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Vilalta C.,Autonomous University of Barcelona | Giboin H.,Vetoquinol Research Center | Schneider M.,Vetoquinol Research Center | El Garch F.,Vetoquinol Research Center | Fraile L.,University of Lleida
Journal of Veterinary Pharmacology and Therapeutics

This study evaluated the theoretical clinical outcome of three marbofloxacin posology regimens in two groups of pigs (weaners and fatteners) for the treatment of Actinobacillus pleuropneumoniae (App) and Haemophilus parasuis (Hp) infection and the appearance of resistant bacteria due to the antibiotic treatment. The probability of target attainment (PTA) for pharmacokinetic/pharmacodynamics (PK/PD) ratios associated with clinical efficacy and with the appearance of antimicrobial resistance for fluoroquinolones at each minimum inhibitory concentration (MIC) or mutant prevention concentration (MPC) were calculated, respectively. The cumulative fraction of response (CFR) was calculated for the three posology regimens against App and they ranged from 91.12% to 96.37% in weaners and from 93% to 97.43% in fatteners, respectively. In the case of Hp, they ranged from 80.52% to 85.14% in weaners and from 82.01% to 88.49% in fatteners, respectively. Regarding the PTA of the PK/PD threshold associated with the appearance of antimicrobial resistance, results showed that marbofloxacin would prevent resistances in most of the animals up to the MPC value of 1 μg/mL. © 2014 The Authors. Journal of Veterinary Pharmacology and Therapeutics Published by John Wiley & Sons Ltd. Source

Grandemange E.,Vetoquinol Research Center | Giboin H.,Vetoquinol Research Center | Schneider M.,Vetoquinol Research Center | El Garch F.,Vetoquinol Research Center | And 2 more authors.
Cattle Practice

This paper presents the pre-clinical and clinical development of single injection marbofloxacin (Forcyl®) for the treatment of acute E. coli mastitis. Coliform mastitis is characterised by typical clinical signs of septic shock and local acute inflammation of the mammary gland (Bürvenich 2003). However, typical signs of coliform mastitis do not mean this is necessarily an E. coli mastitis: approximately half of those mastitis cases are due to E. coli (Belliard 2009). E. coli inoculation in the udder significantly up-regulates within 24 hours the expression of innate immune defences such as beta-defensins, and toll-like receptors in the mammary epithelial cells as well as in mammary lymph nodes (Schukken 2011). 5. aureus, in contrast, does not significantly increase the expression of these genes for several days after pathogen inoculation (Schukken 2011). This strong innate immune response to E. coli mammary infection is characteristic and may explain why this type of mastitis, although potentially fatal due to septic shock, is seldom associated with persistent infections. In theory, this is a perfect match to the single injection short acting antibiotic (SISAAB) treatment approach, as the SISAAB antibiotic will likely eradicate most of the pathogenic bacteria (Vallé and others 2012), allowing the mammal to regain its equilibrium without excessive inflammatory damage. Source

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