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Ben Hadda T.,University Mohammed Premier | Mouhoub R.,University Mohammed Premier | Masand V.,Vidya Bharati Mahavidyalaya Camp | Warad I.,King Saud University
Medicinal Chemistry Research

POM virtual screening and docking of compounds 2-iminobenzimidazoles (IBIZ) as a novel class of trypanothione reductase inhibitors are described. These 2-IBIZ display potent trypanocidal activity against Trypanosoma brucei rhodesiense, with low cytotoxicity. A hypothetical mechanism based on bioinformatic analyses is proposed. The ligands with two neighbor pockets leading to bimetallic (M-Ligand-M/enzyme) complexes are more active than similar ligand without the two terminal arms. Graphical abstract: [InlineMediaObject not available: see fulltext.] © 2012 Springer Science+Business Media New York. Source

Lamdhade G.T.,Vidya Bharati Mahavidyalaya Camp | Raghuwanshi F.C.,Vidya Bharati Mahavidyalaya Camp | Agrawal R.M.,Vidya Bharati Mahavidyalaya Camp | Balkhande V.M.,Vidya Bharati Mahavidyalaya Camp | Shripathi T.,UGC-DAE Consortium for Scientific Research
Advanced Materials Letters

The samples have been prepared in the form of pellets of SnO2 nanoparticles and synthesized via the liquid-phase co-precipitation technique. The ac electrical conductivity of samples is found to be frequency dependent. The dielectric constant increases with temperature and decreases with frequency of applied field. The semiconducting behavior of SnO2 nanoparticles have been studied from I-V characteristics. The characterization of samples has been studied by XRD, FESEM, UV-spectra and TG-DTA plot. © 2015 VBRI Press. Source

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