Lewin G.,University Paris - Sud |
Shridhar N.B.,KVAFSU Veterinary College |
Aubert G.,CNRS Natural Product Chemistry Institute |
Thoret S.,CNRS Natural Product Chemistry Institute |
And 2 more authors.
Bioorganic and Medicinal Chemistry | Year: 2011
Eighteen new analogues of 5,3′-dihydroxy-3,6,7,8,4′- pentamethoxy-flavone, a potent natural cytotoxic and antimitotic flavone, were synthesized from calycopterin, the major flavonoid of Calycopteris floribunda Lamk., a traditional Asian medicinal plant. One of them, the 3′-amino substituted analogue, displayed almost the same activity as the reference compound. Pharmacomodulation at C-3′ on the B-ring, and at C-5,6,7 and 8 on the A-ring allowed to refine structure-activity relationships within the cytotoxic flavones series. © 2010 Elsevier Ltd. All rights reserved.