Vietnam National Institute of Ophthalmology

Hanoi, Vietnam

Vietnam National Institute of Ophthalmology

Hanoi, Vietnam

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Dunstan S.J.,University of Oxford | Dunstan S.J.,University of Melbourne | Hue N.T.,Vietnam National University, Ho Chi Minh City | Han B.,University of Ulsan | And 44 more authors.
Nature Genetics | Year: 2014

Enteric fever affects more than 25 million people annually and results from systemic infection with Salmonella enterica serovar Typhi or Paratyphi pathovars A, B or C 1. We conducted a genome-wide association study of 432 individuals with blood culture-confirmed enteric fever and 2,011 controls from Vietnam. We observed strong association at rs7765379 (odds ratio (OR) for the minor allele = 0.18, P = 4.5 × 10 â '10), a marker mapping to the HLA class II region, in proximity to HLA-DQB1 and HLA-DRB1. We replicated this association in 595 enteric fever cases and 386 controls from Nepal and also in a second independent collection of 151 cases and 668 controls from Vietnam. Imputation-based fine-mapping across the extended MHC region showed that the classical HLA-DRB1∗04:05 allele (OR = 0.14, P = 2.60 × 10 â '11) could entirely explain the association at rs7765379, thus implicating HLA-DRB1 as a major contributor to resistance against enteric fever, presumably through antigen presentation. © 2014 Nature America, Inc. All rights reserved.


PubMed | Genome Institute of Singapore, University of Michigan, University of Florida, Vision Research Foundation and 41 more.
Type: Journal Article | Journal: Human molecular genetics | Year: 2015

Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P = 2.81 10(-33)), we observed one SNP showing significant association to POAG (CDC7-TGFBR3 rs1192415, ORG-allele = 1.13, Pmeta = 1.60 10(-8)). This particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which are regarded as glaucoma-related quantitative traits. Our study now extends this by directly implicating it in POAG disease pathogenesis.


PubMed | London School of Hygiene and Tropical Medicine, University of Liverpool, Vietnam National University, Ho Chi Minh City, Hospital for Tropical Diseases and 10 more.
Type: Letter | Journal: Nature genetics | Year: 2014

Enteric fever affects more than 25 million people annually and results from systemic infection with Salmonella enterica serovar Typhi or Paratyphi pathovars A, B or C(1). We conducted a genome-wide association study of 432 individuals with blood culture-confirmed enteric fever and 2,011 controls from Vietnam. We observed strong association at rs7765379 (odds ratio (OR) for the minor allele = 0.18, P = 4.5 10(-10)), a marker mapping to the HLA class II region, in proximity to HLA-DQB1 and HLA-DRB1. We replicated this association in 595 enteric fever cases and 386 controls from Nepal and also in a second independent collection of 151 cases and 668 controls from Vietnam. Imputation-based fine-mapping across the extended MHC region showed that the classical HLA-DRB1*04:05 allele (OR = 0.14, P = 2.60 10(-11)) could entirely explain the association at rs7765379, thus implicating HLA-DRB1 as a major contributor to resistance against enteric fever, presumably through antigen presentation.


Yuen L.,Singapore National Eye Center | Do N.H.,Vietnam National Institute of Ophthalmology | Vu Q.L.,Vietnam National Institute of Ophthalmology | Gupta S.,Johns Hopkins University | And 2 more authors.
Clinical and Experimental Ophthalmology | Year: 2011

