Vidyabharati Mahavidyalaya

Amrāvati, India

Vidyabharati Mahavidyalaya

Amrāvati, India

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Sonar A.S.,Lc Kherde Arts And Science Junior College | Solanki P.R.,Vidyabharati Mahavidyalaya
Asian Journal of Chemistry | Year: 2012

One of the most attractive concept in chemistry for sustainability is green chemistry, which is the utilization of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and applications of chemical product. Microwave heating has attracted the attention of today's research worker. Reactions in microwave are currently in use for synthesis of medicinally important compounds. Within the framework of green chemistry we had synthesized 6-(substituted phenyl)-2H-imidazo[1,2- a] imidazol-3-one by cyclocondensation of 4-(substituted phenyl)-1H-imidazol-2(5H)-one/thione/imine with amino acids using PTC and triethyl benzyl ammonium chloride. Synthesized compounds have been tested for antimicrobial activity against Staphylococcus aureus, Escherichia coli, Salmonella typhi, Proteus vulgaris using cup-plate methodand their minimum inhibitory concentration (MICs) were determined using broth macrodilution method.

Claisen condensation of (1a-c) with ethyl acetate under basic medium afforded corresponding diketones (2a-c). Cyclization of (2a-c) in presence of (PPA) afforded corresponding chromones (3a-b). Condensation of (2a-c) with substituted aldehydes in presence of phase transfer catalyst (TEBA) afforded the corresponding acrylophenones (4a-l). Solid phase cycloaddition of (2a-c) with substituted amides in presence of TEBA under basic condition afforded corresponding pyrimidine derivatives (5a-i). The structures of the synthesized compounds have been confirmed on the basis of IR, 1H NMR and elemental analysis. The purity of compounds has been checked by HPLC technique. Some of synthesized compounds have been screened for their antimicrobial activity. The cytotoxicity of some newly synthesized compounds has been checked by using seed infusion technique.

Naik A.B.,Sant Gadge Baba Amravati University | Narwade M.L.,Vidyabharati Mahavidyalaya | Bodakhe P.S.,Vidyabharati Mahavidyalaya | Muley G.G.,Sant Gadge Baba Amravati University
Russian Journal of Physical Chemistry A | Year: 2014

Density, ultrasonic speed in pure solvent acetonitrile (AN) and ligand solution of substituted pyrimidine in pure AN were measured at different temperatures (298.15, 303.15, 308.15, 313.15, and 318.15 K). Acoustical parameters such as adiabatic compressibility, intermolecular free length, acoustical impedance and relative association were determined from the experimental data of density and ultrasonic speed. The effect of temperature variations on the strength of molecular interaction has been studied. An excellent correlation represents in terms of solute-solvent interaction at all temperatures. © 2014 Pleiades Publishing, Ltd.

Mandakmare A.U.,Bharatiya Mahavidyalaya | Narwade M.L.,Vidyabharati Mahavidyalaya | Tayade D.T.,G.V. I. H. S | Naik A.B.,Sant Gadge Baba Amravati University
Russian Journal of Physical Chemistry A | Year: 2014

Density, ultrasonic velocity of pure dioxane (Dx) and ligands, 4,6-dimethyl-7-hydroxycoumarin (L1), 6-ethyl-7-hydroxy-4-methylcoumarin (L2), and 3-chloro-7-hydroxy-4-methylcoumarin (L3) in different percent of Dx-water mixture have been investigated at 303.15 K. Acoustical parameters such as adiabatic compressibility (β), intermolecular free length (L f ), acoustical impedance (Z), relative association (R A ), apparent molar compressibility (Φβ), and apparent molar volume (Φ V ) have also been evaluated from the experimental data of density and ultrasonic velocity. An excellent correlation between a given parameters is observed at all percent of dioxane-water and the result suggests nature of intermolecular interactions between the components. © 2014 Pleiades Publishing, Ltd.

Mahale J.D.,Vidyabharati Mahavidyalaya | Manoja S.C.,Vidyabharati Mahavidyalaya | Belsare N.G.,Vidyabharati Mahavidyalaya | Rajput P.R.,Vidyabharati Mahavidyalaya
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2010

Some new chlorosubstituted 4-aroyl/alkoylpyrazolines 5a,b and 4-aroyl/alkoylpyrazoles 7a,b have been synthesized by condensation of 1-(2'-hydroxy-3'-5'-dichlorophenyl)-3-aryl/alkyl-1-3-propanedione 3a,b and valeraldehyde by Baker-Venkatraman transformation of corresponding aroy1/alkoyloxyacetophenones. Aroyl/A1koyloxyacetophenones 2a,b undergo intramolecular Claisen condensation to form l-(2'-hydroxy-3'-5'-dichlorophenyl)- 3-aryl/alkyl-1,3-propanediones 3a,b which on treatment with aliphatic aldehyde in ethanol containing little piperidine forms 3-aroyl/alkoylchromanones 4a,b. From these 3-aroyl/alkoylchromanones 4a,b 4-aroyl/alkoylpyrazolines 5a,b are synthesized. 3-Aroyl/Alkoylchromanones 4a,b are converted into 3-aroyl/alkoylchromones 6a,b. The 3-aroyl/alkoylchromones 6a,b on treatment with Ph.NHNH2.HCl in dioxane containing small amount of piperidine furnish 4-aroyl/alkoylpyrazoles 7a,b. The structures of the newly synthesized chlorosubstituted 4-aroyl/alkoylpyrazolines 5a,b and 4-aroyl/alkoylpyrazoles 7a,b have been elucidated on the basis of spectral analysis and their homogeneity has been established by TLC.

