 1 v/v). The flow rate was 1.0 mL/min and the analyses of column effluents were performed using UV-visible detector at 310 nm. Retention time of P-coumaric acid was found to be 6.617 min. This method has obeyed linearity over the concentration range of 2-10 g/mL and the regression coefficient obtained from linearity plot for P-coumaric acid was found to be 0.999. RP-HPLC method was validated in pursuance of ICH guidelines. © 2015 Ramadoss Karthikeyan et al.

EGFR Kinase domain is a crucial role player cell surface receptor protein activated by specific binding of its ligand like EGFR. Importance of this protein as a therapeutically important drug target towards treating various cancer types has been proven elsewhere in previous literature. In this present study, we have designed a novel series of five compounds and computationally evaluated their potential to act as inhibitors of EGFR kinase domain towards anti-cancer activity. Our docking study shows compounds have the potential to dock into the active site of the EGFR Kinase domain with a binding energy in a range of -5.46 to - 7.32 Kcal/mol, Among all the compounds, compound 2 was found to be the lead like molecule with the binding energy of -7.32 kcal/mol with predicted IC50 value of 4.33 micro molar level. Molecular dynamic simulation studies for this compound 2 in complex with EGFR kinase domain has revealed several interesting molecular interactions with some of the important residues present at the active binding site of EGFR Kinase domain. Conclusively, novel designed compound 2 of the present study have shown promising anti-cancer potential worth considering for further evaluations.

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