Nita S.,Romanian National Institute for Chemical Pharmaceutical Research and Development |
Andries A.A.,Carol Davila University of Medicine and Pharmacy |
Patron L.,Institute of Physical Chemistry Ilie Murgulescu |
Albulescu R.,Romanian National Institute for Chemical Pharmaceutical Research and Development |
And 3 more authors.
Revista de Chimie | Year: 2011
A new concept in the process of design and development of antiinflammatory drugs focuses on the preparation of metallic compounds of drugs with therapeutic activity. These metallic coordination compounds possess the action of both the organic ligand and the metallic ion, so that the gastrointestinal side effects due to the organic compounds' acidity will be eliminated. This paper describes the synthesis and characterization of new cobalt (II) whith oxicams ligands, piroxicam and meloxicam. The structures and formula proposed for these coordination compounds were established on the basis of Quantitative Structure-Activity Relationships/Computer Assisted Drug Design (QSAR/CADD) studies and correlated with the elemental chemical analysis and other physico - chemical studies (UV- VIS, IR, ICP-MS and magnetic and conductometric measurements). Cytotoxicity of cobalt compounds was estimated, comparatively of oxicams ligands.