Gijare S.S.,Vidyabharati Mahavidyalaya | Raja I.A.,Vidyabharati Mahavidyalaya | Raja I.A.,Shri Shivaji Science College | Tantarpale V.T.,Vidyabharati Mahavidyalaya | Kulkarni K.M.,Vidyabharati Mahavidyalaya
Pollution Research | Year: 2012

The agriculture pesticides due to its indiscriminate use in field create pollution problems in water bodies. In this present investigation effect of cypermethrin on histophysiology of liver of freshwater fish Ophiocephalus punctatusjwas studied. The freshwater fish Ophiocephalus punctatus were exposed to sub lethal concentration 0.0007μ/L of cypermethrin. At different time intervals there was hydropic degeneration in liver. The loosening of tissue, distension of cell, hypertrophy of hepatocytes, significant increase of kupffer cell, pycnotic nuclei, vacuolation of cytoplasm was also observed. Copyright © EM International.

Kalyamwar V.S.,Bharatiya Mahavidyalaya | Raghuwanshi F.C.,Vidyabharati Mahavidyalaya
Advanced Materials Letters | Year: 2013

Zinc oxide nanostructures were synthesized by chemical route method. The XRD spectrum indicates that the sample is wurtezite (hexagonal) structured ZnO with lattice constants of a = 3.249A0, c = 5.206 A0. Thick films of synthesized ZnO were prepared by screen printing technique. The TiO2 modified ZnO were obtained by dipping them into an aqueous solution of titanium tetrachloride for different interval of time. Gas sensing properties of pure and modified ZnO thick films were investigated. The TiO2 modified ZnO thick film dipped for 5 min were observed to be more sensitive as compared to other modified thick films at 1250C. The effect of surface microstructure and TiO2 concentrations on the sensitivity, selectivity, response and recovery of the sensor in the presence of NH3 and other gases ware studied and discussed. © 2013 VBRI press.

Bandgar B.P.,University of Solapur | Adsul L.K.,University of Solapur | Chavan H.V.,University of Solapur | Jalde S.S.,University of Solapur | And 5 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2012

A novel series of 3-(substituted)-aryl-5-(9-methyl-3-carbazole)-1H-2- pyrazolines (5a-o) has been synthesized and the structures of newly synthesized compounds were characterized by IR, 1H NMR and mass spectral analysis. All the synthesized compounds were evaluated for their in vitro and in vivo anti-inflammatory activity, and also for their antioxidant activity. Compounds 5b, 5c, 5d and 5n were found to be selective COX-2 inhibitors. Compound 5c was found to potent inhibitor of the carrageenin induced paw edema in rats. Most of the compounds exhibited good DPPH and superoxide radical scavenging activity, while compounds 5c, 5d, 5i and 5k exhibited good hydroxyl radical scavenging activity. Molecular docking result, along with the biological assay data, suggested that compound 5c was a potential anti-inflammatory agent. © 2012 Published by Elsevier Ltd.

Eight New chlorine containing 4-Aroyl/Alkoyl-△2-pyrazolines and isoxazolines have been synthesized with 80-85% yield by a microwave promoted solvent-free condensation of 3-aroyl/ alkoylflavanones 5a-d respectively with Phenylhydrazine hydrochloride and hydroxylaminehydrochloride over potassium carbonate The work-up is simple and involves treatment with ice-cold water. A considerable increase in the reaction rate has been observed, with better yields.

Kapse S.D.,G S College | Raghuwanshi F.C.,Vidyabharati Mahavidyalaya | Kapse V.D.,Science and Commerce College | Patil D.R.,Rl College
Current Applied Physics | Year: 2012

Nanocrystalline powders of Zn1-xCoxAl 2O4 (x = 0, 0.2, 0.4, 0.6, 0.8, 1.0) mixed oxides, with cubic spinel structure were successfully prepared by the ethylene glycol mediated citrate sol-gel method. The structure and crystal phase of the powders were characterized by X-ray diffraction (XRD) and microstructure by transmission electron microscopy (TEM). X-ray diffraction results showed that the samples were in single phase with the space group Fd-3m. TEM analysis showed that the powders with spherical shape were uniform in particle size of about 17-24 nm with mesoporous in nature. Further investigations were carried out by FT-IR. Thick films of as-prepared Zn1-xCoxAl 2O4 powders were fabricated using screen-printing technique. The response of Zn1-xCoxAl 2O4 based thick films towards different reducing gases (liquefied petroleum gas, hydrogen, hydrogen sulfide, ethanol gas and ammonia) was investigated. The sensor response largely depends on the composition, temperature and the test gas species. The Co (cobalt) content has a considerable influence on the gas-sensing properties of Zn1-xCo xAl2O4. Especially, Zn0.4Co 0.6Al2O4 composition exhibited high response with better selectivity to 100 ppm C2H5OH gas at 150 °C. The instant response (∼7 s) and fast recovery (∼16 s) are the main features of this sensor. © 2011 Elsevier B.V. All rights reserved.

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