News Article | March 9, 2016
A new study included 31,951 US veterans with atrial fibrillation, 75 years or older, who were new referrals to Veterans Affairs anticoagulation clinics (for warfarin therapy) between 2002 and 2012. The researchers found that the rate of traumatic intracranial bleeding among older adults with AF initiating warfarin therapy was higher than previously reported in clinical trials.
"The quest for answers for thousands of veterans sickened -- in some cases terminally -- by contaminated water at Camp Lejuene has been stymied by a federal agency that refuses to hand over key documents, attorneys from Yale Law School charged Wednesday. The Veterans Legal Services Clinic at Yale Law School filed a Freedom of Information Act (FOIA) lawsuit in federal court Wednesday against the Department of Veterans Affairs for allegedly withholding information on a group of "experts" denying claims for scores of veterans exposed to cancer-causing chemicals at the North Carolina base. The suit, which represents two veterans groups, seeks to compel the VA to respond to a December 2015 FOIA request about the SME program -- an anonymous group of "subject matter experts" who render medical opinions on the veterans exposed to toxic water at Camp Lejuene between 1953 and 1987." Cristina Corbin reports for Fox News April 27, 2016.
Edible ginger-derived nanoparticles could alleviate symptons of Crohn’s disease and ulceratice colitis, the two main forms of inflammatory bowel disease (IBD), researchers claim. The research team, led by Dr Didier Merlin alongside the Atlanta Veterans Affairs Medical Center and the Institute for Biomedical Sciences at Georgia State University, report their findings in the September 2016 issue of Biomaterials. They tested three Ginger-derived nanoparticles (GDNP), which had been isolated from ginger juice and purified using a sucrose gradient ultracentrifugation method. “GDNPs mainly accumulated at the 8/30% (band 1) and 30/45% (band 2) interfaces of the sucrose gradient; a faint band was also detected at the 45/60% interface (band 3), the study reports. The particles were fed to lab mice, and appeared to be nontoxic. They had significant therapeutic effects, with GDNP 2 seemingly the most beneficial. The study shows they were absorbed mainly by cells in the lining of the intestines, where IBD inflammation occurs. The particles were also shown to reduce acute colitis and prevented chronic colitis and colitis-associated cancer, and they enhanced intestinal repair. This story is reprinted from material from Nutra Ingredients Asia, with editorial changes made by Materials Today. The views expressed in this article do not necessarily represent those of Elsevier. Please click here to access the full study.
Abstract: A recent study by researchers at the Atlanta Veterans Affairs Medical Center took them to a not-so-likely destination: local farmers markets. They went in search of fresh ginger root. Back at the lab, the scientists turned the ginger into what they are calling GDNPs, or ginger-derived nanoparticles. The process started simply enough, with your basic kitchen blender. But then it involved super-high-speed centrifuging and ultrasonic dispersion of the ginger juice, to break it up into single pellets. (Don't try this at home!) The research team, led by Dr. Didier Merlin with VA and the Institute for Biomedical Sciences at Georgia State University, believes the particles may be good medicine for Crohn's disease and ulcerative colitis, the two main forms of inflammatory bowel disease (IBD). The particles may also help fight cancer linked to colitis, the scientists believe. They report their findings, based on experiments with cells and mice, in the September 2016 issue of Biomaterials. Each ginger-based nanoparticle was about 230 nanometers in diameter. More than 300 of them could fit across the width of a human hair. Fed to lab mice, the particles appeared to be nontoxic and had significant therapeutic effects: Importantly, they efficiently targeted the colon. They were absorbed mainly by cells in the lining of the intestines, where IBD inflammation occurs. The particles reduced acute colitis and prevented chronic colitis and colitis-associated cancer. They enhanced intestinal repair. Specifically, they boosted the survival and proliferation of the cells that make up the lining of the colon. They also lowered the production of proteins that promote inflammation, and raised the levels of proteins that fight inflammation. Part of the therapeutic effect, say the researchers, comes from the high levels of lipids--fatty molecules--in the