Background: To evaluate cataract surgical outcomes in four rural districts of Ha Tinh Province, Vietnam. Design: Cross-sectional study. Participants: Post-cataract surgery patients sampled randomly from facilities in four rural districts of Ha Tinh Province >3 months after surgery. Main Outcome Measures: Postoperative visual acuity (VA), visual function and quality of life. Results: Among 412 patients, the mean age was 74.5±9.4 years, 67% (276) were female, and 377 (91.5%) received intraocular lenses (IOL). Nearly two-thirds of patients had no postoperative visits after discharge. Postoperatively, more than 40% of eyes had presenting VA <6/18, while 20% remained <6/60. The mean self-reported visual function and quality of life for all patients were 68.7±23.8 and 73.8±21.6, respectively. Most patients (89.5%) were satisfied with surgery and the majority (94.4%) would recommend surgery to others. One-third of patients paid ≥$US50 for surgery. In multiple regression modelling, older age (P<0.01), intraoperative complications (P<0.01) and failure to receive an IOL (P<0.01) were associated with postoperative VA <6/60. Conclusion: Satisfaction with surgery was high, and many patients were willing to pay for their operations. Poor visual outcomes were common; however, and better surgical training is needed to reduce complications and their impact on visual outcomes. More intensive postoperative follow-up may also be beneficial. © 2011 The Authors. Clinical and Experimental Ophthalmology © 2011 Royal Australian and New Zealand College of Ophthalmologists.


Dong P.N.,Vietnam National Institute of Ophthalmology | Han T.N.,Vietnam National Institute of Ophthalmology | Aldave A.J.,University of California at Los Angeles | Chau H.T.M.,Vietnam National Institute of Ophthalmology
International Journal of Ophthalmology | Year: 2016

Aim: To report the indications for and techniques of corneal transplantation at Vietnam National Institute of Ophthalmology (VNIO) over a period of 12y (2002-2013). Methods: Records of patients who had undergone corneal transplantation at VNIO from January 1, 2002 to January 1, 2014 were reviewed to determine the indication for and type of corneal transplant performed. Patient age, gender, indication for corneal transplantation and surgical technique were recorded and analyzed. Results: Corneal transplantation were underwent in 1390 eyes of 1278 patients with a mean age of 44.9±18.1y during the period under review. The most common indication was infectious corneal ulcer (n=670; 48.2%), followed by corneal scar (n=333, 24.0%), corneal dystrophy (n=138, 9.9%) and failed graft (n=112, 8.1%). Nearly all procedures performed were penetrating keratoplasty (n=1300, 93.5%), with a few lamellar keratoplasty procedures performed: lamellar keratoplasty (n=52, 3.7%), Descemet’s stripping automated endothelial keratoplasty (n=27, 1.9%) and deep anterior lamellar keratoplasty (n=11, 0.8%). Conclusion: While the most common indication for keratoplasty was infectious keratitis, nearly all indications for corneal transplantation were managed with penetrating keratoplasty. However, lamellar keratoplasty techniques, including deep anterior lamellar keratoplasty and Descemet’s stripping automated endothelial keratoplasty, are being performed with increasing frequency for isolated stromal and endothelial disorders, respectively. © 2016, International Journal of Ophthalmology (c/o Editorial Office). All rights reserved.


PubMed | University of California at Los Angeles and Vietnam National Institute of Ophthalmology
Type: Journal Article | Journal: International journal of ophthalmology | Year: 2016

To report the indications for and techniques of corneal transplantation at Vietnam National Institute of Ophthalmology (VNIO) over a period of 12y (2002-2013).Records of patients who had undergone corneal transplantation at VNIO from January 1, 2002 to January 1, 2014 were reviewed to determine the indication for and type of corneal transplant performed. Patient age, gender, indication for corneal transplantation and surgical technique were recorded and analyzed.Corneal transplantation were underwent in 1390 eyes of 1278 patients with a mean age of 44.918.1y during the period under review. The most common indication was infectious corneal ulcer (n=670; 48.2%), followed by corneal scar (n=333, 24.0%), corneal dystrophy (n=138, 9.9%) and failed graft (n=112, 8.1%). Nearly all procedures performed were penetrating keratoplasty (n=1300, 93.5%), with a few lamellar keratoplasty procedures performed: lamellar keratoplasty (n=52, 3.7%), Descemets stripping automated endothelial keratoplasty (n=27, 1.9%) and deep anterior lamellar keratoplasty (n=11, 0.8%).While the most common indication for keratoplasty was infectious keratitis, nearly all indications for corneal transplantation were managed with penetrating keratoplasty. However, lamellar keratoplasty techniques, including deep anterior lamellar keratoplasty and Descemets stripping automated endothelial keratoplasty, are being performed with increasing frequency for isolated stromal and endothelial disorders, respectively.


