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Miles D.G.,Veterinary Research and Consulting Services LLC | Rogers K.C.,Veterinary Research and Consulting Services LLC
Animal Health Research Reviews | Year: 2014

Pasteur described an organism causing fowl cholera in 1880. In 134 years we have progressed from crude vaccines for Pasteurella, to some refined vaccines, to a name change (Mannheimia), to autogenous vaccines (back to crude). In the last 25-30 years, we have attempted to mitigate the problem of bovine respiratory disease with antimicrobials and subsequently have a high incidence of multi-drug resistance. All of these attempts have resulted in little if any improvement in morbidity/mortality. Is it time to focus on the animal's response or lack of response to infectious pressure? Instead of focusing on the 10-50% morbid cattle should we focus on the 50-90% that are not compromised and determine why they stay healthy under the same environmental conditions? Copyright © 2014 Cambridge University Press.


PubMed | Veterinary Research and Consulting Services LLC
Type: Journal Article | Journal: Animal health research reviews | Year: 2014

Pasteur described an organism causing fowl cholera in 1880. In 134 years we have progressed from crude vaccines for Pasteurella, to some refined vaccines, to a name change (Mannheimia), to autogenous vaccines (back to crude). In the last 25-30 years, we have attempted to mitigate the problem of bovine respiratory disease with antimicrobials and subsequently have a high incidence of multi-drug resistance. All of these attempts have resulted in little if any improvement in morbidity/mortality. Is it time to focus on the animals response or lack of response to infectious pressure? Instead of focusing on the 10-50% morbid cattle should we focus on the 50-90% that are not compromised and determine why they stay healthy under the same environmental conditions?

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