Bukhari S.N.A.,National University of Malaysia |
Zhang X.,Nanjing University |
Jantan I.,National University of Malaysia |
Zhu H.-L.,Nanjing University |
And 2 more authors.
Chemical Biology and Drug Design | Year: 2015
A novel series of 1,3-diphenyl-2-propen-1-one (chalcone) derivatives was synthesized by a simple, eco-friendly, and efficient Claisen-Schmidt condensation reaction and used as precursors for the synthesis of new pyrazoline derivatives. All the synthesized compounds were screened for anti-inflammatory related activities such as inhibition of phospholipase A2 (PLA2), cyclooxygenases (COX-1 and COX-2), IL-6, and TNF-α. The results of the above studies show that the compounds synthesized are effective inhibitors of above pro-inflammatory enzymes and cytokines. Overall, the results of the studies reveal that the pyrazolines with chlorophenyl substitution (1b-6b) seem to be important for inhibition of enzymes and cytokines. Molecular docking experiments were performed to clarify the molecular aspects of the observed COX-inhibitory activities of the investigated compounds. © 2014 John Wiley & Sons A/S.
Mishra R.A.,Amolakchand Mahavidyalaya |
Raut N.B.,Vidya Bharati Mahavidyalaya
Proceedings - ISPTS-1, 1st International Symposium on Physics and Technology of Sensors | Year: 2012
The output of transducers which are used in physiological measuring is observed to be nonlinear. This nonlinear characteristic of transducers fails to measure the actual value of physiological parameter like temperature, pulse rate, heart beats, etc. the researcher has developed the body temperature measuring transducer using time base oscillating circuit and thermister as temperature sensing element. The time base circuit, phototransistor and LED are used for designing quick recovery heart beat sensor. The design technique of these transducers, their characteristics and comparisons with existing sensors in similar kind of biomedical instruments is discussed in this paper. © 2012 IEEE.
Ghodile N.G.,Vidya Bharati Mahavidyalaya
International Journal of Pharma and Bio Sciences | Year: 2013
The methods of synthesis of flavones mostly by cyclization and condensation of ohydroxy acetophenone, dehydrogenation of flavanones or using chalcones as starting materials have very limited applicability hence it is need of the time to go for some alternative methods. The present study reports an experiment where a more convenient method is used to synthesize some substituted flavones from the enamines. The bromo and nitro substituted 2-(5-chloro-2-hydroxyphenyl)-4H-chromen-4-ones were synthesized by the reaction of bromo and nitro substituted 1-(2-hydroxy-5- chlorophenyl)ethenyldiphenylamines with heptanedioylchloride followed by the cyclization of intermediate thus obtained in the suitable solvents.
Deotalu C.L.,Commerce and Science College |
Rajput P.R.,Vidya Bharati Mahavidyalaya
Der Pharma Chemica | Year: 2011
Aroyl/alkoylacetophenones (2a-b) undergoes intramolecular claisen condensation to form 1-(2'- hydroxy-3',5'-dichlorophenyl)-3-aryl/alkyl-1,3-propanediones (4a-b) which on treatment with aromatic and aliphatic aldehydes in ethanol containing little piperidine forms 3-aroyl/alkoylchromanones (5ab) subsequently 3-aroyl/ alkoylchromones (6a-b). 3-Aroyl/alkoylchromones (6a-b) on treatment with Ph.NH.NH 2.HCl in DMSO containing small amount of piperidine gave 4-aroyl/alkoylpyrazoles (7a-b).So also 3-aroyl/alkoylchromones (6a-b) on treatment with NH 2OH.HCl in DMSO containing a small amount of piperidine gave 4-aroyl/ alkoylisoxazoles (8a-b). The structures of newly synthesized chlorosubstituted 4-aroyl/alkoyl- pyrazoles (7a-b) and 4-aroyl/alkoylisoxazoles (8a-b) were elucidated on the basis of molecular weight, elemental analysis and their spectral data.
Doshi A.G.,Vidya Bharati Mahavidyalaya |
Raut A.W.,P.A. College
Oriental Journal of Chemistry | Year: 2010
2-Acetylthiophene condenses with different aromatic aldehyde In ethanol in the presence of aqueous NaOH to give 1 -(2'-thienyl)-3-(substituted phenyl) -2- propen-1 -one (la-e) which reacts with hydrazine hydrate in ethanol to give pyrazoline (IIa-e). Similarly, 1 -(2'-thienyl)-3-(substituted phenyl)-2propen-1 -one (Ia-e) reacts with phenyl hydrazine hydrochloride In the presence of ethanol medium and 1,2 drops of NaOH (2N) to give 1 -phenyl pyrazoline (IIIa-e), (la-e) Reacts with 2,4-dinitro phenyl hydrazine in presence of ethanol medium to give 1-(2,4-dinitro phenyl) pyrazoline (IVa-e) and also reacts with semicarbazide hydrochloride in presence of ethanol medium and 1,2 drops of NaOH (2N) to give 1- carboxamido pyrazoline (Va-e). Pyrazoline (Va-e) reacts with acetic acid to give 1-acetyl pyrazoline (VIa-e), as well as it reacts with benzoyl chloride in pyridine medium to give 1-benzoyl pyrazoline (VIIa-e) and also reacts with 1:1 HCl and 10% sodium nitrite to give 1-nitrso pyrazoline (VIIIa-e). Characterization and structural elucidation were done on the basis of melting points determination, analytical and spectral studies.