Nguyen P.H.,University of Sydney | Catt C.,University of Sydney | Nguyen T.X.,Vietnam National Institute of Ophthalmology | Pham V.T.,Hanoi Medical University
Clinical Ophthalmology | Year: 2015

Background: The purpose of this study was to evaluate the refraction of eyes treated with diode laser photocoagulation for prethreshold retinopathy of prematurity (ROP) at a mean of 5 years after treatment. Materials and methods: Fifty infants with prethreshold ROP treated with diode laser at Hanoi Childrens’ Hospital during the period 2008 to 2009 were reviewed. Refractive error was identified by cycloplegic refraction with Cyclogyl 1%. Myopia was divided into two categories based on magnitude: high myopia (more than -5.00 D) and low myopia (between 0 and -5.00 D). Hypermetropia was subdivided into low hypermetropia (between 0 and +5.00 D) and high hypermetropia (greater than +5.00 D). Astigmatism was classified as high if.2.00 D. Eyes with media opacification that interferes with retinoscopy were excluded. The refractive outcome was correlated with birth weight and gestational age. The anatomical and visual out- comes were recorded. Results: One hundred eyes from 50 infants were included in the study. The mean birth weight was 1,426.4 g and the mean gestational age was 29.88 weeks. After 5 years of follow-up, the average spherical equivalent for 100 eyes was -2.87 D. On cycloplegic retinoscopy, high myopia (more than -5.00 D) was seen in 32% of eyes. Twenty (20%) eyes had nonsignificant hypermetropia, and high hypermetropia (more +5.00 D) was seen in only one eye (1%). The prevalence of astigmatism and high astigmatism (more than -2.00 D) was 79% and 49%, respectively. Three infants (6%) had esotropia and two infants (4%) had exotropia. None of the infants had nystagmus. Conclusion: The majority of patients who underwent diode laser therapy for prethreshold ROP had favourable anatomical and visual outcomes. High refractive error is common and may be the cause of visual impairment. © 2015 Nguyen et al.


Ngan N.D.,Hanoi Medical University | Chau H.T.,Vietnam National Institute of Ophthalmology
Clinical and Experimental Ophthalmology | Year: 2011

Background: To describe the outcome of surgery using amniotic membrane transplantation for Mooren's ulcer. Design: A prospective interventional case series from the Vietnam National Institute of Ophthalmology. Participants: Eighteen eyes of 14 patients with Mooren's ulcer. Seven eyes had recurrent episodes of ulceration, and 11 were not responsive to medical therapy or conjunctival resection. Methods: All eyes were treated with amniotic membrane grafts for Mooren's ulcer (10 eyes with multilayer grafts; 8 with a single layer graft). Five eyes with a 360° peripheral ulcer were treated with an overlay amniotic membrane graft, and 13 eyes were treated with a freehand graft tailored to fit the localized defect. Main Outcome Measures: Time to epithelial healing. Visual acuity outcome. Result: Sixteen of 18 eyes were treated by a single surgery with amniotic membrane with rapid healing of the epithelial defect (mean time to complete epithelialization 12.4days). Two eyes required a second amniotic membrane graft: one eye required regrafting following a subgraft haemorrhage and another eye required regrafting for a persistent epithelial defect. Vision was stabilized in all eyes with 10 of 18 eyes obtaining vision of 6/12 or better. Conclusion: Amniotic membrane transplantation may be a useful treatment for selected patients with Mooren's ulcer especially where systemic immunosuppressive drugs are unavailable. © 2011 The Authors. Clinical and Experimental Ophthalmology © 2011 Royal Australian and New Zealand College of Ophthalmologists.