particles, a result of the natural lipids in the ginger plant. One of the lipids is phosphatidic acid, an important building block of cell membranes. The particles also retained key active constituents found naturally in ginger, such as 6-gingerol and 6-shogaol. Past lab studies have shown the compounds to be active against oxidation, inflammation, and cancer. They are what make standard ginger an effective remedy for nausea and other digestion problems. Traditional cultures have used ginger medicinally for centuries, and health food stores carry ginger-based supplements--such as chews, or the herb mixed with honey in a syrup--as digestive aids. Delivering these compounds in a nanoparticle, says Merlin's team, may be a more effective way to target colon tissue than simply providing the herb as a food or supplement. The idea of fighting IBD with nanoparticles is not new. In recent years, Merlin's lab and others have explored how to deliver conventional drugs via nanotechnology. Some of this research is promising. The approach may allow low doses of drugs to be delivered only where they are needed--inflamed tissue in the colon--and thus avoid unwanted systemic effects. The advantage of ginger, say the researchers, is that it's nontoxic, and could represent a very cost-effective source of medicine. The group is looking at ginger, and other plants, as potential "nanofactories for the fabrication of medical nanoparticles." Merlin and his VA and Georgia State University coauthors elaborated on the idea in a report earlier this year titled "Plant-derived edible nanoparticles as a new therapeutic approach against diseases." They wrote that plants are a "bio-renewable, sustainable, diversified platform for the production of therapeutic nanoparticles." ### The ginger nanoparticle work was supported by VA, the National Institutes of Health, and the Crohn's and Colitis Foundation of America. For more information, please click If you have a comment, please us. Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
News Article | October 29, 2015
NEW YORK, Oct 29 Profit-taking drove the dollar down on Thursday as markets pulled back one day after a hawkish statement from the U.S. Federal Reserve that pushed the greenback up sharply against other major currencies. The Fed's hint that it was likely to raise interest rates in December remained supportive of the dollar's long-term future. Still, the euro, British pound and Swiss franc all gained against the greenback with markets consolidating as traders awaited further U.S. economic data. "I think it's just kind of a one-day thing," said Mark McCormick, FX strategist at Credit Agricole CIB, of the dollar's Thursday tumble. "It's really going to matter how the data plays out next week. We've got consumer sentiment, manufacturing PMI and payrolls coming up, so if we get in-line expectations for any of those numbers I think that's going to be good for the dollar." The dollar briefly rallied on Thursday after the release of U.S. gross domestic product figures that fell short of economists' expectations, but those gains were short-lived. After the Fed's statement on Wednesday, the dollar index rose to its highest since early August. The statement put a December rate increase firmly in play and rebutted earlier speculation that China's cooling economy would delay this move. The economy grew 1.5 percent in the third quarter, just missing the 1.6 percent estimate from economists in a Reuters poll. Consumption was strong, with consumer spending up 3.2 percent and advance sales growing by 3 percent. A drawdown in inventories weighed on the overall figure. The dollar index, which measures the greenback against six major currencies, fell throughout the day and was down 0.5 percent at 97.276. The euro rose 0.5 percent to $1.0974, after falling on Wednesday to its lowest since August. The pound picked up 0.38 percent to $1.5317 while the dollar was flat against the Japanese yen at 121.11. China's decision to change its 35-year-old one-baby policy had a short but noticeable impact on the markets, with the currency of dairy exporter New Zealand jolting upward before reversing course and falling 0.1 percent. Win Thin, global head of emerging markets at Brown Brothers Harriman & Co, said he believed the new policy would benefit China and trading partners like New Zealand in the long term since bigger families in China would result in more spending, and therefore more trade. "That (policy decision) will help New Zealand, he said, "but this is going to take decades to have an impact." (Reporting by Dion Rabouin; Editing by Lisa Von Ahn and Diane Craft)