Vidyasirimedhi Institute of Science and Technology VISTEC

Rayong, Thailand

Vidyasirimedhi Institute of Science and Technology VISTEC

Rayong, Thailand
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Davaa E.,Inha University | Lee J.,Inha University | Jenjob R.,Vidyasirimedhi Institute of Science and Technology VISTEC | Yang S.-G.,Inha University
ACS Applied Materials and Interfaces | Year: 2017

In this study, we demonstrated that the MT1- MMP-responsive peptide (sequence: GPLPLRSWGLK) and doxorubicin-conjugated poly(lactic-co-glycolic acid/poly- (styrene-alt-maleic anhydride) core/shell microparticles (PLGA/pSMA MPs) can be applied for intrahepatic arterial injection for hepatocellular carcinoma (HCC). PLGA/pSMA MPs were prepared with a capillary-focused microfluidic device. The particle size, observed by scanning electron microscopy (SEM), was around 22 ± 3 μm. MT1-MMPresponsive peptide and doxorubicin (DOX) were chemically conjugated with pSMA segments on the shell of MPs to form a PLGA/pSMA-peptide-DOX complex, resulting in high encapsulation efficiency (91.1%) and loading content (2.9%). DOX was released from PLGA/pSMA-peptide-DOX MPs in a pH-dependent manner (∼25% at pH 5.4 and ∼8% at pH 7.4) and accumulated significantly in an MT1-MMP-overexpressing Hep3B cell line. An in vivo intrahepatic injection study showed localization of MPs on the hepatic vessels and hepatic lobes up to 24 h after the injection without any shunting to the lung. Moreover, MPs efficiently inhibited tumor growth of Hep3B hepatic tumor xenografted mouse models. We expect that PLGA/pSMA-peptide-DOX MPs can be utilized as an effective intrahepatic drug delivery system for the treatment of HCC. © 2016 American Chemical Society.


Pattanasattayavong P.,Vidyasirimedhi Institute of Science and Technology VISTEC | Promarak V.,Vidyasirimedhi Institute of Science and Technology VISTEC | Anthopoulos T.D.,Imperial College London
Advanced Electronic Materials | Year: 2017

With the emerging applications of copper(I) thiocyanate (CuSCN) as a transparent and solution-processable hole-transporting semiconductor in numerous opto/electronic devices, fundamental studies that cast light on the charge transport physics are essential as they provide insights critical for further materials and devices performance advancement. The aim of this article is to provide a comprehensive and up-to-date report of the electronic properties of CuSCN with key emphasis on the structure–property relationship. The article is divided into four parts. In the first section, recent works on density functional theory calculations of the electronic band structure of hexagonal β-CuSCN are reviewed. Following this, various defects that may contribute to the conductivity of CuSCN are discussed, and newly predicted phases characterized by layered 2-dimensional-like structures are highlighted. Finally, a summary of recent studies on the band-tail states and hole transport mechanisms in solution-deposited, polycrystalline CuSCN layers is presented. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim


Amornwatcharapong W.,Mahidol University | Maenpuen S.,Burapha University | Chitnumsub P.,National Science and Technology Development Agency | Leartsakulpanich U.,National Science and Technology Development Agency | And 2 more authors.
Archives of Biochemistry and Biophysics | Year: 2017

Serine hydroxymethyltransferase (SHMT), an essential enzyme for cell growth and development, catalyzes the transfer of -CH2OH from L-serine to tetrahydrofolate (THF) to form glycine and 5,10-methylenetetrahydrofolate (MTHF) which is used for nucleotide synthesis. Insights into the ligand binding and inhibition properties of human cytosolic SHMT (hcSHMT) and Plasmodium SHMT (PvSHMT) are crucial for designing specific drugs against malaria and cancer. The results presented here revealed strong and pH-dependent THF inhibition of hcSHMT. In contrast, in PvSHMT, THF inhibition and the influence of pH were not as pronounced. Ligand binding experiments performed at various pH values indicated that the hcSHMT:Gly complex binds THF more tightly at lower pH conditions, while the binding affinity of the PvSHMT:Gly complex for THF is not pH-dependent. Pre-steady state kinetic (rapid-quench) analysis of hcSHMT showed burst kinetics, indicating that glycine formation occurs fastest in the first turnover relative to the subsequent turnovers i.e. glycine release is the rate-limiting step in the hcSHMT reaction. All data suggest that excess THF likely binds E:Gly binary complex and forms the E:Gly:THF dead-end complex before glycine is released. A unique flap motif found in the structure of hcSHMT may be the key structural feature that imparts these described characteristics of hcSHMT. © 2017 Elsevier Inc.