Do T.,Vietnam National Institute of Ophthalmology | Hon D.N.,Vietnam National Institute of Ophthalmology | Aung T.,Singapore National Eye Center | Hien N.D.T.N.,Vietnam National Institute of Ophthalmology | Cowan C.L.,Georgetown University
Clinical Ophthalmology | Year: 2014

Background/aims: To compare treatment outcomes with and without silicone oil tamponade in patients undergoing pars plana vitrectomy (PPV) for severe endogenous bacterial endophthalmitis (BEE).Methods: One hundred and eight consecutive patients with severe BEE (defined by the absence of pupil red reflex at presentation and/or dense vitreous opacity on ultrasound and no improvement after 24–36 hours of medical treatment) were randomly assigned to two treatment groups: Group 1, standard PPV with intravitreal antibiotics; and Group 2, PPV with intravitreal antibiotics and silicone tamponade. Overall success was defined as: a visual acuity ≥ count fingers at 1 meter, with an attached retina, and no intraocular oil.Results: Fifty three patients were randomized to Group 1 and 55 patients to Group 2. The mean age of study subjects was 32 years and baseline clinical characteristics were similar in both groups. At the final follow-up visit at 9 months, the overall success rate of Group 2 (67.3%) was significantly better than Group 1 (43.4%; P=0.01). There were also fewer devastating complications (such as inoperable retinal detachment, phthisis bulbi) in Group 2 compared with Group 1 (21.8% versus 43.4%; P=0.01).Conclusion: The outcome at 9 months of patients with BEE treated by vitrectomy with silicone oil was better than those treated by vitrectomy alone. © 2014 Do et al.


Limburg H.,London School of Hygiene and Tropical Medicine | Gilbert C.,London School of Hygiene and Tropical Medicine | Hon D.N.,Vietnam National Institute of Ophthalmology | Dung N.C.,Vietnam National Institute of Ophthalmology | Hoang T.H.,Ho Chi Minh Hospital
Ophthalmology | Year: 2012

Objective: To estimate the prevalence of blindness in children in Vietnam and to assess the major causes. Design: A population-based study sampled children from 16 provinces across Vietnam. The second study examined children attending all blind schools in Vietnam. Participants: In 16 provinces, 28 800 children aged 0-15 were sampled. In 28 blind schools, 569 children aged 0-15 were examined. Intervention: In children not seeing well according to the parents, presenting visual acuity (PVA) was assessed. If PVA was <3/60 in one or both eyes, the child was examined by an ophthalmologist. All children in blind schools were examined by a pediatric ophthalmologist. Main Outcome Measures: Blindness was defined as PVA <3/60 in the better eye. Causes of visual loss were classified using the World Health Organization classification. Results: In the population-based study, 22 children had a PVA <3/60 in the better eye, a prevalence of 7.6/10 000 children (95% confidence interval [CI], 4.9-11.8/10 000). Fourteen children had a pinhole visual acuity <3/60 in the better eye, a prevalence of 4.9/10 000 (95% CI, 2.88.4/10 000). An estimated 16 400 (95% CI, 10 50025 300), children were blind from all causes, with 36.4% from uncorrected refractive errors. In the blind schools, 411 children had a PVA <3/60 in the better eye and 55.5% were male. Conditions of the retina (24.6%) and cornea (24.0%) predominated. Retinopathy of prematurity (ROP) caused blindness in 32.6% of children younger than 10 years, but in only 6% of older children. The converse was true for corneal scarring and phthisis (14.0% and 27.3%, respectively). All other causes were similar between age groups (53.5% and 66.7%, respectively). More than half of all causes were avoidable. Conclusions: Vietnam is developing very rapidly, and this is impacting health indices. The mortality rate of those younger than 5 years declined from 65/100 live births in 1980 to 14/100 in 2008. The findings of this study show these changes, because the childhood blindness prevalence was relatively low, and the causes show improved control of measles and vitamin A deficiency, as well as increased services for premature babies. Eye care services for children should now focus on refractive errors, cataract, and control of ROP. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. © 2012 American Academy of Ophthalmology.

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