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Lewin G.,University Paris - Sud | Shridhar N.B.,KVAFSU Veterinary College | Aubert G.,CNRS Natural Product Chemistry Institute | Thoret S.,CNRS Natural Product Chemistry Institute | And 2 more authors.
Bioorganic and Medicinal Chemistry | Year: 2011

Eighteen new analogues of 5,3′-dihydroxy-3,6,7,8,4′- pentamethoxy-flavone, a potent natural cytotoxic and antimitotic flavone, were synthesized from calycopterin, the major flavonoid of Calycopteris floribunda Lamk., a traditional Asian medicinal plant. One of them, the 3′-amino substituted analogue, displayed almost the same activity as the reference compound. Pharmacomodulation at C-3′ on the B-ring, and at C-5,6,7 and 8 on the A-ring allowed to refine structure-activity relationships within the cytotoxic flavones series. © 2010 Elsevier Ltd. All rights reserved.

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