Abulikemu M.,King Abdullah University of Science and Technology | Barbe J.,King Abdullah University of Science and Technology | El Labban A.,King Abdullah University of Science and Technology | Eid J.,King Abdullah University of Science and Technology | And 2 more authors.
Thin Solid Films | Year: 2017

We report on planar heterojunction perovskite solar cells employing a metal chalcogenide (CdS) electron transport layer with power conversion efficiency up to 10.8%. The CdS layer was deposited via solution-process chemical bath deposition at low-temperature (60 °C). Pinhole-free and uniform thin films were obtained with good structural, optical and morphological properties. An optimal layer thickness of 60 nm yielded an improved open-circuit voltage and fill factor compared to the standard TiO2-based solar cells. Devices showed a higher reproducibility of the results compared to TiO2-based ones. We also tested the effect of annealing temperature on the CdS film and the effect of CdCl2 treatment followed by high temperature annealing (410 °C) that is expected to passivate the surface, thus eliminating eventual trap-states inducing recombination. © 2016


Jiang S.,Max Planck Institute for Polymer Research | Jiang S.,Shanxi Institute of Coal CAS Chemistry | Mable C.J.,University of Sheffield | Armes S.P.,University of Sheffield | And 2 more authors.
Macromolecular rapid communications | Year: 2016

Directed assembly of triblock copolymer worms to produce nanostructured fibers is achieved via colloid electrospinning. These copolymer worms are conveniently prepared by polymerization-induced self-assembly in concentrated aqueous dispersion. Addition of a second water-soluble component, poly(vinyl alcohol), is found to be critical for the production of well-defined fibers: trial experiments performed using the worms alone produce only spherical microparticles. Transmission electron microscopy studies confirm that the worm morphology survives electrospinning and the worms become orientated parallel to the main axis of the fibers during their generation. The average deviant angle (θdev ) between the worm orientation and fiber axis decreases from 17° to 9° as the worm/PVA mass ratio increases from 1.15:1 to 5:1, indicating a greater degree of worm alignment within fibers with higher worm contents and smaller fiber diameters. Thus triblock copolymer fibers of ≈300 ± 120 nm diameter can be readily produced that comprise aligned worms on the nanoscale. © 2016 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Hashimoto R.,Waseda University | Ogawa M.,Waseda University | Ogawa M.,Vidyasirimedhi Institute of Science and Technology VISTEC
Journal of Porous Materials | Year: 2017

Well-defined spherical particles of silica, containing phenyl group, with the diameter of ca. 2 microns were prepared by the co-condensation of tetraethoxysilane with phenyltriethoxysilane in basic aqueous methanol solutions of hexadecyltrimethylammonium chloride. The products were hydrophobic. The content of phenyl group was controlled by the ratio of tetraethoxysilane and phenyltriethoxysilane in the starting solution. Hexadecyltrimethylammonium was extracted with methanolic HCl to obtain nanoporous silica spherical particle containing phenyl group. The spherical particle possessed pore size of 1.8 nm and the BET surface area of 750 m2 g−1. © 2017 Springer Science+Business Media New York


Fickert J.,Max Planck Institute for Polymer Research | Landfester K.,Max Planck Institute for Polymer Research | Crespy D.,Max Planck Institute for Polymer Research | Crespy D.,Vidyasirimedhi Institute of Science and Technology VISTEC
Polymer Chemistry | Year: 2016

