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Scotland, United Kingdom

Williams H.J.,University of Liverpool | Revell S.G.,Genus Breeding Ltd. | Scholes S.F.E.,Veterinary Laboratories Agency Lasswade | Courtenay A.E.,University of Liverpool | Smith R.F.,University of Liverpool
Reproduction in Domestic Animals | Year: 2010

On assessment for use in an AI stud, a 12-month-old bull was found to produce low volume ejaculates with 41% of the sperm having morphological abnormalities. No left epididymal tail was palpable and the head of the epididymis on the left was twice the size compared with the right. Ultrasound examination showed the left testis to contain a large central area of decreased echogenicity, which could be followed proximally to a 15-mm echolucent lesion at the site of the epididymal head. Postmortem examination revealed a 15-mm diameter cyst in the region of the left epididymal head, and absence of the body and tail of the epididymis. The mediastinum testis of the left testis was dilated, corresponding to the area of decreased echogenicity observed on ultrasonography. No left seminal vesicle was present and the ampulla was significantly smaller than the same structure on the right. Histological examination revealed incomplete or absent spermatogenesis involving the majority of seminiferous tubules in the left testis, and a small proportion of those of the right testis. The cystic structure at the site of the left epididymal head was lined by irregular, sometimes attenuated, epithelium and contained sparse spermatozoa. This case demonstrates the adverse impact, which segmental aplasia of the mesonephric duct had on the testicular and epididymal function of a bull, and highlights the importance of careful clinical assessment in its diagnosis. © 2009 Blackwell Verlag GmbH. Source

Edwards G.T.,Veterinary Laboratories Agency Aberystwyth | Schock A.,Veterinary Laboratories Agency Lasswade
Journal of Comparative Pathology | Year: 2010

Obstructive jaundice and photosensitization occurred in a 9-month-old lamb as a sequela to a diaphragmatic hernia. A loop of proximal duodenum was displaced, resulting in occlusion of the common bile duct, cholecystitis and necrotizing hepatitis. © 2009. Source

Twomey D.F.,Veterinary Laboratories Agency | Boon J.D.,Veterinary Laboratories Agency | Sayers G.,Paignton Zoo | Schock A.,Veterinary Laboratories Agency Lasswade
Journal of Zoo and Wildlife Medicine | Year: 2010

A 14-year-old female pudu (Pudu puda) developed a uterine prolapse after unassisted parturition. The length of time between the prolapse and replacement of the organ was not known but was less than 24 hr. When the prolapse was first noticed, uterine tissue appeared undamaged and was immediately cleaned with antiseptic solution, handled carefully during replacement, and prophylactic antibiotic and anti-inflammatory drugs were given. The pudu appeared clinically normal until 4 days postpartum, when she developed clinical signs of tenesmus, dysuria, and a purulent discharge from the vulva. Despite further treatment, the animal was found dead 10 days postpartum, even though it had not shown any other signs of systemic illness. Gross and histologic lesions supported a diagnosis of septicemia secondary to metritis. Arcanobacterium pyogenes was isolated from lung, liver, and uterine exudate. Copyright 2010 by American Association of Zoo Veterinarians. Source

Foster A.P.,Veterinary Laboratories Agency Shrewsbury | Skuse A.M.,University of Bristol | Higgins R.J.,Veterinary Laboratories Agency Lasswade | Barrett D.C.,University of Glasgow | And 6 more authors.
Journal of Comparative Pathology | Year: 2010

Epidermolysis bullosa (EB) was diagnosed in eight calves from four farms in the United Kingdom on the basis of clinical, histological and ultrastructural findings. In three affected herds, pedigree Simmental bulls had been mated with Simmental-cross cows. In a fourth herd two Holstein-Friesian calves were affected. Lesions included multifocal erosion and ulceration of the hard and soft palates, tongue, nares and gingiva, with onychomadesis (dysungulation). There was alopecia, erosion and crusting of the coronets, pasterns, fetlocks, carpi, hocks, flanks and axillae. Histopathological findings included segmental separation of full thickness epidermis from the dermis, with formation of large clefts containing eosinophilic fluid, extravasated red blood cells and small numbers of neutrophils. Follicular and interfollicular areas of skin were affected, with clefts extending around hair follicles and sometimes involving whole follicles. Ultrastructurally, there was evidence of vacuolar change within basal keratinocytes, corresponding to areas of histological clefting. Preliminary genetic screening of the candidate keratin genes (bKRT5 and bKRT14) has excluded mutations of these as the cause of this condition. © 2009. Source

Foster A.P.,Veterinary Laboratories Agency Shrewsbury | Johnston P.E.,University of Glasgow | Duignan P.J.,University of Calgary | Schock A.,Veterinary Laboratories Agency Lasswade
Journal of Comparative Pathology | Year: 2011

A pericardial myxoid liposarcoma was diagnosed in a common eland (Taurotragus oryx) based on gross, microscopical and immunohistochemical findings. The pericardial and epicardial tissues were soft and uniformly thickened. Microscopically, the neoplastic mass consisted of stellate cells embedded in a myxoid matrix. These cells contained cytoplasmic vacuoles stained by oil red O. Immunohistochemical analysis showed the neoplastic cells to express vimentin and S-100. © 2010. Source

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