We introduce here a concept allowing the synthesis of smart nanocapsules without a surfactant. Copolymers with masked carboxylic acid groups are desilylated during the nanocapsule preparation and this leads to pH-responsive and self-stabilized nanocontainers encapsulating a large amount of hydrophobic substances. The nanocapsules can be either disrupted for release applications or reversibly aggregated by lowering the pH of the dispersion. The concentration of the nanocapsules in water can be increased by more than 6 times by isolating the nanocontainers at low pH and re-dispersing them at high pH values. © 2016 The Royal Society of Chemistry.


Wald S.,Max Planck Institute for Polymer Research | Wurm F.R.,Max Planck Institute for Polymer Research | Landfester K.,Max Planck Institute for Polymer Research | Crespy D.,Max Planck Institute for Polymer Research | Crespy D.,Vidyasirimedhi Institute of Science and Technology VISTEC
Polymers | Year: 2016

Inverse (water-in-oil) miniemulsions are an important method to encapsulate hydrophilic payloads such as oligonucleotides or peptides. However, the stabilization of inverse miniemulsions usually requires block copolymers that are difficult to synthesize and/or cannot be easily removed after transfer from a hydrophobic continuous phase to an aqueous continuous phase. We describe here a new strategy for the synthesis of a surfactant for inverse miniemulsions by radical addition-fragmentation chain transfer (RAFT) polymerization, which consists in a homopolymer with triisopropylsilyl protecting groups. The protecting groups ensure the efficient stabilization of the inverse (water-in-oil, w/o) miniemulsions. Nanocapsules can be formed and the protecting group can be subsequently cleaved for the re-dispersion of nanocapsules in an aqueous medium with a minimal amount of additional surfactant. © 2016 by the authors.


Dohler D.,Martin Luther University of Halle Wittenberg | Rana S.,Martin Luther University of Halle Wittenberg | Rupp H.,Martin Luther University of Halle Wittenberg | Bergmann H.,Martin Luther University of Halle Wittenberg | And 4 more authors.
Chemical Communications | Year: 2016

A simple and unique damage-sensing tool mediated by a Cu(i)-catalyzed [3+2] cycloaddition reaction is reported, where a fluorogenic "click"-reaction highlights physical damage by a strong fluorescence increase accompanied by in situ monitoring of localized self-healing. © The Royal Society of Chemistry.


PubMed | Inha University and Vidyasirimedhi Institute of Science and Technology VISTEC
Type: Journal Article | Journal: ACS applied materials & interfaces | Year: 2016

In this study, we demonstrated that the MT1-MMP-responsive peptide (sequence: GPLPLRSWGLK) and doxorubicin-conjugated poly(lactic-co-glycolic acid/poly(styrene-alt-maleic anhydride) core/shell microparticles (PLGA/pSMA MPs) can be applied for intrahepatic arterial injection for hepatocellular carcinoma (HCC). PLGA/pSMA MPs were prepared with a capillary-focused microfluidic device. The particle size, observed by scanning electron microscopy (SEM), was around 22 3 m. MT1-MMP-responsive peptide and doxorubicin (DOX) were chemically conjugated with pSMA segments on the shell of MPs to form a PLGA/pSMA-peptide-DOX complex, resulting in high encapsulation efficiency (91.1%) and loading content (2.9%). DOX was released from PLGA/pSMA-peptide-DOX MPs in a pH-dependent manner (25% at pH 5.4 and 8% at pH 7.4) and accumulated significantly in an MT1-MMP-overexpressing Hep3B cell line. An in vivo intrahepatic injection study showed localization of MPs on the hepatic vessels and hepatic lobes up to 24 h after the injection without any shunting to the lung. Moreover, MPs efficiently inhibited tumor growth of Hep3B hepatic tumor xenografted mouse models. We expect that PLGA/pSMA-peptide-DOX MPs can be utilized as an effective intrahepatic drug delivery system for the treatment of HCC.

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